{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:04:45Z","timestamp":1790370285624,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"FNIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Heart Failure"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jchf.2026.103369","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:00:43Z","timestamp":1787925643000},"page":"103369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myocardial Histopathology-Based Heart Failure Phenotyping"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-1777","authenticated-orcid":false,"given":"Gregorio","family":"Tersalvi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Maleszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Dasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy","family":"Arab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katlyn E.","family":"Koepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie C.","family":"Bois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar F.","family":"AbouEzzeddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed U.","family":"Fayyaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Redfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchf.2026.103369_bib1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/jama.2023.2020","article-title":"Heart failure with preserved ejection fraction: a review","volume":"329","author":"Redfield","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jchf.2026.103369_bib2","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jchf.2026.103369_bib3","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1093\/cvr\/cvac179","article-title":"Phenomapping in heart failure with preserved ejection fraction: insights, limitations, and future directions","volume":"118","author":"Peters","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jchf.2026.103369_bib4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1161\/CIRCULATIONAHA.119.041886","article-title":"Research priorities for heart failure with preserved ejection fraction: National Heart, Lung, and Blood Institute Working Group Summary","volume":"141","author":"Shah","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132320","article-title":"Prevalence and outcomes of heart failure phenotypes in patients with atrial fibrillation","volume":"412","author":"Tersalvi","year":"2024","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ejhf.3105","article-title":"Clinical phenogroup diversity and multiplicity: impact on mechanisms of exercise intolerance in heart failure with preserved ejection fraction","volume":"26","author":"Larson","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jchf.2026.103369_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006414","article-title":"Obese-inflammatory phenotypes in heart failure with preserved ejection fraction","volume":"13","author":"Sabbah","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2026.103369_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.114.010637","article-title":"Phenomapping for novel classification of heart failure with preserved ejection fraction","volume":"131","author":"Shah","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchf.2025.102714","article-title":"Rationale and design of the HeartShare\/AMP-HF deep phenotyping study to improve understanding of heart failure with preserved ejection fraction","volume":"13","author":"Borlaug","year":"2025","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jchf.2026.103369_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41569-024-01067-1","article-title":"Pathophysiological insights into HFpEF from studies of human cardiac tissue","volume":"22","author":"Fayyaz","year":"2025","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib11","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jchf.2020.04.007","article-title":"Endomyocardial biopsy characterization of heart failure with preserved ejection fraction and prevalence of cardiac amyloidosis","volume":"8","author":"Hahn","year":"2020","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jchf.2026.103369_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/CIRCULATIONAHA.120.050498","article-title":"Myocardial gene expression signatures in human heart failure with preserved ejection fraction","volume":"143","author":"Hahn","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib13","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/CIRCULATIONAHA.122.061846","article-title":"Myocardial metabolomics of human heart failure with preserved ejection fraction","volume":"147","author":"Hahn","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCULATIONAHA.114.009625","article-title":"Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction","volume":"131","author":"Mohammed","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib15","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.jacc.2021.03.008","article-title":"Myocardial histopathology in patients with obstructive hypertrophic cardiomyopathy","volume":"77","author":"Cui","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1056\/NEJMoa052256","article-title":"Trends in prevalence and outcome of heart failure with preserved ejection fraction","volume":"355","author":"Owan","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jchf.2026.103369_bib17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0002-9149(86)90620-X","article-title":"Extent of myocardial fibrosis and cellular hypertrophy in dilated cardiomyopathy","volume":"57","author":"Unverferth","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.125.041927","article-title":"Increasing left ventricular mass and death in men and women investigated with echocardiography","volume":"14","author":"Playford","year":"2025","journal-title":"JAHA"},{"key":"10.1016\/j.jchf.2026.103369_bib19","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/01.CIR.0000155257.33485.6D","article-title":"Cardiomyocyte stiffness in diastolic heart failure","volume":"111","author":"Borb\u00e9ly","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib20","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/01.CIR.0000140973.60992.9A","article-title":"Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis","volume":"110","author":"Querejeta","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2006.01.077","article-title":"Alterations in the pattern of collagen deposition may contribute to the deterioration of systolic function in hypertensive patients with heart failure","volume":"48","author":"L\u00f3pez","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib22","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/CIRCULATIONAHA.114.013215","article-title":"Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin","volume":"131","author":"Zile","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/CIRCHEARTFAILURE.109.931451","article-title":"Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction","volume":"4","author":"Westermann","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jchf.2026.103369_bib24","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jchf.2015.10.007","article-title":"Myocardial microvascular inflammatory endothelial activation in heart failure with preserved ejection fraction","volume":"4","author":"Franssen","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jchf.2026.103369_bib25","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1253\/circj.CJ-11-0568","article-title":"Prognostic impact of myocardial interstitial fibrosis in non-ischemic heart failure. -Comparison between preserved and reduced ejection fraction heart failure","volume":"75","author":"Aoki","year":"2011","journal-title":"Circ J"},{"key":"10.1016\/j.jchf.2026.103369_bib26","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.jacc.2023.01.049","article-title":"Heart failure with preserved ejection fraction","volume":"81","author":"Borlaug","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib27","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jacc.2025.06.055","article-title":"The adipokine hypothesis of heart failure with a preserved ejection fraction: a novel framework to explain pathogenesis and guide treatment","volume":"86","author":"Packer","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/science.adz7118","article-title":"Severe obesity in human HFpEF alters contractile protein function and organization","volume":"392","author":"Jani","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.jchf.2026.103369_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/CIRCULATIONAHA.116.026807","article-title":"Evidence supporting the existence of a distinct Obese phenotype of heart failure with preserved ejection fraction","volume":"136","author":"Obokata","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib30","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jchf.2026.103369_bib31","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1161\/CIRCULATIONAHA.105.587519","article-title":"Myocardial structure and function differ in systolic and diastolic heart failure","volume":"113","author":"Van Heerebeek","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib32","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/eurheartj\/ehp189","article-title":"Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction","volume":"30","author":"Hamdani","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jchf.2026.103369_bib33","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/0022-2828(90)90060-F","article-title":"Changes in heart function and cardiac cell size in rats with chronic myocardial infarction","volume":"22","author":"Zimmer","year":"1990","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib34","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jacc.2010.09.080","article-title":"Cardiomyocyte hypertrophy, oncosis, and autophagic vacuolization predict mortality in idiopathic dilated cardiomyopathy with advanced heart failure","volume":"57","author":"Vigliano","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijcard.2006.02.031","article-title":"Myocyte diameter and fractional area of collagen are not associated with survival time of outpatients with idiopathic dilated cardiomyopathy: a study based on right ventricular endomyocardial biopsies","volume":"116","author":"Benvenuti","year":"2007","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jchf.2026.103369_bib36","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/s41467-017-01747-2","article-title":"Region and cell-type resolved quantitative proteomic map of the human heart","volume":"8","author":"Doll","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jchf.2026.103369_bib37","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/CIRCULATIONAHA.119.045401","article-title":"Transcriptional and cellular diversity of the human heart","volume":"142","author":"Tucker","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jchf.2026.103369_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32154-2","article-title":"Regional differences in mRNA and lncRNA expression profiles in non-failing human atria and ventricles","volume":"8","author":"Johnson","year":"2018","journal-title":"Sci Rep"}],"container-title":["JACC: Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177926004737?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213177926004737?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:36:50Z","timestamp":1790368610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213177926004737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":38,"alternative-id":["S2213177926004737"],"URL":"https:\/\/doi.org\/10.1016\/j.jchf.2026.103369","relation":{},"ISSN":["2213-1779"],"issn-type":[{"value":"2213-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial Histopathology-Based Heart Failure Phenotyping","name":"articletitle","label":"Article Title"},{"value":"JACC: Heart Failure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchf.2026.103369","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American College of Cardiology Foundation. Published by Elsevier.","name":"copyright","label":"Copyright"}],"article-number":"103369"}}