{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:03:09Z","timestamp":1790820189865,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jchf.2025.102563","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:00:20Z","timestamp":1756278020000},"page":"102563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Are We Waiting Too Long to Implant Cardiac Resynchronization Therapy Devices in Patients With Heart Failure and Reduced Left Ventricular Function?"],"prefix":"10.1016","volume":"13","author":[{"given":"Andrea M.","family":"Russo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2025.102563_bib1","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.hrthm.2012.07.025","article-title":"2012 EHRA\/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management","volume":"9","author":"Daubert","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jchf.2025.102563_bib2","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2025.102563_bib3","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2025.102563_bib4","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.hrthm.2023.03.1538","article-title":"2023 HRS\/APHRS\/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure","volume":"20","author":"Chung","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jchf.2025.102563_bib5","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1161\/CIRCULATIONAHA.122.062124","article-title":"Cardiac resynchronization therapy improves outcomes in patients with intraventricular conduction delay but not right bundle branch block: a patient-level meta-analysis of randomized controlled trials","volume":"147","author":"Friedman","year":"2023","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.jchf.2025.102563_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchf.2025.102515","article-title":"Timing of cardiac resynchronization therapy following stable medical therapy in patients with heart failure","volume":"13","author":"Villaschi","year":"2025","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jchf.2025.102563_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad059","article-title":"Timing of cardiac resynchronization therapy implantation","volume":"25","author":"Leyva","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.jchf.2025.102563_bib8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/clc.23135","article-title":"Timing of cardiac resynchronization therapy device implantation in heart failure patients and its association with outcomes","volume":"42","author":"Goldstein","year":"2019","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jchf.2025.102563_bib9","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.hrthm.2023.03.022","article-title":"Variation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomes","volume":"20","author":"Chui","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jchf.2025.102563_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1253\/circrep.CR-22-0036","article-title":"Utilization and efficacy of cardiac resynchronization therapy in patients with chronic heart failure: a report from the CHART-2 study","volume":"4","author":"Hayashi","year":"2022","journal-title":"Circ Rep"},{"issue":"10408","key":"10.1016\/j.jchf.2025.102563_bib11","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(23)00912-1","article-title":"Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial","volume":"402","author":"Wilkoff","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2025.102563_bib12","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.hrthm.2011.04.015","article-title":"Cardiac resynchronization therapy and the relationship of percent biventricular pacing to symptoms and survival","volume":"8","author":"Hayes","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jchf.2025.102563_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jacc.2017.11.020","article-title":"Impaired recovery of left ventricular function in patients with cardiomyopathy and left bundle branch block","volume":"71","author":"Sze","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2025.102563_bib14","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2459\/JCM.0000000000001231","article-title":"Impact of QRS duration on left ventricular remodelling and survival in patients with heart failure","volume":"22","author":"Straw","year":"2021","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"10.1016\/j.jchf.2025.102563_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/pace.13264","article-title":"New-onset left bundle branch block-associated idiopathic nonischemic cardiomyopathy and time from diagnosis to cardiac resynchronization therapy: the NEOLITH II study","volume":"41","author":"Wang","year":"2018","journal-title":"Pacing Clin Electrophysiol"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177925004901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177925004901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:26:06Z","timestamp":1790817966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177925004901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2213177925004901"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2025.102563","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are We Waiting Too Long to Implant Cardiac Resynchronization Therapy Devices in Patients With Heart Failure and Reduced Left Ventricular Function?","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2025.102563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2025.102515","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier on behalf of the American College of Cardiology Foundation","name":"copyright","label":"Copyright"}],"article-number":"102563"}}