{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:02:28Z","timestamp":1783533748562,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001850","name":"Department of Chemicals and Petrochemicals, Ministry of Chemicals and Fertilizers, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jchromb.2020.121993","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T01:45:36Z","timestamp":1579311936000},"page":"121993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Amalgamation of stress degradation and metabolite profiling in rat urine and feces for characterization of oxidative metabolites of flibanserin using UHPLC-Q-TOF-MS\/MS, H\/D exchange and NMR technique"],"prefix":"10.1016","volume":"1139","author":[{"given":"Manish Kumar","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinaki","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2020.121993_b0005","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/mas.20128","article-title":"Analytical strategies for identifying drug metabolites","volume":"26","author":"Prakash","year":"2007","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.jchromb.2020.121993_b0010","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1359-6446(03)03018-6","article-title":"Strategies for dealing with reactive intermediates in drug discovery and development","author":"Nassar","year":"2004","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jchromb.2020.121993_b0015","doi-asserted-by":"crossref","unstructured":"W.W. Lam, J. Chen, R.F. Xu, J. Silva, H. Lim, Optimization in drug Discovery, 2014, pp. 445\u2013459. https:\/\/doi.org\/10.1007\/978-1-62703-742-6.","DOI":"10.1007\/978-1-62703-742-6_26"},{"key":"10.1016\/j.jchromb.2020.121993_b0020","doi-asserted-by":"crossref","first-page":"10904","DOI":"10.1021\/ac402339s","article-title":"Practical and economical implementation of online H\/D exchange in LC-MS","volume":"85","author":"Shah","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2020.121993_b0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4155\/bio.09.32","article-title":"From known knowns to known unknowns: predicting in vivo drug metabolites","volume":"1","author":"Pelkonen","year":"2009","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jchromb.2020.121993_b0030","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1097\/AOG.0b013e3181898cdb","article-title":"Sexual problems and distress in United States women prevalence and correlates","volume":"112","author":"Shifren","year":"2008","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jchromb.2020.121993_b0035","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/2040622316679933","article-title":"Flibanserin for hypoactive sexual desire disorder: place in therapy","volume":"8","author":"Gelman","year":"2017","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.jchromb.2020.121993_b0040","first-page":"1073","article-title":"Re: FDA approves first treatment for sexual desire disorder","volume":"195","author":"Seftel","year":"2016","journal-title":"J. Urol."},{"key":"10.1016\/j.jchromb.2020.121993_b0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00210-010-0515-8","article-title":"Flibanserin, a drug intended for treatment of hypoactive sexual desire disorder in pre-menopausal women, affects spontaneous motor activity and brain neurochemistry in female rats","volume":"381","author":"Ferger","year":"2010","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"10.1016\/j.jchromb.2020.121993_b0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1743-6109.2010.02032.x","article-title":"Multifunctional pharmacology of flibanserin: possible mechanism of therapeutic action in hypoactive sexual desire disorder","volume":"8","author":"Stahl","year":"2011","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.jchromb.2020.121993_b0055","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/sj.bjp.0705341","article-title":"Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT 1A receptors","volume":"139","author":"Invernizzi","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jchromb.2020.121993_b0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jpba.2011.08.027","article-title":"Isolation and structural elucidation of flibanserin as an adulterant in a health supplement used for female sexual performance enhancement","volume":"57","author":"Low","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2020.121993_b0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpba.2014.01.021","article-title":"Determination of flibanserin and tadalafil in supplements for women sexual desire enhancement using high-performance liquid chromatography with tandem mass spectrometer, diode array detector and charged aerosol detector","volume":"94","author":"Poplawska","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2020.121993_b0070","unstructured":"2019 WADA PROHIBITED LIST, WORLD ANTI-DOPING CODE Int. Stand., 2019. https:\/\/www.wada-ama.org\/sites\/default\/files\/wada_2019_english_prohibited_list.pdf (accessed Jan 1, 2019)."},{"key":"10.1016\/j.jchromb.2020.121993_b0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5005\/jp-journals-10028-1063","article-title":"Drug abuse in sports: an overview","volume":"47","author":"Beotra","year":"2013","journal-title":"J. Postgrad. Med. Educ. Res."},{"key":"10.1016\/j.jchromb.2020.121993_b0080","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jpba.2014.05.020","article-title":"Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls","volume":"101","author":"Thevis","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2020.121993_b0085","first-page":"1","article-title":"Flibanserin toxicity in a toddler following ingestion","author":"Granzella","year":"2017","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.jchromb.2020.121993_b0090","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/jms.513","article-title":"New designer drug 1- (3-trifluoromethylphenyl) piperazine (TFMPP): gas chromatography\/mass spectrometry and liquid chromatography\/mass spectrometry studies on its phase I and II metabolism and on its toxicological detection in rat urine \u2020","volume":"38","author":"Staack","year":"2003","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2020.121993_b0095","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0887-2333(03)00120-6","article-title":"Drugs of abuse and abuse of drugs in sportsmen: the role of in vitro models to study effects and mechanisms","volume":"17","author":"Botr\u00e8","year":"2003","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.jchromb.2020.121993_b0100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jms.1498","article-title":"Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen\/deuterium exchange HR-LC\/MS","volume":"44","author":"Chen","year":"2009","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2020.121993_b0105","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jpba.2014.06.008","article-title":"Degradation kinetics study of cabozantinib by a novel stability-indicating LC method and identification of its major degradation products by LC\/TOF-MS and LC-MS\/MS","volume":"98","author":"Wu","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2020.121993_b0110","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/rcm.4023","article-title":"Characterization of imatinib metabolites in rat and human liver microsomes : differentiation of hydroxylation from N -oxidation by liquid chromatography\/atmospheric pressure chemical ionization mass spectrometry","volume":"23","author":"Ma","year":"2009","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2020.121993_b0115","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/dta.307","article-title":"Current awareness of piperazines : pharmacology and toxicology","volume":"3","author":"Elliott","year":"2011","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.jchromb.2020.121993_b0120","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4161\/oxim.3.4.13246","article-title":"Deleterious effects of reactive metabolites","volume":"3","author":"Attia","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jchromb.2020.121993_b0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/138920011794520044","article-title":"Role of cyclic tertiary amine bioactivation to reactive iminium species : structure toxicity relationship","volume":"12","author":"Lucija Peterlin Masic","year":"2011","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jchromb.2020.121993_b0130","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/978-1-62703-742-6_26","article-title":"In vitro methods, methods in pharmacology and toxicology","author":"Lam","year":"2014","journal-title":"Optim. Drug Discov."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219317568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023219317568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:59:10Z","timestamp":1761605950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023219317568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":26,"alternative-id":["S1570023219317568"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2020.121993","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amalgamation of stress degradation and metabolite profiling in rat urine and feces for characterization of oxidative metabolites of flibanserin using UHPLC-Q-TOF-MS\/MS, H\/D exchange and NMR technique","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2020.121993","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121993"}}