{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:01:30Z","timestamp":1791000090399,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Preparedness and Response","award":["14460"],"award-info":[{"award-number":["14460"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jchromb.2019.05.005","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T19:55:40Z","timestamp":1557345340000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["A quantitative method to detect human exposure to sulfur and nitrogen mustards via protein adducts"],"prefix":"10.1016","volume":"1121","author":[{"given":"Brooke G.","family":"Pantazides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Qui\u00f1ones-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danisha M.","family":"Rivera Nazario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Crow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas W.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2019.05.005_bb0005","series-title":"Medical Aspects of Chemical and Biological Warfare, Office of the Surgeon General, Department of the Army, United States of America, Washington, DC","first-page":"197","article-title":"Vesicants","author":"Sidell","year":"1997"},{"key":"10.1016\/j.jchromb.2019.05.005_bb0010","series-title":"Convention of the Prohibition of the Development, Production, Stockpiling, and Use of Chemical Weapons and Their Destruction, Organisation for the Prohibition of Chemical Weapons","year":"2005"},{"key":"10.1016\/j.jchromb.2019.05.005_bb0015","unstructured":"United Nations Security Council, Report of the Specialists Appointed by the Secretary-General to Investigate Allegations by the Islamic Republic of Iran Concerning the Use of Chemical Weapons, New York, NY, 1984, pp. 28."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0020","unstructured":"United Nations Security Council, Report of the Mission Dispatched by the Secretary-General to Investigate Allegations of the Use of Chemical Weapons in the Conflict Between the Islamic Republic of Iran and Iraq, New York, NY, 1986, pp. 26."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0025","unstructured":"United Nations Security Council, Report of the Mission Dispatched by the Secretary-General to Investigate Allegations of the Use of Chemical Weapons in the Conflict Between the Islamic Republic of Iran and Iraq, New York, NY, 1988, pp. 16."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0030","series-title":"Medical Response to Terrorism: Preparedness and Clinical Practice","author":"Keyes","year":"2004"},{"key":"10.1016\/j.jchromb.2019.05.005_bb0035","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1021\/tx9900369","article-title":"Alkylation of human serum albumin by sulfur mustard in vitro and in vivo: mass spectrometric analysis of a cysteine adduct as a sensitive biomarker of exposure","volume":"12","author":"Noort","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0040","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/004982597240460","article-title":"Biological fate of sulphur mustard: identification of valine and histidine adducts in haemoglobin from casualties of sulphur mustard poisoning","volume":"27","author":"Black","year":"1997","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jchromb.2019.05.005_bb0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00204-001-0318-2","article-title":"Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin","volume":"76","author":"Noort","year":"2002","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0050","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/jat\/28.5.327","article-title":"Quantitation of the sulfur mustard metabolites 1,1\u2032-sulfonylbis[2-(methylthio)ethane] and thiodiglycol in urine using isotope-dilution gas chromatography-tandem mass spectrometry","volume":"28","author":"Boyer","year":"2004","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0055","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jchromb.2006.11.031","article-title":"A sensitive method for quantitation of beta-lyase metabolites of sulfur mustard as 1,1\u2032-sulfonylbis[2-(methylthio)ethane] (SBMTE) in human urine by isotope dilution liquid chromatography-positive ion-electrospray-tandem mass spectrometry","volume":"850","author":"Daly","year":"2007","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2019.05.005_bb0060","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.jasms.2007.04.016","article-title":"Mass spectral behavior of the hydrolysis products of sesqui- and oxy-mustard type chemical warfare agents in atmospheric pressure chemical ionization","volume":"18","author":"Lemire","year":"2007","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0065","unstructured":"T.A. Blake, E.I. Hamelin, C. Desoubries, C.-C. Liu, H. Xu, Y. Zhang, Biomedical samples: urine samples, in: P. Vanninen (Ed.) Recommended Operating Procedures for Analysis in the Verification of Chemical Disarmament, 2017 Edition, University of Helsinki, Helsinki, Finland, 2017, pp. 673\u2013696."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2017.02.030","article-title":"High throughput quantitative analysis of the beta-lyase sulfur mustard metabolite, 1,1\u2032-sulfonylbis[2-(methylsulfinyl)ethane] in urine via high performance liquid chromatography tandem mass spectrometry","volume":"1051","author":"Bevan","year":"2017","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0075","first-page":"1","article-title":"Chemical warfare agents: estimating oral reference doses","volume":"156","author":"Opresko","year":"1998","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0080","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/jat\/28.5.320","article-title":"Quantitation of biomarkers of exposure to nitrogen mustards in urine from rats dosed with nitrogen mustards and from an unexposed human population","volume":"28","author":"Lemire","year":"2004","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0085","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1472-8206.2005.00325.x","article-title":"The pharmacology, toxicology, and medical treatment of sulphur mustard poisoning","volume":"19","author":"Balali-Mood","year":"2005","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0090","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/tx00038a013","article-title":"Synthesis, characterization, and quantitation of the major adducts formed between sulfur mustard and DNA of calf thymus and human blood","volume":"7","author":"Fidder","year":"1994","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0095","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1021\/tx7004508","article-title":"Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards","volume":"21","author":"Loeber","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0100","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.toxrep.2014.07.017","article-title":"Four sulfur mustard exposure cases: overall analysis of four types of biomarkers in clinical samples provides positive implication for early diagnosis and treatment monitoring","volume":"1","author":"Xu","year":"2014","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jchromb.2014.04.050","article-title":"Simultaneous determination of four sulfur mustard-DNA adducts in rabbit urine after dermal exposure by isotope-dilution liquid chromatography-tandem mass spectrometry","volume":"961","author":"Zhang","year":"2014","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0110","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1021\/jo01175a019","article-title":"Chemical reactions of the nitrogen mustard gases; the reactions of the nitrogen mustard gases with protein constituents","volume":"11","author":"Fruton","year":"1946","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0115","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1021\/tx400188w","article-title":"Covalent adduction of nitrogen mustards to model protein nucleophiles","volume":"26","author":"Thompson","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1021\/tx500468h","article-title":"Simplified method for quantifying sulfur mustard adducts to blood proteins by ultrahigh pressure liquid chromatography-isotope dilution tandem mass spectrometry","volume":"28","author":"Pantazides","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/jat\/32.1.51","article-title":"Development of a liquid chromatography-multiple reaction monitoring procedure for concurrent verification of exposure to different forms of mustard agents","volume":"32","author":"Yeo","year":"2008","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0130","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/jat\/bkt054","volume":"37","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0135","series-title":"Bioanalytical Method Validation, Guidance for Industry, Food and Drug Administration","year":"2018"},{"key":"10.1016\/j.jchromb.2019.05.005_bb0140","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/jat\/28.5.333","article-title":"Retrospective detection of exposure to sulfur mustard: improvements on an assay for liquid chromatography-tandem mass spectrometry analysis of albumin-sulfur mustard adducts","volume":"28","author":"Noort","year":"2004","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jat\/32.1.17","article-title":"Analysis for plasma protein biomarkers following an accidental human exposure to sulfur mustard","volume":"32","author":"Smith","year":"2008","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0150","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/jat\/bkt088","article-title":"An enhanced throughput method for quantification of sulfur mustard adducts to human serum albumin via isotope dilution tandem mass spectrometry","volume":"38","author":"Andacht","year":"2014","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0155","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.1021\/acs.analchem.6b02199","article-title":"Procedures for analysis of dried plasma using microsampling devices to detect sulfur mustard-albumin adducts for verification of poisoning","volume":"88","author":"John","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0160","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1002\/sim.3222","article-title":"Multi-rule quality control for the age-related eye disease study","volume":"27","author":"Caudill","year":"2008","journal-title":"Stat. Med."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0165","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/clinchem\/27.3.493","article-title":"A multi-rule Shewhart chart for quality control in clinical chemistry","volume":"27","author":"Westgard","year":"1981","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jchromb.2019.05.005_bb0170","series-title":"Quality Assurance of Chemical Measurements","author":"Taylor","year":"1987"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219302600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219302600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:57:21Z","timestamp":1761605841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023219302600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":34,"alternative-id":["S1570023219302600"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2019.05.005","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A quantitative method to detect human exposure to sulfur and nitrogen mustards via protein adducts","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2019.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}