{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:06:43Z","timestamp":1761973603520,"version":"build-2065373602"},"reference-count":24,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["A-HL-13-002-001","HHSN268200900049C"],"award-info":[{"award-number":["A-HL-13-002-001","HHSN268200900049C"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015340","name":"Bayer Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004702","name":"Baxter International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["9U54TR000017-06","UL1RR024134","UL1RR025752","UL1RR025755","UL1RR025771","UL1TR000002","UL1TR000003","UL1TR000005","UL1TR000050","UL1TR000064","UL1TR000073","UL1TR000075","UL1TR000093","UL1TR000105-05","UL1TR000433","UL1TR000439","UL1TR000445","UL1TR001064"],"award-info":[{"award-number":["9U54TR000017-06","UL1RR024134","UL1RR025752","UL1RR025755","UL1RR025771","UL1TR000002","UL1TR000003","UL1TR000005","UL1TR000050","UL1TR000064","UL1TR000073","UL1TR000075","UL1TR000093","UL1TR000105-05","UL1TR000433","UL1TR000439","UL1TR000445","UL1TR001064"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jchf.2019.08.018","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T15:51:09Z","timestamp":1574697069000},"page":"1032-1041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Heart\u00a0Failure Prevention in Older Patients Using Intensive Blood Pressure Reduction"],"prefix":"10.1016","volume":"7","author":[{"given":"Bharathi","family":"Upadhya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C.","family":"Lovato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Oparil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Cushman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Kostis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos J.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique E.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loretta W.","family":"Cloud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjay","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive","family":"Rosendorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalane W.","family":"Kitzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2019.08.018_bib1","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A\u00a0randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Wright","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2019.08.018_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003613","article-title":"Effect of intensive blood pressure treatment on heart failure events in the systolic blood pressure reduction intervention trial","volume":"10","author":"Upadhya","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2019.08.018_bib3","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1001\/jama.2016.7050","article-title":"Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged >\/\u00a0=\u00a075 years: a randomized clinical trial","volume":"315","author":"Williamson","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2019.08.018_bib4","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","article-title":"2017 ACC\/AHA\/HFSA focused update of the 2013 ACCF\/AHA guideline for the management of heart failure","volume":"70","author":"Yancy","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.08.018_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/08037051.2015.1130775","article-title":"The SPRINT study: outcome may be driven by difference in diuretic treatment demasking heart failure and study design may support systolic blood pressure target below 140\u00a0mm\u00a0Hg rather than below 120\u00a0mm\u00a0Hg","volume":"25","author":"Kjeldsen","year":"2016","journal-title":"Blood Press"},{"key":"10.1016\/j.jchf.2019.08.018_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/HYPERTENSIONAHA.115.06723","article-title":"SPRINT: what remains unanswered and where do we go from here?","volume":"67","author":"Jones","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.jchf.2019.08.018_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/1740774514537404","article-title":"The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)","volume":"11","author":"Ambrosius","year":"2014","journal-title":"Clin Trials"},{"key":"10.1016\/j.jchf.2019.08.018_bib8","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1161\/HYPERTENSIONAHA.117.10479","article-title":"Blood pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial)","volume":"71","author":"Johnson","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.jchf.2019.08.018_bib9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1161\/CIRCHEARTFAILURE.111.963199","article-title":"Classification of heart failure in the Atherosclerosis Risk In Communities (ARIC) study: a comparison of diagnostic criteria","volume":"5","author":"Rosamond","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2019.08.018_bib10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2019.08.018_bib11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1005419","article-title":"Diuretic strategies in patients with acute decompensated heart failure","volume":"364","author":"Felker","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2019.08.018_bib12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1001\/jama.1997.03550030052033","article-title":"Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension","volume":"278","author":"Kostis","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2019.08.018_bib13","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1056\/NEJMoa0801369","article-title":"Treatment of hypertension in patients 80 years of age or older","volume":"358","author":"Beckett","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2019.08.018_bib14","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(97)05381-6","article-title":"Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) trial investigators","volume":"350","author":"Staessen","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2019.08.018_bib15","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1001\/jama.288.23.2981","article-title":"Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)","volume":"288","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2019.08.018_bib16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/HJH.0000000000000848","article-title":"Effects of blood pressure-lowering treatment. 6. Prevention of heart failure and new-onset heart failure\u2013meta-analyses of randomized trials","volume":"34","author":"Thomopoulos","year":"2016","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.jchf.2019.08.018_bib17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(15)01225-8","article-title":"Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis","volume":"387","author":"Ettehad","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2019.08.018_bib18","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1161\/HYPERTENSIONAHA.117.10646","article-title":"Impact of intensive versus standard blood pressure management by tertiles of blood pressure in SPRINT (Systolic Blood Pressure Intervention Trial)","volume":"71","author":"Shapiro","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.jchf.2019.08.018_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCULATIONAHA.112.111302","article-title":"Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure","volume":"127","author":"Fujimoto","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.08.018_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/CIRCHEARTFAILURE.114.001731","article-title":"Differential hemodynamic effects of exercise and volume expansion in people with and without heart failure","volume":"8","author":"Andersen","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2019.08.018_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/01.RES.70.1.9","article-title":"Mechanism of augmented rate of left ventricle filling during exercise","volume":"70","author":"Cheng","year":"1992","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2019.08.018_bib22","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/FJC.0b013e3181d89670","article-title":"Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease","volume":"55","author":"Cohen","year":"2010","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.jchf.2019.08.018_bib23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1161\/CIRCRESAHA.118.312763","article-title":"Optimal blood pressure target in diabetic and nondiabetic hypertensive patients","volume":"123","author":"Kjeldsen","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2019.08.018_bib24","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1161\/CIRCRESAHA.118.313057","article-title":"SPRINTING toward the optimal blood pressure target for hypertensive patients","volume":"123","author":"Oparil","year":"2018","journal-title":"Circulation"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221317791930736X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221317791930736X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:51:37Z","timestamp":1761972697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221317791930736X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S221317791930736X"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2019.08.018","relation":{},"ISSN":["2213-1779"],"issn-type":[{"type":"print","value":"2213-1779"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heart\u00a0Failure Prevention in Older Patients Using Intensive Blood Pressure Reduction","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2019.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}