{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:34:19Z","timestamp":1792694059024,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903701"],"award-info":[{"award-number":["81903701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jchromb.2021.122915","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T02:19:19Z","timestamp":1630462759000},"page":"122915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Absorption, distribution, metabolism, and excretion of [14C]NBP (3-n-butylphthalide) in rats"],"prefix":"10.1016","volume":"1181","author":[{"given":"Junjun","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2021.122915_b0005","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1124\/dmd.112.049684","article-title":"Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation","volume":"41","author":"Diao","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jchromb.2021.122915_b0010","first-page":"3800","article-title":"DL-3-n-butylphthalide therapy for parkinson's disease: a randomized controlled trial","volume":"17","author":"Zhou","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jchromb.2021.122915_b0015","first-page":"1760","article-title":"Therapeutic effects of dl-3-n-butylphthalide in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"125","author":"Feng","year":"2012","journal-title":"Chin. Med. J."},{"issue":"12","key":"10.1016\/j.jchromb.2021.122915_b0020","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/cns.12594","article-title":"L-3-n-butylphthalide rescues hippocampal synaptic failure and attenuates neuropathology in aged APP\/PS1 mouse model of alzheimer\u2019s disease","volume":"22","author":"Zhang","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jchromb.2021.122915_b0025","first-page":"780","article-title":"Investigation on in vivo metabolism of n-butyl phthalide","volume":"31","author":"Peng","year":"1996","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.jchromb.2021.122915_b0030","first-page":"641","article-title":"A study on the metabolism of dl-3-n-butyphthalide in rats","volume":"32","author":"Wang","year":"1997","journal-title":"Acta Pham. Sin."},{"issue":"4","key":"10.1016\/j.jchromb.2021.122915_b0035","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1124\/dmd.113.056218","article-title":"Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1","volume":"42","author":"Diao","year":"2014","journal-title":"Drug Metab. Dispos."},{"issue":"12","key":"10.1016\/j.jchromb.2021.122915_b0040","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/aps.2015.64","article-title":"Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier","volume":"36","author":"Diao","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jchromb.2021.122915_b0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpba.2013.01.033","article-title":"Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS\/MS using deuterated internal standards","volume":"78\u201379","author":"Diao","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2021.122915_b0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchromb.2013.09.014","article-title":"Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry","volume":"939","author":"Diao","year":"2013","journal-title":"J. Chromatogr. B"},{"issue":"3","key":"10.1016\/j.jchromb.2021.122915_b0055","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1021\/tx2005212","article-title":"Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies","volume":"25","author":"Isin","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.jchromb.2021.122915_b0060","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1021\/tx300050f","article-title":"Radiolabeled absorption, distribution, metabolism, and excretion studies in drug development: why, when, and how?","volume":"25","author":"Penner","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"4","key":"10.1016\/j.jchromb.2021.122915_b0065","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/bdd.661","article-title":"Human radiolabeled mass balance studies: objectives, utilities and limitations","volume":"30","author":"Penner","year":"2009","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.jchromb.2021.122915_b0070","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.2174\/1381612043383494","article-title":"The use of radiolabeled compounds for ADME studies in discovery and exploratory development","volume":"10","author":"Marathe","year":"2004","journal-title":"Curr. Pharm. Design."},{"issue":"7","key":"10.1016\/j.jchromb.2021.122915_b0075","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1021\/js970486q","article-title":"Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening","volume":"87","author":"Hop","year":"1998","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.jchromb.2021.122915_b0080","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/clpt.1981.56","article-title":"Determination of mean valproic acid serum level by assay of a single pooled sample","volume":"29","author":"Hamilton","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.jchromb.2021.122915_b0085","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1021\/ac025934f","article-title":"On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development","volume":"75","author":"Nassar","year":"2003","journal-title":"Anal. Chem."},{"issue":"29","key":"10.1016\/j.jchromb.2021.122915_b0090","doi-asserted-by":"crossref","first-page":"25419","DOI":"10.1074\/jbc.R110.200055","article-title":"Drug metabolite profiling and identification by high-resolution mass spectrometry","volume":"286","author":"Zhu","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jchromb.2021.122915_b0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/03602532.2014.1001029","article-title":"Applications of mass spectrometry in drug metabolism: 50 years of progress","volume":"47","author":"Wen","year":"2015","journal-title":"Drug Metab. Rev."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023221003962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023221003962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:06:20Z","timestamp":1761606380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023221003962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":19,"alternative-id":["S1570023221003962"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2021.122915","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Absorption, distribution, metabolism, and excretion of [14C]NBP (3-n-butylphthalide) in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2021.122915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122915"}}