{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:42:17Z","timestamp":1789058537756,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL128526"],"award-info":[{"award-number":["R01 HL128526"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U10 HL110262"],"award-info":[{"award-number":["U10 HL110262"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["61\/798,382"],"award-info":[{"award-number":["61\/798,382"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL 126638"],"award-info":[{"award-number":["R01 HL 126638"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL125205"],"award-info":[{"award-number":["U01 HL125205"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jchf.2019.03.021","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T18:28:09Z","timestamp":1561400889000},"page":"574-585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":162,"title":["The Role of the Pericardium in Heart\u00a0Failure"],"prefix":"10.1016","volume":"7","author":[{"given":"Barry A.","family":"Borlaug","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh N.V.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2019.03.021_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.RES.42.3.433","article-title":"The pericardium substantially affects the left ventricular diastolic pressure-volume relationship in the dog","volume":"42","author":"Glantz","year":"1978","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2019.03.021_bib2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.CIR.57.6.1191","article-title":"Alteration of the left ventricular diastolic pressure-segment length relation produced by the pericardium. Effects of cardiac distension and afterload reduction in conscious dogs","volume":"57","author":"Shirato","year":"1978","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.CIR.71.1.158","article-title":"Assessment of pericardial constraint in dogs","volume":"71","author":"Smiseth","year":"1985","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.RES.58.4.523","article-title":"The effect of pericardiectomy on maximal oxygen consumption and maximal cardiac output in untrained dogs","volume":"58","author":"Stray-Gundersen","year":"1986","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2019.03.021_bib5","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/jappl.1987.63.3.1025","article-title":"Influence of the pericardium on right and left ventricular filling in the dog","volume":"63","author":"Assanelli","year":"1987","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib6","first-page":"H1079","article-title":"External pressure of undisturbed left\u00a0ventricle","volume":"258","author":"Applegate","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib7","first-page":"H1675","article-title":"Heart size and maximal cardiac output are limited by the pericardium","volume":"263","author":"Hammond","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib8","first-page":"H1725","article-title":"Restraining effect of intact pericardium during acute volume loading","volume":"262","author":"Applegate","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib9","first-page":"H494","article-title":"The pericardium and ventricular interaction, distensibility, and function","volume":"238","author":"Janicki","year":"1980","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib10","doi-asserted-by":"crossref","first-page":"H2385","DOI":"10.1152\/ajpheart.2001.281.6.H2385","article-title":"Ventricular interaction and external constraint account for decreased stroke work during volume loading in CHF","volume":"281","author":"Moore","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.7326\/0003-4819-122-10-199505150-00001","article-title":"Contribution of external forces to left ventricular diastolic pressure. Implications for the clinical use of the Starling law","volume":"122","author":"Dauterman","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jchf.2019.03.021_bib12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/01.CIR.73.3.428","article-title":"The relationship between pericardial pressure and right atrial pressure: an intraoperative study","volume":"73","author":"Tyberg","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0735-1097(86)80496-X","article-title":"Assessment of pericardial constraint: the relation between right ventricular filling pressure and pericardial pressure measured after pericardiocentesis","volume":"7","author":"Smiseth","year":"1986","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib14","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1161\/01.CIR.64.5.997","article-title":"Ventricular diastolic pressure-volume relations and the pericardium. Effects of changes in blood volume and pericardial effusion in dogs","volume":"64","author":"Refsum","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0002-8703(84)90430-7","article-title":"Pericardial pressure assessed by right atrial pressure: a basis for calculation of left ventricular transmural pressure","volume":"108","author":"Smiseth","year":"1984","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2019.03.021_bib16","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/0002-9149(81)90556-7","article-title":"Contractile mechanics and interaction of the right and left ventricles","volume":"47","author":"Weber","year":"1981","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/01.RES.54.3.294","article-title":"Pericardial adaptations during chronic cardiac dilation in dogs","volume":"54","author":"Freeman","year":"1984","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2019.03.021_bib18","first-page":"H1688","article-title":"Effects of pericardial constraint and ventricular interaction on left ventricular hemodynamics in the unloaded heart","volume":"300","author":"Fujimoto","year":"2011","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib19","first-page":"15","article-title":"Influence of the pericardium and ventricular interdependence on left ventricular diastolic and systolic function in patients with heart failure","volume":"81","author":"Janicki","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib20","doi-asserted-by":"crossref","first-page":"H2247","DOI":"10.1152\/ajpheart.00613.2002","article-title":"Pericardium modulates left and right ventricular stroke volumes to compensate for sudden changes in atrial volume","volume":"284","author":"Kroeker","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib21","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/0002-8703(83)90048-0","article-title":"The role of the pericardium in interactions between the cardiac chambers","volume":"106","author":"Hess","year":"1983","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2019.03.021_bib22","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1093\/eurheartj\/ehy268","article-title":"Hemodynamics, dyspnea, and pulmonary reserve in heart failure with preserved ejection fraction","volume":"39","author":"Obokata","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.03.021_bib23","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1093\/eurheartj\/ehy331","article-title":"Exercise unmasks distinct pathophysiologic features in heart failure with preserved ejection fraction and pulmonary vascular disease","volume":"39","author":"Gorter","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.03.021_bib24","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCHEARTFAILURE.114.001575","article-title":"The hemodynamic basis of exercise intolerance in tricuspid regurgitation","volume":"7","author":"Andersen","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2019.03.021_bib25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1136\/hrt.2010.212787","article-title":"Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction","volume":"97","author":"Borlaug","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.jchf.2019.03.021_bib26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/CIRCULATIONAHA.116.026807","article-title":"Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction","volume":"136","author":"Obokata","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib27","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/S0140-6736(96)05109-4","article-title":"Diastolic ventricular interaction in chronic heart failure","volume":"349","author":"Atherton","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2019.03.021_bib28","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/eurheartj\/ehy809","article-title":"Deterioration in right ventricular structure and function over time in patients with heart failure and preserved ejection fraction","volume":"40","author":"Obokata","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.03.021_bib29","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1161\/01.CIR.67.5.1045","article-title":"Influence of atrial systole on the Frank-Starling relation and the end-diastolic pressure-diameter relation of the left ventricle","volume":"67","author":"Linderer","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.CIR.80.1.178","article-title":"Effects of volume loading during experimental acute pulmonary embolism","volume":"80","author":"Belenkie","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1164\/rccm.201110-1860OC","article-title":"Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study","volume":"186","author":"Kasner","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jchf.2019.03.021_bib32","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1378\/chest.119.6.1761","article-title":"Impaired left ventricular filling due to right ventricular pressure overload in primary pulmonary hypertension: noninvasive monitoring using MRI","volume":"119","author":"Marcus","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.jchf.2019.03.021_bib33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0002-9149(86)90857-X","article-title":"A\u00a0mechanism for the nitroglycerin-induced downward shift of the left ventricular diastolic pressure-diameter relation","volume":"57","author":"Kingma","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2019.03.021_bib34","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/01.CIR.76.4.875","article-title":"Modulation of vascular capacitance by angiotensin and nitroprusside: a mechanism of changes in pericardial pressure","volume":"76","author":"Smiseth","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0002-9343(84)91038-6","article-title":"Mechanism of action of nitrates. Role of changes in venous capacitance and in the left ventricular diastolic pressure-volume relation","volume":"76","author":"Smith","year":"1984","journal-title":"Am J Med"},{"key":"10.1016\/j.jchf.2019.03.021_bib36","first-page":"15","article-title":"Effect of acute angiotensin converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes","volume":"81","author":"Konstam","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib37","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1161\/01.CIR.0000145169.82004.CF","article-title":"Left ventricular pacing minimizes diastolic ventricular interaction, allowing improved preload-dependent systolic performance","volume":"110","author":"Bleasdale","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib38","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1093\/eurheartj\/ehu193","article-title":"Right heart dysfunction in heart failure with preserved ejection fraction","volume":"35","author":"Melenovsky","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.03.021_bib39","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/CIRCRESAHA.118.313832","article-title":"The beta-adrenergic agonist albuterol improves pulmonary vascular reserve in heart failure with preserved ejection fraction","volume":"124","author":"Reddy","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2019.03.021_bib40","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1161\/01.CIR.87.6.1921","article-title":"Increased left ventricular mass after thoracotomy and pericardiotomy. A role for relief of pericardial constraint?","volume":"87","author":"Tischler","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib41","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0002-8703(90)90131-G","article-title":"The effects of lying position on ventricular volume in congenital absence of the pericardium","volume":"120","author":"Beppu","year":"1990","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2019.03.021_bib42","first-page":"665","article-title":"Hemodynamic correlates and diagnostic role of cardiopulmonary exercise testing in heart failure with preserved ejection fraction","volume":"6","author":"Reddy","year":"2018","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2019.03.021_bib43","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003612","article-title":"Percutaneous pericardial resection: a novel potential treatment for heart failure with preserved ejection fraction","volume":"10","author":"Borlaug","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2019.03.021_bib44","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1161\/CIRCULATIONAHA.118.036006","article-title":"Pericardiotomy enhances left ventricular diastolic reserve with volume loading in humans","volume":"138","author":"Borlaug","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.03.021_bib45","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.healun.2013.05.004","article-title":"Marked changes in right ventricular contractile pattern after cardiothoracic surgery: implications for post-surgical assessment of right ventricular function","volume":"32","author":"Raina","year":"2013","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jchf.2019.03.021_bib46","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.healun.2017.03.014","article-title":"A\u00a0new \"twist\" on right heart failure with left ventricular assist systems","volume":"36","author":"Houston","year":"2017","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.jchf.2019.03.021_bib47","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.athoracsur.2007.03.095","article-title":"Clinical evaluation of the CorCap cardiac support device in patients with dilated cardiomyopathy","volume":"84","author":"Mann","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jchf.2019.03.021_bib48","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1161\/01.CIR.91.9.2314","article-title":"Reverse remodeling from cardiomyoplasty in human heart failure. External constraint versus active assist","volume":"91","author":"Kass","year":"1995","journal-title":"Circulation"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177919303361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177919303361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:46:35Z","timestamp":1778852795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177919303361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S2213177919303361"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2019.03.021","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of the Pericardium in Heart\u00a0Failure","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2019.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}