{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:20:37Z","timestamp":1790230837572,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102504"],"award-info":[{"award-number":["81102504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High-Tech Program of China"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jchromb.2017.02.013","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T09:15:23Z","timestamp":1487063723000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["A quantification method for determination of racemate praziquantel and R-enantiomer in rat plasma for comparison of their pharmacokinetics"],"prefix":"10.1016","volume":"1048","author":[{"given":"Danlu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dequn","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2017.02.013_bib0005","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1517\/14656566.5.2.263","article-title":"Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control","volume":"5","author":"Utzinger","year":"2004","journal-title":"Exp. Opin. Pharmacother."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0010","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jchromb.2017.02.013_bib0015","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jchromb.2017.02.013_bib0020","doi-asserted-by":"crossref","first-page":"e1260","DOI":"10.1371\/journal.pntd.0001260","article-title":"Resolution of praziquantel","volume":"5","author":"Woelfle","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0025","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0169-4758(96)30007-0","article-title":"The epidemiology of Bilharzia in Ancient Egypt: 5000 years of schistosomiasis","volume":"12","author":"Contis","year":"1996","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.jchromb.2017.02.013_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.00594","article-title":"Morphological characteristics of schistosoma mansoni PZQ-resistant and \u2013susceptible strains are different in presence of praziquantel","volume":"7","author":"Pinto-Almeida","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0035","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00436-006-0175-2","article-title":"Schistosomiasis-a century searching for chemotherapeutic drugs","volume":"99","author":"Ribeiro-Dos-Santos","year":"2006","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0040","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cbpa.2007.05.031","article-title":"Chemotherapy of schistosomiasis: present and future","volume":"11","author":"Caffrey","year":"2007","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0045","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/infdis\/159.3.589","article-title":"Comparative in vitro and in vivo activity of racemic praziquantel and its levorotated isomer on Schistosoma mansoni","volume":"159","author":"Xiao","year":"1989","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4269\/ajtmh.1991.45.345","article-title":"Comparison of the therapeutic efficacy and side effects of a single dose of levo-praziquantel with mixed isomer praziquantel in 278 cases of schistosomiasis japonica","volume":"45","author":"Wu","year":"1991","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0055","first-page":"935","article-title":"Comparative efficacy of praziquantel and its optic isomers in experimental therapy of schistosomiasis japonica in rabbits","volume":"99","author":"Liu","year":"1987","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0060","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4269\/ajtmh.1989.41.198","article-title":"A comparison of the antischistosomal effect of levo- and dextro-praziquantel on Schistosoma japonicum and S. mansoni in mice","volume":"41","author":"Tanaka","year":"1989","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0065","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/j.bmcl.2014.07.039","article-title":"Development of chiral praziquantel analogues as potential drug candidates with activity to juvenile Schistosoma japonicum","volume":"24","author":"Zheng","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0070","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ijpara.2004.05.001","article-title":"Determination of ED 50, values for praziquantel in praziquantel-resistant and \u2013susceptible Schistosoma mansoni isolates","volume":"34","author":"Cioli","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0075","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/jac\/dkt491","article-title":"The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)","volume":"69","author":"Olliaro","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0080","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bcp.2014.05.001","article-title":"Metabolic profiling of praziquantel enantiomers","volume":"90","author":"Wang","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0085","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1021\/ac3002353","article-title":"Chemicalome and metabolome matching approach to elucidating biological metabolic networks of complex mixtures","volume":"84","author":"Gong","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0090","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.tips.2014.02.001","article-title":"Insights into drug discovery from natural medicines using reverse pharmacokinetics","volume":"35","author":"Hao","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0095","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1016\/j.jchromb.2009.07.036","article-title":"Enantioselective analysis of praziquantel and trans-4-hydroxypraziquantel in human plasma by chiral LC\u2013MS\/MS: Application to pharmacokinetics","volume":"877","author":"Lima","year":"2009","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2017.02.013_bib0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jpba.2014.12.025","article-title":"Development and validation of a HPLC\u2013MS\/MS method for the determination of phytolaccagenin in rat plasma and application to a pharmacokinetic study","volume":"107","author":"Wei","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpba.2014.12.023","article-title":"Determination of isobavachalcone in rat plasma by LC\u2013MS\/MS and its application to a pharmacokinetic study","volume":"107","author":"Ma","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0110","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpba.2015.11.031","article-title":"Simultaneous quantification of picfeltarraenins IA and IB in rat plasmaby UPLC\u2013MS\/MS: application to a pharmacokinetic study","volume":"120","author":"He","year":"2016","journal-title":"J. Pharm. Biomed Anal."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0115","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jpha.2014.06.001","article-title":"Analytical quality-by-design approach for sample treatment of BSA-containing solutions","volume":"5","author":"Taevernier","year":"2015","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jchromb.2017.02.013_bib0120","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0141-0229(93)90149-V","article-title":"Enzymes in the synthesis of chiral drugs","volume":"15","author":"Margolin","year":"1993","journal-title":"Enzyme Microb. Technol."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023216309606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023216309606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T13:25:03Z","timestamp":1568813103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023216309606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":24,"alternative-id":["S1570023216309606"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2017.02.013","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A quantification method for determination of racemate praziquantel and R-enantiomer in rat plasma for comparison of their pharmacokinetics","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2017.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}