{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:44:30Z","timestamp":1792154670869,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jchf.2026.103296","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:08:41Z","timestamp":1788404921000},"page":"103296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Residual Inflammatory Risk of Heart Failure and Atherosclerotic CVD in Diabetes"],"prefix":"10.1016","author":[{"given":"Kershaw V.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn R.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Maria","family":"Belalcazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-0897","authenticated-orcid":false,"given":"Matthew W.","family":"Segar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Espeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M.","family":"Ballantyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambarish","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2026.103296_bib1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jchf.2026.103296_bib2","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jchf.2026.103296_bib3","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1016\/j.jacc.2018.06.082","article-title":"Clinician's guide to reducing inflammation to reduce atherothrombotic risk: JACC review topic of the week","volume":"72","author":"Ridker","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2026.103296_bib4","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","article-title":"Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure","volume":"139","author":"Everett","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103296_bib5","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/eurheartj\/ehy310","article-title":"Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS)","volume":"39","author":"Ridker","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2026.103296_bib6","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jchf.2026.103296_bib7","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIR.0000000000001184","article-title":"Cardiovascular-kidney-metabolic health: a presidential advisory from the American Heart Association","volume":"148","author":"Ndumele","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103296_bib8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijcard.2018.02.027","article-title":"The prognostic value of high sensitivity C-reactive protein in a multi-ethnic population after >10 years of follow-up: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"264","author":"Cainzos-Achirica","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2026.103296_bib9","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1056\/NEJMoa0707402","article-title":"Genetically elevated C-reactive protein and ischemic vascular disease","volume":"359","author":"Zacho","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jchf.2026.103296_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/jama.2009.954","article-title":"Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease","volume":"302","author":"Elliott","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2026.103296_bib11","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0140-6736(11)61931-4","article-title":"Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies","volume":"379","author":"Sarwar","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2026.103296_bib12","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0140-6736(12)60110-X","article-title":"The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis","volume":"379","author":"Swerdlow","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jchf.2026.103296_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/jamacardio.2025.4491","article-title":"Rationale, design, and baseline clinical characteristics of the ziltivekimab cardiovascular outcomes trial: interleukin-6 inhibition and atherosclerotic event rate reduction","volume":"11","author":"Ridker","year":"2026","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jchf.2026.103296_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cardfail.2023.10.024","article-title":"HERMES: effects of ziltivekimab versus placebo on morbidity and mortality in patients with heart failure with mildly reduced or preserved ejection fraction and systemic inflammation","volume":"30","author":"Petrie","year":"2024","journal-title":"J Card Fail"},{"key":"10.1016\/j.jchf.2026.103296_bib15","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.2337\/dc10-0728","article-title":"A 1-year lifestyle intervention for weight loss in individuals with type 2 diabetes reduces high C-reactive protein levels and identifies metabolic predictors of change: from the look AHEAD (Action for Health in Diabetes) study","volume":"33","author":"Belalcazar","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jchf.2026.103296_bib16","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1001\/jama.289.14.1799","article-title":"Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial","volume":"289","author":"Esposito","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2026.103296_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2024.117461","article-title":"Comparison of interleukin-6 and high-sensitivity C-reactive protein for cardiovascular risk assessment: findings from the MESA study","volume":"390","author":"Ferreira","year":"2024","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jchf.2026.103296_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJMoa1212914","article-title":"Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes","volume":"369","author":"Look","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jchf.2026.103296_bib19","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/eurjpc\/zwad197","article-title":"Association of interleukin-6 and interleukin-18 with cardiovascular disease in older adults: atherosclerosis risk in communities study","volume":"30","author":"Jia","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jchf.2026.103296_bib20","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1161\/CIRCULATIONAHA.119.044865","article-title":"Association of intensive lifestyle intervention, fitness, and body mass index with risk of heart failure in overweight or obese adults with type 2 diabetes mellitus: an analysis from the look AHEAD trial","volume":"141","author":"Pandey","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103296_bib21","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1161\/CIRCULATIONAHA.120.050941","article-title":"Association of baseline and longitudinal changes in body composition measures with risk of heart failure and myocardial infarction in type 2 diabetes: findings from the look AHEAD trial","volume":"142","author":"Patel","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103296_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.atherosclerosis.2018.09.034","article-title":"The prognostic value of interleukin 6 in multiple chronic diseases and all-cause death: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"278","author":"Cainzos-Achirica","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jchf.2026.103296_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCRESAHA.115.306656","article-title":"From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection","volume":"118","author":"Ridker","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jchf.2026.103296_bib24","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1073\/pnas.92.11.4862","article-title":"Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice","volume":"92","author":"Hirota","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jchf.2026.103296_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.734400","article-title":"Genetically determined inflammatory biomarkers and the risk of heart failure: a Mendelian randomization study","volume":"8","author":"Li","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jchf.2026.103296_bib26","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa032804","article-title":"C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease","volume":"350","author":"Danesh","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jchf.2026.103296_bib27","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.2337\/diabetes.54.5.1566","article-title":"Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance","volume":"54","author":"Haffner","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jchf.2026.103296_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13910","article-title":"The effect of dietary weight-loss interventions on the inflammatory markers interleukin-6 and TNF-alpha in adults with obesity: a systematic review and meta-analysis of randomized controlled clinical trials","volume":"26","author":"Bulmer","year":"2025","journal-title":"Obes Rev"},{"key":"10.1016\/j.jchf.2026.103296_bib29","doi-asserted-by":"crossref","DOI":"10.1161\/circ.150.suppl_1.4139912","article-title":"Abstract 4139912: inflammatory biomarkers in people treated with tirzepatide living with overweight or obesity, without and with T2D: a post-hoc analysis from SURMOUNT-1 and SURMOUNT-2","volume":"150","author":"Sattar","year":"2024","journal-title":"Circulation"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177926003987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177926003987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:48:15Z","timestamp":1792151295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177926003987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":29,"alternative-id":["S2213177926003987"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2026.103296","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Residual Inflammatory Risk of Heart Failure and Atherosclerotic CVD in Diabetes","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2026.103296","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}],"article-number":"103296"}}