{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:20:52Z","timestamp":1781871652474,"version":"3.54.5"},"reference-count":111,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jchf.2023.03.010","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T16:08:00Z","timestamp":1683130080000},"page":"235-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Role of Oxygen Starvation in Right Ventricular Decompensation and Failure in Pulmonary Arterial Hypertension"],"prefix":"10.1016","volume":"12","author":[{"given":"Marta","family":"Okni\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Zajda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzanna","family":"Zambrowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Grzanka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Paterek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Mackiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezary","family":"Szczylik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Kurzyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Piekie\u0142ko-Witkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Torbicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Kieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-4141","authenticated-orcid":false,"given":"Micha\u0142","family":"M\u0105czewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2023.03.010_bib1","article-title":"Mortality in pulmonary arterial hypertension in the modern era: early insights from the Pulmonary Hypertension Association registry","volume":"11","author":"Chang","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jchf.2023.03.010_bib2","doi-asserted-by":"crossref","first-page":"D22","DOI":"10.1016\/j.jacc.2013.10.027","article-title":"Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology","volume":"62","author":"Vonk-Noordegraaf","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib3","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2011.06.068","article-title":"Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy","volume":"58","author":"van de Veerdonk","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib4","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1161\/CIRCULATIONAHA.114.006979","article-title":"Emerging concepts in the molecular basis of pulmonary arterial hypertension","volume":"131","author":"Ryan","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2023.03.010_bib5","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01887-2018","article-title":"Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives","volume":"53","author":"Humbert","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jchf.2023.03.010_bib6","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.cardfail.2009.06.357","article-title":"Regional right ventricular wall stress and thickness in pulmonary hypertension","volume":"15","author":"Chauhan","year":"2009","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2023.03.010_bib7","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1161\/CIRCRESAHA.116.304937","article-title":"Mechanotransduction in cardiac hypertrophy and failure","volume":"116","author":"Lyon","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2023.03.010_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ceb.2010.12.001","article-title":"The sarcomeric cytoskeleton: who picks up the strain?","volume":"23","author":"Gautel","year":"2011","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jchf.2023.03.010_bib9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1172\/JCI0215380","article-title":"Mixed signals in heart failure: cancer rules","volume":"109","author":"Hoshijima","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jchf.2023.03.010_bib10","article-title":"Ultrastructural changes of the right ventricular myocytes in pulmonary arterial hypertension","volume":"8","author":"Shults","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jchf.2023.03.010_bib11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1378\/chest.14-0701","article-title":"Signs of right ventricular deterioration in clinically stable patients with pulmonary arterial hypertension","volume":"147","author":"van de Veerdonk","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.jchf.2023.03.010_bib12","article-title":"Echocardiographic prognosis relevance of attenuated right heart remodeling in idiopathic pulmonary arterial hypertension","volume":"8","author":"Zhao","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jchf.2023.03.010_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jacc.2016.10.047","article-title":"The relationship between the right ventricle and its load in pulmonary hypertension","volume":"69","author":"Vonk Noordegraaf","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib14","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1378\/chest.08-0492","article-title":"The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension","volume":"135","author":"Bogaard","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.jchf.2023.03.010_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/bph.14866","article-title":"Right heart failure in pulmonary hypertension: Diagnosis and new perspectives on vascular and direct right ventricular treatment","volume":"178","author":"Tello","year":"2021","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jchf.2023.03.010_bib16","article-title":"Multi-beat right ventricular-arterial coupling predicts clinical worsening in pulmonary arterial hypertension","volume":"9","author":"Hsu","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jchf.2023.03.010_bib17","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jcmg.2020.10.008","article-title":"Right ventricular adaptation assessed using cardiac magnetic resonance predicts survival in pulmonary arterial hypertension","volume":"14","author":"Goh","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jchf.2023.03.010_bib18","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1136\/heartjnl-2021-320733","article-title":"Right ventricular remodelling in pulmonary arterial hypertension predicts treatment response","volume":"108","author":"Goh","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.jchf.2023.03.010_bib19","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jcmg.2020.08.013","article-title":"Cardiac-MRI predicts clinical worsening and mortality in pulmonary arterial hypertension: a systematic review and meta-analysis","volume":"14","author":"Alabed","year":"2021","journal-title":"J\u00a0Am Coll Cardiol Img"},{"key":"10.1016\/j.jchf.2023.03.010_bib20","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1378\/chest.129.5.1313","article-title":"Serum N-terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension","volume":"129","author":"Fijalkowska","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jchf.2023.03.010_bib21","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.CIR.0000084544.54513.E2","article-title":"Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension","volume":"108","author":"Torbicki","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2023.03.010_bib22","first-page":"1244","article-title":"Treatment targets for right ventricular dysfunction in pulmonary arterial hypertension","volume":"5","author":"Prisco","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Basic Trans Science"},{"key":"10.1016\/j.jchf.2023.03.010_bib23","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/CIRCULATIONAHA.109.883843","article-title":"Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure","volume":"120","author":"Bogaard","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2023.03.010_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0168-9525(02)02642-2","article-title":"The anterior heart-forming field: voyage to the arterial pole of the heart","volume":"18","author":"Kelly","year":"2002","journal-title":"Trends Genet"},{"key":"10.1016\/j.jchf.2023.03.010_bib25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/ALN.0000000000001891","article-title":"Right ventricular perfusion: physiology and clinical implications","volume":"128","author":"Crystal","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jchf.2023.03.010_bib26","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10741-019-09778-1","article-title":"Right ventricular mechanical pattern in health and disease: beyond longitudinal shortening","volume":"24","author":"Kov\u00e1cs","year":"2019","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jchf.2023.03.010_bib27","first-page":"5","article-title":"The relative impact of circumferential and longitudinal shortening on left ventricular ejection fraction and stroke volume","volume":"17","author":"Maciver","year":"2012","journal-title":"Exp Clin Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib28","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1152\/japplphysiol.01345.2003","article-title":"Matching coronary blood flow to myocardial oxygen consumption","volume":"97","author":"Tune","year":"2004","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/eurheartj\/ehm567","article-title":"Right coronary artery flow impairment in patients with pulmonary hypertension","volume":"29","author":"van Wolferen","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2023.03.010_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1983.63.1.1","article-title":"Coronary physiology","volume":"63","author":"Feigl","year":"1983","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jchf.2023.03.010_bib31","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/01.RES.49.4.877","article-title":"Measurements of coronary velocity and reactive hyperemia in the coronary circulation of humans","volume":"49","author":"Marcus","year":"1981","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2023.03.010_bib32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1203\/pdr.0b013e31805365a6","article-title":"Microvascular development in porcine right and left ventricular walls","volume":"61","author":"Ohuchi","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jchf.2023.03.010_bib33","first-page":"379","article-title":"The effects of acute and intermittent hypoxia on the expressions of HIF-1\u03b1 and VEGF in the left and right ventricles of the rabbit heart","volume":"11","author":"Tekin","year":"2011","journal-title":"Anatol J Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib34","first-page":"74","article-title":"Myocardial perfusion and right ventricular function","volume":"5","author":"Klima","year":"1999","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jchf.2023.03.010_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1148\/radiol.10100725","article-title":"Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension","volume":"258","author":"Vogel-Claussen","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.jchf.2023.03.010_bib36","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0735-1097(01)01496-6","article-title":"Right ventricular ischemia in patients with primary pulmonary hypertension","volume":"38","author":"G\u00f3mez","year":"2001","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12968-020-00694-0","article-title":"Right ventricular myocardial deoxygenation in patients with pulmonary artery hypertension","volume":"23","author":"Sree Raman","year":"2021","journal-title":"J\u00a0Cardiovasc Magn Reson"},{"key":"10.1016\/j.jchf.2023.03.010_bib38","first-page":"11","article-title":"Right ventricular myocardial oxygen partial pressure is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by Myo-inositol trispyrophosphate","author":"Okni\u0144ska","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jchf.2023.03.010_bib39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jchf.2023.03.010_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrm1911","article-title":"VEGF receptor signalling: in control of vascular function","volume":"7","author":"Olsson","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jchf.2023.03.010_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000521584","article-title":"VEGF-independent angiogenic factors: beyond VEGF\/VEGFR2 signaling","volume":"59","author":"Eguchi","year":"2022","journal-title":"J\u00a0Vasc Res"},{"key":"10.1016\/j.jchf.2023.03.010_bib42","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/onc.2012.198","article-title":"Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer","volume":"32","author":"Sutendra","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.jchf.2023.03.010_bib43","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00109-013-1059-4","article-title":"A\u00a0metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension","volume":"91","author":"Sutendra","year":"2013","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.jchf.2023.03.010_bib44","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1165\/rcmb.2010-0412OC","article-title":"Molecular signature of a right heart failure program in chronic severe pulmonary hypertension","volume":"45","author":"Drake","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jchf.2023.03.010_bib45","first-page":"H1948","article-title":"Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension","volume":"275","author":"Partovian","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib46","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00109-013-1064-7","article-title":"Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension","volume":"91","author":"Piao","year":"2013","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.jchf.2023.03.010_bib47","doi-asserted-by":"crossref","first-page":"L675","DOI":"10.1152\/ajplung.00351.2020","article-title":"Endothelial cell PHD2-HIF1\u03b1-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension","volume":"321","author":"Kassa","year":"2021","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib48","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jchf.2023.03.010_bib49","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.HYP.0000215207.54689.31","article-title":"Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload","volume":"47","author":"Izumiya","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.jchf.2023.03.010_bib50","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00395-005-0581-0","article-title":"Vascular endothelial growth factor delays onset of failure in pressure-overload hypertrophy through matrix metalloproteinase activation and angiogenesis","volume":"101","author":"Friehs","year":"2006","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib51","doi-asserted-by":"crossref","first-page":"E841","DOI":"10.1073\/pnas.1202081109","article-title":"Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-\u03b2 signaling","volume":"109","author":"Wei","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jchf.2023.03.010_bib52","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1002\/ehf2.13555","article-title":"Soluble vascular endothelial growth factor receptor 2 and prognosis in patients with chronic heart failure","volume":"8","author":"Iguchi","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jchf.2023.03.010_bib53","first-page":"131","article-title":"HIF in the heart: development, metabolism, ischemia, and atherosclerosis","author":"Knutson","year":"2021","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jchf.2023.03.010_bib54","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1172\/JCI137558","article-title":"Hypoxia-inducible factor signaling in pulmonary hypertension","volume":"130","author":"Pullamsetti","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jchf.2023.03.010_bib55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1165\/rcmb.2020-0325ED","article-title":"Heart of the matter: divergent roles of hypoxia-inducible factors in hypoxia-induced right ventricle hypertrophy","volume":"63","author":"Nozik-Grayck","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jchf.2023.03.010_bib56","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/dbio.1999.9253","article-title":"Defective vascularization of HIF-1 alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death","volume":"209","author":"Kotch","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.jchf.2023.03.010_bib57","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1096\/fj.04-1510fje","article-title":"Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart","volume":"18","author":"Huang","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.jchf.2023.03.010_bib58","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.jacc.2005.08.045","article-title":"Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse","volume":"46","author":"Kido","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib59","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1038\/s41467-019-11500-6","article-title":"CD146-HIF-1\u03b1 hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension","volume":"10","author":"Luo","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jchf.2023.03.010_bib60","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1182\/blood-2012-01-406108","article-title":"CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis","volume":"120","author":"Jiang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jchf.2023.03.010_bib61","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jacc.2017.05.034","article-title":"Basic biology of oxidative stress and the cardiovascular system: Part 1 of a 3-part series","volume":"70","author":"Sack","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib62","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/antiox7080106","article-title":"Redox biology of right-sided heart failure","volume":"7","author":"Shults","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.jchf.2023.03.010_bib63","article-title":"Proteomic profiling of early chronic pulmonary hypertension: evidence for both adaptive and maladaptive pathology","volume":"5","author":"Aziz","year":"2015","journal-title":"J\u00a0Pulm Respir Med"},{"key":"10.1016\/j.jchf.2023.03.010_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01799","article-title":"Review on chamber-specific differences in right and left heart reactive oxygen species handling","volume":"9","author":"Schl\u00fcter","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib65","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/expphysiol.2006.033506","article-title":"Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia","volume":"91","author":"Guzy","year":"2006","journal-title":"Exp Physiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib66","first-page":"658","article-title":"Right heart failure in mice upon pressure overload is promoted by mitochondrial oxidative stress","volume":"7","author":"M\u00fcller","year":"2022","journal-title":"J\u00a0Am Coll Cardiol Basic Trans Science"},{"key":"10.1016\/j.jchf.2023.03.010_bib67","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cardiores.2007.05.012","article-title":"Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species","volume":"75","author":"Redout","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jchf.2023.03.010_bib68","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1089\/ars.2014.6139","article-title":"Specific mechanisms underlying right heart failure: the missing upregulation of superoxide dismutase-2 and its decisive role in antioxidative defense","volume":"23","author":"Schreckenberg","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jchf.2023.03.010_bib69","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1161\/CIRCULATIONAHA.114.012975","article-title":"Molecular mechanisms of right ventricular failure","volume":"132","author":"Reddy","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2023.03.010_bib70","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3390\/biomedicines10020341","article-title":"Mitochondrial metabolism, redox, and calcium homeostasis in pulmonary arterial hypertension","volume":"10","author":"Liang","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jchf.2023.03.010_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101536","article-title":"NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess","volume":"34","author":"Kra\u010dun","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.jchf.2023.03.010_bib72","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCHEARTFAILURE.111.961565","article-title":"p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation","volume":"5","author":"Nakamura","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2023.03.010_bib73","doi-asserted-by":"crossref","first-page":"11995","DOI":"10.1074\/jbc.273.20.11995","article-title":"p53 inhibits hypoxia-inducible factor-stimulated transcription","volume":"273","author":"Blagosklonny","year":"1998","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jchf.2023.03.010_bib74","article-title":"Modeling the interplay between the HIF-1 and p53 pathways in hypoxia","volume":"5","author":"Zhou","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jchf.2023.03.010_bib75","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1101\/gad.14.1.34","article-title":"Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha","volume":"14","author":"Ravi","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.jchf.2023.03.010_bib76","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1007\/s00018-020-03694-6","article-title":"The regulatory roles of p53 in cardiovascular health and disease","volume":"78","author":"Men","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jchf.2023.03.010_bib77","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of HIF-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jchf.2023.03.010_bib78","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.yjmcc.2011.07.030","article-title":"Heat shock transcription factor 1 protects heart after pressure overload through promoting myocardial angiogenesis in male mice","volume":"51","author":"Zou","year":"2011","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib79","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2023.03.010_bib80","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00109-009-0524-6","article-title":"The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle","volume":"88","author":"Piao","year":"2010","journal-title":"J\u00a0Mol Med (Berlin)"},{"key":"10.1016\/j.jchf.2023.03.010_bib81","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cardfail.2020.10.006","article-title":"Ranolazine improves right ventricular function in patients with precapillary pulmonary hypertension: results from a double-blind, randomized, placebo-controlled trial","volume":"27","author":"Han","year":"2021","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2023.03.010_bib82","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao0303","article-title":"PPAR-gamma agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation","volume":"10","author":"Legchenko","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jchf.2023.03.010_bib83","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12107","article-title":"l-Carnitine therapy improves right heart dysfunction through Cpt1-dependent fatty acid oxidation","volume":"12","author":"Agrawal","year":"2022","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jchf.2023.03.010_bib84","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/CIRCULATIONAHA.120.051937","article-title":"Suppression of myocardial hypoxia-inducible factor-1\u03b1 compromises metabolic adaptation and impairs cardiac function in patients with cyanotic congenital heart disease during puberty","volume":"143","author":"Liu","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2023.03.010_bib85","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1164\/rccm.200912-1856OC","article-title":"Prognostic significance of sympathetic nervous system activation in pulmonary arterial hypertension","volume":"181","author":"Ciarka","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jchf.2023.03.010_bib86","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003703","article-title":"Use of \u03b2-blockers in pulmonary hypertension","volume":"10","author":"Perros","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2023.03.010_bib87","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1164\/rccm.201203-0411OC","article-title":"Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension","volume":"186","author":"de Man","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jchf.2023.03.010_bib88","doi-asserted-by":"crossref","DOI":"10.1136\/heartasia-2018-010999","article-title":"Renin-angiotensin-aldosterone inhibition improves right ventricular function: a meta-analysis","volume":"10","author":"Cao","year":"2018","journal-title":"Heart Asia"},{"key":"10.1016\/j.jchf.2023.03.010_bib89","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.115.002636","article-title":"Right ventricular myocardial stiffness in experimental pulmonary arterial hypertension","volume":"9","author":"Rain","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2023.03.010_bib90","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12890-018-0604-x","article-title":"Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension","volume":"18","author":"Boehm","year":"2018","journal-title":"BMC Pulmon Med"},{"key":"10.1016\/j.jchf.2023.03.010_bib91","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehab724.093","article-title":"Right ventricular reverse remodeling assessed by echocardiography as a new goal-oriented treatment strategy in PAH patients","volume":"42","author":"Fauvel","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2023.03.010_bib92","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/cvr\/cvz310","article-title":"Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding","volume":"116","author":"Boehm","year":"2019","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jchf.2023.03.010_bib93","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1148\/radiol.2015150765","article-title":"MR imaging-derived regional pulmonary parenchymal perfusion and cardiac function for monitoring patients with chronic thromboembolic pulmonary hypertension before and after pulmonary endarterectomy","volume":"279","author":"Schoenfeld","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.jchf.2023.03.010_bib94","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/pace.14572","article-title":"Right ventricular function and long-term clinical outcomes after cardiac resynchronization therapy: a cardiovascular magnetic resonance study","volume":"45","author":"Zegard","year":"2022","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib95","doi-asserted-by":"crossref","DOI":"10.1177\/10742484211069005","article-title":"A\u00a0review of pulmonary arterial hypertension treatment in extracorporeal membrane oxygenation: a case series of adult patients","volume":"27","author":"Torbic","year":"2022","journal-title":"J\u00a0Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.jchf.2023.03.010_bib96","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1378\/chest.06-1227","article-title":"Atrial septostomy in treatment of end-stage right heart failure in patients with pulmonary hypertension","volume":"131","author":"Kurzyna","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jchf.2023.03.010_bib97","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2023.03.010_bib98","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/bph.13721","article-title":"Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature","volume":"174","author":"Maarman","year":"2017","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jchf.2023.03.010_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.01233","article-title":"Oxidative stress and its implications in the right ventricular remodeling secondary to pulmonary hypertension","volume":"10","author":"Mikhael","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib100","first-page":"1365","article-title":"Angiogenic gene therapy in cardiovascular diseases: dream or vision?","volume":"38","author":"Yl\u00e4-Herttuala","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2023.03.010_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113544","article-title":"New potential treatment for cardiovascular disease through modulation of hemoglobin oxygen binding curve: Myo-inositol trispyrophosphate (ITPP), from cancer to cardiovascular disease","volume":"154","author":"Okni\u0144ska","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jchf.2023.03.010_bib102","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1183\/09031936.00037711","article-title":"Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target","volume":"38","author":"Rhodes","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jchf.2023.03.010_bib103","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00616-2020","article-title":"Oral iron supplementation with ferric maltol in patients with pulmonary hypertension","volume":"56","author":"Olsson","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jchf.2023.03.010_bib104","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1513\/AnnalsATS.202009-1131OC","article-title":"Supplementation with iron in pulmonary arterial hypertension. two randomized crossover trials","volume":"18","author":"Howard","year":"2021","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jchf.2023.03.010_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005924","article-title":"Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic","volume":"16","author":"Boehme","year":"2018","journal-title":"PLOS Biol"},{"key":"10.1016\/j.jchf.2023.03.010_bib106","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00109-013-0992-6","article-title":"Stable tumor vessel normalization with pO(2) increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment","volume":"91","author":"Kieda","year":"2013","journal-title":"J\u00a0Mol Med (Berlin)"},{"key":"10.1016\/j.jchf.2023.03.010_bib107","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jacc.2008.06.003","article-title":"Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure","volume":"52","author":"Watanabe","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2023.03.010_bib108","doi-asserted-by":"crossref","first-page":"II351","DOI":"10.1161\/circ.100.suppl_2.Ii-351","article-title":"RSR13, a synthetic allosteric modifier of hemoglobin, improves myocardial recovery following hypothermic cardiopulmonary bypass","volume":"100","author":"Kilgore","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2023.03.010_bib109","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1038\/s41467-021-24069-w","article-title":"Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors","volume":"12","author":"Schneider","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jchf.2023.03.010_bib110","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/01.RES.56.4.586","article-title":"Optimal arterial resistance for the maximal stroke work studied in isolated canine left ventricle","volume":"56","author":"Sunagawa","year":"1985","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2023.03.010_bib111","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1161\/01.RES.39.6.760","article-title":"Phasic right coronary artery blood flow in conscious dogs with normal and elevated right ventricular pressures","volume":"39","author":"Lowensohn","year":"1976","journal-title":"Circ Res"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177923001403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177923001403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:04:49Z","timestamp":1761973489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177923001403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":111,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S2213177923001403"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2023.03.010","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Oxygen Starvation in Right Ventricular Decompensation and Failure in Pulmonary Arterial Hypertension","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2023.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}]}}