{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:07:12Z","timestamp":1789420032333,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Indonesian Ministry of Research, Technology and Higher Education"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.jchromb.2016.10.024","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T12:02:28Z","timestamp":1477137748000},"page":"28-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["HPLC-based metabolomics to identify cytotoxic compounds from Plectranthus amboinicus (Lour.) Spreng against human breast cancer MCF-7Cells"],"prefix":"10.1016","volume":"1039","author":[{"given":"Wahid","family":"Yulianto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Andarwulan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puspo Edi","family":"Giriwono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joko","family":"Pamungkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2016.10.024_bib0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0010","first-page":"4103","article-title":"Medicinal plants: their use in anticancer treatment","volume":"6","author":"Greenwell","year":"2015","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0015","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: a review","volume":"33","author":"Atanasov","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0020","first-page":"488","article-title":"Coleus aromaticus benth \u2013 a nutritive medicinal plant of potential therapeutic value","volume":"2","author":"Khare","year":"2011","journal-title":"Int. J. Pharma Bio. Sci."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/508137","article-title":"Analgesic and antiinflammatory activities of the aqueous extract from Plectranthus amboinicus (Lour.) Spreng. both in vitro and in vivo","volume":"2012","author":"Chiu","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0030","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jep.2009.07.006","article-title":"In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae)","volume":"125","author":"Gurgel","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/ecam\/nem168","article-title":"Potential use of plectranthus amboinicus in the treatment of rheumatoid arthritis","volume":"7","author":"Chang","year":"2010","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/291592","article-title":"Efficacy of plectranthus amboinicus (Lour.) spreng in a murine model of methicillin-resistant staphylococcus aureus skin abscesses","volume":"2013","author":"De Oliveira","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0045","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4236\/fns.2012.32022","article-title":"Antioxidant and antibacterial activities in the leaf extracts of Indian borage (Plectranthus amboinicus)","volume":"3","author":"Bhatt","year":"2012","journal-title":"Food Nutr. Sci."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/S2222-1808(12)60250-3","article-title":"Studies on the antidandruff activity of the essential oil of coleus amboinicus and eucalyptus globulus","volume":"2","author":"Selvakumar","year":"2012","journal-title":"Asian Pac. J. Trop. Dis."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0055","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.foodchem.2008.10.064","article-title":"Fungitoxic activity of Indian borage (Plectranthus amboinicus) volatiles","volume":"114","author":"Murthy","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0060","first-page":"267","article-title":"Lactagogue effects of Torbangun, a Bataknese tradicional cuisine","volume":"15","author":"Damanik","year":"2006","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0065","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11101-013-9297-1","article-title":"Metabolomics for the rapid dereplication of bioactive compounds from natural sources","volume":"12","author":"Yuliana","year":"2013","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0070","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/10826076.2015.1032419","article-title":"Rapid identification of antibacterial compounds from Turkey berry by HPLC-based metabolomics","volume":"38","author":"Maser","year":"2015","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0075","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jep.2012.05.019","article-title":"Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds","volume":"142","author":"Chen","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0080","first-page":"1","article-title":"Phenolic constituents and biological activities of leaf extracts of traditional medicinal plant Plectranthus amboinicus Benth (Lamiaceae)","volume":"3","author":"Gupta","year":"2013","journal-title":"TANG HUMANITAS Med."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0085","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1021\/np400172k","article-title":"Antiproliferative activity of abietane diterpenoids against human tumor cells","volume":"76","author":"Burmistrova","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0090","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/320329","article-title":"Chemical composition and nutraceutical potential of Indian borage (Plectranthus amboinicus) stem extract","author":"Bhatt","year":"2013","journal-title":"J. Chem."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0095","series-title":"Phytochemical and Pharmacological Investigation of Different Parts of Coleus Amboinicus (Lour.)","author":"Bhattacharjee","year":"2010"},{"key":"10.1016\/j.jchromb.2016.10.024_bib0100","first-page":"755","article-title":"Antioxidant and cytotoxic activities of Plectranthus amboinicus (Lour.) Spreng. extracts","volume":"4","author":"Hasibuan","year":"2013","journal-title":"Int. J. Pharm. Teach. Pract."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0105","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.phytochem.2010.06.008","article-title":"Diterpenoids from Pinus massoniana resin and their cytotoxicity against A431 and A549 cells","volume":"71","author":"Yang","year":"2010","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jchromb.2016.10.024_bib0110","doi-asserted-by":"crossref","first-page":"882","DOI":"10.3390\/molecules13040822","article-title":"A structure-activity study of antibacterial diterpenoids","volume":"13","author":"Urz\u00faa","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2016.10.024_bib0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cem.695","article-title":"Orthogonal projections to latent structures (O-PLS)","volume":"16","author":"Trygg","year":"2002","journal-title":"J. Chemom."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0120","first-page":"91","article-title":"Rapid identification of antibacterial compounds from Turkey berry by HPLC-based metabolomics","volume":"159","author":"Chang","year":"2015","journal-title":"Limnetica"},{"key":"10.1016\/j.jchromb.2016.10.024_bib0125","series-title":"Phytochemistry and Arthropod Bioactivity of Australian Lamiaceae","author":"Rasikari","year":"2007"},{"key":"10.1016\/j.jchromb.2016.10.024_bib0130","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/70200271","article-title":"Chemistry of the genus Plectranthus","volume":"7","author":"Abdel-Mogib","year":"2002","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2016.10.024_bib0135","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.foodchem.2008.10.015","article-title":"Rosmarinic acid, scutellarein 4\u2032-methyl ether 7-O-glucuronide and (16S)-coleon E are the main compounds responsible for the antiacetylcholinesterase and antioxidant activity in herbal tea of Plectranthus barbatus (falso boldo)","volume":"114","author":"Fal\u00e9","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0140","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1016\/j.bmc.2011.06.067","article-title":"In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica","volume":"19","author":"Fronza","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jep.2005.05.033","article-title":"Ethnopharmacology and systems biology: a perfect holistic match","volume":"100","author":"Verpoorte","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2016.10.024_bib0150","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1055\/s-0030-1249898","article-title":"Metabolomics: a tool for anticancer lead-finding from natural products","volume":"76","author":"Kim","year":"2010","journal-title":"Planta Med."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023216305517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023216305517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T05:24:14Z","timestamp":1536297854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023216305517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":30,"alternative-id":["S1570023216305517"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2016.10.024","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HPLC-based metabolomics to identify cytotoxic compounds from Plectranthus amboinicus (Lour.) Spreng against human breast cancer MCF-7Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2016.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}