{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:07:15Z","timestamp":1790482035814,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.jchf.2019.03.011","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T13:59:52Z","timestamp":1558965592000},"page":"505-515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":204,"title":["Sex-Based Differences in Heart\u00a0Failure Across the Ejection Fraction Spectrum"],"prefix":"10.1016","volume":"7","author":[{"given":"Davide","family":"Stolfo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Uijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Vedin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Str\u00f6mberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika Ljung","family":"Fax\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe M.C.","family":"Rosano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Dahlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Savarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2019.03.011_bib1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","volume":"70","author":"Yancy","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.011_bib2","first-page":"1","article-title":"Heart failure","volume":"1","author":"Braunwald","year":"2013","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2019.03.011_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jacc.2009.02.066","article-title":"Heart failure in women: a need for prospective data","volume":"54","author":"Hsich","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.011_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jacc.2018.09.081","article-title":"Differential impact of heart failure with reduced ejection fraction on men and women","volume":"73","author":"Dewan","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.011_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/eurjhf\/hfp175","article-title":"Heart failure registry: a valuable tool for improving the management of patients with\u00a0heart failure","volume":"12","author":"Jonsson","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.03.011_bib6","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.ahj.2009.07.012","article-title":"Baseline differences in the HF-ACTION trial by sex","volume":"158","author":"Pina","year":"2009","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2019.03.011_bib7","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/CIRCULATIONAHA.105.541078","article-title":"Age\u2013 and gender-related ventricular-vascular stiffening: a community-based study","volume":"112","author":"Redfield","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.011_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/heartjnl-2015-308852","article-title":"Microvascular endothelial dysfunction in heart failure with preserved ejection fraction","volume":"102","author":"Lam","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.jchf.2019.03.011_bib9","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1093\/eurheartj\/ehy626","article-title":"Prognostic implications of atrial fibrillation in heart failure with reduced, mid-range, and preserved ejection fraction: a report from 14,964 patients in the European Society of Cardiology Heart\u00a0Failure Long-Term Registry","volume":"39","author":"Zafrir","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.03.011_bib10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/CIRCULATIONAHA.118.034271","article-title":"Sex differences in cardiovascular pathophysiology: why women are overrepresented in heart failure with preserved ejection fraction","volume":"138","author":"Beale","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.011_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jacc.2018.10.041","article-title":"Women with heart failure: unheard, untreated, and unstudied","volume":"73","author":"Walsh","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.011_bib12","first-page":"1485","article-title":"Increasing sex differences in the use of cardiac resynchronization therapy with or without implantable cardioverter-defibrillator","volume":"38","author":"Chatterjee","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.03.011_bib13","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/jamainternmed.2014.2717","article-title":"Cardiac resynchronization therapy in women: US Food and Drug Administration meta-analysis of patient-level data","volume":"174","author":"Zusterzeel","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jchf.2019.03.011_bib14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ejhf.496","article-title":"Use of evidence-based therapy and survival in heart failure in Sweden 2003-2012","volume":"18","author":"Thorvaldsen","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.03.011_bib15","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/ejhf.929","article-title":"Effect of expanding evidence and evolving clinical guidelines on the prevalence of indication for cardiac resynchronization therapy in patients with heart failure","volume":"20","author":"Lund","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.03.011_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0735-1097(92)90094-4","article-title":"Prevalence and mortality rate of congestive heart failure in the United States","volume":"20","author":"Schocken","year":"1992","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.011_bib17","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/01.CIR.0000012546.20194.33","article-title":"Metoprolol CR\/XL in female patients with heart failure: analysis of the experience in Metoprolol Extended-Release Randomized Intervention Trial in Heart\u00a0Failure (MERIT-HF)","volume":"105","author":"Ghali","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.011_bib18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/01.CIR.103.3.375","article-title":"Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II)","volume":"103","author":"Simon","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.011_bib19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/eurjhf\/hfs026","article-title":"Gender and survival in patients with heart failure: interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis","volume":"14","author":"Martinez-Selles","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.03.011_bib20","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1161\/CIRCULATIONAHA.106.673442","article-title":"Sex differences in clinical characteristics and prognosis in a broad spectrum of patients with heart failure: results of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program","volume":"115","author":"O'Meara","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.011_bib21","doi-asserted-by":"crossref","first-page":"14A","DOI":"10.1016\/0735-1097(93)90456-B","article-title":"Natural history and patterns of current practice in heart failure. The Studies of Left Ventricular Dysfunction (SOLVD) Investigators","volume":"22","author":"Bourassa","year":"1993","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.011_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/ehjcvp\/pvw042","article-title":"Gender differences in the effects of cardiovascular drugs","volume":"3","author":"Tamargo","year":"2017","journal-title":"Eur Heart J Cardiovascular pharmacotherapy"},{"key":"10.1016\/j.jchf.2019.03.011_bib23","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.jacc.2003.05.012","article-title":"Gender differences in advanced heart failure: insights from the BEST study","volume":"42","author":"Ghali","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.011_bib24","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/ejhf.807","article-title":"Characterization of heart failure patients with mid-range left ventricular ejection fraction-a report from the CHART-2 study","volume":"19","author":"Tsuji","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.03.011_bib25","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.jacc.2009.09.065","article-title":"Sex-related differences in myocardial remodeling","volume":"55","author":"Piro","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.011_bib26","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/ejhf.762","article-title":"Association between enrolment in a heart failure quality registry and subsequent mortality-a nationwide cohort study","volume":"19","author":"Lund","year":"2017","journal-title":"Eur J Heart Fail"}],"updated-by":[{"DOI":"10.1016\/j.jchf.2020.02.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000}}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177919302318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177919302318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:51:03Z","timestamp":1761972663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177919302318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S2213177919302318"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2019.03.011","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-Based Differences in Heart\u00a0Failure Across the Ejection Fraction Spectrum","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2019.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}