{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:34:20Z","timestamp":1791275660440,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":1535,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.jchf.2013.09.008","type":"journal-article","created":{"date-parts":[[2014,1,26]],"date-time":"2014-01-26T00:00:32Z","timestamp":1390694432000},"page":"84-92","source":"Crossref","is-referenced-by-count":141,"title":["Design of a Phase 2b Trial of Intracoronary Administration of AAV1\/SERCA2a in Patients With Advanced Heart Failure"],"prefix":"10.1016","volume":"2","author":[{"given":"Barry","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Yaroshinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina M.","family":"Zsebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Michael","family":"Felker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Rudy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Hajjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2013.09.008_bib1","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/CIRCULATIONAHA.109.192667","article-title":"Heart disease and stroke statistics-2010 update: a report from the American Heart Association","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.09.008_bib2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1161\/CIRCRESAHA.113.300268","article-title":"Epidemiology of heart failure","volume":"113","author":"Roger","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2013.09.008_bib3","series-title":"Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine","first-page":"543","article-title":"Management of heart failure patients with reduced ejection fraction","author":"Mann","year":"2011"},{"key":"10.1016\/j.jchf.2013.09.008_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2010.165","article-title":"Epidemiology and risk profile of heart failure","volume":"8","author":"Bui","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib5","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jacc.2012.12.038","article-title":"Heart failure\u2013associated hospitalizations in the United States","volume":"61","author":"Blecker","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib6","series-title":"Hospitalization for congestive heart failure: United States, 2000\u20132010. NCHS data brief No 108","author":"Hall","year":"2012"},{"key":"10.1016\/j.jchf.2013.09.008_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jacc.2012.09.038","article-title":"Rehospitalization for heart failure: problems and perspectives","volume":"61","author":"Gheorghiade","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jacc.2012.11.027","article-title":"Risk factors for hospital admission among older persons with newly diagnosed heart failure: findings from the Cardiovascular Health Study","volume":"61","author":"Chaudhry","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jacc.2012.03.067","article-title":"Contemporary evidence about hospital strategies for reducing 30-day readmissions: a national study","volume":"60","author":"Bradley","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib10","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jacc.2012.11.057","article-title":"National trends in heart failure hospital stay rates, 2001 to 2009","volume":"61","author":"Chen","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cardfail.2004.02.003","article-title":"Hospitalized heart failure: rates and long-term mortality","volume":"10","author":"Shahar","year":"2004","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2013.09.008_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ahj.2007.01.041","article-title":"Repeated hospitalizations predict mortality in the community population with heart failure","volume":"154","author":"Setoguchi","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2013.09.008_bib13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/HHF.0b013e318291329a","article-title":"Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association","volume":"6","author":"Heidenreich","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2013.09.008_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/CIRCHEARTFAILURE.109.885210","article-title":"Recent national trends in readmission rates after heart failure hospitalization","volume":"3","author":"Ross","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2013.09.008_bib15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10741-011-9256-0","article-title":"The dilemma, causes and approaches to avoid recurrent hospital readmissions for patients with chronic heart failure","volume":"17","author":"Zaya","year":"2012","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jchf.2013.09.008_bib16","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1056\/NEJMsa0803563","article-title":"Rehospitalizations among patients in the Medicare fee-for-service program","volume":"360","author":"Jencks","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2013.09.008_bib17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jama.2012.216476","article-title":"Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia","volume":"309","author":"Dharmarajan","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2013.09.008_bib18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrcardio.2012.145","article-title":"Altered sarcoplasmic reticulum calcium cycling\u2014targets for heart failure therapy","volume":"9","author":"Kho","year":"2012","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib19","doi-asserted-by":"crossref","first-page":"H2356","DOI":"10.1152\/ajpheart.01310.2006","article-title":"Targeted gene transfer increases contractility and decreases oxygen cost of contractility in normal rat hearts","volume":"292","author":"Sakata","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib20","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.yjmcc.2007.01.003","article-title":"Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins","volume":"42","author":"Sakata","year":"2007","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib21","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1073\/pnas.0305778101","article-title":"Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling","volume":"101","author":"del Monte","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jchf.2013.09.008_bib22","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1161\/CIRCULATIONAHA.111.071480","article-title":"Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart","volume":"126","author":"Cutler","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.09.008_bib23","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1161\/CIRCULATIONAHA.108.770883","article-title":"Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion","volume":"118","author":"Prunier","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.09.008_bib24","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/hc3601.095574","article-title":"Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca2+-ATPase in a rat model of heart failure","volume":"104","author":"del Monte","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.09.008_bib25","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCULATIONAHA.111.022889","article-title":"Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure","volume":"124","author":"Jessup","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.09.008_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cardfail.2008.02.005","article-title":"Design of a phase 1\/2 trial of intracoronary administration of AAV1\/SERCA2a in patients with heart failure","volume":"14","author":"Hajjar","year":"2008","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2013.09.008_bib27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cardfail.2009.01.013","article-title":"Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID trial), a first-in-human phase 1\/2 clinical trial","volume":"15","author":"Jaski","year":"2009","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2013.09.008_bib28","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.ehj.2003.07.005","article-title":"N-terminal pro-brain natriuretic peptide. A new gold standard in predicting mortality in patients with advanced heart failure","volume":"24","author":"Gardner","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2013.09.008_bib29","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1161\/01.CIR.0000143059.68996.A7","article-title":"Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial","volume":"110","author":"Hartmann","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.09.008_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/0962280206071926","article-title":"Wei, Lin and Weissfeld's marginal analysis of multivariate failure time data: should it be applied to a recurrent events outcome?","volume":"16","author":"Metcalfe","year":"2007","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.jchf.2013.09.008_bib31","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.jacc.2009.09.021","article-title":"Cardiovascular outcomes in randomized trials: should time to first event for \u201chard\u201d end points remain the standard approach?","volume":"54","author":"Nissen","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2013.09.008_bib32","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/sim.3077","article-title":"The use of Gaussian quadrature for estimation in frailty proportional hazards models","volume":"27","author":"Liu","year":"2008","journal-title":"Statist Med"},{"key":"10.1016\/j.jchf.2013.09.008_bib33","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.mcm.2010.02.002","article-title":"Statistical models for recurrent events and death: Application to cancer events","volume":"52","author":"Rondeau","year":"2010","journal-title":"Math Comput Model"},{"key":"10.1016\/j.jchf.2013.09.008_bib34","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/biostatistics\/kxl043","article-title":"Joint frailty models for recurring events and death using maximum penalized likelihood estimation: application on cancer events","volume":"8","author":"Rondeau","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.jchf.2013.09.008_bib35","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/CIRCULATIONAHA.108.793273","article-title":"Cardiac resynchronization therapy reduces the risk of hospitalizations in patients with advanced heart failure: results from the Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure (COMPANION) trial","volume":"119","author":"Anand","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.09.008_bib36","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2013.09.008_bib37","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1161\/CIRCULATIONAHA.112.110536","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms: analysis of repeat hospitalizations","volume":"126","author":"Rogers","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2013.09.008_bib38","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac resynchronization in chronic heart failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2013.09.008_bib39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/hgtb.2012.243","article-title":"Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy","volume":"24","author":"Louis Jeune","year":"2013","journal-title":"Hum Gene Ther Methods"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177913004186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177913004186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T02:55:01Z","timestamp":1538880901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177913004186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S2213177913004186"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2013.09.008","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}