{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:10:42Z","timestamp":1791835842878,"version":"4.3.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jchf.2025.02.015","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T14:51:28Z","timestamp":1746715888000},"page":"102433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex Differences in Diabetic Cardiomyopathy and Treatment Response to AT-001"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-5015","authenticated-orcid":false,"given":"Vanessa","family":"Blumer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James L.","family":"Januzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-4086","authenticated-orcid":false,"given":"Justin A.","family":"Ezekowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Perfetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Rosenstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Del Prato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-735X","authenticated-orcid":false,"given":"W.H. Wilson","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Urbinati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7456-1570","authenticated-orcid":false,"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Hedge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrien E.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn S.P.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2025.02.015_bib1","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1093\/eurheartj\/ehz835","article-title":"Sex differences in heart failure","volume":"40","author":"Lam","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2025.02.015_bib2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jchf.2020.12.011","article-title":"Sex differences in clinical course and patient-reported outcomes among patients hospitalized for heart failure","volume":"9","author":"Blumer","year":"2021","journal-title":"JACC Heart Fail"},{"issue":"4","key":"10.1016\/j.jchf.2025.02.015_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11897-024-00666-w","article-title":"Impact of sex and diabetes in patients with heart failure","volume":"21","author":"\u00c1lvarez-Zaballos","year":"2024","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.jchf.2025.02.015_bib4","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1007\/s00125-012-2579-0","article-title":"High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes","volume":"55","author":"Boonman-de Winter","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.jchf.2025.02.015_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/743503","article-title":"Evidence for a specific diabetic cardiomyopathy: an observational retrospective echocardiographic study in 656 asymptomatic type 2 diabetic patients","volume":"2015","author":"Pham","year":"2015","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.jchf.2025.02.015_bib6","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s00125-023-05891-x","article-title":"Sex differences in type 2 diabetes","volume":"66","author":"Kautzky-Willer","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.jchf.2025.02.015_bib7","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/ehjci\/jeaa070","article-title":"Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus","volume":"21","author":"Nishi","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.jchf.2025.02.015_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jacc.2024.03.380","article-title":"Randomized trial of a selective aldose reductase inhibitor in patients with diabetic cardiomyopathy","volume":"84","author":"Januzzi","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2025.02.015_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ahj.2022.11.003","article-title":"Rationale and design of the Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure Trial (ARISE-HF) in patients with high-risk diabetic cardiomyopathy","volume":"256","author":"Januzzi","year":"2023","journal-title":"Am Heart J"},{"key":"10.1016\/j.jchf.2025.02.015_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026828","article-title":"Contributions of women to cardiovascular science over two decades: authorship, leadership, and mentorship","volume":"12","author":"Blumer","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jchf.2025.02.015_bib11","article-title":"Representation of women in heart failure clinical trials: barriers to enrollment and strategies to close the gap","volume":"13","author":"Reza","year":"2022","journal-title":"Am Heart J Plus"},{"key":"10.1016\/j.jchf.2025.02.015_bib12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jchf.2023.11.007","article-title":"Prognostic impact of repeated NT-proBNP measurements in patients with heart failure with reduced ejection fraction","volume":"12","author":"Fuery","year":"2024","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jchf.2025.02.015_bib13","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa0706824","article-title":"Cardiac troponin and outcome in acute heart failure","volume":"358","author":"Peacock","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jchf.2025.02.015_bib14","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.1161\/CIR.0000000000000691","article-title":"Type 2 diabetes mellitus and heart failure: a scientific statement from the American Heart Association and the Heart Failure Society of America: this statement does not represent an update of the 2017 ACC\/AHA\/HFSA heart failure guideline update","volume":"140","author":"Dunlay","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2025.02.015_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.661297","article-title":"Sex differences of the diabetic heart","volume":"12","author":"Fourny","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.jchf.2025.02.015_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/ENDO:25:2:073","article-title":"Diabetic cardiomyopathy: do women differ from men?","volume":"25","author":"Ren","year":"2004","journal-title":"Endocrine"},{"key":"10.1016\/j.jchf.2025.02.015_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2023.117279","article-title":"Sex differences in the genetic and molecular mechanisms of coronary artery disease","volume":"384","author":"Sakkers","year":"2023","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jchf.2025.02.015_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006134","article-title":"Sex differences in quality of life and clinical outcomes in patients with advanced heart failure","volume":"13","author":"Truby","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2025.02.015_bib19","article-title":"Gender-related differences in heart failure biomarkers","volume":"7","author":"Cediel","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jchf.2025.02.015_bib20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/ejhf.1771","article-title":"Sex-related differences in contemporary biomarkers for heart failure: a review","volume":"22","author":"Suthahar","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2025.02.015_bib21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/ehf2.12483","article-title":"Sex differences on peak oxygen uptake in heart failure","volume":"6","author":"Palau","year":"2019","journal-title":"ESC Heart Fail"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177925002355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177925002355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:02:14Z","timestamp":1772139734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177925002355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2213177925002355"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2025.02.015","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex Differences in Diabetic Cardiomyopathy and Treatment Response to AT-001","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2025.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"102433"}}