{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:04:13Z","timestamp":1790111053367,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","cysticfibrosisjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cystic Fibrosis"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jcf.2026.04.009","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:19:02Z","timestamp":1777943942000},"page":"836-843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ocular surface and anterior segment changes in cystic fibrosis: evidence of a corneal and conjunctival epithelial phenotype - a case-control study"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-2506","authenticated-orcid":false,"given":"S\u0142awomir","family":"Liberski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3048-7837","authenticated-orcid":false,"given":"Bartosz","family":"Skulimowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5591-5585","authenticated-orcid":false,"given":"Aleksandra","family":"Ka\u0142u\u017cna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Petrovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szczepan","family":"Cofta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7321-1835","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"Koci\u0119cki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcf.2026.04.009_bib0001","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/ame2.12180","article-title":"A review of cystic fibrosis: basic and clinical aspects","volume":"4","author":"Chen","year":"2021","journal-title":"Anim Models Exp Med"},{"key":"10.1016\/j.jcf.2026.04.009_bib0002","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1001\/jama.2023.8120","article-title":"Cystic fibrosis: a review","volume":"329","author":"Ong","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jcf.2026.04.009_bib0003","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00018-016-2393-9","article-title":"Cystic fibrosis: a clinical view","volume":"74","author":"Castellani","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jcf.2026.04.009_bib0004","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.3390\/jcm14113978","article-title":"Cystic Fibrosis transmembrane conductance regulator modulators in Cystic Fibrosis: a review of registry-based evidence","volume":"14","author":"Salvatore","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.jcf.2026.04.009_bib0005","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.3390\/ijms25126692","article-title":"Ocular changes in cystic fibrosis: a review","volume":"25","author":"Liberski","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcf.2026.04.009_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcf.2024.12.009","article-title":"Dry eye disease and morphological changes in the anterior chamber in people with cystic fibrosis","author":"Guti\u00e9rrez","year":"2025","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.jcf.2026.04.009_bib0007","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1007\/s10792-021-01928-5","article-title":"Impact of age, sex and refractive error on conjunctival and Tenon\u2019s capsule thickness: swept-source OCT study","volume":"41","author":"Fern\u00e1ndez-Vigo","year":"2021","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0008","doi-asserted-by":"crossref","unstructured":"Quanjer, P.H., Stanojevic, S., Cole, T.J., Baur, X., Hall, G.L., Culver, B.H., \u2026 & ERS Global Lung Function Initiative. (2012). Multi-ethnic reference values for spirometry for the 3\u201395-yr age range: the global lung function 2012 equations.","DOI":"10.1183\/09031936.00080312"},{"key":"10.1016\/j.jcf.2026.04.009_bib0009","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/sj.eye.6702867","article-title":"Impression cytology of the conjunctival epithelial cells in patients with cystic fibrosis","volume":"22","author":"Mrugacz","year":"2008","journal-title":"Eye"},{"key":"10.1016\/j.jcf.2026.04.009_bib0010","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1167\/iovs.12-11003","article-title":"Bulbar conjunctival thickness measurements with optical coherence tomography in healthy Chinese subjects","volume":"54","author":"Zhang","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jcf.2026.04.009_bib0011","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/aos.16606","article-title":"Assessment of conjunctival, episcleral and scleral thickness in healthy individuals using anterior segment optical coherence tomography","volume":"102","author":"Teeuw","year":"2024","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0012","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1167\/iovs.11-7988","article-title":"Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography","volume":"52","author":"Francoz","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jcf.2026.04.009_bib0013","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajo.2021.02.009","article-title":"Conjunctivochalasis and tear osmolarity are associated with reduced conjunctival epithelial thickness in dry eye","volume":"227","author":"Gumus","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1628469","article-title":"Ocular surface epithelial thickness evaluation in dry eye patients: clinical correlations","volume":"2016","author":"Liang","year":"2016","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0015","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s40135-022-00295-3","article-title":"Ocular surface ion transport and dry eye disease","volume":"10","author":"Lindgren","year":"2022","journal-title":"Curr Ophthalmol Rep"},{"key":"10.1016\/j.jcf.2026.04.009_bib0016","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.3390\/ijms22083954","article-title":"Isorhamnetin ameliorates dry eye disease via CFTR activation in mice","volume":"22","author":"Lee","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcf.2026.04.009_bib0017","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.molmed.2007.05.001","article-title":"Cystic fibrosis: a disease of vulnerability to airway surface dehydration","volume":"13","author":"Boucher","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jcf.2026.04.009_bib0018","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.2147\/OPTH.S480704","article-title":"Corneal epithelial thickness correlation with dry eye symptom severity: a cross-sectional study","volume":"18","author":"Barbosa Ribeiro","year":"2024","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0019","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1128\/IAI.67.3.1481-1492.1999","article-title":"CFTR-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa: role in experimental murine keratitis","volume":"67","author":"Zaidi","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.jcf.2026.04.009_bib0020","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1097\/OPX.0000000000000417","article-title":"Assessment of corneal epithelial thickness in dry eye patients","volume":"91","author":"Cui","year":"2014","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.jcf.2026.04.009_bib0021","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0002-9394(14)73367-7","article-title":"Morphologic and fluorophotometric analysis of the corneal endothelium in type 1 diabetes mellitus and cystic fibrosis","volume":"100","author":"Lass","year":"1985","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0022","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3390\/diagnostics15050643","article-title":"Cornea oculomics: extending corneal diagnostics for systemic health insights","volume":"15","author":"Lee","year":"2025","journal-title":"Diagnostics"},{"key":"10.1016\/j.jcf.2026.04.009_bib0023","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.ajo.2008.01.028","article-title":"The value of keratometry and central corneal thickness in Marfan syndrome","volume":"145","author":"Heur","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0024","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.exer.2010.03.013","article-title":"Chloride channels and transporters in human corneal epithelium","volume":"90","author":"Cao","year":"2010","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jcf.2026.04.009_bib0025","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1096\/fj.201500180","article-title":"Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease","volume":"30","author":"Flores","year":"2016","journal-title":"FASEB J"},{"key":"10.1016\/j.jcf.2026.04.009_bib0026","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3928\/1081597X-20090610-06","article-title":"Corneal epithelial thickness profile in the diagnosis of keratoconus","volume":"25","author":"Reinstein","year":"2009","journal-title":"J Refract Surg"},{"key":"10.1016\/j.jcf.2026.04.009_bib0027","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.3390\/molecules27165324","article-title":"Cystic fibrosis and oxidative stress: the role of CFTR","volume":"27","author":"Moliteo","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jcf.2026.04.009_bib0031","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1167\/iovs.04-1314","article-title":"CFTR-regulated chloride transport at the ocular surface in living mice","volume":"46","author":"Levin","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jcf.2026.04.009_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2024.101299","article-title":"The role of CFTR in the eye and effect of early modulator therapy","volume":"103","author":"Schneider-Futschik","year":"2024","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jcf.2026.04.009_bib0030","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/sj.eye.6700559","article-title":"Biology of the corneal endothelium in health and disease","volume":"17","author":"Bourne","year":"2003","journal-title":"Eye"},{"key":"10.1016\/j.jcf.2026.04.009_bib0032","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/11206721211006577","article-title":"Evaluation of corneal endothelium in obstructive sleep apnea","volume":"32","author":"Songur","year":"2022","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0033","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/crj.13408","article-title":"Evaluation of the corneal endothelium in COPD","volume":"15","author":"Songur","year":"2021","journal-title":"Clin Respir J"},{"issue":"4","key":"10.1016\/j.jcf.2026.04.009_bib0034","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II report executive summary","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"issue":"2","key":"10.1016\/j.jcf.2026.04.009_bib0035","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1177\/11206721211008780","article-title":"Ophthalmologic manifestations of adult patients with cystic fibrosis","volume":"32","author":"Giannakouras","year":"2022","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.jcf.2026.04.009_bib0036","first-page":"90","article-title":"Evaluation of the secretion of the tears in young patients with cystic fibrosis","volume":"107","author":"Mrugacz","year":"2005","journal-title":"Klin Ocz"},{"key":"10.1016\/j.jcf.2026.04.009_bib0037","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/S0161-6420(89)32676-5","article-title":"The ocular surface in cystic fibrosis","volume":"96","author":"Sheppard","year":"1989","journal-title":"Ophthalmology"}],"container-title":["Journal of Cystic Fibrosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199326001025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569199326001025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:06:11Z","timestamp":1790107571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569199326001025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1569199326001025"],"URL":"https:\/\/doi.org\/10.1016\/j.jcf.2026.04.009","relation":{},"ISSN":["1569-1993"],"issn-type":[{"value":"1569-1993","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ocular surface and anterior segment changes in cystic fibrosis: evidence of a corneal and conjunctival epithelial phenotype - a case-control study","name":"articletitle","label":"Article Title"},{"value":"Journal of Cystic Fibrosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcf.2026.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}