{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:16:04Z","timestamp":1777641364414,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jchf.2024.05.021","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T18:46:24Z","timestamp":1722883584000},"page":"1473-1486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sacubitril\/Valsartan Versus Enalapril in Chronic Chagas Cardiomyopathy"],"prefix":"10.1016","volume":"12","author":[{"given":"Edimar Alcides","family":"Bocchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Echeverria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Demacq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Gabriel Melo","family":"de Barros e Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian","family":"Mazza Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-May","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-3379","authenticated-orcid":false,"given":"Lucas","family":"Damiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Morillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Kevorkian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Ramires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-4076","authenticated-orcid":false,"given":"M. Cecilia","family":"Bahit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Chavez-Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Antonio","family":"Maga\u00f1a-Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-3975","authenticated-orcid":false,"given":"John J.V.","family":"McMurray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Gimpelewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato D.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2024.05.021_bib1","first-page":"33","article-title":"Chagas disease in Latin America: an epidemiological update based on 2010 estimates","volume":"90","year":"2015","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.jchf.2024.05.021_bib2","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2024.05.021_bib3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jacc.2013.05.046","article-title":"Chagas\u2019 disease. An overview of clinical and epidemiological aspects","volume":"62","author":"Nunes","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/1573403X11309020007","article-title":"Heart failure in South America","volume":"9","author":"Bocchi","year":"2013","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.jchf.2024.05.021_bib5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1590\/S0066-782X2010005000102","article-title":"Epidemiological, clinical e therapeutic profile of heart failure in a tertiary hospital","volume":"95","author":"Nogueira","year":"2010","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijcard.2004.05.025","article-title":"Risk stratification in a Brazilian hospital-based cohort of 1220 outpatients with heart failure: role of Chagas\u2019 heart disease","volume":"102","author":"Freitas","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib7","first-page":"523","article-title":"Update on indications and results of the surgical treatment of heart failure","volume":"63","author":"Bocchi","year":"1994","journal-title":"Arq Bras Cardiolog"},{"key":"10.1016\/j.jchf.2024.05.021_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002176","article-title":"Mode of death on Chagas\u2019 heart disease: comparison with other etiologies. A subanalysis of the REMADHE prospective trial","volume":"7","author":"Ayub-Ferreira","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jchf.2024.05.021_bib9","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1161\/CIRCHEARTFAILURE.115.002229","article-title":"Prevalence and Impact of Chagas Disease Among Latin American Immigrants With Nonischemic Cardiomyopathy in Los Angeles, California","volume":"8","author":"Traina","year":"2015","journal-title":"Circ Heart Fail"},{"issue":"5","key":"10.1016\/j.jchf.2024.05.021_bib10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.cardfail.2023.08.014","article-title":"In-hospital management and long-term clinical outcomes and adherence in patients with acute decompensated heart failure: primary results of the first Brazilian Registry of Heart\u00a0Failure (BREATHE)","volume":"30","author":"de Albuquerque","year":"2024","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jchf.2024.05.021_bib11","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004361","article-title":"Contemporary characteristics and outcomes in chagasic heart failure compared with other nonischemic and ischemic cardiomyopathy","volume":"10","author":"Shen","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2024.05.021_bib12","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1016\/j.ijcard.2013.04.015","article-title":"Prognosis of patients with chronic systolic heart failure: Chagas disease versus systemic arterial hypertension","volume":"168","author":"Bestetti","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ijcard.2012.01.033","article-title":"Outcome of Chagas cardiomyopathy in comparison to ischemic cardiomyopathy","volume":"167","author":"Vilas Boas","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/CIRCHEARTFAILURE.109.882035","article-title":"Beta-blocker therapy and mortality of patients with Chagas cardiomyopathy: a subanalysis of the REMADHE prospective trial","volume":"3","author":"Issa","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2024.05.021_bib15","article-title":"SBC Guideline on the diagnosis and treatment of patients with cardiomyopathy of Chagas disease - 2023","volume":"120","author":"Marin-Neto","year":"2023","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib16","first-page":"436","article-title":"Diretriz Brasileira de Insufici\u00eancia Card\u00edaca Cr\u00f4nica e Aguda","volume":"111","year":"2018","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib17","first-page":"273","article-title":"[Beneficial effects of enalapril on the diastolic ventricular function in Chagas myocardiopathy]","volume":"60","author":"Szajnbok","year":"1993","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ahj.2006.12.017","article-title":"A\u00a0randomized trial of carvedilol after renin-angiotensin system inhibition in chronic Chagas cardiomyopathy","volume":"153","author":"Botoni","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2024.05.021_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ehf2.12240","article-title":"Safety profile and efficacy of ivabradine in heart failure due to Chagas heart disease: a post hoc analysis of the SHIFT trial","volume":"5","author":"Bocchi","year":"2018","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jchf.2024.05.021_bib20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/0091270009343932","article-title":"Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)","volume":"50","author":"Gu","year":"2010","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.jchf.2024.05.021_bib21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2024.05.021_bib22","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/eurheartj\/ehu455","article-title":"A\u00a0putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure","volume":"36","author":"McMurray","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2024.05.021_bib23","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/ehf2.12355","volume":"5","author":"Ramires","year":"2018","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jchf.2024.05.021_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/08037059209077502","article-title":"Prospective randomized open blinded end-point (PROBE) study. A novel design for intervention trials. prospective randomized open blinded end-point","volume":"1","author":"Hansson","year":"1992","journal-title":"Blood Press"},{"key":"10.1016\/j.jchf.2024.05.021_bib25","article-title":"SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of Chagas disease - 2023","volume":"120","author":"Marin-Neto","year":"2023","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib26","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.jacc.2016.09.931","article-title":"Prognostic implications of changes in N-terminal pro-B-type natriuretic peptide in patients with heart failure","volume":"68","author":"Zile","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib27","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1507574","article-title":"Randomized trial of benznidazole for chronic Chagas\u2019 cardiomyopathy","volume":"373","author":"Morillo","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2024.05.021_bib28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/eurheartj\/ehr352","article-title":"The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities","volume":"33","author":"Pocock","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2024.05.021_bib29","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jacc.2017.08.004","article-title":"Chronic Chagas heart disease management: from etiology to cardiomyopathy treatment","volume":"70","author":"Bocchi","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jchf.2024.05.021_bib30","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1002\/ehf2.13648","article-title":"Mortality risk in chronic Chagas cardiomyopathy: a systematic review and meta-analysis","volume":"8","author":"Chadalawada","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jchf.2024.05.021_bib31","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/oxfordjournals.eurheartj.a060301","article-title":"Chagas cardiomyopathy and captopril","volume":"13","author":"Roberti","year":"1992","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2024.05.021_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0167-5273(96)02776-3","article-title":"Acute effects of digitalis and enalapril on the neurohormonal profile of chagasic patients with severe congestive heart failure","volume":"57","author":"Khoury","year":"1996","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0167-5273(02)00181-X","article-title":"Effects of metoprolol in chagasic patients with severe congestive heart failure","volume":"85","author":"D\u00e1vila","year":"2002","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijcard.2010.05.033","article-title":"Effects of \u03b2-blockers on outcome of patients with Chagas\u2019 cardiomyopathy with chronic heart failure","volume":"151","author":"Bestetti","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1590\/S0066-782X2012005000015","article-title":"Carvedilol attenuates oxidative stress in chronic chagasic cardiomyopathy","volume":"98","author":"Budni","year":"2012","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000380812","article-title":"Effect of Combining ivabradine and \u03b2-blockers: focus on the use of carvedilol in the SHIFT population","volume":"131","author":"Bocchi","year":"2015","journal-title":"Cardiology"},{"key":"10.1016\/j.jchf.2024.05.021_bib37","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/bcp.14978","article-title":"Clinical and echocardiographic characteristics after six months of sacubitril\/valsartan in Chagas heart disease\u2014a case series","volume":"88","author":"Figueiredo","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jchf.2024.05.021_bib38","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ahj.2013.08.027","article-title":"Chronic use of amiodarone aGAinSt Implantable cardioverter-defibrillator therapy for primary prevention of death in patients with Chagas cardiomyopathy Study: Rationale and design of a randomized clinical trial","volume":"166","author":"Martinelli","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2024.05.021_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijcard.2010.05.012","article-title":"Mortality of newly diagnosed heart failure treated with amiodarone: a propensity-matched study","volume":"151","author":"Andrey","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2024.05.021_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1745-6215-7-21","article-title":"CHARITY: Chagas cardiomyopathy bisoprolol intervention study: a randomized double-blind placebo force-titration controlled study with bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT 00323973]","volume":"7","author":"Quiros","year":"2006","journal-title":"Trials"},{"key":"10.1016\/j.jchf.2024.05.021_bib41","article-title":"Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy","volume":"7","author":"Mart\u00ed-Carvajal","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jchf.2024.05.021_bib42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure","volume":"325","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2024.05.021_bib43","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM199209033271003","article-title":"Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions","volume":"327","year":"1992","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2024.05.021_bib44","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJM199108013250502","article-title":"A\u00a0comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of congestive heart failure","volume":"325","author":"Cohn","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jchf.2024.05.021_bib45","first-page":"3192","article-title":"Brain natriuretic peptide biomarkers in current clinical and therapeutic scenarios of heart failure","volume":"11","author":"Alcidi","year":"2022","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jchf.2024.05.021_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011847","article-title":"Assessment of biomarkers and clinical parameters as predictors of survival in patients with chagasic heart failure","volume":"17","author":"Bocchi","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"10.1016\/j.jchf.2024.05.021_bib47","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/ehf2.13232","article-title":"The course of patients with Chagas heart disease during episodes of decompensated heart failure","volume":"8","author":"Issa","year":"2021","journal-title":"ESC Heart Fail"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221317792400492X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221317792400492X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T13:48:31Z","timestamp":1726753711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221317792400492X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S221317792400492X"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2024.05.021","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sacubitril\/Valsartan Versus Enalapril in Chronic Chagas Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2024.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}