{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:48:26Z","timestamp":1791326906231,"version":"4.3.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":1293,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"crossref","award":["HHSN268201300025C and HHSN268201300026C"],"award-info":[{"award-number":["HHSN268201300025C and HHSN268201300026C"]}],"id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"crossref","award":["HHSN268201300027C"],"award-info":[{"award-number":["HHSN268201300027C"]}],"id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"crossref","award":["HHSN268201300028C"],"award-info":[{"award-number":["HHSN268201300028C"]}],"id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007241","name":"Kaiser Foundation Research Institute","doi-asserted-by":"crossref","award":["HHSN268201300029C"],"award-info":[{"award-number":["HHSN268201300029C"]}],"id":[{"id":"10.13039\/100007241","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Johns Hopkins University School of Medicine","award":["HHSN268200900041C"],"award-info":[{"award-number":["HHSN268200900041C"]}]},{"name":"Intramural Research Program of the National Institute on Aging (NIA)"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jchf.2014.03.001","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:50:39Z","timestamp":1409896239000},"page":"500-508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Association of Obesity in Early Adulthood\u00a0and Middle Age With Incipient\u00a0Left Ventricular Dysfunction and\u00a0Structural Remodeling"],"prefix":"10.1016","volume":"2","author":[{"given":"Satoru","family":"Kishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson C.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Gidding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Colangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath A.","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Jeffery","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Terry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"David C.","family":"Goff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A.C.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2014.03.001_bib1","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1056\/NEJMoa0807265","article-title":"Racial differences in incident heart failure among young adults","volume":"360","author":"Bibbins-Domingo","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2014.03.001_bib2","first-page":"93","article-title":"Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure","volume":"1","author":"Lavie","year":"2013","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2014.03.001_bib3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jcmg.2009.10.012","article-title":"The impact of obesity on the left ventricle. The Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"3","author":"Turkbey","year":"2010","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jchf.2014.03.001_bib4","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.jacc.2010.10.042","article-title":"Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort","volume":"57","author":"Russo","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2014.03.001_bib5","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1161\/01.CIR.0000147184.13872.0F","article-title":"Alterations of left ventricular myocardial characteristics associated with obesity","volume":"110","author":"Wong","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2014.03.001_bib6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.echo.2010.02.015","article-title":"Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications","volume":"23","author":"Geyer","year":"2010","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jchf.2014.03.001_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.echo.2008.11.023","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography","volume":"22","author":"Nagueh","year":"2009","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jchf.2014.03.001_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/CIRCIMAGING.109.862334","article-title":"Prediction of\u00a0all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring","volume":"2","author":"Stanton","year":"2009","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jchf.2014.03.001_bib9","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: study design, recruitment, and some characteristics of the examined subjects","volume":"41","author":"Friedman","year":"1988","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jchf.2014.03.001_bib10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/00008483-198911000-00003","article-title":"Validity and reliability of short physical activity history: CARDIA and the Minnesota Heart Health Program","volume":"9","author":"Jacobs","year":"1989","journal-title":"J\u00a0Cardiopulm Rehabil Prev"},{"key":"10.1016\/j.jchf.2014.03.001_bib11","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.jchf.2014.03.001_bib12","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nature05487","article-title":"Mechanisms linking obesity with cardiovascular disease","volume":"444","author":"Van Gaal","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jchf.2014.03.001_bib13","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.106.171016","volume":"113","author":"Poirier","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2014.03.001_bib14","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.amjcard.2007.06.040","article-title":"Disparate effects of left ventricular geometry and obesity on mortality in patients with preserved left ventricular ejection fraction","volume":"100","author":"Lavie","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2014.03.001_bib15","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1161\/CIRCULATIONAHA.110.937821","article-title":"Correlates of echocardiographic indices of cardiac remodeling over the adult life course: longitudinal observations from the Framingham Heart Study","volume":"122","author":"Cheng","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2014.03.001_bib16","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1161\/CIRCULATIONAHA.108.824243","article-title":"Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the Framingham Offspring Study","volume":"119","author":"Lieb","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2014.03.001_bib17","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1540-8175.2009.01024.x","article-title":"Effects of isolated obesity on left and right ventricular function: a tissue Doppler and strain rate imaging study","volume":"27","author":"Orhan","year":"2010","journal-title":"Echocardiography"},{"key":"10.1016\/j.jchf.2014.03.001_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00000441-200104000-00003","article-title":"Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome","volume":"321","author":"Alpert","year":"2001","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jchf.2014.03.001_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/01.CIR.96.2.535","article-title":"Noninvasive measurement of shortening in the fiber and cross-fiber directions in the normal human left ventricle and in idiopathic dilated cardiomyopathy","volume":"96","author":"MacGowan","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2014.03.001_bib20","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1161\/CIRCULATIONAHA.112.093146","article-title":"Age, sex, and hypertension-related remodeling influences left ventricular torsion assessed by tagged cardiac magnetic resonance in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis","volume":"126","author":"Yoneyama","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2014.03.001_bib21","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/CIRCULATIONAHA.106.662882","article-title":"Global diastolic strain rate for the assessment of left ventricular relaxation and filling pressures","volume":"115","author":"Wang","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2014.03.001_bib22","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/echo.12164","article-title":"Severe obesity impairs systolic and diastolic heart function - the significance of pulsed tissue Doppler, strain, and strain rate parameters","volume":"30","author":"Wierzbowska-Drabik","year":"2013","journal-title":"Echocardiography"},{"key":"10.1016\/j.jchf.2014.03.001_bib23","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1038\/oby.2011.157","article-title":"Early myocardial deformation changes associated to isolated obesity: a study based on 3D-wall motion tracking analysis","volume":"19","author":"Saltijeral","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jchf.2014.03.001_bib24","unstructured":"World Health Organization. Obesity and overweight. WHO Fact Sheet 2013. Available at: http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/. Accessed March\u00a02013."},{"key":"10.1016\/j.jchf.2014.03.001_bib25","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1161\/CIRCULATIONAHA.107.188965","volume":"117","author":"Schocken","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2014.03.001_bib26","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/CIRCIMAGING.112.000450","article-title":"Longitudinal determinants of left ventricular mass and geometry: the Coronary Artery Risk Development in Young Adults (CARDIA) study","volume":"6","author":"Gidding","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jchf.2014.03.001_bib27","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1093\/eurheartj\/eht133","article-title":"Prognostic value of myocardial circumferential strain for incident heart failure and cardiovascular events in asymptomatic individuals: the Multi-Ethnic Study of Atherosclerosis","volume":"34","author":"Choi","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2014.03.001_bib28","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jacc.2009.04.061","article-title":"Global 2-dimensional strain as a new prognosticator in patients with heart failure","volume":"54","author":"Cho","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2014.03.001_bib29","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jacc.2011.11.013","article-title":"Changes in fitness and fatness on the development of cardiovascular disease risk factors: hypertension, metabolic syndrome, and hypercholesterolemia","volume":"59","author":"Lee","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2014.03.001_bib30","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jacc.2013.01.022","article-title":"Lifetime risk for heart failure among white and black Americans: cardiovascular lifetime risk pooling project","volume":"61","author":"Huffman","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177914000730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177914000730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T23:21:15Z","timestamp":1538263275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177914000730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S2213177914000730"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2014.03.001","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Obesity in Early Adulthood\u00a0and Middle Age With Incipient\u00a0Left Ventricular Dysfunction and\u00a0Structural Remodeling","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2014.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}