{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:42:39Z","timestamp":1790746959638,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jchf.2020.11.010","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T22:12:46Z","timestamp":1612563166000},"page":"268-277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF"],"prefix":"10.1016","volume":"9","author":[{"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Job","family":"Verdonschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Pizard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fozia Z.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Brunner-La-Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Cosmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Cuthbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Edelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Grojean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hazebroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Latini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Mariottoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blerim","family":"Mujaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Pellicori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Petutschnigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkert","family":"Pieske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Rouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A.","family":"Staessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.F.","family":"Cleland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Heymans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2020.11.010_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/ejhf.1716","volume":"22","author":"Pellicori","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2020.11.010_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005897","article-title":"Proteomic bioprofiles and mechanistic pathways of progression to heart failure","volume":"12","author":"Ferreira","year":"2019","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2020.11.010_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/ehjcvp\/pvw016","article-title":"Mineralocorticoid receptor antagonists in patients with heart failure: current experience and future perspectives","volume":"3","author":"Pitt","year":"2017","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1016\/j.jchf.2020.11.010_bib4","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/eurheartj\/ehaa758","article-title":"The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart \u2018OMics\u2019 in AGEing (HOMAGE) randomized clinical trial.","volume":"42","author":"Cleland","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2020.11.010_bib5","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1161\/CIRCULATIONAHA.108.809194","volume":"119","author":"Iraqi","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2020.11.010_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1124\/pr.115.011106","article-title":"Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology","volume":"68","author":"Jaisser","year":"2016","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jchf.2020.11.010_bib7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2020.11.010_bib8","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1161\/01.CIR.102.22.2700","article-title":"Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the Randomized Aldactone Evaluation Study (RALES). Rales Investigators","volume":"102","author":"Zannad","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2020.11.010_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00392-017-1157-3","article-title":"Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER study","volume":"107","author":"Ferreira","year":"2018","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jchf.2020.11.010_bib10","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/ejhf.1812","article-title":"Eplerenone prevents an increase in serum carboxy-terminal propeptide of procollagen type I after myocardial infarction complicated by left ventricular dysfunction and\/or heart failure","volume":"22","author":"Stienen","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2020.11.010_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11906-016-0626-9","article-title":"Aldosterone production and signaling dysregulation in obesity","volume":"18","author":"Vecchiola","year":"2016","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.jchf.2020.11.010_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/HYPERTENSIONAHA.115.05674","article-title":"Low-dose mineralocorticoid receptor blockade prevents western diet-induced arterial stiffening in female mice","volume":"66","author":"DeMarco","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.jchf.2020.11.010_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ejhf.203","article-title":"Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial","volume":"17","author":"Edelmann","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2020.11.010_bib14","article-title":"Aldosterone induced galectin-3 secretion in\u00a0vitro and in\u00a0vivo: from cells to humans","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jchf.2020.11.010_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/90100","article-title":"Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome","volume":"28","author":"Martignetti","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.jchf.2020.11.010_bib16","doi-asserted-by":"crossref","first-page":"117153","DOI":"10.1016\/j.lfs.2019.117153","article-title":"Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats","volume":"244","author":"Mendes","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jchf.2020.11.010_bib17","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/HYPERTENSIONAHA.111.00055","article-title":"Matrix metalloproteinase enhances big-endothelin-1 constriction in mesenteric vessels of pregnant rats with reduced uterine blood flow","volume":"61","author":"Abdalvand","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.jchf.2020.11.010_bib18","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/FJC.0b013e3181d4ca66","article-title":"Caspase inhibition modulates left ventricular remodeling following myocardial infarction through cellular and extracellular mechanisms","volume":"55","author":"Yarbrough","year":"2010","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.jchf.2020.11.010_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ghir.2018.10.006","article-title":"Pappa2 deletion has sex- and age-specific effects on bone in mice","volume":"44","author":"Christians","year":"2019","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.jchf.2020.11.010_bib20","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1182\/blood-2010-08-301549","article-title":"Structural determinants of vascular endothelial growth factor-D receptor binding and specificity","volume":"117","author":"Leppanen","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2020.11.010_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41467-018-08125-6","article-title":"Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related\u00a0macular degeneration","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jchf.2020.11.010_bib22","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.yexcr.2004.06.004","article-title":"CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk","volume":"299","author":"Peters","year":"2004","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jchf.2020.11.010_bib23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/ehf2.12634","article-title":"Clinical determinants and prognostic implications of renin and aldosterone in patients with symptomatic heart failure","volume":"7","author":"Kobayashi","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jchf.2020.11.010_bib24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbrc.2012.05.103","article-title":"A\u00a0novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells","volume":"423","author":"Yamawaki","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jchf.2020.11.010_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/bbrc.1998.8762","article-title":"Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity","volume":"247","author":"Youn","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jchf.2020.11.010_bib26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1365-2265.2010.03922.x","article-title":"The\u00a0association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertension","volume":"74","author":"Vaidya","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jchf.2020.11.010_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ki.1997.10","article-title":"Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas(lpr) mice with renal injury","volume":"51","author":"Fan","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.jchf.2020.11.010_bib28","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","article-title":"Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system","volume":"292","author":"Mehta","year":"2007","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177920307058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177920307058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:57:41Z","timestamp":1761973061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177920307058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S2213177920307058"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2020.11.010","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2020.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}