{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:37:41Z","timestamp":1793745461299,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":142,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["152"],"award-info":[{"award-number":["152"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["K 116263"],"award-info":[{"award-number":["K 116263"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015269","name":"Magyarorsz\u00e1g Korm\u00e1nya","doi-asserted-by":"publisher","award":["NN 127062"],"award-info":[{"award-number":["NN 127062"]}],"id":[{"id":"10.13039\/501100015269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jchromb.2019.121913","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T13:55:49Z","timestamp":1576158949000},"page":"121913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Comparative analysis of the human serum N-glycome in lung cancer, COPD and their comorbidity using capillary electrophoresis"],"prefix":"10.1016","volume":"1137","author":[{"given":"Brigitta","family":"M\u00e9sz\u00e1ros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"J\u00e1rv\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton","family":"Szigeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e1ta","family":"Kun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Cs\u00e1nky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Guttman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2019.121913_b0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jchromb.2019.121913_b0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.lungcan.2015.08.017","article-title":"The relationship between COPD and lung cancer","volume":"90","author":"Durham","year":"2015","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jchromb.2019.121913_b0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/resp.12660","article-title":"Global burden of COPD","volume":"21","author":"L\u00f3pez-Campos","year":"2016","journal-title":"Respirology"},{"key":"10.1016\/j.jchromb.2019.121913_b0020","first-page":"101","article-title":"Chronic obstructive pulmonary disease in patients with lung cancer: prevalence, impact and management challenges","volume":"8","author":"Spyratos","year":"2017","journal-title":"Lung Cancer (Auckl)"},{"key":"10.1016\/j.jchromb.2019.121913_b0025","doi-asserted-by":"crossref","first-page":"e4460","DOI":"10.1097\/MD.0000000000004460","article-title":"CT-guided percutaneous transthoracic needle biopsy for paramediastinal and nonparamediastinal lung lesions: diagnostic yield and complications in 1484 patients","volume":"95","author":"Wang","year":"2016","journal-title":"Medicine"},{"key":"10.1016\/j.jchromb.2019.121913_b0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/2231-0762.129446","article-title":"Risk of tumor cell seeding through biopsy and aspiration cytology","volume":"4","author":"Shyamala","year":"2014","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"10.1016\/j.jchromb.2019.121913_b0035","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.7150\/jca.20784","article-title":"Distant metastasis and survival outcomes after computed tomography-guided needle biopsy in resected stage I-III non-small cell lung cancer","volume":"8","author":"Xi","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.jchromb.2019.121913_b0040","first-page":"1318","article-title":"Alternative glycosylation modulates function of IgG and other proteins - implications on evolution and disease","volume":"2012","author":"Gornik","year":"1820","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jchromb.2019.121913_b0045","doi-asserted-by":"crossref","unstructured":"T. Suzuki, K. Ohtsubo, N. Taniguchi, Sugar chains: decoding the functions of glycans, 2015.","DOI":"10.1007\/978-4-431-55381-6"},{"key":"10.1016\/j.jchromb.2019.121913_b0050","series-title":"Advances in Cancer Research","first-page":"305","article-title":"Chapter Nine - Glycosylation alterations in lung and brain cancer","author":"Lemjabbar-Alaoui","year":"2015"},{"key":"10.1016\/j.jchromb.2019.121913_b0055","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10719-015-9626-2","article-title":"Human plasma protein N-glycosylation","volume":"33","author":"Clerc","year":"2016","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.jchromb.2019.121913_b0060","unstructured":"A. Varki, R.D. Cummings, J.D. Esko, P. Stanley, G.W. Hart, M. Aebi, A.G. Darvill, T. Kinoshita, H.P. Packer, J.H. Prestegard, R.L. Schnaar, P.H. Seeberger, Essentials of Glycobiology, Cold Spring Harbor Laboratory Press, DOI (2015\u20132017)."},{"key":"10.1016\/j.jchromb.2019.121913_b0065","series-title":"Techniques in Glycobiology","author":"Townsend","year":"1997"},{"key":"10.1016\/j.jchromb.2019.121913_b0070","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/glycob\/cwm100","article-title":"Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG","volume":"17","author":"Saldova","year":"2007","journal-title":"Glycobiology"},{"key":"10.1016\/j.jchromb.2019.121913_b0075","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12967-018-1695-0","article-title":"N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease","volume":"16","author":"Pavic","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jchromb.2019.121913_b0080","doi-asserted-by":"crossref","first-page":"27955","DOI":"10.1038\/srep27955","article-title":"Longitudinal monitoring of immunoglobulin A glycosylation during pregnancy by simultaneous MALDI-FTICR-MS analysis of N- and O-glycopeptides","volume":"6","author":"Bondt","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2019.121913_b0085","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13075-017-1367-0","article-title":"IgA N- and O-glycosylation profiling reveals no association with the pregnancy-related improvement in rheumatoid arthritis","volume":"19","author":"Bondt","year":"2017","journal-title":"Arthritis Res. Therapy"},{"key":"10.1016\/j.jchromb.2019.121913_b0090","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/glycob\/cwu115","article-title":"Differentially expressed glycosylated patterns of alpha-1-antitrypsin as serum biomarkers for the diagnosis of lung cancer","volume":"25","author":"Liang","year":"2015","journal-title":"Glycobiology"},{"key":"10.1016\/j.jchromb.2019.121913_b0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/ijc.22958","article-title":"Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects","volume":"122","author":"Fujimura","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jchromb.2019.121913_b0100","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/elps.201300041","article-title":"Analysis of haptoglobin N-glycome alterations in inflammatory and malignant lung diseases by capillary electrophoresis","volume":"34","author":"Varadi","year":"2013","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jchromb.2019.121913_b0105","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/glycob\/cwg071","article-title":"N-glycan structures of human transferrin produced by Lymantria dispar (gypsy moth) cells using the LdMNPV expression system","volume":"13","author":"Choi","year":"2003","journal-title":"Glycobiology"},{"key":"10.1016\/j.jchromb.2019.121913_b0110","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1007\/s00216-016-9570-4","article-title":"N-Glycan profile analysis of transferrin using a microfluidic compact disc and MALDI-MS","volume":"408","author":"Quaranta","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2019.121913_b0115","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jprot.2015.07.011","article-title":"Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease","volume":"127","author":"Ito","year":"2015","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jchromb.2019.121913_b0120","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1021\/pr101034t","article-title":"Novel glycan biomarkers for the detection of lung cancer","volume":"10","author":"Arnold","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jchromb.2019.121913_b0125","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/prca.201200131","article-title":"Enrichment strategies in glycomics-based lung cancer biomarker development","volume":"7","author":"Ruhaak","year":"2013","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.jchromb.2019.121913_b0130","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-3016.2008.00956.x","article-title":"To pool or not to pool, from whether to when: applications of pooling to biospecimens subject to a limit of detection","volume":"22","author":"Schisterman","year":"2008","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.jchromb.2019.121913_b0135","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.talanta.2018.03.101","article-title":"Evaporative fluorophore labeling of carbohydrates via reductive animation","volume":"185","author":"Reider","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2019.121913_b0140","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0021-9673(97)00724-3","article-title":"Exoglycosidase matrix-mediated sequencing of a complex glycan pool by capillary electrophoresis","volume":"781","author":"Guttman","year":"1997","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2019.121913_b0145","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1002\/elps.201500397","article-title":"GUcal: an integrated application for capillary electrophoresis based glycan analysis","volume":"36","author":"Jarvas","year":"2015","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jchromb.2019.121913_b0150","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1021\/pr401092y","article-title":"Association of N-glycosylation with breast carcinoma and systemic features using high-resolution quantitative UPLC","volume":"13","author":"Saldova","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jchromb.2019.121913_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ab.2007.12.012","article-title":"HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software","volume":"376","author":"Royle","year":"2008","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jchromb.2019.121913_b0160","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10719-012-9453-7","article-title":"N-glycan analysis of human alpha1-antitrypsin produced in Chinese hamster ovary cells","volume":"30","author":"Lee","year":"2013","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.jchromb.2019.121913_b0165","doi-asserted-by":"crossref","first-page":"11663","DOI":"10.1038\/s41598-017-11493-6","article-title":"Automated N-glycosylation sequencing of biopharmaceuticals by capillary electrophoresis","volume":"7","author":"Szigeti","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2019.121913_b0170","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/abio.1996.0118","article-title":"Effect of the quantity and linkage position of mannose (alpha 1,2) residues in capillary gel electrophoresis of high-mannose-type oligosaccharides","volume":"235","author":"Guttman","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jchromb.2019.121913_b0175","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1021\/ac4006099","article-title":"Unraveling the glyco-puzzle: glycan structure identification by capillary electrophoresis","volume":"85","author":"Mittermayr","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2019.121913_b0180","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1002\/pmic.201100300","article-title":"Symbol nomenclature for representing glycan structures: extension to cover different carbohydrate types","volume":"11","author":"Harvey","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.jchromb.2019.121913_b0185","article-title":"High throughput multiplex SNP-analysis in chronic obstructive pulmonary disease and lung cancer","volume":"19","author":"Elek","year":"2019","journal-title":"Curr. Mol. Med."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219312966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219312966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:58:20Z","timestamp":1761605900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023219312966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":37,"alternative-id":["S1570023219312966"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2019.121913","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative analysis of the human serum N-glycome in lung cancer, COPD and their comorbidity using capillary electrophoresis","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2019.121913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121913"}}