{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:27:17Z","timestamp":1788546437488,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007176","name":"Scuola Superiore Sant'Anna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jchf.2022.02.006","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T15:52:48Z","timestamp":1651679568000},"page":"662-676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Chemoreflex and Baroreflex Sensitivity Hold a Strong Prognostic Value in Chronic Heart\u00a0Failure"],"prefix":"10.1016","volume":"10","author":[{"given":"Alberto","family":"Giannoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Buoncristiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Sciarrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Spiesshoefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bramanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Iudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh","family":"Javaheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Passino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2022.02.006_bib1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/eurjhf\/hfn028","article-title":"Prevalence and prognostic significance of adrenergic escape during chronic \u03b2-blocker therapy in chronic heart failure","volume":"11","author":"Frankenstein","year":"2009","journal-title":"Eur J Heart Fail"},{"issue":"9","key":"10.1016\/j.jchf.2022.02.006_bib3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/01.CIR.0000030935.89559.04","article-title":"Elevated plasma aldosterone levels despite complete inhibition of the vascular angiotensin-converting enzyme in chronic heart failure","volume":"106","author":"Jorde","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2022.02.006_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijcard.2019.08.040","article-title":"Sympathetic and renin-angiotensin-aldosterone system activation in heart failure with preserved, mid-range and reduced ejection fraction","volume":"296","author":"Vergaro","year":"2019","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.jchf.2022.02.006_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10741-018-9747-3","article-title":"Chronic heart failure: a disease of the brain","volume":"24","author":"Singh","year":"2019","journal-title":"Heart Fail Rev"},{"issue":"10","key":"10.1016\/j.jchf.2022.02.006_bib6","first-page":"786","article-title":"Novel interventional therapies to modulate the autonomic tone in heart failure","volume":"3","author":"Chatterjee","year":"2015","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jchf.2022.02.006_bib7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ejhf.138","article-title":"Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: a proof-of-concept study","volume":"16","author":"Gronda","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2020.05.015","article-title":"Baroreflex activation therapy in patients with heart failure with reduced ejection fraction","volume":"76","author":"Zile","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/ejhf.641","article-title":"Carotid body resection for sympathetic modulation in systolic heart failure: results from first-in-man study","volume":"19","author":"Niewinski","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ejhf.1854","article-title":"Benefit of buspirone on chemoreflex and central apnoeas in heart failure: a randomized controlled crossover trial","volume":"23","author":"Giannoni","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib11","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/hc3101.093699","article-title":"Peripheral chemoreceptor hypersensitivity","volume":"104","author":"Piotr","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2022.02.006_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2008.09.034","article-title":"Prognostic implications of baroreflex sensitivity in heart failure patients in the beta-blocking era","volume":"53","author":"La Rovere","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib13","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.jacc.2009.02.030","article-title":"Combined increased chemosensitivity to hypoxia and hypercapnia as a prognosticator in heart failure","author":"Giannoni","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib14","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1161\/01.CIR.96.10.3450","article-title":"Arterial baroreflex modulation of heart rate in chronic heart failure","volume":"96","author":"Andrea","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2022.02.006_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cardfail.2016.11.003","article-title":"Central chemoreceptor sensitivity is not enhanced in contemporary patients with chronic systolic heart failure receiving optimal treatment","volume":"23","author":"Paleczny","year":"2017","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/ejhf.1306","article-title":"Assessment of baroreflex sensitivity has no prognostic value in contemporary, optimally managed patients with mild-to-moderate heart failure with reduced ejection fraction: a retrospective analysis of 5-year survival","volume":"21","author":"Paleczny","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib17","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/ehf2.13183","article-title":"A\u00a0novel echocardiographic method for estimation of pulmonary artery wedge pressure and pulmonary vascular resistance","volume":"8","author":"Chubuchny","year":"2021","journal-title":"ESC Hear Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib18","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.jacc.2017.07.740","article-title":"Prognostic significance of central apneas throughout a 24-hour period in patients with heart failure","volume":"70","author":"Emdin","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib19","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1016\/j.jacc.2020.04.033","article-title":"Upright Cheyne-Stokes respiration in patients with heart failure","volume":"75","author":"Giannoni","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10286-010-0079-1","article-title":"New method to measure and improve consistency of baroreflex sensitivity values","volume":"20","author":"Bernardi","year":"2010","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.jchf.2022.02.006_bib21","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.ijcard.2013.08.120","article-title":"A\u00a0simple method for measuring baroreflex sensitivity holds prognostic value in heart failure","volume":"169","author":"Mirizzi","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib22","article-title":"Contribution of the lung to the genesis of Cheyne-Stokes respiration in heart failure: plant gain beyond chemoreflex gain and circulation time","volume":"8","author":"Giannoni","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jchf.2022.02.006_bib23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1042\/CS20070292","article-title":"Clinical significance of chemosensitivity in chronic heart failure: influence on neurohormonal derangement, Cheyne\u2013Stokes respiration and arrhythmias","volume":"114","author":"Giannoni","year":"2008","journal-title":"Clin Sci"},{"key":"10.1016\/j.jchf.2022.02.006_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0167-9473(02)00225-6","article-title":"On the exact distribution of maximally selected rank statistics","volume":"43","author":"Hothorn","year":"2003","journal-title":"Comput Stat Data Anal"},{"key":"10.1016\/j.jchf.2022.02.006_bib25","doi-asserted-by":"crossref","first-page":"824","DOI":"10.4330\/wjc.v7.i12.824","article-title":"Peripheral reflex feedbacks in chronic heart failure: is it time for a direct treatment?","volume":"7","author":"Giannoni","year":"2015","journal-title":"World J Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib26","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/ejhf.921","article-title":"The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart\u00a0Failure Association of the European Society of Cardiology","volume":"19","author":"van Bilsen","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jacc.2009.03.061","article-title":"Sympathetic nervous system activation in human heart failure: clinical implications of an updated model","volume":"54","author":"Floras","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib28","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/eurheartj\/ehv087","article-title":"The sympathetic\/parasympathetic imbalance in heart failure with reduced ejection fraction","volume":"36","author":"Floras","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.02.006_bib29","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0735-1097(00)00900-1","article-title":"Nonselective beta-adrenergic blocking agent, carvedilol, improves arterial baroflex gain and heart rate variability in patients with stable chronic heart failure","volume":"36","author":"Mortara","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2013.01.277","article-title":"Multiparametric comparison of Carvedilol, vs. Nebivolol, vs. Bisoprolol in moderate heart failure: the CARNEBI trial","volume":"168","author":"Contini","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10286-018-0572-5","article-title":"The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications","volume":"29","author":"Miller","year":"2019","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.jchf.2022.02.006_bib32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijcard.2021.02.012","article-title":"Sacubitril\u2013valsartan treatment is associated with decrease in central apneas in patients with heart failure with reduced ejection fraction","volume":"330","author":"Passino","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cardfail.2014.12.013","article-title":"Modulation of ventilatory reflex control by cardiac resynchronization therapy","volume":"21","author":"Cundrle","year":"2015","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib34","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.resp.2010.02.015","article-title":"An interdependent model of central\/peripheral chemoreception: evidence and implications for ventilatory control","volume":"173","author":"Smith","year":"2010","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-3-319-18440-1_19","article-title":"Role of the carotid body chemoreflex in the pathophysiology of heart failure: a perspective from animal studies","volume":"860","author":"Schultz","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jchf.2022.02.006_bib36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-94-007-4584-1_46","article-title":"Role of central\/peripheral chemoreceptors and their interdependence in the pathophysiology of sleep apnea","volume":"758","author":"Dempsey","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jchf.2022.02.006_bib37","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1113\/JP277691","article-title":"Simultaneous assessment of central and peripheral chemoreflex regulation of muscle sympathetic nerve activity and ventilation in healthy young men","volume":"597","author":"Keir","year":"2019","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib38","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(97)11144-8","article-title":"Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction","volume":"351","author":"Rovere","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2022.02.006_bib39","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/eurjhf\/hfp085","article-title":"A\u00a0meta-analysis of the prognostic significance of atrial fibrillation in chronic heart failure","volume":"11","author":"LMamas","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.006_bib40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.resp.2008.12.002","article-title":"Role of chemoreceptors in mediating dyspnea","volume":"167","author":"Buchanan","year":"2009","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.jchf.2022.02.006_bib41","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1161\/01.CIR.99.22.2958","article-title":"Ganglionic mechanisms contribute to diminished vagal control in heart failure","volume":"99","author":"Bibevski","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2022.02.006_bib42","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1152\/physrev.00012.2009","article-title":"The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis","volume":"90","author":"Teppema","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jchf.2022.02.006_bib43","doi-asserted-by":"crossref","first-page":"737","DOI":"10.5664\/jcsm.27032","article-title":"Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable Monitoring Task Force of the American Academy of Sleep Medicine","volume":"3","author":"Collop","year":"2007","journal-title":"J\u00a0Clin Sleep Med"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177922001718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177922001718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:00:22Z","timestamp":1761973222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177922001718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2213177922001718"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2022.02.006","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemoreflex and Baroreflex Sensitivity Hold a Strong Prognostic Value in Chronic Heart\u00a0Failure","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2022.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}