{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:09:09Z","timestamp":1777540149026,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.jchromb.2019.06.008","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T11:23:58Z","timestamp":1559733838000},"page":"161-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Determination of ceftriaxone concentration in human cerebrospinal fluid by high-performance liquid chromatography with UV detection"],"prefix":"10.1016","volume":"1124","author":[{"given":"Akira","family":"Kotani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hakamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2019.06.008_bb0005","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0025-7125(16)30034-7","article-title":"Third-generation cephalosporins","volume":"79","author":"Klein","year":"1995","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.jchromb.2019.06.008_bb0010","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2165\/00003495-200262070-00005","article-title":"Ceftriaxone: an update of its use in the management of community-acquired and nosocomial infections","volume":"62","author":"Lamb","year":"2002","journal-title":"Drugs"},{"key":"10.1016\/j.jchromb.2019.06.008_bb0015","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.ekir.2017.03.009","article-title":"Three cases of hemodialysis patients receiving high-dose ceftriaxone: serum concentrations and its neurotoxicity","volume":"2","author":"Inoue","year":"2017","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/postgradmedj-2017-134999","article-title":"Iatrogenic coma: ceftriaxone-associated encephalopathy","volume":"94","author":"Dubin","year":"2018","journal-title":"Postgrad. Md. J."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0025","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.2169\/internalmedicine.8774-16","article-title":"Ceftriaxone-induced neurotoxicity in a patient after pancreas-kidney transplantation","volume":"56","author":"Hagiya","year":"2017","journal-title":"Intern. Med."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0030","first-page":"108185","article-title":"Ceftriaxone-induced acute encephalopathy in a peritoneal dialysis patient","volume":"2014","author":"Safadi","year":"2014","journal-title":"Case Rep. Nephrol."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0035","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/0253-7613.91884","article-title":"Ceftriaxone-induced acute reversible encephalopathy in a patient with enteric fever","volume":"44","author":"Sharma","year":"2012","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0040","first-page":"72","article-title":"Ceftriaxone-induced acute reversible encephalopathy in a patient treated for a urinary tract infection","volume":"67","author":"Roncon-Albuquerque","year":"2009","journal-title":"Neth. J. Med."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0045","doi-asserted-by":"crossref","DOI":"10.2169\/internalmedicine.1785-18","article-title":"Encephalopathy induced by high plasma and cerebrospinal fluid ceftriaxone concentrations in a hemodialysis patient","author":"Suzuki","year":"2019","journal-title":"Intern. Med."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0050","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jchromb.2018.12.019","article-title":"Determination of 18 antibiotics in urine using LC-QqQ-MS\/MS","volume":"1105","author":"Huang","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2019.06.008_bb0055","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jchromb.2017.09.014","article-title":"A simple ultra-high-performance liquid chromatography-high resolution mass spectrometry assay for the simultaneous quantification of 15 antibiotics in plasma","volume":"1065-1066","author":"Lefeuvre","year":"2017","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2019.06.008_bb0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jchromb.2012.09.016","article-title":"A method for determining the free (unbound) concentration of ten beta-lactam antibiotics in human plasma using high performance liquid chromatography with ultraviolet detection","volume":"907","author":"Briscoe","year":"2012","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2019.06.008_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4322","article-title":"Enhanced HPLC-MS\/MS method for the quantitative determination of the co-administered drugs ceftriaxone sodium and lidocaine hydrochloride in human plasma following an intramuscular injection and application to a pharmacokinetic study","author":"Mohamed","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0070","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1248\/bpb.32.1139","article-title":"Pharmacokinetics of ceftriaxone, a third-generation cephalosporin, in pediatric patients","volume":"32","author":"Fukumoto","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0075","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.diagmicrobio.2017.02.012","article-title":"Ceftriaxone pharmacokinetics by new simple and sensitive ultra-high-performance liquid chromatography method","volume":"88","author":"Campos","year":"2017","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0080","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/jcph.317","article-title":"Systemic pharmacokinetics and cerebrospinal fluid uptake of intravenous ceftriaxone in patients with amyotrophic lateral sclerosis","volume":"54","author":"Zhao","year":"2014","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0085","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/clpt.1981.90","article-title":"Effects of concentration-dependent plasma protein binding on ceftriaxone kinetics","volume":"29","author":"Stoeckel","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jchromb.2019.06.008_bb0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-4347(98)00549-0","article-title":"Simultaneous determination of purine metabolites, creatinine and pseudouridine in ruminant urine by reversed-phase high-performance liquid chromatography","volume":"723","author":"Shingfield","year":"1999","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2019.06.008_bb0095","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02688478","article-title":"Direct injection of plasma into column liquid chromatographic systems","volume":"24","author":"Westerlund","year":"1987","journal-title":"Chromatographia"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219303071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219303071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:56:59Z","timestamp":1761605819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023219303071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":19,"alternative-id":["S1570023219303071"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2019.06.008","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of ceftriaxone concentration in human cerebrospinal fluid by high-performance liquid chromatography with UV detection","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2019.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}