{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T21:32:07Z","timestamp":1792359127650,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jchf.2022.02.015","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T15:52:54Z","timestamp":1651679574000},"page":"459-466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Happy Heart Syndrome"],"prefix":"10.1016","volume":"10","author":[{"given":"Thomas","family":"Stiermaier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Walliser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"El-Battrawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"P\u00e4tz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mezger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Rawish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-4782","authenticated-orcid":false,"given":"Manuel","family":"Almendro-Delia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Martinez-Sell\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-7480","authenticated-orcid":false,"given":"Aitor","family":"Uribarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"P\u00e9rez-Castellanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Novo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Mariano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-7981","authenticated-orcid":false,"given":"Maria Beatrice","family":"Musumeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Arcari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cacciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Montisci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-7408","authenticated-orcid":false,"given":"Natale Daniele","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan J.","family":"N\u00fa\u00f1ez-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-6513","authenticated-orcid":false,"given":"Francesco","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2022.02.015_bib1","first-page":"479","article-title":"Current knowledge and future challenges in takotsubo syndrome: part 1-pathophysiology and diagnosis","volume":"10","author":"Rawish","year":"2021","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jchf.2022.02.015_bib2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMoa1406761","article-title":"Clinical features and outcomes of takotsubo (stress) cardiomyopathy","volume":"373","author":"Templin","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2022.02.015_bib3","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/eurheartj\/ehy076","article-title":"International expert consensus document on takotsubo syndrome (part i): clinical characteristics, diagnostic criteria, and pathophysiology","volume":"39","author":"Ghadri","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.02.015_bib4","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.CIR.0000153801.51470.EB","article-title":"Acute and reversible cardiomyopathy provoked by stress in women from the United States","volume":"111","author":"Sharkey","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2022.02.015_bib5","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1093\/eurheartj\/ehv757","article-title":"Happy heart syndrome: role of positive emotional stress in takotsubo syndrome","volume":"37","author":"Ghadri","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.02.015_bib6","article-title":"Short- and long-term prognosis of patients with takotsubo syndrome based on different triggers: importance of the physical nature","volume":"8","author":"Uribarri","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jchf.2022.02.015_bib7","first-page":"308","article-title":"Secondary forms of takotsubo cardiomyopathy: a whole different prognosis","volume":"5","author":"Nunez-Gil","year":"2016","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.jchf.2022.02.015_bib8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ahj.2007.11.008","article-title":"Apical ballooning syndrome (tako-tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction","volume":"155","author":"Prasad","year":"2008","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2022.02.015_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ejhf.424","article-title":"Current state of knowledge on takotsubo syndrome: a position statement from the Taskforce on Takotsubo Syndrome of the Heart\u00a0Failure Association of the European Society of Cardiology","volume":"18","author":"Lyon","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.015_bib10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJMoa0707992","article-title":"Noninvasive ventilation in acute cardiogenic pulmonary edema","volume":"359","author":"Gray","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2022.02.015_bib11","first-page":"489","article-title":"Incidence, determinants and prognostic relevance of cardiogenic shock in patients with takotsubo cardiomyopathy","volume":"5","author":"Stiermaier","year":"2016","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.jchf.2022.02.015_bib12","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1161\/STR.0b013e318296aeca","article-title":"An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"44","author":"Sacco","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.jchf.2022.02.015_bib13","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.116.027121","article-title":"Pathophysiology of takotsubo syndrome","volume":"135","author":"Pelliccia","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2022.02.015_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/CIRCRESAHA.116.308446","article-title":"Heart-brain axis: effects of neurologic injury on cardiovascular function","volume":"120","author":"Tahsili-Fahadan","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2022.02.015_bib15","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.neuroimage.2003.10.001","article-title":"Brain areas and time course of emotional processing","volume":"21","author":"Esslen","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.jchf.2022.02.015_bib16","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jacc.2020.10.060","article-title":"Pathophysiology of takotsubo syndrome: JACC state-of-the-art review","volume":"77","author":"Lyon","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.015_bib17","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jacc.2017.06.061","article-title":"Catecholamine-dependent beta-adrenergic signaling in a pluripotent stem cell model of takotsubo cardiomyopathy","volume":"70","author":"Borchert","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.015_bib18","article-title":"Incidence and clinical impact of recurrent takotsubo syndrome: results from the GEIST Registry","volume":"8","author":"El-Battrawy","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jchf.2022.02.015_bib19","doi-asserted-by":"crossref","first-page":"696413","DOI":"10.3389\/fcvm.2021.696413","article-title":"The synergy of ADAM17-induced myocardial inflammation and metabolic lipids dysregulation during acute stress: new pathophysiologic insights into takotsubo cardiomyopathy","volume":"8","author":"Adu-Amankwaah","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jchf.2022.02.015_bib20","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1001\/jamacardio.2019.2597","article-title":"Assessment of the German and Italian stress cardiomyopathy score for risk stratification for in-hospital complications in patients with takotsubo syndrome","volume":"4","author":"Santoro","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jchf.2022.02.015_bib21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ejhf.494","article-title":"Long-term excess mortality in takotsubo cardiomyopathy: predictors, causes and clinical consequences","volume":"18","author":"Stiermaier","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.02.015_bib22","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jacc.2018.06.016","article-title":"Long-term prognosis of patients with takotsubo syndrome","volume":"72","author":"Ghadri","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.02.015_bib23","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.amjcard.2016.08.055","article-title":"Prognostic usefulness of the ballooning pattern in patients with takotsubo cardiomyopathy","volume":"118","author":"Stiermaier","year":"2016","journal-title":"Am J Cardiol"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177922002360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177922002360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:00:09Z","timestamp":1761973209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177922002360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S2213177922002360"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2022.02.015","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Happy Heart Syndrome","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2022.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}