{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:29:17Z","timestamp":1778585357144,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773481"],"award-info":[{"award-number":["81773481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402723"],"award-info":[{"award-number":["81402723"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jchromb.2020.122246","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T19:24:48Z","timestamp":1592076288000},"page":"122246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Rapid and simultaneous determination of ten anti-tuberculosis drugs in human plasma by UPLC-MS\/MS with applications in therapeutic drug monitoring"],"prefix":"10.1016","volume":"1152","author":[{"given":"Xiangji","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haichao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhen","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianfeng","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2020.122246_b0005","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1086\/313562","article-title":"Old Testament biblical references to tuberculosis","volume":"29","author":"Daniel","year":"1999","journal-title":"Clin. Infect. Diseases Off. Publ. Infect. Diseases Soc. Am."},{"key":"10.1016\/j.jchromb.2020.122246_b0010","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.phrs.2016.01.020","article-title":"T.B.S.G. Italian Pediatric, Recommendations for treating children with drug-resistant tuberculosis","volume":"105","author":"Galli","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jchromb.2020.122246_b0015","unstructured":"World Health Organization, Global TB report 2018, 2019. Available at: http:\/\/www.who.int\/tb\/ publications\/global_report\/en\/ (accessed 5 February 2019)."},{"key":"10.1016\/j.jchromb.2020.122246_b0020","unstructured":"A. Cohen, V.D. Mathiasen, T. Schon, C. Wejse, The global prevalence of latent tuberculosis: a systematic review and meta-analysis, Eur. Respir. J. doi: 10.1183\/13993003.00655-2019(2019)."},{"key":"10.1016\/j.jchromb.2020.122246_b0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/1120009X.2020.1716479","article-title":"Molecular identification of mutations conferring resistance to rifampin, isoniazid and pyrazinamide among Mycobacterium tuberculosis isolates from Iran","volume":"32","author":"Haratiasl","year":"2020","journal-title":"J. Chemother."},{"key":"10.1016\/j.jchromb.2020.122246_b0030","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1038\/s41598-019-43547-2","article-title":"Prevalence and molecular characterization of multidrug-resistant M. tuberculosis in Jiangxi province","volume":"9","author":"Luo","year":"2019","journal-title":"China, Sci. Rep."},{"key":"10.1016\/j.jchromb.2020.122246_b0035","doi-asserted-by":"crossref","first-page":"858","DOI":"10.5588\/ijtld.18.0526","article-title":"Second nationwide anti-tuberculosis drug resistance survey in Namibia","volume":"23","author":"Ruswa","year":"2019","journal-title":"Int. J. Tuberc. Lung. Dis."},{"key":"10.1016\/j.jchromb.2020.122246_b0040","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cnur.2019.02.008","article-title":"Tuberculosis","volume":"54","author":"Kelly","year":"2019","journal-title":"Nurs. Clin. North Am."},{"key":"10.1016\/j.jchromb.2020.122246_b0045","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/j.cegh.2015.10.005","article-title":"Prevalence of adverse drug reaction with first-line drugs among patients treated for pulmonary tuberculosis","volume":"3","author":"Singh","year":"2015","journal-title":"Clin. Epidemiol. Global Health"},{"key":"10.1016\/j.jchromb.2020.122246_b0050","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pupt.2011.12.001","article-title":"Therapeutic drug monitoring in the treatment of tuberculosis patients","volume":"25","author":"Magis-Escurra","year":"2012","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.jchromb.2020.122246_b0055","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/infdis\/jit352","article-title":"Serum drug concentrations predictive of pulmonary tuberculosis outcomes","volume":"208","author":"Pasipanodya","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jchromb.2020.122246_b0060","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1086\/599040","article-title":"Isoniazid, rifampin, ethambutol, and pyrazinamide pharmacokinetics and treatment outcomes among a predominantly HIV-infected cohort of adults with tuberculosis from Botswana","volume":"48","author":"Chideya","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jchromb.2020.122246_b0065","first-page":"225","article-title":"Therapeutic drug monitoring in the treatment of active tuberculosis","volume":"18","author":"Babalik","year":"2011","journal-title":"Can. Respir. J."},{"key":"10.1016\/j.jchromb.2020.122246_b0070","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.3201\/eid1610.100374","article-title":"Therapeutic drug monitoring for slow response to tuberculosis treatment in a state control program, Virginia, USA","volume":"16","author":"Heysell","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jchromb.2020.122246_b0075","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/j.ijid.2019.01.040","article-title":"Challenging MDR-TB clinical problems \u2013 The case for a new Global TB Consilium supporting the compassionate use of new anti-TB drugs","volume":"80S","author":"Tiberi","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.jchromb.2020.122246_b0080","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1378\/chest.113.5.1178","article-title":"Low serum antimycobacterial drug levels in non-HIV-infected tuberculosis patients","volume":"113","author":"Kimerling","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.jchromb.2020.122246_b0085","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbrc.2018.02.030","article-title":"First-line anti-tuberculosis drugs induce hepatotoxicity: A novel mechanism based on a urinary metabolomics platform","volume":"497","author":"Cao","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jchromb.2020.122246_b0090","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.tube.2019.04.012","article-title":"Pharmacokinetics of isoniazid: The good, the bad, and the alternatives","volume":"116S","author":"Erwin","year":"2019","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.jchromb.2020.122246_b0095","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.meegid.2018.10.006","article-title":"The association between BACH1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort","volume":"66","author":"Zhang","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.jchromb.2020.122246_b0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijid.2014.12.001","article-title":"Therapeutic drug monitoring: how to improve drug dosage and patient safety in tuberculosis treatment","volume":"32","author":"Sotgiu","year":"2015","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.jchromb.2020.122246_b0105","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/10826079708010663","article-title":"High performance liquid chromatographic determination of anti-tuberculosis drugs in human body fluids","volume":"20","author":"Pan Zhen","year":"2006","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.jchromb.2020.122246_b0110","doi-asserted-by":"crossref","DOI":"10.2478\/s11532-012-0102-6","article-title":"Simultaneous analysis of first-line anti-tuberculosis drugs in tablets by UV spectrophotometry compared to capillary zone electrophoresis","volume":"10","author":"Marcellos","year":"2012","journal-title":"Open Chem."},{"key":"10.1016\/j.jchromb.2020.122246_b0115","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.talanta.2010.04.044","article-title":"Simultaneous determination of first-line anti-tuberculosis drugs by capillary zone electrophoresis using direct UV detection","volume":"82","author":"Faria","year":"2010","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2020.122246_b0120","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/rcm.2961","article-title":"Simultaneous determination of first-line anti-tuberculosis drugs and their major metabolic ratios by liquid chromatography\/tandem mass spectrometry","volume":"21","author":"Song","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2020.122246_b0125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jpba.2014.09.019","article-title":"Development and validation of liquid chromatography tandem mass spectrometry method for simultaneous quantification of first line tuberculosis drugs and metabolites in human plasma and its application in clinical study","volume":"102","author":"Hee","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2020.122246_b0130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tube.2017.11.012","article-title":"Rapid and sensitive method for simultaneous determination of first-line anti-tuberculosis drugs in human plasma by HPLC-MS\/MS: Application to therapeutic drug monitoring","volume":"109","author":"Gao","year":"2018","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.jchromb.2020.122246_b0135","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jchromb.2018.07.041","article-title":"The development and validation of a LC-MS\/MS method for the quantitation of metformin, rifampicin and isoniazid in rat plasma using HILIC chromatography","volume":"1095","author":"Govender","year":"2018","journal-title":"J. Chromatog.r B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2020.122246_b0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jchromb.2018.10.027","article-title":"Simultaneous quantification of four first line antitubercular drugs and metabolites in human plasma by hydrophilic interaction chromatography and tandem mass spectrometry","volume":"1105","author":"Sundell","year":"2019","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2020.122246_b0145","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/apm.12590","article-title":"Simultaneous quantification of isoniazid, rifampicin, ethambutol and pyrazinamide by liquid chromatography\/tandem mass spectrometry","volume":"124","author":"Prahl","year":"2016","journal-title":"APMIS"},{"key":"10.1016\/j.jchromb.2020.122246_b0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpba.2014.08.026","article-title":"Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry","volume":"102","author":"Kim","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2020.122246_b0155","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00426-19","article-title":"Shortening Buruli ulcer treatment with combination therapy targeting the respiratory chain and exploiting mycobacterium ulcerans gene decay","volume":"63","author":"Converse","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jchromb.2020.122246_b0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.addr.2016.04.026","article-title":"New agents for the treatment of drug-resistant Mycobacterium tuberculosis","volume":"102","author":"Hoagland","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jchromb.2020.122246_b0165","unstructured":"Guidance for Industry Bioanalytical Method Validation, US Department of Health and Human Services, FDA, WA, USA, 2013."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023220303470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023220303470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:02:03Z","timestamp":1761606123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023220303470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":33,"alternative-id":["S1570023220303470"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2020.122246","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid and simultaneous determination of ten anti-tuberculosis drugs in human plasma by UPLC-MS\/MS with applications in therapeutic drug monitoring","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2020.122246","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122246"}}