{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:35:14Z","timestamp":1782452114331,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.jchromb.2014.02.014","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T15:01:02Z","timestamp":1392735662000},"page":"212-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Quantification of vorinostat and its main metabolites in plasma and intracellular vorinostat in PBMCs by liquid chromatography coupled to tandem mass spectrometry and its relation to histone deacetylase activity in human blood"],"prefix":"10.1016","volume":"964","author":[{"given":"Lu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Christoph","family":"Detering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Milde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter Emil","family":"Haefeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Burhenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2014.02.014_bib0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0065-230X(04)91004-4","volume":"91","author":"Marks","year":"2004","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molonc.2007.01.001","volume":"1","author":"Ropero","year":"2007","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc1779","volume":"6","author":"Minucci","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jchromb.2014.02.014_bib0020","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1158\/1541-7786.MCR-07-0324","volume":"5","author":"Dokmanovic","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0025","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1200\/JCO.2009.22.1291","volume":"27","author":"Lane","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0030","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.tig.2007.07.005","volume":"23","author":"Smith","year":"2007","journal-title":"Trends Genet."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0035","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1093\/annonc\/mdn792","volume":"20","author":"Stimson","year":"2009","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0040","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1158\/0008-5472.CAN-06-0049","volume":"66","author":"Geng","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0045","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1158\/1078-0432.CCR-05-1132","volume":"12","author":"Qian","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1756-8722-3-5","volume":"3","author":"Tan","year":"2010","journal-title":"J. Haematol. Oncol."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0055","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1634\/theoncologist.12-10-1247","volume":"12","author":"Mann","year":"2007","journal-title":"Oncologist"},{"key":"10.1016\/j.jchromb.2014.02.014_bib0060","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/sj.onc.1210204","volume":"26","author":"Marks","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.jchromb.2014.02.014_bib0065","first-page":"187","volume":"15","author":"Komatsu","year":"2006","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0070","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1158\/1078-0432.CCR-06-1261","volume":"13","author":"Yin","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0075","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/ijc.22558","volume":"121","author":"Kumagai","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jchromb.2014.02.014_bib0080","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00401-011-0866-3","volume":"122","author":"Milde","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1756-8722-2-31","volume":"2","author":"Siegel","year":"2009","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0090","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1200\/JCO.2005.14.167","volume":"23","author":"Kelly","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0095","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/rcm.1984","volume":"19","author":"Du","year":"2005","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0100","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jchromb.2006.04.044","volume":"840","author":"Parise","year":"2006","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jchromb.2007.12.014","volume":"863","author":"Patel","year":"2008","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jchromb.2006.11.037","volume":"850","author":"Ehrhardt","year":"2007","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0115","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1128\/AAC.46.10.3228-3235.2002","volume":"46","author":"Khoo","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0120","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jac\/dkf161","volume":"50","author":"Meaden","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jchromb.2005.02.010","volume":"819","author":"Colombo","year":"2005","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0130","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1074-5521(02)00305-8","volume":"10","author":"Wegener","year":"2003","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0135","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0003-2697(03)00426-3","volume":"321","author":"Wegener","year":"2003","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0140","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1158\/1078-0432.CCR-07-4427","volume":"14","author":"Bonfils","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0145","series-title":"Guidance for Industry, Bioanalytical Method Validation","author":"US Department of Health and Human Services FDA","year":"2001"},{"key":"10.1016\/j.jchromb.2014.02.014_bib0150","series-title":"Guideline on Bioanalytical Method Validation","author":"European Medicines Agency (EMA)","year":"2012"},{"key":"10.1016\/j.jchromb.2014.02.014_bib0155","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jpba.2006.05.005","volume":"42","author":"Du","year":"2006","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0160","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/AAC.00283-10","volume":"54","author":"Burhenne","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0165","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1128\/AAC.01236-10","volume":"55","author":"Simiele","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jchromb.2014.02.014_bib0170","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/pbc.24271","volume":"60","author":"Muscal","year":"2013","journal-title":"Pediatr. Blood Cancer"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023214000968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023214000968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T10:58:23Z","timestamp":1538823503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023214000968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":34,"alternative-id":["S1570023214000968"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2014.02.014","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of vorinostat and its main metabolites in plasma and intracellular vorinostat in PBMCs by liquid chromatography coupled to tandem mass spectrometry and its relation to histone deacetylase activity in human blood","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2014.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}