{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:14:19Z","timestamp":1770819259498,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81374049"],"award-info":[{"award-number":["81374049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jchromb.2018.02.045","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T17:09:55Z","timestamp":1520096995000},"page":"93-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Intestinal absorption differences of major bioactive compounds of Gegenqinlian Decoction between normal and bacterial diarrheal mini-pigs in vitro and in situ"],"prefix":"10.1016","volume":"1083","author":[{"given":"Xiao","family":"Ling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqiang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feilong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfa","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jchromb.2018.02.045_bb0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.taap.2013.04.007","article-title":"Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development","volume":"270","author":"Vamathevan","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.jchromb.2018.02.045_bb0010","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/0300985811402846","article-title":"Swine as models in biomedical research and toxicology testing","volume":"49","author":"Swindle","year":"2012","journal-title":"Vet. Pathol."},{"issue":"1\u20133","key":"10.1016\/j.jchromb.2018.02.045_bb0015","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tox.2006.09.013","article-title":"Swine models in the design of more effective medical countermeasures against organophosphorus poisoning","volume":"233","author":"Dorandeu","year":"2007","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.jchromb.2018.02.045_bb0020","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jss.2012.07.025","article-title":"The pig as a preclinical model for intestinal ischemia-reperfusion and transplantation studies","volume":"178","author":"Yandza","year":"2012","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.vascn.2014.12.005","article-title":"Comparison of minipig, dog, monkey and human drug metabolism and disposition","volume":"74","author":"Dalgaard","year":"2015","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.jchromb.2018.02.045_bb0030","series-title":"Pharmacopeia of China","first-page":"333","author":"Chaninese Pharmacopeia Commission","year":"2015"},{"key":"10.1016\/j.jchromb.2018.02.045_bb0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chroma.2016.05.056","article-title":"Simultaneous quantification of 50 bioactive compounds of the traditional Chinese medicine formula Gegen-Qinlian decoction using ultra-high performance liquid chromatography coupled with tandem mass spectrometry","volume":"1454","author":"Wang","year":"2016","journal-title":"J. Chromatogr. A"},{"issue":"4","key":"10.1016\/j.jchromb.2018.02.045_bb0040","first-page":"9","article-title":"Advances in studies on Gegen Qinlian Decoction","volume":"41","author":"Chen","year":"2010","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"01","key":"10.1016\/j.jchromb.2018.02.045_bb0045","first-page":"230","article-title":"Determination of biological titers of active components aligenments in Gegen Qinlian Decoction on bacterioasis","volume":"28","author":"Xue","year":"2013","journal-title":"China J. Tradit. Chin. Med. Pharm."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0050","first-page":"99","article-title":"Study on pharmacodynamics of GQF","volume":"13","author":"Xu","year":"2011","journal-title":"J. Liaoning Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0055","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jchromb.2017.01.015","article-title":"Comparative pharmacokinetics of eight major bioactive components in normal and bacterial diarrhea mini-pigs after oral administration of Gegen Qinlian Decoction","volume":"1044-1045","author":"Ling","year":"2017","journal-title":"J. Chromatogr. B"},{"issue":"10","key":"10.1016\/j.jchromb.2018.02.045_bb0060","first-page":"1611","article-title":"Analysis and comparison of intestinal absorption of components of Gegenqinlian decoction in different combinations based on pharmacokinetic parameters","volume":"48","author":"Zhang","year":"2013","journal-title":"Yao Xue Xue Bao"},{"issue":"12","key":"10.1016\/j.jchromb.2018.02.045_bb0065","first-page":"1696","article-title":"Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ","volume":"47","author":"An","year":"2012","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.jchromb.2018.02.045_bb0070","first-page":"1504","article-title":"Stability of flavonippophae in Krebs-Ringer solution","volume":"9","author":"Xie","year":"2010","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0075","series-title":"Studies on the Preparation Standardization of Gegen-Qinlian Decoction's Active Fractions","author":"Tan","year":"2006"},{"issue":"12","key":"10.1016\/j.jchromb.2018.02.045_bb0080","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.phymed.2014.06.016","article-title":"Effect of chito-oligosaccharide on the intestinal absorptions of phenylethanoid glycosides in Fructus Forsythiae extract","volume":"21","author":"Zhou","year":"2014","journal-title":"Phytomedicine"},{"issue":"63","key":"10.1016\/j.jchromb.2018.02.045_bb0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejps.2014.07.003","article-title":"A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices","volume":"15","author":"Westerhout","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.jchromb.2018.02.045_bb0090","first-page":"543","article-title":"Intestinal absorption of pulchinenosides from Pulsatilla chinensis in rats","volume":"40","author":"Liu","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"7","key":"10.1016\/j.jchromb.2018.02.045_bb0095","first-page":"554","article-title":"Absorption characteristics of the total alkaloids from Mahonia bealei in an in situ single-pass intestinal perfusion assay","volume":"12","author":"Sun","year":"2014","journal-title":"Chin. J. Nat. Med."},{"issue":"10","key":"10.1016\/j.jchromb.2018.02.045_bb0100","first-page":"1487","article-title":"Study on intestinal absorption kinetics of syringopicroside in rats","volume":"37","author":"Cao","year":"2012","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jchromb.2018.02.045_bb0105","series-title":"Guidance for Industry Bioanalytical Method Validation. Rockville, USA","author":"Food and Drug Administration","year":"2001"},{"key":"10.1016\/j.jchromb.2018.02.045_bb0110","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0378-1135(99)00202-3","article-title":"Experimental models of porcine post-weaning colibacillosis and their relationship to post-weaning diarrhoea and digestive disorders as encountered in the field","volume":"72","author":"Madec","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jchromb.2014.09.015","article-title":"Simultaneous determination of Puerarin and its active metabolite in human plasma by UPLC-MS\/MS: application to a pharmacokinetic study","volume":"971","author":"Jung","year":"2014","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0120","first-page":"2313","article-title":"Oral absorption of flavonoids and analysis of their metabolism characteristics and law","volume":"16","author":"Zhou","year":"2013","journal-title":"Chin. Tradit. Herb. Drug"},{"key":"10.1016\/j.jchromb.2018.02.045_bb0125","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jcph.96","article-title":"Radix Puerariae: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"53","author":"Zhang","year":"2013","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0130","first-page":"3897","article-title":"The effect and mechanism of Puerarin on the activity of isolated intestinal smooth muscle of rats","volume":"33","author":"Diao","year":"2013","journal-title":"Chin. J. Gerontol."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0135","first-page":"107","article-title":"Pharmacological research progress of Coptis chinensis","volume":"29","author":"Yu","year":"2006","journal-title":"J. Chongqing Univ. (Nat. Sci. Ed.)"},{"key":"10.1016\/j.jchromb.2018.02.045_bb0140","first-page":"137","article-title":"Pharmacological research progress of Radix Scutellariae","volume":"8","author":"Li","year":"2009","journal-title":"J. Clin. Exp.Med."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0145","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1093\/carcin\/16.11.2833","article-title":"Genistein suppresses mammary cancer in rats","volume":"16","author":"Lamartiniere","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jchromb.2018.02.045_bb0150","doi-asserted-by":"crossref","first-page":"C886","DOI":"10.1152\/ajpcell.1995.268.4.C886","article-title":"Cyclic AMP independent activation of the CFTR Cl channel by the tyrosinekinase inhibitor genistein","volume":"268","author":"Illek","year":"1995","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.jchromb.2018.02.045_bb0155","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1210\/jc.2002-020716","article-title":"Estrogenicity of isoflavoneson human endometrial stromal and glandular cells","volume":"87","author":"Kayisli","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023217317518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023217317518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T17:22:17Z","timestamp":1535044937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023217317518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":31,"alternative-id":["S1570023217317518"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2018.02.045","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal absorption differences of major bioactive compounds of Gegenqinlian Decoction between normal and bacterial diarrheal mini-pigs in vitro and in situ","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2018.02.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}