{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:17:52Z","timestamp":1791361072229,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["U54 ES027698"],"award-info":[{"award-number":["U54 ES027698"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010200","name":"U.S. Army Medical Research Institute of Chemical Defense","doi-asserted-by":"publisher","award":["AOD16026-001-00000\/A120B.P2016-01"],"award-info":[{"award-number":["AOD16026-001-00000\/A120B.P2016-01"]}],"id":[{"id":"10.13039\/100010200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010200","name":"U.S. Army Medical Research Institute of Chemical Defense","doi-asserted-by":"publisher","award":["AOD18015-001-00000\/MRICD-IAA-18-0129-00"],"award-info":[{"award-number":["AOD18015-001-00000\/MRICD-IAA-18-0129-00"]}],"id":[{"id":"10.13039\/100010200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014055","name":"U.S. Army Medical Research Acquisition Activity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jchromb.2022.123392","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T20:55:52Z","timestamp":1658868952000},"page":"123392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Analysis of bisaminotetrazole cobinamide, a next-generation antidote for cyanide, hydrogen sulfide and methanethiol poisoning, in swine plasma by liquid chromatography-tandem mass spectrometry"],"prefix":"10.1016","volume":"1208","author":[{"given":"Subrata","family":"Bhadra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara B.","family":"Hendry-Hofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry R.","family":"Boss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikhyat S.","family":"Bebarta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Logue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2022.123392_b0005","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s13181-016-0566-4","article-title":"The vitamin B 12 analog cobinamide is an effective antidote for oral cyanide poisoning","volume":"12","author":"Lee","year":"2016","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.jchromb.2022.123392_b0010","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.annemergmed.2009.12.002","article-title":"Intramuscular cobinamide sulfite in a rabbit model of sublethal cyanide toxicity","volume":"55","author":"Brenner","year":"2010","journal-title":"Ann. Emerg. Med."},{"issue":"1","key":"10.1016\/j.jchromb.2022.123392_b0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/nyas.14339","article-title":"Intramuscular aminotetrazole cobinamide as a treatment for inhaled hydrogen sulfide poisoning in a large swine model","volume":"1479","author":"Hendry\u2010Hofer","year":"2020","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.jchromb.2022.123392_b0020","series-title":"The acute toxicity of brief exposures to hydrogen fluoride, hydrogen chloride, nitrogen dioxide, and hydrogen cyanide singly and in combination with carbon monoxide","author":"DiPasquale","year":"1971"},{"key":"10.1016\/j.jchromb.2022.123392_b0025","series-title":"Toxicological profile for cyanide","first-page":"322","author":"Taylor","year":"2006"},{"key":"10.1016\/j.jchromb.2022.123392_b0030","series-title":"Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning","author":"Ellenhorn","year":"1997"},{"key":"10.1016\/j.jchromb.2022.123392_b0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chroma.2019.01.058","article-title":"Analysis of potential cyanide antidote, dimethyl trisulfide, in whole blood by dynamic headspace gas chromatography\u2013mass spectroscopy","volume":"1591","author":"Bhadra","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2022.123392_b0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jchromb.2015.11.027","article-title":"Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography\u2013tandem mass spectrometry","volume":"1008","author":"Stutelberg","year":"2016","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2022.123392_b0045","series-title":"Sax's dangerous properties of industrial materials","author":"Richard","year":"2012"},{"key":"10.1016\/j.jchromb.2022.123392_b0050","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.toxrep.2019.05.006","article-title":"Preliminary results of toxicity studies in rats following low-dose and short-term exposure to methyl mercaptan","volume":"6","author":"Fang","year":"2019","journal-title":"Toxicol. Rep."},{"issue":"1","key":"10.1016\/j.jchromb.2022.123392_b0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/08958378.2020.1866123","article-title":"Intramuscular cobinamide as an antidote to methyl mercaptan poisoning","volume":"33","author":"Hendry-Hofer","year":"2021","journal-title":"Inhalation toxicology, DO"},{"issue":"1","key":"10.1016\/j.jchromb.2022.123392_b0060","article-title":"Hydrogen sulfide\u2014mechanisms of toxicity and development of an antidote","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jchromb.2022.123392_b0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s13181-017-0650-4","article-title":"Midazolam efficacy against acute hydrogen sulfide-induced mortality and neurotoxicity","volume":"14","author":"Anantharam","year":"2018","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.jchromb.2022.123392_b0070","doi-asserted-by":"crossref","first-page":"461856","DOI":"10.1016\/j.chroma.2020.461856","article-title":"Analysis of the Soil Fumigant, Dimethyl Disulfide, in Swine Blood by Dynamic Headspace Gas Chromatography-Mass Spectroscopy","volume":"1638","author":"Bhadra","year":"2021","journal-title":"J. Chromatogr. A"},{"issue":"4","key":"10.1016\/j.jchromb.2022.123392_b0075","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/20961790.2017.1323570","article-title":"Screening for volatile sulphur compounds in a fatal accident case","volume":"2","author":"Xiang","year":"2017","journal-title":"Forensic sciences research"},{"key":"10.1016\/j.jchromb.2022.123392_b0080","unstructured":"P.D. Bryson, Comprehensive reviews in toxicology: for emergency clinicians, CRC press1996."},{"key":"10.1016\/j.jchromb.2022.123392_b0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1432-1033.1973.tb02735.x","article-title":"Cyanide Binding to Carbonic Anhydrase: A 13C-Nuclear-Magnetic-Resonance Study","volume":"34","author":"Feeney","year":"1973","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jchromb.2022.123392_b0090","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jchromb.2019.05.020","article-title":"Determination of free cyano-cobinamide in swine and rabbit plasma by liquid chromatography tandem mass spectrometry","volume":"1124","author":"Dzisam","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2022.123392_b0095","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4037\/ccn2011799","article-title":"A review of acute cyanide poisoning with a treatment update","volume":"31","author":"Hamel","year":"2011","journal-title":"Critical care nurse"},{"issue":"1","key":"10.1016\/j.jchromb.2022.123392_b0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/15563650.2021.1935992","article-title":"Evaluation of aqueous dimethyl trisulfide as an antidote to a highly lethal cyanide poisoning in a large swine model","volume":"60","author":"Hendry-Hofer","year":"2022","journal-title":"Clinical Toxicology, DO"},{"issue":"3","key":"10.1016\/j.jchromb.2022.123392_b0105","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/15563650.2021.1953517","article-title":"Development of sodium tetrathionate as a cyanide and methanethiol antidote","volume":"60","author":"Chan","year":"2022","journal-title":"Clinical Toxicology, DO"},{"key":"10.1016\/j.jchromb.2022.123392_b0110","unstructured":"Cyanokit, Cyanokit (hydroxocobalamin for injection) drug, RxList, 2019."},{"key":"10.1016\/j.jchromb.2022.123392_b0115","unstructured":"Nithiodote, Nithiodote (sodium nitrite injection for intravenous infusion) drug, RxList, 2021."},{"key":"10.1016\/j.jchromb.2022.123392_b0120","doi-asserted-by":"crossref","DOI":"10.1117\/1.3290816","article-title":"Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring","volume":"15","author":"Brenner","year":"2010","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.jchromb.2022.123392_b0125","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.annemergmed.2014.02.009","article-title":"Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model","volume":"64","author":"Bebarta","year":"2014","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.jchromb.2022.123392_b0130","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/acem.13213","article-title":"Efficacy of intravenous cobinamide versus hydroxocobalamin or saline for treatment of severe hydrogen sulfide toxicity in a swine (Sus scrofa) model","volume":"24","author":"Bebarta","year":"2017","journal-title":"Acad. Emerg. Med."},{"key":"10.1016\/j.jchromb.2022.123392_b0135","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm501565k","article-title":"Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection","volume":"58","author":"Chan","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jchromb.2022.123392_b0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/15563650.2018.1504955","article-title":"Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine","volume":"57","author":"Ng","year":"2019","journal-title":"Clinical Toxicology"},{"key":"10.1016\/j.jchromb.2022.123392_b0145","first-page":"1","article-title":"Hydrogen sulfide toxicity: mechanism of action, clinical presentation, and countermeasure development","volume":"I","author":"Ng","year":"2019","journal-title":"Journal of Medical Toxicology, DO"},{"key":"10.1016\/j.jchromb.2022.123392_b0150","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biomaterials.2015.06.033","article-title":"Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions","volume":"64","author":"Wassenaar","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jchromb.2022.123392_b0155","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jorganchem.2006.08.081","article-title":"Tetrazole derivatives and matrices as novel cobalamin coordinating compounds","volume":"692","author":"Fedosov","year":"2007","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.jchromb.2022.123392_b0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jchromb.2015.10.008","article-title":"High performance liquid chromatography tandem mass spectrometry assay for the determination of cobinamide in pig plasma","volume":"1006","author":"McCracken","year":"2015","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2022.123392_b0165","first-page":"1","article-title":"Food and Drug Administration","author":"M10 Bioanalytical Method Validation","year":"2019","journal-title":"Center for Drug Evaluation and Research"},{"key":"10.1016\/j.jchromb.2022.123392_b0170","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.talanta.2018.07.046","article-title":"Percent residual accuracy for quantifying goodness-of-fit of linear calibration curves","volume":"189","author":"Logue","year":"2018","journal-title":"Talanta"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023222002963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023222002963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:08:50Z","timestamp":1761606530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023222002963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":34,"alternative-id":["S1570023222002963"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2022.123392","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of bisaminotetrazole cobinamide, a next-generation antidote for cyanide, hydrogen sulfide and methanethiol poisoning, in swine plasma by liquid chromatography-tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2022.123392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123392"}}