{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T03:01:09Z","timestamp":1782010869411,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"am","delay-in-days":341,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603277\/H2803"],"award-info":[{"award-number":["81603277\/H2803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004315","name":"Shenyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007763","name":"Engineering Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013141","name":"Jilin Province Key R&D Plan Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jchromb.2019.121734","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T19:40:39Z","timestamp":1563997239000},"page":"121734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Simultaneous determination of five active alkaloids from Compound Kushen Injection in rat plasma by LC\u2013MS\/MS and its application to a comparative pharmacokinetic study in normal and NSCLC nude rats"],"prefix":"10.1016","volume":"1126-1127","author":[{"given":"Song","family":"Cang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaishun","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2019.121734_bb0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jchromb.2019.121734_bb0010","first-page":"220","article-title":"Cancer treatment and survivorship statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jchromb.2019.121734_bb0015","doi-asserted-by":"crossref","first-page":"9077","DOI":"10.1002\/jcp.27585","article-title":"Novel pathways involved in cisplatin resistance identified by a proteomics approach in non-small-cell lung cancer cells","volume":"234","author":"Milone","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jchromb.2019.121734_bb0020","first-page":"1","article-title":"Efficacy of compound Kushen injection in relieving cancer-related pain: a systematic review and meta-analysis","volume":"2015","author":"Guo","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jchromb.2019.121734_bb0025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/10826076.2012.738623","article-title":"Identification and determination of the chemical constituents in a herbal preparation, compound Kushen injection, by HPLC and LC-DAD-MS\/MS","volume":"37","author":"Ma","year":"2013","journal-title":"J Liq Chromatogr R T"},{"key":"10.1016\/j.jchromb.2019.121734_bb0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0254-6272(16)30002-4","article-title":"Effect of compound Kushen injection on T-cell subgroups and natural killer cells in patients with locally advanced non-small-cell lung cancer treated with concomitant radiochemotherapy","volume":"36","author":"Zhao","year":"2016","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jchromb.2019.121734_bb0035","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/aps.2015.24","article-title":"Anti-tumor activities of active ingredients in compound Kushen injection","volume":"36","author":"Wang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jchromb.2019.121734_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers11010049","article-title":"Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model","volume":"11","author":"Jung","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jchromb.2019.121734_bb0045","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/cam4.1269","article-title":"Oxymatrine inhibits non-small cell lung cancer via suppression of EGFR signaling pathway","volume":"7","author":"Li","year":"2018","journal-title":"Cancer Med"},{"key":"10.1016\/j.jchromb.2019.121734_bb0050","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10616-009-9211-2","article-title":"Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration","volume":"59","author":"Zhang","year":"2009","journal-title":"Cytotechnology"},{"key":"10.1016\/j.jchromb.2019.121734_bb0055","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3892\/or.2013.2529","article-title":"Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-kappaB-mediated VEGF signaling pathway","volume":"30","author":"Chen","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jchromb.2019.121734_bb0060","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1248\/bpb.b17-00010","article-title":"Oxymatrine promotes S-phase arrest and inhibits cell proliferation of human breast cancer cells in vitro through mitochondria-mediated apoptosis","volume":"40","author":"Wu","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jchromb.2019.121734_bb0065","first-page":"115","article-title":"Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells","volume":"26","author":"Zhang","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jchromb.2019.121734_bb0070","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1080\/10717544.2016.1223210","article-title":"Sophoridine-loaded PLGA microspheres for lung targeting: preparation, in vitro, and in vivo evaluation","volume":"23","author":"Wang","year":"2016","journal-title":"Drug Deliv"},{"key":"10.1016\/j.jchromb.2019.121734_bb0075","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.3390\/molecules23030510","article-title":"N-methylcytisine ameliorates dextran-sulfate-sodium-induced colitis in mice by inhibiting the inflammatory response","volume":"23","author":"Jiao","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2019.121734_bb0080","first-page":"4083","article-title":"Oxysophocarpine inhibits lung injury induced by respiratory syncytial virus","volume":"9","author":"Gao","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.jchromb.2019.121734_bb0085","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/pca.829","article-title":"Determination of quinolizidine alkaloids in Sophora tonkinensis by HPCE","volume":"16","author":"Ding","year":"2005","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jchromb.2019.121734_bb0090","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/pca.832","article-title":"A phytochemical study of the quinolizidine alkaloids from Genista tenera by gas chromatography\u2013mass spectrometry","volume":"16","author":"Martins","year":"2005","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jchromb.2019.121734_bb0095","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/bmc.348","article-title":"High-performance liquid chromatographic method for simultaneous determination of sophoridine and matrine in rat plasma","volume":"18","author":"Li","year":"2004","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jchromb.2019.121734_bb0105","author":"European Medicines Agency"},{"key":"10.1016\/j.jchromb.2019.121734_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8162952","article-title":"Study of the effects of betaine and\/or C-phycocyanin on the growth of lung cancer A549 cells in vitro and in vivo","volume":"2016","author":"Bingula","year":"2016","journal-title":"J Oncol"},{"key":"10.1016\/j.jchromb.2019.121734_bb0115","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s12149-015-0984-4","article-title":"Evaluation of the therapeutic efficacy of a MEK inhibitor (TAK-733) using 18F-fluorodeoxyglucose-positron emission tomography in the human lung xenograft model A549","volume":"29","author":"Ishino","year":"2015","journal-title":"Ann. Nucl. Med."},{"key":"10.1016\/j.jchromb.2019.121734_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/580531","article-title":"Improvement of radiation-mediated immunosuppression of human NSCLC tumour xenografts in a nude rat model","volume":"2010","author":"Tokalov","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.jchromb.2019.121734_bb0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9673(02)01812-5","article-title":"Comparison of peak shapes obtained with volatile (mass spectrometry-compatible) buffers and conventional buffers in reversed-phase high-performance liquid chromatography of bases on particulate and monolithic columns","volume":"987","author":"M. D.V","year":"2003","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2019.121734_bb0130","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.chroma.2014.01.060","article-title":"Comparative assessment of achiral stationary phases for high throughput analysis in supercritical fluid chromatography","volume":"1332","author":"Ebinger","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2019.121734_bb0135","first-page":"641","article-title":"Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs","volume":"11","author":"Li","year":"2016","journal-title":"Asian J Pharm Sci"},{"key":"10.1016\/j.jchromb.2019.121734_bb0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpba.2013.05.003","article-title":"Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS\/MS method","volume":"83","author":"Tang","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2019.121734_bb0145","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.2147\/DDDT.S92276","article-title":"Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4","volume":"9","author":"Liu","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.jchromb.2019.121734_bb0150","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.2741\/2232","article-title":"Cytochrome P450 expression (CYP) in non-small cell lung cancer","volume":"12","author":"Oyama","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jchromb.2019.121734_bb0155","first-page":"1","article-title":"The expression levels of CYP3A4 and CYP3A5 serve as potential prognostic biomarkers in lung adenocarcinoma","volume":"39","author":"Mao","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.jchromb.2019.121734_bb0160","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1742-7843.2010.00596.x","article-title":"Effects of matrine and oxymatrine on catalytic activity of cytochrome P450s in rats","volume":"107","author":"Yuan","year":"2010","journal-title":"Basic Clin Pharmacol"},{"key":"10.1016\/j.jchromb.2019.121734_bb0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-0028-1112207","article-title":"Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay","volume":"75","author":"Madgula","year":"2009","journal-title":"Planta Med."},{"key":"10.1016\/j.jchromb.2019.121734_bb0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.fitote.2015.05.021","article-title":"Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat","volume":"105","author":"Wu","year":"2015","journal-title":"Fitoterapia"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219305951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219305951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:57:39Z","timestamp":1761605859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023219305951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":33,"alternative-id":["S1570023219305951"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2019.121734","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous determination of five active alkaloids from Compound Kushen Injection in rat plasma by LC\u2013MS\/MS and its application to a comparative pharmacokinetic study in normal and NSCLC nude rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2019.121734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121734"}}