{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:22:41Z","timestamp":1781184161736,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["EudraCT 2010-020808-29"],"award-info":[{"award-number":["EudraCT 2010-020808-29"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7-242209-BIOSTAT-CHF"],"award-info":[{"award-number":["FP7-242209-BIOSTAT-CHF"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014941","name":"Cytokinetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jchf.2019.11.005","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T15:58:01Z","timestamp":1580918281000},"page":"234-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Distinct Pathological Pathways in Patients With Heart\u00a0Failure and Diabetes"],"prefix":"10.1016","volume":"8","author":[{"given":"Jasper","family":"Tromp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o P.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Ouwerkerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans L.","family":"Hillege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla A.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Dickstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Metra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chim C.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leong L.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"van der Harst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"van Veldhuisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn S.P.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iziah E.","family":"Sama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2019.11.005_bib1","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1093\/eurheartj\/ehy596","article-title":"Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart\u00a0Failure Association\u2013European Society of Cardiology","volume":"39","author":"Maack","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.11.005_bib2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/ejhf.1170","article-title":"Type 2 diabetes mellitus and heart failure: a position statement from the Heart\u00a0Failure Association of the European Society of Cardiology","volume":"20","author":"Seferovi\u0107","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.11.005_bib3","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004646","article-title":"Trends in noncardiovascular comorbidities among patients hospitalized for heart failure: insights from the Get With the Guidelines\u2013Heart Failure Registry","volume":"11","author":"Sharma","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2019.11.005_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.002560","article-title":"Risk related to pre-diabetes mellitus and diabetes mellitus in heart failure with reduced ejection fraction: insights from Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart\u00a0Failure Trial","volume":"9","author":"Kristensen","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2019.11.005_bib5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0735-1097(03)00856-8","article-title":"The effect of diabetes on outcomes of patients with advanced heart failure in the BEST trial","volume":"42","author":"Domanski","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.11.005_bib6","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/eurheartj\/ehn153","article-title":"Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM) programme","volume":"29","author":"MacDonald","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.11.005_bib7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/heartjnl-2016-310342","article-title":"Diabetic cardiomyopathy","volume":"105","author":"Lee","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.jchf.2019.11.005_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.15420\/cfr.2016:20:2","article-title":"Heart failure in patients with diabetes mellitus","volume":"3","author":"Rosano","year":"2017","journal-title":"Card Fail Rev"},{"key":"10.1016\/j.jchf.2019.11.005_bib9","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/ejhf.912","article-title":"A\u00a0network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure","volume":"19","author":"Sharma","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.11.005_bib10","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jacc.2018.06.050","article-title":"Identifying pathophysiological mechanisms in heart failure with reduced versus preserved ejection fraction","volume":"72","author":"Tromp","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.11.005_bib11","article-title":"Biomarker profiles in heart failure patients with preserved and reduced ejection fraction","volume":"6","author":"Tromp","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jchf.2019.11.005_bib12","first-page":"507","article-title":"Biomarker profiles of acute heart failure patients with a mid-range ejection fraction","volume":"5","author":"Tromp","year":"2017","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2019.11.005_bib13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/ejhf.531","article-title":"A\u00a0Systems Biology Study to Tailored Treatment in Chronic Heart\u00a0Failure: rationale, design, and baseline characteristics of BIOSTAT-CHF","volume":"18","author":"Voors","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.11.005_bib14","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/eurheartj\/ehx026","article-title":"Determinants and clinical outcome of uptitration of ACE-inhibitors and beta-blockers in patients with heart failure: a prospective European study","volume":"38","author":"Ouwerkerk","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.11.005_bib15","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1093\/eurheartj\/ehy712","article-title":"Novel endotypes in heart failure: effects on guideline-directed medical therapy","volume":"39","author":"Tromp","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2019.11.005_bib16","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/nar\/gkg056","article-title":"BIND: the Biomolecular Interaction Network Database","volume":"31","author":"Bader","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib18","doi-asserted-by":"crossref","first-page":"D535","DOI":"10.1093\/nar\/gkj109","article-title":"BioGRID: a general repository for interaction datasets","volume":"34","author":"Stark","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/nar\/28.1.289","article-title":"DIP: the database of interacting proteins","volume":"28","author":"Xenarios","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib20","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1101\/gr.1680803","article-title":"Development of Human Protein Reference Database as an initial platform for approaching systems biology in humans","volume":"13","author":"Peri","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib21","doi-asserted-by":"crossref","first-page":"D841","DOI":"10.1093\/nar\/gkr1088","article-title":"The IntAct molecular interaction database in 2012","volume":"40","author":"Kerrien","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib22","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/bioinformatics\/bti098","article-title":"PDZBase: a protein-protein interaction database for PDZ-domains","volume":"21","author":"Beuming","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jchf.2019.11.005_bib23","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1093\/bioinformatics\/btq474","article-title":"Measuring the physical cohesiveness of proteins using physical interaction enrichment","volume":"26","author":"Sama","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jchf.2019.11.005_bib24","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib25","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib26","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jchf.2019.11.005_bib27","author":"Therneau"},{"key":"10.1016\/j.jchf.2019.11.005_bib28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jacc.2019.05.052","article-title":"Age-related characteristics and outcomes of patients with heart failure with preserved ejection fraction","volume":"74","author":"Tromp","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2019.11.005_bib29","first-page":"724","article-title":"Utility of growth differentiation factor-15, a marker of oxidative stress and inflammation, in chronic heart failure: insights from the HF-ACTION study","volume":"5","author":"Sharma","year":"2017","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2019.11.005_bib30","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.amjcard.2014.06.020","article-title":"Usefulness of growth differentiation factor-15 levels to predict diabetic cardiomyopathy in asymptomatic patients with type 2 diabetes mellitus","volume":"114","author":"Dominguez-Rodriguez","year":"2014","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2019.11.005_bib31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/01.RES.0000202804.84885.d0","article-title":"GDF15\/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation","volume":"98","author":"Xu","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s13238-016-0262-9","article-title":"The role of galectin-4 in physiology and diseases","volume":"7","author":"Cao","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.jchf.2019.11.005_bib33","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/JOE-17-0031","article-title":"Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease","volume":"233","author":"Rodr\u00edguez-Calvo","year":"2017","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.jchf.2019.11.005_bib34","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/heartjnl-2013-303735","article-title":"Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women","volume":"99","author":"Engeli","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.jchf.2019.11.005_bib35","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1161\/01.RES.0000264499.48737.69","article-title":"Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice","volume":"100","author":"Shih","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2019.11.005_bib36","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2016.10.025","article-title":"Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance","volume":"167","author":"Li","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jchf.2019.11.005_bib37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10557-014-6520-2","article-title":"Galectin-3: a modifiable risk factor in heart failure","volume":"28","author":"De Boer","year":"2014","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jchf.2019.11.005_bib38","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.2337\/db17-1513","article-title":"Inhibition of epidermal growth factor receptor activation is associated with improved diabetic nephropathy and insulin resistance in type 2 diabetes","volume":"67","author":"Li","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.jchf.2019.11.005_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039066","article-title":"Activation of EGFR\/ERBB2 via pathways involving ERK1\/2, P38 MAPK, AKT and FOXO enhances recovery of diabetic hearts from ischemia-reperfusion injury","volume":"7","author":"Akhtar","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jchf.2019.11.005_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.lfs.2018.08.018","article-title":"EGFR tyrosine kinase inhibition decreases cardiac remodeling and SERCA2a\/NCX1 depletion in streptozotocin induced cardiomyopathy in C57\/BL6 mice","volume":"210","author":"Shah","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.jchf.2019.11.005_bib41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1517\/14728222.2011.648617","article-title":"Targeting the EGFR signaling pathway in cancer therapy","volume":"16","author":"Seshacharyulu","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jchf.2019.11.005_bib42","first-page":"1","article-title":"Distinct myocardial targets for diabetes therapy in heart failure with preserved or reduced ejection fraction","volume":"6","author":"Paulus","year":"2018","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2019.11.005_bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCULATIONAHA.107.728550","article-title":"Diastolic stiffness of the failing diabetic heart","volume":"117","author":"van Heerebeek","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2019.11.005_bib44","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.ahj.2012.07.027","article-title":"The role of advanced glycation end-products and their receptor on outcome in heart failure patients with preserved and reduced ejection fraction","volume":"164","author":"Willemsen","year":"2012","journal-title":"Am. Heart J"},{"key":"10.1016\/j.jchf.2019.11.005_bib45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/eurjhf\/hfq168","article-title":"Tissue advanced glycation end products are associated with diastolic function and aerobic exercise capacity in diabetic heart failure patients","volume":"13","author":"Willemsen","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2019.11.005_bib46","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10741-010-9225-z","article-title":"Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome","volume":"17","author":"Willemsen","year":"2012","journal-title":"Heart Fail Rev"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177919308686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177919308686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:52:39Z","timestamp":1761972759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177919308686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S2213177919308686"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2019.11.005","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct Pathological Pathways in Patients With Heart\u00a0Failure and Diabetes","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2019.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}