{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:51:04Z","timestamp":1794282664355,"version":"4.9.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004785","name":"NordForsk","doi-asserted-by":"publisher","award":["90580"],"award-info":[{"award-number":["90580"]}],"id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005747","name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF20OC0065799"],"award-info":[{"award-number":["NNF20OC0065799"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["0134-00363B"],"award-info":[{"award-number":["0134-00363B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jchf.2022.07.009","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T18:10:08Z","timestamp":1662574208000},"page":"792-803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Family Screening in Dilated\u00a0Cardiomyopathy"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-206X","authenticated-orcid":false,"given":"Christoffer R.","family":"Vissing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiri","family":"Espersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil D.","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Jurlander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie V.","family":"Skriver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Ghouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Thune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Axelsson Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2022.07.009_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199201093260201","article-title":"The frequency of familial dilated cardiomyopathy in\u00a0a series of patients with idiopathic dilated cardiomyopathy","volume":"326","author":"Michels","year":"1992","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2022.07.009_bib2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/0002-9149(90)91353-8","article-title":"Clinical and pathologic study of familial dilated cardiomyopathy","volume":"65","author":"Mestroni","year":"1990","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2022.07.009_bib3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cardfail.2006.03.009","article-title":"Clinical characteristics of 304 kindreds evaluated for familial dilated cardiomyopathy","volume":"12","author":"Kushner","year":"2006","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0735-1097(97)00434-8","article-title":"Frequency and phenotypes of familial dilated cardiomyopathy","volume":"31","author":"Gr\u00fcnig","year":"1998","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2022.07.009_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006701","article-title":"Clinical and genetic investigations of 109 index patients with dilated cardiomyopathy and 445 of their relatives","volume":"13","author":"Hey","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jama.2021.24674","article-title":"Prevalence and cumulative risk of familial idiopathic dilated cardiomyopathy","volume":"327","author":"Huggins","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2022.07.009_bib7","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/eurheartj\/ehu301","article-title":"Atlas of the clinical genetics of human dilated cardiomyopathy","volume":"36","author":"Haas","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.07.009_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1388-9842(02)00179-4","article-title":"Prognostic value of serial cardiac assessment and familial screening in patients with dilated cardiomyopathy","volume":"5","author":"Gr\u00fcnig","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.hlc.2011.06.004","article-title":"A\u00a0randomised, placebo-controlled trial of carvedilol in early familial dilated cardiomyopathy","volume":"20","author":"Yeoh","year":"2011","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.jchf.2022.07.009_bib10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/CIRCGENETICS.112.962761","article-title":"Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy","volume":"5","author":"Lakdawala","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jchf.2022.07.009_bib11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/CIRCGENETICS.110.958918","article-title":"Evaluation of left ventricular enlargement as a marker of early disease in familial dilated cardiomyopathy","volume":"4","author":"Fatkin","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jchf.2022.07.009_bib12","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/eurheartj\/ehv727","article-title":"Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases","volume":"37","author":"Pinto","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.07.009_bib13","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/eurheartj\/ehq271","article-title":"Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"31","author":"Charron","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.07.009_bib14","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","article-title":"Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2022.07.009_bib15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.7326\/0003-4819-143-2-200507190-00009","article-title":"Echocardiographic evaluation in asymptomatic relatives of patients with dilated cardiomyopathy reveals preclinical disease","volume":"143","author":"Mahon","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jchf.2022.07.009_bib16","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/ejhf.1815","article-title":"The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy","volume":"22","author":"Finocchiaro","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib17","series-title":"Arvelige hjertesygdomme. Kbh.","year":"2013"},{"key":"10.1016\/j.jchf.2022.07.009_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cardfail.2018.03.004","article-title":"Genetic evaluation of cardiomyopathy\u2014a Heart\u00a0Failure Society of America Practice Guideline","volume":"24","author":"Hershberger","year":"2018","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib19","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1002\/ehf2.12925","article-title":"ESC EORP Cardiomyopathy Registry: real-life practice of genetic counselling and testing in adult cardiomyopathy patients","volume":"7","author":"Heli\u00f6","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: a position statement from the European Society of Cardiology working group on myocardial and pericardial diseases","volume":"29","author":"Elliott","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.07.009_bib21","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/ejhf.1216","article-title":"Sex- and age-based differences in the natural history and outcome of dilated cardiomyopathy","volume":"20","author":"Halliday","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib22","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1136\/jmedgenet-2020-107178","article-title":"Dilated cardiomyopathy caused by truncating titin variants: long-term outcomes, arrhythmias, response to treatment and sex differences","volume":"58","author":"Vissing","year":"2021","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.jchf.2022.07.009_bib23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/gim.2017.218","article-title":"Adaptation and validation of the ACMG\/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: recommendations by ClinGen\u2019s Inherited Cardiomyopathy Expert Panel","volume":"20","author":"Kelly","year":"2018","journal-title":"Genet Med"},{"key":"10.1016\/j.jchf.2022.07.009_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.119.002480","article-title":"Variant interpretation for dilated cardiomyopathy","volume":"13","author":"Morales","year":"2020","journal-title":"Circ Genomic Precis Med"},{"key":"10.1016\/j.jchf.2022.07.009_bib25","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005220","article-title":"Clinical phenotype and genotype associations with improvement in left ventricular function in dilated cardiomyopathy","volume":"11","author":"Verdonschot","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib26","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/ejhf.1236","article-title":"Advanced heart failure: a position statement of the Heart\u00a0Failure Association of the European Society of Cardiology","volume":"20","author":"Crespo-Leiro","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib27","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/eurjhf\/hfs191","article-title":"Gender-specific differences in major cardiac events and mortality in lamin A\/C mutation carriers","volume":"15","author":"Rijsingen","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2022.07.009_bib28","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1093\/eurheartj\/ehv253","article-title":"Genetics and genotype-phenotype correlations in Finnish patients with dilated cardiomyopathy","volume":"36","author":"Akinrinade","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.07.009_bib29","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/01.CIR.80.3.564","article-title":"Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984","volume":"80","author":"Codd","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2022.07.009_bib30","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.ehj.2004.06.038","article-title":"Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure: The Rotterdam Study","volume":"25","author":"Bleumink","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2022.07.009_bib31","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrcardio.2013.105","article-title":"Dilated cardiomyopathy: the complexity of a diverse genetic architecture","volume":"10","author":"Hershberger","year":"2013","journal-title":"Nat Rev Cardiol"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177922004267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177922004267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:01:39Z","timestamp":1761973299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177922004267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S2213177922004267"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2022.07.009","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Family Screening in Dilated\u00a0Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2022.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}