{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:54:15Z","timestamp":1777902855659,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR000142"],"award-info":[{"award-number":["UL1 TR000142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jchromb.2018.01.008","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T18:16:03Z","timestamp":1515176163000},"page":"124-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The determination of 5-methoxytryptophan in human plasma"],"prefix":"10.1016","volume":"1074-1075","author":[{"given":"George M.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua T.","family":"Eighmie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2018.01.008_bb0005","first-page":"11","article-title":"Medical implications of melatonin: receptor-mediated and receptor-independent actions","volume":"52","author":"Reiter","year":"2007","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/jpi.12267","article-title":"Melatonin: an ancient molecule that makes oxygen metabolically tolerable","volume":"59","author":"Manchester","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0015","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00204-015-1513-x","article-title":"The hallucinogenic world of tryptamines: an updated review","volume":"89","author":"Ara\u00fajo","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0020","doi-asserted-by":"crossref","first-page":"13231","DOI":"10.1073\/pnas.1209919109","article-title":"Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan","volume":"109","author":"Cheng","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1423-0127-21-17","article-title":"5-Methoxyindole metabolites of l-tryptophan: control of COX-2 expression, inflammation and tumorigenesis","volume":"21","author":"Wu","year":"2014","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152166","article-title":"Endothelium-derived 5-methoxytryptophan protects endothelial barrier function by blocking p38 MAPK activation","volume":"11","author":"Chu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jchromb.2018.01.008_bb0035","doi-asserted-by":"crossref","first-page":"25374","DOI":"10.1038\/srep25374","article-title":"A novel protective function of 5-methoxytryptophan in vascular injury","volume":"6","author":"Ho","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0040","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1161\/CIRCRESAHA.116.308559","article-title":"Endothelium-derived 5-methoxytryptophan is a circulating anti-inflammatory molecule that blocks systemic inflammation: novelty and significance","volume":"119","author":"Wang","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0045","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijcard.2016.07.293","article-title":"5-Methoxytryptophan is a potential marker for post-myocardial infarction heart failure - a preliminary approach to clinical utility","volume":"222","author":"Lin","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0050","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijcard.2016.12.151","article-title":"5-Methoxytryptophan: a promising early marker for predicting post-myocardial infarction heart failure","volume":"234","author":"Yang","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijcard.2016.12.154","article-title":"Reply to letter: \u201c5-methoxytryptophan: a promising early marker for predicting post-myocardial infarction heart failure\u201d","volume":"234","author":"Lin","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0060","doi-asserted-by":"crossref","first-page":"11133","DOI":"10.1038\/s41598-017-11077-4","article-title":"5-Methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR","volume":"7","author":"Chang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0003-2697(85)90087-9","article-title":"Identification and quantification of 5-methoxyindole-3-acetic acid in human urine","volume":"144","author":"Higa","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/jpi.12336","article-title":"On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: comparisons across species","volume":"61","author":"Tan","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF01249192","article-title":"Seasonal variations in HIOMT activity during the night in the pineal gland of 21day old male wistar rats","volume":"49","author":"Balemans","year":"1980","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0080","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF01248958","volume":"51","author":"Pevet","year":"1981","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0085","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-4347(91)80073-L","article-title":"Determination of 5-methoxyindoles in pineal gland and plasma samples by high-performance liquid chromatography with electrochemical detection","volume":"564","author":"Raynaud","year":"1991","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2018.01.008_bb0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01249130","article-title":"The influence of some pteridines on pineal 5-methoxyindole synthesis in male Wistar rats periodically exposed to either white or green light","volume":"58","author":"Balemans","year":"1983","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0095","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/gm334","article-title":"Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)","volume":"4","author":"Ugarte","year":"2012","journal-title":"Genome Med."},{"key":"10.1016\/j.jchromb.2018.01.008_bb0100","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.redox.2017.03.017","article-title":"Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt\/\u03b2-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease","volume":"12","author":"Chen","year":"2017","journal-title":"Redox Biol."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023217320901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023217320901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T21:53:21Z","timestamp":1535147601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023217320901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":20,"alternative-id":["S1570023217320901"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2018.01.008","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The determination of 5-methoxytryptophan in human plasma","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2018.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}