{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:46:28Z","timestamp":1787165188192,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jchromb.2020.122148","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T21:52:07Z","timestamp":1588888327000},"page":"122148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Liquid chromatography-tandem mass spectrometry (LC-MS\/MS) method development for screening of potential tamoxifen-drug\/herb interaction via in vitro cytochrome P450 inhibition assay"],"prefix":"10.1016","volume":"1148","author":[{"given":"Y.F.","family":"Yong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn W.O.","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.S.","family":"Yaacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2020.122148_b0005","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2125.2011.03903.x","article-title":"Perpetrators of pharmacokinetic drug-drug interactions arising from altered cytochrome P450 activity: a criteria-based assessment","volume":"71","author":"Polasek","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jchromb.2020.122148_b0010","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/cpt.1435","article-title":"Clinical studies on drug-drug interactions involving metabolism and transport: methodology, pitfalls, and interpretation","volume":"105","author":"Tornio","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jchromb.2020.122148_b0015","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jep.2010.09.022","article-title":"Cytochrome P450 inhibitory potential of Triphala\u2014A Rasayana from Ayurveda","volume":"133","author":"Ponnusankar","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2020.122148_b0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/004982599238812","article-title":"Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential","volume":"29","author":"Moody","year":"1999","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jchromb.2020.122148_b0025","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.tiv.2015.06.014","article-title":"Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice","volume":"29","author":"He","year":"2015","journal-title":"Toxicol. In Vitro"},{"issue":"839-834","key":"10.1016\/j.jchromb.2020.122148_b0030","first-page":"839","article-title":"Improved prediction of clinical drug-drug interactions using a novel numerical method for evaluation of time-dependent inhibition of cytochrome P450","volume":"834","author":"Yadav","year":"2018","journal-title":"FASEB J. 32"},{"key":"10.1016\/j.jchromb.2020.122148_b0035","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1080\/00498254.2019.1581301","article-title":"Investigation of the inhibition of eight major human cytochrome P450 isozymes by a probe substrate cocktail in vitro with emphasis on CYP2E1","volume":"49","author":"Valicherla","year":"2019","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jchromb.2020.122148_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2017.08.020","article-title":"Effects of diosmetin on nine cytochrome P450 isoforms, UGTs and three drug transporters in vitro","volume":"334","author":"Chen","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jchromb.2020.122148_b0045","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jpba.2012.10.016","article-title":"A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC\u2013MS\/MS","volume":"74","author":"Pillai","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2020.122148_b0050","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1373\/49.7.1041","article-title":"Ion suppression in mass spectrometry","volume":"49","author":"Annesley","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jchromb.2020.122148_b0055","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S1044-0305(00)00163-X","article-title":"Mechanistic investigation of ionization suppression in electrospray ionization","volume":"11","author":"King","year":"2000","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2020.122148_b0060","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jchromb.2007.01.006","article-title":"Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography\u2013tandem mass spectrometry","author":"Li","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci. 852"},{"key":"10.1016\/j.jchromb.2020.122148_b0065","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0165-9936(00)00009-1","article-title":"Exploring the boundaries of bioanalytical quantitative LC\u2013MS\u2013MS","volume":"19","author":"Lagerwerf","year":"2000","journal-title":"TrAC-Trend. Anal. Chem."},{"key":"10.1016\/j.jchromb.2020.122148_b0070","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.apsb.2012.10.004","article-title":"Preclinical experimental models of drug metabolism and disposition in drug discovery and development","volume":"2","author":"Zhang","year":"2012","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jchromb.2020.122148_b0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s13318-016-0323-8","article-title":"Inhibitory effects of triptolide on human liver cytochrome P450 enzymes and P-glycoprotein","volume":"42","author":"Zhang","year":"2017","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.jchromb.2020.122148_b0080","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/00498254.2015.1071502","article-title":"Effect of buffer conditions on CYP2C8-mediated paclitaxel 6\u03b1-hydroxylation and CYP3A4-mediated triazolam \u03b1- and 4-hydroxylation by human liver microsomes","volume":"46","author":"Kudo","year":"2016","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jchromb.2020.122148_b0085","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0026-895X(24)12046-9","article-title":"CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants","volume":"28","author":"Hesse","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jchromb.2020.122148_b0090","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1124\/dmd.32.4.460","article-title":"The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6","volume":"32","author":"Madeira","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jchromb.2020.122148_b0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1570-0232(02)00914-5","article-title":"Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography\u2013tandem mass spectrometry","author":"Polson","year":"2003","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci. 785"},{"key":"10.1016\/j.jchromb.2020.122148_b0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jchromb.2006.12.030","article-title":"Systematic and comprehensive strategy for reducing matrix effects in LC\/MS\/MS analyses","author":"Chambers","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci. 852"},{"key":"10.1016\/j.jchromb.2020.122148_b0105","series-title":"Modern Physical Organic Chemistry","author":"Anslyn","year":"2006"},{"key":"10.1016\/j.jchromb.2020.122148_b0110","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0165-9936(03)00402-3","article-title":"New trends in sample preparation for clinical and pharmaceutical analysis","volume":"22","author":"Kataoka","year":"2003","journal-title":"TrAC-Trend. Anal. Chem."},{"key":"10.1016\/j.jchromb.2020.122148_b0115","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0140-6736(00)02677-5","article-title":"Risk and prognosis of endometrial cancer after tamoxifen for breast cancer","volume":"356","author":"Bergman","year":"2000","journal-title":"The Lancet"},{"key":"10.1016\/j.jchromb.2020.122148_b0120","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3892\/ol.2015.2962","article-title":"Molecular mechanisms of tamoxifen-associated endometrial cancer (review)","volume":"9","author":"Hu","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jchromb.2020.122148_b0125","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/sj.bjc.6603214","article-title":"Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden","volume":"95","author":"Chandanos","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jchromb.2020.122148_b0130","doi-asserted-by":"crossref","first-page":"10186","DOI":"10.1021\/ac102337d","article-title":"Tamoxifen metabolite isomer separation and quantification by liquid chromatography\u2212tandem mass spectrometry","volume":"82","author":"Jaremko","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2020.122148_b0135","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1124\/jpet.104.065607","article-title":"Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6","volume":"310","author":"Desta","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jchromb.2020.122148_b0140","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/jphp.12055","article-title":"Effects of herbal supplements on the bioactivation of chemotherapeutic agents","volume":"65","author":"Gorman","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jchromb.2020.122148_b0145","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c693","article-title":"Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study","volume":"340","author":"Kelly","year":"2010","journal-title":"The BMJ"},{"key":"10.1016\/j.jchromb.2020.122148_b0150","series-title":"Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses","author":"Perry","year":"1980"},{"key":"10.1016\/j.jchromb.2020.122148_b0155","first-page":"2045","article-title":"Phytochemistry, pharmacology and toxicology properties of Strobilanthes crispus","volume":"20","author":"Nurraihana","year":"2013","journal-title":"Int. Food Res. J."},{"key":"10.1016\/j.jchromb.2020.122148_b0160","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1472-6882-14-252","article-title":"Synergistic anticancer effects of a bioactive subfraction of Strobilanthes crispus and tamoxifen on MCF-7 and MDA-MB-231 human breast cancer cell lines","volume":"14","author":"Yaacob","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.jchromb.2020.122148_b0165","doi-asserted-by":"crossref","unstructured":"N.S. Yaacob, H.M. Yankuzo, S. Devaraj, J.K.M. Wong, C.S. Lai, Anti-tumor action, clinical biochemistry profile and phytochemical constituents of a pharmacologically active fraction of S. crispus in NMU-induced rat mammary tumour model, PLoS One 10 (2015) e0126426. http:\/\/doi.org\/10.1371\/journal.pone.0126426.","DOI":"10.1371\/journal.pone.0126426"},{"key":"10.1016\/j.jchromb.2020.122148_b0170","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jep.2017.10.024","article-title":"Immunomodulatory effects of a bioactive fraction of Strobilanthes crispus in NMU-induced rat mammary tumor model","volume":"213","author":"Yankuzo","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2020.122148_b0175","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S2221-1691(13)60005-2","article-title":"Subacute oral toxicity study of ethanolic leaves extracts of Strobilanthes crispus in rats","volume":"2","author":"Lim","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.jchromb.2020.122148_b0180","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1570-0232(02)00244-1","article-title":"Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods","volume":"774","author":"Almeida","year":"2002","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci."},{"key":"10.1016\/j.jchromb.2020.122148_b0185","unstructured":"Food and Drug Administration, Guidance for industry: bioanalytical method validation. https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/bioanalytical-method-validation-guidance-industry, 2018 (3 March 2020)."},{"key":"10.1016\/j.jchromb.2020.122148_b0190","doi-asserted-by":"crossref","unstructured":"C.R. Sanquetta, A.P. Dalla Corte, A. Behling, L.R. de Oliveira Piva, S. P\u00e9llico Netto, A.L. Rodrigues, M.N.I. Sanquetta, Selection criteria for linear regression models to estimate individual tree biomasses in the Atlantic Rain Forest, Brazil, Carbon Balance Manag. 13 (2018) 25. http:\/\/doi.org\/10.1186\/s13021-018-0112-6.","DOI":"10.1186\/s13021-018-0112-6"},{"key":"10.1016\/j.jchromb.2020.122148_b0195","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jchromb.2007.03.017","article-title":"Reconsideration of sample pH adjustment in bioanalytical liquid\u2013liquid extraction of ionisable compounds","author":"Hendriks","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci. 853"},{"key":"10.1016\/j.jchromb.2020.122148_b0200","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.talanta.2008.01.039","article-title":"Separation and determination of amitriptyline and nortriptyline by dispersive liquid\u2013liquid microextraction combined with gas chromatography flame ionization detection","volume":"75","author":"Yazdi","year":"2008","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2020.122148_b0205","unstructured":"AOAC International, Appendix K: guidelines for dietary supplements and botanicals, part 1 AOAC guidelines for single laboratory validation of chemical methods for dietary supplements and botanicals. http:\/\/www.eoma.aoac.org\/app_k.pdf, 2013 (3 March 2020)."},{"key":"10.1016\/j.jchromb.2020.122148_b0210","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.talanta.2014.10.040","volume":"132","author":"Antunes","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2020.122148_b0215","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.jchromb.2011.04.011","article-title":"Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry","author":"Teunissen","year":"2011","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci. 879"},{"key":"10.1016\/j.jchromb.2020.122148_b0220","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/j.jchromb.2009.06.029","article-title":"Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry","volume":"877","author":"Teunissen","year":"2009","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci."},{"key":"10.1016\/j.jchromb.2020.122148_b0225","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/1087057108317480","article-title":"Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery","volume":"13","author":"Bell","year":"2008","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.jchromb.2020.122148_b0230","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2133\/dmpk.DMPK-12-RG-014","article-title":"Reliable high-throughput method for inhibition assay of 8 cytochrome P450 isoforms using cocktail of probe substrates and stable isotope-labeled internal standards","volume":"27","author":"Kozakai","year":"2012","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.jchromb.2020.122148_b0235","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4236\/abb.2013.45083","article-title":"Evaluation of the effect of compound aqueous solubility in cytochrome P450 inhibition assays","volume":"4","author":"Perez","year":"2013","journal-title":"Adv. Biosci. Biotechnol."},{"key":"10.1016\/j.jchromb.2020.122148_b0240","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1067\/mcp.2000.110561","article-title":"In vivo modulation of CYP enzymes by quinidine and rifampin","volume":"68","author":"Branch","year":"2000","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jchromb.2020.122148_b0245","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.phymed.2012.01.005","article-title":"Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes","volume":"19","author":"Zhou","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2020.122148_b0250","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ptr.3564","article-title":"Aloe vera juice: IC50 and dual mechanistic inhibition of CYP3A4 and CYP2D6","volume":"26","author":"Djuv","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jchromb.2020.122148_b0255","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2133\/dmpk.18.287","article-title":"In vitro inhibitory effect of 1-Aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole","volume":"18","author":"Emoto","year":"2003","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.jchromb.2020.122148_b0260","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1124\/dmd.31.7.938","article-title":"In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes P450: role of CYP3A4 and CYP3A5","volume":"31","author":"Patki","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jchromb.2020.122148_b0265","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/ptr.5220","article-title":"Evaluation of inhibitory effects of caffeic acid and quercetin on human liver cytochrome P450 activities","volume":"28","author":"Rastogi","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jchromb.2020.122148_b0270","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.2042-7158.2010.01202.x","article-title":"Mechanism of cytochrome P450\u20133A inhibition by ketoconazole","volume":"63","author":"Greenblatt","year":"2011","journal-title":"J. Pharm. Pharmacol."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023220300799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023220300799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:00:28Z","timestamp":1761606028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023220300799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":54,"alternative-id":["S1570023220300799"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2020.122148","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquid chromatography-tandem mass spectrometry (LC-MS\/MS) method development for screening of potential tamoxifen-drug\/herb interaction via in vitro cytochrome P450 inhibition assay","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2020.122148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122148"}}