{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:47:20Z","timestamp":1791384440360,"version":"4.3.3"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.jchf.2018.03.017","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T18:02:19Z","timestamp":1529949739000},"page":"596-604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure"],"prefix":"10.1016","volume":"6","author":[{"given":"Oriana","family":"Ciani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Piepoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Smart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona C.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann D.","family":"Zwisler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos H.","family":"Davos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2018.03.017_bib1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2018.03.017_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","volume":"70","author":"Yancy","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2018.03.017_bib3","first-page":"919","article-title":"The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure","volume":"132","author":"Guyatt","year":"1985","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.jchf.2018.03.017_bib4","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.jacc.2016.09.936","article-title":"Natriuretic peptides 6-min walk test, and quality-of-life questionnaires as clinically meaningful endpoints in HF trials","volume":"68","author":"Ferreira","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2018.03.017_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jval.2016.10.011","article-title":"Time to review the role of surrogate end points in health policy: state of the art and the way forward","volume":"20","author":"Ciani","year":"2017","journal-title":"Value Health"},{"key":"10.1016\/j.jchf.2018.03.017_bib6","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1161\/CIRCULATIONAHA.110.948349","article-title":"Exercise and physical activity: clinical outcomes and applications","volume":"122","author":"Kokkinos","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2018.03.017_bib7","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015: elaboration and explanation","volume":"349","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.jchf.2018.03.017_bib8","doi-asserted-by":"crossref","first-page":"e000163","DOI":"10.1136\/openhrt-2014-000163","article-title":"Exercise-based rehabilitation for heart failure: systematic review and meta-analysis","volume":"2","author":"Sagar","year":"2015","journal-title":"Open Heart"},{"key":"10.1016\/j.jchf.2018.03.017_bib9","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Higgins J, Green S, editors: The Cochrane Collaboration; 2011. Available at: http:\/\/handbook-5-1.cochrane.org\/. Accessed February 1, 2017."},{"key":"10.1016\/j.jchf.2018.03.017_bib10","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.jchf.2018.03.017_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0266462314000300","article-title":"Validation of surrogate endpoints in advanced solid tumours: systematic review of statistical methods, results, and implications for policy makers","volume":"30","author":"Ciani","year":"2014","journal-title":"Int J Technol Assess Health Care"},{"key":"10.1016\/j.jchf.2018.03.017_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/pst.207","article-title":"Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation","volume":"5","author":"Burzykowski","year":"2006","journal-title":"Pharm Stat"},{"key":"10.1016\/j.jchf.2018.03.017_bib13","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.2009.454","article-title":"Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial","volume":"301","author":"O'Connor","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2018.03.017_bib14","doi-asserted-by":"crossref","first-page":"e0159267","DOI":"10.1371\/journal.pone.0159267","article-title":"Empirical evidence of study design biases in randomized trials: systematic review of meta-epidemiological studies","volume":"11","author":"Page","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jchf.2018.03.017_bib15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/bmj.39465.451748.AD","article-title":"Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study","volume":"336","author":"Wood","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jchf.2018.03.017_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jpsychores.2010.01.013","article-title":"Combined exercise and cognitive behavioral therapy improves outcomes in patients with heart failure","volume":"69","author":"Gary","year":"2010","journal-title":"J\u00a0Psychosom Res"},{"key":"10.1016\/j.jchf.2018.03.017_bib17","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0002-8703(92)90986-6","article-title":"Assessment of patient outcome with the Minnesota Living with Heart Failure questionnaire: reliability and validity during a randomized, double-blind, placebo-controlled trial of pimobendan. Pimobendan Multicenter Research Group","volume":"124","author":"Rector","year":"1992","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2018.03.017_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/01823246-201223040-00004","article-title":"Effects of exercise training versus attention on plasma B-type natriuretic peptide, 6-minute walk test and quality of life in individuals with heart failure","volume":"23","author":"Norman","year":"2012","journal-title":"Cardiopulm Phys Ther J"},{"key":"10.1016\/j.jchf.2018.03.017_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejheart.2005.05.002","article-title":"The effect of physical training in chronic heart failure","volume":"8","author":"Jonsdottir","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2018.03.017_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ijcard.2009.09.478","article-title":"Impact of home-based, supervised exercise on congestive heart failure","volume":"145","author":"Wall","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2018.03.017_bib21","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.amjcard.2005.01.031","article-title":"Effect of a seated exercise program to improve physical function and health status in frail patients > or\u00a0= 70 years of age with heart failure","volume":"95","author":"Witham","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2018.03.017_bib22","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.CIR.0000081780.38477.FA","article-title":"Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure: results of the Exercise in Left Ventricular Dysfunction and Chronic Heart Failure (ELVD-CHF) Trial","volume":"108","author":"Giannuzzi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2018.03.017_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0167-5273(00)00383-1","article-title":"Effects on quality of life, symptoms and daily activity 6 months after termination of an exercise training programme in heart failure patients","volume":"77","author":"Willenheimer","year":"2001","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2018.03.017_bib24","doi-asserted-by":"crossref","first-page":"f457","DOI":"10.1136\/bmj.f457","article-title":"Comparison of treatment effect sizes associated with surrogate and final patient relevant outcomes in randomised controlled trials: meta-epidemiological study","volume":"346","author":"Ciani","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.jchf.2018.03.017_bib25","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/CIRCHEARTFAILURE.111.965186","article-title":"Modest increase in peak VO2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training","volume":"5","author":"Swank","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2018.03.017_bib26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nrclinonc.2010.43","article-title":"Biomarkers and surrogate end points\u2014the challenge of statistical validation","volume":"7","author":"Buyse","year":"2010","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jchf.2018.03.017_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/XEB.0000000000000020","article-title":"Validation of a new tool for the assessment of study quality and reporting in exercise training studies: TESTEX","volume":"13","author":"Smart","year":"2015","journal-title":"Int J Evid Based Healthc"},{"key":"10.1016\/j.jchf.2018.03.017_bib28","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1111\/jgs.14867","article-title":"Response to endurance exercise training in older adults with heart failure with preserved or reduced ejection fraction","volume":"65","author":"Pandey","year":"2017","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jchf.2018.03.017_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1249\/MSS.0b013e3181896c4e","article-title":"Volume of exercise and fitness non-response in sedentary, post-menopausal women","volume":"41","author":"Sisson","year":"2009","journal-title":"Med Sci Sports Exerc"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177918302324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177918302324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T17:29:42Z","timestamp":1717349382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177918302324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S2213177918302324"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2018.03.017","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2018.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}