{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:33:49Z","timestamp":1786991629173,"version":"build-2736575974"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jchromb.2022.123438","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T18:05:02Z","timestamp":1661709902000},"page":"123438","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["A Second-generation opioid LC-MS\/MS assay improves laboratory workflow and capacity"],"prefix":"10.1016","volume":"1210","author":[{"given":"Hsuan-Chieh","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Laha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey S.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Keung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Hoofnagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2022.123438_b0005","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1001\/jama.2017.0935","article-title":"History of the joint commission's pain standards: lessons for today's prescription opioid epidemic","volume":"317","author":"Baker","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jchromb.2022.123438_b0010","first-page":"1","article-title":"Drug overdose deaths in the united states, 1999\u20132018","author":"Hedegaard","year":"2020","journal-title":"NCHS Data Brief, DOI"},{"key":"10.1016\/j.jchromb.2022.123438_b0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.5055\/jom.2014.0234","article-title":"Beliefs and attitudes about opioid prescribing and chronic pain management: survey of primary care providers","volume":"10","author":"Jamison","year":"2014","journal-title":"J. Opioid. Manag."},{"key":"10.1016\/j.jchromb.2022.123438_b0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.36076\/ppj.2011\/14\/123","article-title":"Urine drug testing in chronic pain","volume":"14","author":"Christo","year":"2011","journal-title":"Pain Physician."},{"key":"10.1016\/j.jchromb.2022.123438_b0025","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/jat\/bkz066","article-title":"LC-MS-MS vs ELISA: validation of a comprehensive urine toxicology screen by LC-MS-MS and a comparison of 100 forensic specimens","volume":"43","author":"Kahl","year":"2019","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2022.123438_b0030","first-page":"E583","article-title":"Clinical benefits of direct-to-definitive testing for monitoring compliance in pain management","volume":"21","author":"Gencheva","year":"2018","journal-title":"Pain Physician"},{"issue":"7","key":"10.1016\/j.jchromb.2022.123438_b0035","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jat\/bku075","article-title":"False-positive interferences of common urine drug screen immunoassays: a review","volume":"38","author":"Saitman","year":"2014","journal-title":"J. Anal. Toxicol."},{"issue":"22","key":"10.1016\/j.jchromb.2022.123438_b0040","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.4155\/bio.13.244","article-title":"The challenges of LC-MS\/MS analysis of opiates and opioids in urine","volume":"5","author":"French","year":"2013","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jchromb.2022.123438_b0045","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jchromb.2011.11.044","article-title":"The role of liquid chromatography-tandem mass spectrometry in the clinical laboratory","volume":"883\u2013884","author":"van den Ouweland","year":"2012","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2022.123438_b0050","first-page":"5","article-title":"LC-MS\/MS in the clinical laboratory - where to from here?","volume":"32","author":"Grebe","year":"2011","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.jchromb.2022.123438_b0055","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/jat\/bks063","article-title":"Improved detection of opioid use in chronic pain patients through monitoring of opioid glucuronides in urine","volume":"36","author":"Dickerson","year":"2012","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jchromb.2022.123438_b0060","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cca.2014.06.023","article-title":"Evaluation of matrix effects using a spike recovery approach in a dilute-and-inject liquid chromatography-tandem mass spectrometry opioid monitoring assay","volume":"437","author":"Mathias","year":"2014","journal-title":"Clin. Chim. Acta."},{"key":"10.1016\/j.jchromb.2022.123438_b0065","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cca.2012.10.055","article-title":"Design and implementation of software for automated quality control and data analysis for a complex LC\/MS\/MS assay for urine opiates and metabolites","volume":"415","author":"Dickerson","year":"2013","journal-title":"Clin. Chim. Acta."},{"issue":"Suppl 1","key":"10.1016\/j.jchromb.2022.123438_b0070","first-page":"S49","article-title":"Limit of blank, limit of detection and limit of quantitation","volume":"29","author":"Armbruster","year":"2008","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.jchromb.2022.123438_b0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jmsacl.2021.12.003","article-title":"Listening to your mass spectrometer: An open-source toolkit to visualize mass spectrometer data","volume":"23","author":"Pablo","year":"2022","journal-title":"J. Mass Spectrom. Adv. Clin. Lab."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023222003427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023222003427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:09:21Z","timestamp":1761606561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023222003427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":15,"alternative-id":["S1570023222003427"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2022.123438","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Second-generation opioid LC-MS\/MS assay improves laboratory workflow and capacity","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2022.123438","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123438"}}