{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:56:13Z","timestamp":1790538973674,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":897,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jchf.2015.06.016","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T07:02:22Z","timestamp":1444978942000},"page":"860-869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Inhibition of ADAMTS-13 by Doxycycline Reduces von Willebrand Factor Degradation During Supraphysiological\u00a0Shear\u00a0Stress"],"prefix":"10.1016","volume":"3","author":[{"given":"Carlo R.","family":"Bartoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooeun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Restle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Shabahang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Acker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Atluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2015.06.016_bib1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.healun.2014.04.010","article-title":"Sixth INTERMACS annual report: a 10,000-patient database","volume":"33","author":"Kirklin","year":"2014","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jchf.2015.06.016_bib2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/CIRCHEARTFAILURE.109.877597","article-title":"Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device","volume":"3","author":"Meyer","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2015.06.016_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/MAT.0b013e3181e5de0a","article-title":"Comparative analysis of von Willebrand factor profiles in pulsatile and continuous left ventricular assist device recipients","volume":"56","author":"Crow","year":"2010","journal-title":"ASAIO J"},{"key":"10.1016\/j.jchf.2015.06.016_bib4","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jacc.2010.05.016","article-title":"Acquired von Willebrand syndrome after continuous-flow mechanical device support contributes to a high prevalence of bleeding during long-term support and at the time of transplantation","volume":"56","author":"Uriel","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2015.06.016_bib5","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.jacc.2009.02.048","article-title":"Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II)","volume":"53","author":"Klovaite","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2015.06.016_bib6","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.athoracsur.2010.04.099","article-title":"Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients","volume":"90","author":"Crow","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jchf.2015.06.016_bib7","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejcts.2007.12.047","article-title":"Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease","volume":"33","author":"Geisen","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jchf.2015.06.016_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jtcvs.2014.09.031","article-title":"Pathologic von Willebrand factor degradation with a left ventricular assist device occurs\u00a0via two distinct mechanisms: mechanical demolition and enzymatic cleavage","volume":"149","author":"Bartoli","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jchf.2015.06.016_bib9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/clc.22096","article-title":"Left ventricular assist devices and gastrointestinal bleeding: a narrative review of case reports and case series","volume":"36","author":"Islam","year":"2013","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jchf.2015.06.016_bib10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.biochem.67.1.395","article-title":"Biochemistry and genetics of von Willebrand factor","volume":"67","author":"Sadler","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jchf.2015.06.016_bib11","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1126\/science.1170905","article-title":"Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor","volume":"324","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jchf.2015.06.016_bib12","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1182\/blood.V83.8.2171.2171","article-title":"Shear stress enhances the proteolysis of von Willebrand factor in normal plasma","volume":"83","author":"Tsai","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2015.06.016_bib13","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1182\/blood.V89.6.1954","article-title":"Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: inhibition by doxycycline and by monoclonal antibody VP-1","volume":"89","author":"Tsai","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2015.06.016_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1182\/blood-2003-08-2861","article-title":"VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for\u00a0ADAMTS-13","volume":"103","author":"Kokame","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2015.06.016_bib15","unstructured":"ACTIFLUOR ADAMTS-13 activity assay. Stamford, CT: American Diagnostica."},{"key":"10.1016\/j.jchf.2015.06.016_bib16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/aor.12428","article-title":"Preclinical models for translational investigations of LVAD-associated von Willebrand factor degradation","volume":"39","author":"Restle","year":"2014","journal-title":"Artif Organs"},{"key":"10.1016\/j.jchf.2015.06.016_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0079-6107(02)00052-4","article-title":"Fluid shear stress and the vascular endothelium: for better and for worse","volume":"81","author":"Resnick","year":"2003","journal-title":"Progress in biophysics and molecular biology"},{"key":"10.1016\/j.jchf.2015.06.016_bib18","doi-asserted-by":"crossref","first-page":"081002","DOI":"10.1115\/1.4007092","article-title":"A\u00a0quantitative comparison of mechanical blood damage parameters in rotary ventricular assist devices: shear stress, exposure time and hemolysis index","volume":"134","author":"Fraser","year":"2012","journal-title":"J\u00a0Biomech Eng"},{"key":"10.1016\/j.jchf.2015.06.016_bib19","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.jtcvs.2013.08.043","article-title":"Insights into the mechanism(s) of von Willebrand factor degradation during mechanical circulatory support","volume":"147","author":"Bartoli","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jchf.2015.06.016_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/MAT.0b013e318283815c","article-title":"Mechanistic pathway(s) of acquired von Willebrand syndrome with a continuous-flow ventricular assist device: in\u00a0vitro findings","volume":"59","author":"Dassanayaka","year":"2013","journal-title":"ASAIO J"},{"key":"10.1016\/j.jchf.2015.06.016_bib21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.taap.2010.07.013","article-title":"Exposure to acrolein by inhalation causes platelet activation","volume":"248","author":"Sithu","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jchf.2015.06.016_bib22","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1172\/JCI115376","article-title":"Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit","volume":"88","author":"Dent","year":"1991","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jchf.2015.06.016_bib23","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1182\/blood-2009-07-231597","article-title":"Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage","volume":"114","author":"Turner","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2015.06.016_bib24","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1182\/blood-2011-02-306597","article-title":"Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor","volume":"118","author":"Crawley","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2015.06.016_bib25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis","volume":"349","author":"Vincentelli","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2015.06.016_bib26","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1160\/TH09-07-0497","article-title":"Acquired von Willebrand syndrome in patients with ventricular assist device or total artificial heart","volume":"103","author":"Heilmann","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jchf.2015.06.016_bib27","first-page":"1328","article-title":"Acquired von Willebrand syndrome is an early-onset problem in ventricular assist device patients","volume":"40","author":"Heilmann","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jchf.2015.06.016_bib28","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood-2004-06-2096","article-title":"Fatal congenital thrombotic thrombocytopenic purpura with apparent ADAMTS13 inhibitor: in\u00a0vitro inhibition of ADAMTS13 activity by hemoglobin","volume":"105","author":"Studt","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2015.06.016_bib29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1182\/blood-2004-01-0107","article-title":"Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow","volume":"104","author":"Bernardo","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2015.06.016_bib30","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1160\/th14-02-0148","article-title":"Antibody-based prevention of von Willebrand factor degradation mediated by circulatory assist devices","volume":"112","author":"Rauch","year":"2014","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jchf.2015.06.016_bib31","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.phrs.2011.05.005","article-title":"Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases","volume":"64","author":"Castro","year":"2011","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jchf.2015.06.016_bib32","first-page":"1407","article-title":"Doxycycline and minocycline for the management of acne: a review of efficacy and safety with emphasis on clinical implications","volume":"9","author":"Kircik","year":"2010","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.jchf.2015.06.016_bib33","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/CIRCULATIONAHA.112.128132","article-title":"Prospective, multicenter study of ventricular assist device infections","volume":"127","author":"Gordon","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2015.06.016_bib34","first-page":"471","article-title":"Safety and efficacy review of doxycycline","volume":"1","author":"Holmes","year":"2009","journal-title":"Clin Med Ther"},{"key":"10.1016\/j.jchf.2015.06.016_bib35","series-title":"Material safety data sheet: doxycycline hyclate. Version 4.0","year":"2008"},{"key":"10.1016\/j.jchf.2015.06.016_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1313385","article-title":"Unexpected abrupt increase in left ventricular assist device thrombosis","volume":"370","author":"Starling","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2015.06.016_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/jocs.12238","article-title":"Diagnosis, nonsurgical management, and prevention of LVAD thrombosis","volume":"29","author":"Bartoli","year":"2014","journal-title":"J\u00a0Card Surg"},{"key":"10.1016\/j.jchf.2015.06.016_bib38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jtcvs.2003.11.059","article-title":"Platelet activation and aggregation profile in prolonged external ventricular support","volume":"128","author":"Houel","year":"2004","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jchf.2015.06.016_bib39","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1525-1594.2005.29050.x","article-title":"Platelet activation markers in patients with heart assist device","volume":"29","author":"Dewald","year":"2005","journal-title":"Artif Organs"},{"key":"10.1016\/j.jchf.2015.06.016_bib40","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1016\/j.biomaterials.2004.01.023","article-title":"Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes","volume":"25","author":"Gorbet","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jchf.2015.06.016_bib41","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00002480-200005000-00022","article-title":"Anticoagulation during use of a left ventricular assist device","volume":"46","author":"Takahama","year":"2000","journal-title":"ASAIO J"},{"key":"10.1016\/j.jchf.2015.06.016_bib42","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.athoracsur.2009.06.095","article-title":"Activation of endothelial and coagulation systems in left ventricular assist device recipients","volume":"88","author":"John","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jchf.2015.06.016_bib43","doi-asserted-by":"crossref","first-page":"E89","DOI":"10.1111\/j.1525-1594.2011.01416.x","article-title":"Computational fluid dynamics analysis to determine shear stresses and rates in a centrifugal left ventricular assist device","volume":"36","author":"Selgrade","year":"2012","journal-title":"Artif Organs"},{"key":"10.1016\/j.jchf.2015.06.016_bib44","doi-asserted-by":"crossref","first-page":"111005","DOI":"10.1115\/1.3212114","article-title":"Numerical study of blood flow at the end-to-side anastomosis of a left ventricular assist device for adult patients","volume":"131","author":"Yang","year":"2009","journal-title":"J\u00a0Biomech Eng"},{"key":"10.1016\/j.jchf.2015.06.016_bib45","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/CIRCHEARTFAILURE.112.000206","article-title":"Pulsatility and the risk of nonsurgical bleeding in patients supported with the continuous-flow left ventricular assist device HeartMate II","volume":"6","author":"Wever-Pinzon","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2015.06.016_bib46","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1016\/j.healun.2012.01.242","article-title":"Thrombus within the HeartMate II left ventricular assist device (LVAD): are all clots created equal?","volume":"31","author":"Ledford","year":"2012","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jchf.2015.06.016_bib47","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/MAT.0b013e3181b235af","article-title":"Increased leukocyte-platelet interactions during circulatory support with left ventricular assist devices","volume":"55","author":"Radovancevic","year":"2009","journal-title":"ASAIO J"},{"key":"10.1016\/j.jchf.2015.06.016_bib48","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1510\/icvts.2010.232603","article-title":"Enhanced microparticles in ventricular assist device patients predict platelet, leukocyte and endothelial cell activation","volume":"11","author":"Diehl","year":"2010","journal-title":"Interactive cardiovascular and thoracic surgery"},{"key":"10.1016\/j.jchf.2015.06.016_bib49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-0031-1300951","article-title":"Thrombotic microangiopathies, thrombotic thrombocytopenic purpura, and ADAMTS-13","volume":"38","author":"Chapman","year":"2012","journal-title":"Semin Thromb Hemost"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177915004795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177915004795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T01:38:30Z","timestamp":1620092310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177915004795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S2213177915004795"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2015.06.016","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of ADAMTS-13 by Doxycycline Reduces von Willebrand Factor Degradation During Supraphysiological\u00a0Shear\u00a0Stress","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2015.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}