{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:13:35Z","timestamp":1792145615385,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":1653,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.jchf.2013.04.004","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T22:30:41Z","timestamp":1375741841000},"page":"308-314","source":"Crossref","is-referenced-by-count":84,"title":["Effect of Amlodipine on the Survival of Patients With Severe Chronic Heart Failure Due to a Nonischemic Cardiomyopathy"],"prefix":"10.1016","volume":"1","author":[{"given":"Milton","family":"Packer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Elkayam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin A.","family":"Konstam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Lucien","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Schocken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"DeMets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2013.04.004_bib1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1161\/01.CIR.82.6.1954","article-title":"A\u00a0prospective randomized, double-blind crossover study to compare the efficacy and safety of chronic nifedipine therapy to isosorbide dinitrate and their combination in the treatment of chronic congestive heart failure","volume":"82","author":"Elkayam","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.04.004_bib2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0735-1097(87)80057-8","article-title":"Chronic renal and neurohormonal effects of the calcium entry blocker nisoldipine in patients with congestive heart failure","volume":"9","author":"Barjon","year":"1987","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.04.004_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/01.CIR.83.1.52","article-title":"Diltiazem increases late-onset congestive heart failure in postinfarction patients with early reduction in ejection fraction","volume":"83","author":"Goldstein","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.04.004_bib4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1136\/hrt.58.2.122","article-title":"Felodipine in patients with chronic heart failure: discrepant hemodynamic and clinical effects","volume":"58","author":"Tan","year":"1987","journal-title":"Br Heart J"},{"key":"10.1016\/j.jchf.2013.04.004_bib5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/hrt.73.5.428","article-title":"Placebo controlled trial of felodipine in patients with mild to moderate heart failure","volume":"73","author":"Littler","year":"1995","journal-title":"Br Heart J"},{"issue":"Suppl IV","key":"10.1016\/j.jchf.2013.04.004_bib6","first-page":"59","article-title":"Pathophysiologic mechanisms underlying the adverse effects of calcium channel blocking drugs in patients with chronic heart failure","volume":"80","author":"Packer","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.04.004_bib7","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/S0735-1097(01)01683-7","article-title":"ACC\/AHA Guidelines for the evaluation and management of chronic heart failure in the adult","volume":"38","author":"Hunt","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.04.004_bib8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0002-8703(00)90095-4","article-title":"Effects of amlodipine on exercise tolerance, quality of life, and left ventricular function in patients with heart failure from left ventricular systolic dysfunction","volume":"139","author":"Udelson","year":"2000","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2013.04.004_bib9","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1056\/NEJM199610103351504","article-title":"Effect of amlodipine on morbidity and mortality in severe chronic heart failure","volume":"335","author":"Packer","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2013.04.004_bib10","doi-asserted-by":"crossref","first-page":"20G","DOI":"10.1016\/0002-9149(88)90027-6","article-title":"Catecholamines, calcium and cardiomyopathy","volume":"62","author":"Sole","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2013.04.004_bib11","first-page":"154","article-title":"Coronary vasodilatory capacity is impaired in patients with dilated cardiomyopathy","volume":"10","author":"Weismuller","year":"1996","journal-title":"Am J Card Imaging"},{"key":"10.1016\/j.jchf.2013.04.004_bib12","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.CIR.65.4.660","article-title":"Hemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man","volume":"65","author":"Packer","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.04.004_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2307\/2336502","article-title":"Discrete sequential boundaries of clinical trials","volume":"70","author":"Lan","year":"1983","journal-title":"Biometrika"},{"key":"10.1016\/j.jchf.2013.04.004_bib14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2307\/2530245","article-title":"A\u00a0multiple testing procedure for clinical trials","volume":"35","author":"O'Brien","year":"1979","journal-title":"Biometrics"},{"key":"10.1016\/j.jchf.2013.04.004_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.jchf.2013.04.004_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J\u00a0R Stat Soc B"},{"key":"10.1016\/j.jchf.2013.04.004_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1056\/NEJM199307153290301","article-title":"Effects of vesnarinone on morbidity and mortality in patients with heart failure","volume":"329","author":"Feldman","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2013.04.004_bib18","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1056\/NEJM199812173392503","article-title":"A\u00a0dose-dependent increase in mortality with vesnarinone among patients with severe heart failure","volume":"339","author":"Cohn","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2013.04.004_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0140-6736(97)01187-2","article-title":"Randomised trial of losartan versus\u00a0captopril in patients over 65 with heart failure (Evaluation of\u00a0Losartan in the Elderly Study, ELITE)","volume":"349","author":"Pitt","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2013.04.004_bib20","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(00)02213-3","article-title":"Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial\u2014the Losartan Heart Failure Survival Study ELITE II","volume":"355","author":"Pitt","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2013.04.004_bib21","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(02)09895-1","article-title":"Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction","volume":"360","author":"Dickstein","year":"2002","journal-title":"Lancet"},{"issue":"Suppl 1","key":"10.1016\/j.jchf.2013.04.004_bib22","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/00005344-200000001-00005","article-title":"Ankle edema formation during treatment with the calcium channel blockers lacidipine and amlodipine: a single-centre study","volume":"35","author":"Andresdottir","year":"2000","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.jchf.2013.04.004_bib23","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1136\/bmj.280.6229.1420","article-title":"Pulmonary oedema precipitated by nifedipine","volume":"280","author":"Gillmer","year":"1980","journal-title":"Br Med J"},{"key":"10.1016\/j.jchf.2013.04.004_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000194763","article-title":"Pulmonary edema with nifedipine in primary pulmonary hypertension","volume":"47","author":"Batra","year":"1985","journal-title":"Respiration"},{"key":"10.1016\/j.jchf.2013.04.004_bib25","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1378\/chest.63.5.843","article-title":"The paradoxical effect of tolazoline hydrochloride on the pulmonary hypertension of mitral stenosis","volume":"63","author":"Yoran","year":"1973","journal-title":"Chest"},{"key":"10.1016\/j.jchf.2013.04.004_bib26","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/0735-1097(94)90859-1","article-title":"Hemodynamic effects of inhaled nitric oxide in heart failure","volume":"24","author":"Semigran","year":"1994","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.04.004_bib27","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.CIR.86.3.896","article-title":"Adenosine infusion for the reversal of pulmonary vasoconstriction in biventricular failure, a good test but a poor therapy","volume":"86","author":"Haywood","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.04.004_bib28","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(01)06178-5","article-title":"Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack","volume":"358","year":"2001","journal-title":"Lancet"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177913001844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177913001844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T02:11:19Z","timestamp":1715825479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177913001844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S2213177913001844"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2013.04.004","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}