{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:31:48Z","timestamp":1792233108133,"version":"4.4.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jchromb.2020.122455","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T18:31:35Z","timestamp":1606588295000},"page":"122455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Simultaneous determination of tazarotene, clindamycin phosphate and their active metabolites in Bama mini-pig skin by LC-MS\/MS: Application to the development of a tazarotene\/clindamycin phosphate cream"],"prefix":"10.1016","volume":"1162","author":[{"given":"Yu-ting","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-liang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-xian","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-jun","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2020.122455_b0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clindermatol.2017.09.006","article-title":"Acne vulgaris: the metabolic syndrome of the pilosebaceous follicle","volume":"36","author":"Melnik","year":"2018","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.jchromb.2020.122455_b0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/bmj.325.7362.475","article-title":"Acne vulgaris","volume":"325","author":"Webster","year":"2002","journal-title":"BMJ-Brit. Med. J."},{"key":"10.1016\/j.jchromb.2020.122455_b0015","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21081063","article-title":"Treatment modalities for acne","volume":"21","author":"Fox","year":"2016","journal-title":"Molecules"},{"issue":"Suppl 5","key":"10.1016\/j.jchromb.2020.122455_b0020","first-page":"1","article-title":"From new findings in acne pathogenesis to new approaches in treatment","volume":"29","author":"Gollnick","year":"2015","journal-title":"J. Eur. Acad. Dermatol."},{"key":"10.1016\/j.jchromb.2020.122455_b0025","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s40257-019-00423-z","article-title":"Topical retinoids in acne vulgaris: a systematic review","volume":"20","author":"Kolli","year":"2019","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.jchromb.2020.122455_b0030","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1067\/mjd.2000.108321","article-title":"Pharmacokinetics and safety of tazarotene","volume":"43","author":"Menter","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jchromb.2020.122455_b0035","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaad.2009.01.019","article-title":"New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group","volume":"60","author":"Thiboutot","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jchromb.2020.122455_b0040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/09546630260199451","article-title":"Comparative efficacy of clindamycin and benzoyl peroxide for in vivo suppression of Propionibacterium acnes","volume":"13","author":"Gans","year":"2002","journal-title":"J. Dermatol. Treat."},{"issue":"Suppl 1","key":"10.1016\/j.jchromb.2020.122455_b0045","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0926-9959(98)00089-0","article-title":"Transdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data","volume":"11","author":"van Hoogdalem","year":"1998","journal-title":"J. Eur. Acad. Dermatol."},{"key":"10.1016\/j.jchromb.2020.122455_b0050","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s40261-017-0568-2","article-title":"Efficacy and safety of tazarotene 0.1% plus clindamycin 1% gel versus adapalene 0.1% plus clindamycin 1% gel in facial acne vulgaris: a randomized, controlled clinical trial","volume":"37","author":"Maiti","year":"2017","journal-title":"Clin. Drug Invest."},{"key":"10.1016\/j.jchromb.2020.122455_b0055","first-page":"256","article-title":"Tazarotene versus tazarotene plus clindamycin\/benzoyl peroxide in the treatment of acne vulgaris: a multicenter, double-blind, randomized parallel-group trial","volume":"5","author":"Tanghetti","year":"2006","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.jchromb.2020.122455_b0060","unstructured":"C.P. Zhang, J.R. Zheng, Y. Chen, X.Y. Li, L.F. Xu, M.Y. Tang, J.W. Gao, Combination topical medicine for acne vulgaris treatments and its preparation method. Faming Zhuanli Shenqing Gongkai Shuomingshu. CN 1528327 A (Chinese) (2003)."},{"key":"10.1016\/j.jchromb.2020.122455_b0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/cpdd.7","article-title":"Bioavailability of clindamycin from a new clindamycin phosphate 1.2%-benzoyl peroxide 3% combination gel","volume":"2","author":"Jones","year":"2013","journal-title":"Clin. Pharm. Drug Dev."},{"key":"10.1016\/j.jchromb.2020.122455_b0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2165\/00003088-199937040-00001","article-title":"Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis","volume":"37","author":"Tang-Liu","year":"1999","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jchromb.2020.122455_b0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jchromb.2017.06.035","article-title":"LC-MS\/MS quantitation of antimalarial drug piperaquine and metabolites in human plasma","volume":"1063","author":"Aziz","year":"2017","journal-title":"J. Chromatogr. B."},{"key":"10.1016\/j.jchromb.2020.122455_b0080","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jpha.2018.05.004","article-title":"Simultaneous determination of indapamide, perindopril and perindoprilat in human plasma or whole blood by UPLC-MS\/MS and its pharmacokinetic application","volume":"8","author":"Tao","year":"2018","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jchromb.2020.122455_b0085","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jchromb.2014.11.030","article-title":"Simultaneous determination of tazarotene and its active metabolite tazarotenic acid in minipig plasma by LC-MS\/MS and its application in pharmacokinetic study after topical administration of tazarotene gel","volume":"978\u2013979","author":"Tong","year":"2015","journal-title":"J. Chromatogr. B."},{"key":"10.1016\/j.jchromb.2020.122455_b0090","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jps.24383","article-title":"Use of minipig skin biopsy model as an innovative tool to design topical formulation to achieve desired pharmacokinetics in humans","volume":"104","author":"Mitra","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jchromb.2020.122455_b0095","first-page":"1434","article-title":"In vivo antibacterial effects of tretinoin-clindamycin and clindamycin alone on Propionibacterium acnes with varying clindamycin minimum inhibitory","volume":"11","author":"Leyden","year":"2012","journal-title":"J. Drugs Dermatol."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023220313313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023220313313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:02:01Z","timestamp":1761606121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023220313313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":19,"alternative-id":["S1570023220313313"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2020.122455","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous determination of tazarotene, clindamycin phosphate and their active metabolites in Bama mini-pig skin by LC-MS\/MS: Application to the development of a tazarotene\/clindamycin phosphate cream","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2020.122455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122455"}}