{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:08:14Z","timestamp":1768777694201,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":526,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jchf.2016.06.003","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T10:18:52Z","timestamp":1470910732000},"page":"726-735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Rationale and Design of the ATHENA-HF Trial"],"prefix":"10.1016","volume":"4","author":[{"given":"Javed","family":"Butler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian F.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Anstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kalogeropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"Redfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin A.","family":"Konstam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.H. Wilson","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Michael","family":"Felker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica R.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Braunwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2016.06.003_bib1","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/CIRCULATIONAHA.109.192667","article-title":"Heart disease and stroke statistics\u20132010 update: a report from the American Heart Association","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2016.06.003_bib2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCULATIONAHA.108.191259","article-title":"Heart disease and stroke statistics\u20132009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"119","author":"Lloyd-Jones","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2016.06.003_bib3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cardfail.2004.02.011","article-title":"Risk stratification after hospitalization for decompensated heart failure","volume":"10","author":"Felker","year":"2004","journal-title":"J\u00a0Cardiac Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib4","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa0912613","article-title":"Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure","volume":"363","author":"Massie","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2016.06.003_bib5","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0002-9149(97)00214-2","article-title":"Correlates of early hospital readmission or death in patients with congestive heart failure","volume":"79","author":"Chin","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2016.06.003_bib6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cardfail.2006.10.002","article-title":"Prediction of rehospitalization and death in severe heart failure by physicians and nurses of the ESCAPE trial","volume":"13","author":"Yamokoski","year":"2007","journal-title":"J\u00a0Cardiac Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/CIRCOUTCOMES.109.883256","article-title":"Patterns of hospital performance in acute myocardial infarction and heart failure 30-day mortality and readmission","volume":"2","author":"Krumholz","year":"2009","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jchf.2016.06.003_bib8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/CIRCHEARTFAILURE.109.893222","article-title":"Clinical trials of pharmacological therapies in acute heart failure syndromes: lessons learned and directions forward","volume":"3","author":"Felker","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrcardio.2012.181","article-title":"The disconnect between phase II and phase III trials of drugs for heart failure","volume":"10","author":"Vaduganathan","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jchf.2016.06.003_bib10","doi-asserted-by":"crossref","first-page":"B13","DOI":"10.1093\/eurheartj\/sui008","article-title":"Reassessing treatment of acute heart failure syndromes: the ADHERE Registry","volume":"7","author":"Gheorghiade","year":"2005","journal-title":"Eur Heart J Suppl"},{"key":"10.1016\/j.jchf.2016.06.003_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jacc.2012.09.038","article-title":"Rehospitalization for heart failure: problems and perspectives","volume":"61","author":"Gheorghiade","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2016.06.003_bib12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/eurheartj\/ehs444","article-title":"Clinical course and predictive value of congestion during hospitalization in patients admitted for worsening signs and symptoms of heart failure with reduced ejection fraction: findings from the EVEREST trial","volume":"34","author":"Ambrosy","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2016.06.003_bib13","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1161\/CIRCHEARTFAILURE.114.001957","volume":"8","author":"Lala","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ijcard.2009.08.001","article-title":"BNP at discharge in acute heart failure patients: is it all about volemia? A study using impedance cardiography to assess fluid and hemodynamic status","volume":"145","author":"Pimenta","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2016.06.003_bib15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/CIRCHEARTFAILURE.108.769778","article-title":"Value of clinician assessment of hemodynamics in advanced heart failure: the ESCAPE trial","volume":"1","author":"Drazner","year":"2008","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib16","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/eurjhf\/hft100","article-title":"Serum aldosterone is associated with mortality and re-hospitalization in patients with reduced ejection fraction hospitalized for acute heart failure: analysis from the EVEREST trial","volume":"15","author":"Girerd","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib17","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1681\/ASN.V1271335","article-title":"Loop diuretic infusion increases thiazide-sensitive Na(+)\/Cl(-)-cotransporter abundance: role of aldosterone","volume":"12","author":"Abdallah","year":"2001","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jchf.2016.06.003_bib18","first-page":"97","article-title":"Decongestion strategies and renin-angiotensin-aldosterone system activation in acute heart failure","volume":"3","author":"Mentz","year":"2015","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2016.06.003_bib19","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/CIRCHEARTFAILURE.108.821199","article-title":"Sodium retention in heart failure and cirrhosis: potential role of natriuretic doses of mineralocorticoid antagonist?","volume":"2","author":"Bansal","year":"2009","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib20","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0002-9149(96)00465-1","article-title":"Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (the Randomized Aldactone Evaluation Study [RALES])","volume":"78","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2016.06.003_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000168356","article-title":"Aldosterone in congestive heart failure: analysis of determinants and role in sodium retention","volume":"11","author":"Hensen","year":"1991","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.jchf.2016.06.003_bib22","doi-asserted-by":"crossref","first-page":"21a","DOI":"10.1016\/0002-9149(93)90241-4","article-title":"Spironolactone in congestive heart failure refractory to high-dose loop diuretic and low-dose angiotensin-converting enzyme inhibitor","volume":"71","author":"van Vliet","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2016.06.003_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejim.2013.08.711","article-title":"Mineralocorticoid receptor antagonism in acutely decompensated chronic heart failure","volume":"25","author":"Ferreira","year":"2014","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jchf.2016.06.003_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cardfail.2014.01.017","article-title":"Utilization pattern of mineralocorticoid receptor antagonists in contemporary patients hospitalized with acute decompensated heart failure: a single-center experience","volume":"20","author":"Chamsi-Pasha","year":"2014","journal-title":"J\u00a0Cardiac Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11897-012-0120-x","article-title":"Mineralocorticoid receptor antagonism confers cardioprotection in heart failure","volume":"10","author":"Seawell","year":"2013","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.jchf.2016.06.003_bib26","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.mce.2011.06.025","article-title":"Molecular pharmacology of the mineralocorticoid receptor: prospects for novel therapeutics","volume":"350","author":"Kolkhof","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jchf.2016.06.003_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10741-005-2345-1","article-title":"Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis","volume":"10","author":"Sica","year":"2005","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jchf.2016.06.003_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000346447","article-title":"Increased spironolactone in advanced heart failure: effect of doses greater than 25 mg\/day on plasma potassium concentration","volume":"3","author":"Shchekochikhin","year":"2013","journal-title":"Cardiorenal Med"},{"key":"10.1016\/j.jchf.2016.06.003_bib29","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1161\/01.CIR.0000144310.04433.BE","article-title":"N-terminal-pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients","volume":"110","author":"Bettencourt","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2016.06.003_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1388-9842(03)00098-9","article-title":"Pre-discharge, but not admission, levels of NT-proBNP predict adverse prognosis following acute LVF","volume":"5","author":"O'Brien","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/eurjhf\/hfs188","article-title":"Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF","volume":"15","author":"Mentz","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib32","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/eurheartj\/eht497","article-title":"Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial","volume":"35","author":"Filippatos","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2016.06.003_bib33","first-page":"103","article-title":"Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure","volume":"1","author":"Packer","year":"2013","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2016.06.003_bib34","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/jama.297.12.1319","article-title":"Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial","volume":"297","author":"Konstam","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2016.06.003_bib35","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1001\/jama.2011.1474","article-title":"National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998-2008","volume":"306","author":"Chen","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2016.06.003_bib36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/CIR.0000000000000366","article-title":"Executive Summary: Heart Disease and Stroke Statistics\u20132016 Update: A Report From the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2016.06.003_bib37","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/ejhf.333","article-title":"In-hospital worsening heart failure","volume":"17","author":"Butler","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2016.06.003_bib38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1472-8206.2009.00697.x","article-title":"Early worsening heart failure in patients admitted with acute heart failure\u2013a new outcome measure associated with long-term prognosis?","volume":"23","author":"Weatherley","year":"2009","journal-title":"Fundament Clin Pharmacol"},{"key":"10.1016\/j.jchf.2016.06.003_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ahj.2004.08.005","article-title":"Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)","volume":"149","author":"Adams","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2016.06.003_bib40","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijcard.2007.06.007","article-title":"Transient worsening of renal function during hospitalization for acute heart failure alters outcome","volume":"127","author":"Logeart","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2016.06.003_bib41","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1056\/NEJMoa1210357","article-title":"Ultrafiltration in decompensated heart failure with cardiorenal syndrome","volume":"367","author":"Bart","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2016.06.003_bib42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/096228029900800102","article-title":"Multiple imputation: a primer","volume":"8","author":"Schafer","year":"1999","journal-title":"Stat Methods Medical Res"},{"key":"10.1016\/j.jchf.2016.06.003_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/CIRCULATIONAHA.114.013255","article-title":"Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial","volume":"131","author":"Pfeffer","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2016.06.003_bib44","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ejhf.218","article-title":"Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and\/or chronic kidney disease","volume":"17","author":"Pitt","year":"2015","journal-title":"Eur J Heart Fail"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221317791630289X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221317791630289X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T20:09:23Z","timestamp":1657051763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221317791630289X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S221317791630289X"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2016.06.003","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale and Design of the ATHENA-HF Trial","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2016.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American College of Cardiology Foundation. Published by Elsevier","name":"copyright","label":"Copyright"}]}}