{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:04:28Z","timestamp":1782237868470,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003706","name":"Korea Research Institute of Standards and Science","doi-asserted-by":"publisher","award":["23011071"],"award-info":[{"award-number":["23011071"]}],"id":[{"id":"10.13039\/501100003706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jchromb.2023.123925","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T22:23:18Z","timestamp":1700346198000},"page":"123925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Simultaneous quantification method for multiple antiviral drugs in serum using isotope dilution liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1016","volume":"1231","author":[{"given":"Nordiana Binti","family":"Rosli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha-Jeong","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Seon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2023.123925_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17249411","article-title":"Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives","volume":"17","author":"Roychoudhury","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jchromb.2023.123925_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.116964","article-title":"Analytical approaches for determination of COVID-19 candidate drugs in human biological matrices","volume":"160","author":"Mahdavi","year":"2023","journal-title":"Trends Analyt Chem"},{"key":"10.1016\/j.jchromb.2023.123925_b0015","article-title":"The Need for Antiviral Drugs for Pandemic Coronaviruses From a Global Health Perspective","volume":"7","author":"Villamagna","year":"2020","journal-title":"Front Med (lausanne)"},{"key":"10.1016\/j.jchromb.2023.123925_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104859","article-title":"Candidate drugs against SARS-CoV-2 and COVID-19","volume":"157","author":"McKee","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jchromb.2023.123925_b0025","doi-asserted-by":"crossref","first-page":"e208857","DOI":"10.1001\/jamanetworkopen.2020.8857","article-title":"Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial","volume":"3","author":"Borba","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jchromb.2023.123925_b0030","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.mjafi.2020.08.004","article-title":"Favipiravir: A new and emerging antiviral option in COVID-19","volume":"76","author":"Agrawal","year":"2020","journal-title":"Med J Armed Forces India"},{"key":"10.1016\/j.jchromb.2023.123925_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121862","article-title":"Detection and quantification of Covid-19 antiviral drugs in biological fluids and tissues","volume":"224","author":"Acquavia","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2023.123925_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104866","article-title":"Anrs-Ac43 Clinical Pharmacology Committee, g. Treatment Personalization, Concerns about pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) studies in the new therapeutic area of COVID-19 infection","volume":"181","author":"Venisse","year":"2020","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jchromb.2023.123925_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118275","article-title":"Utilizing drug repurposing against COVID-19 - Efficacy, limitations, and challenges","volume":"259","author":"Parvathaneni","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jchromb.2023.123925_b0050","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/cpt.1909","article-title":"Prioritization of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics","volume":"108","author":"Arshad","year":"2020","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jchromb.2023.123925_b0055","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s13181-020-00777-5","article-title":"COVID-19: Therapeutics and Their Toxicities","volume":"16","author":"Chary","year":"2020","journal-title":"J Med Toxicol"},{"key":"10.1016\/j.jchromb.2023.123925_b0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bj.2020.11.005","article-title":"Lopinavir\/ritonavir: Repurposing an old drug for HIV infection in COVID-19 treatment","volume":"44","author":"Magro","year":"2021","journal-title":"Biomed J"},{"key":"10.1016\/j.jchromb.2023.123925_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.113935","article-title":"Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS\/MS method in human serum","volume":"196","author":"Habler","year":"2021","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.jchromb.2023.123925_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-3252-8_1","article-title":"Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology","volume":"1383","author":"Garg","year":"2016","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jchromb.2023.123925_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123552","article-title":"Development and validation of an analytical method using liquid chromatography-tandem mass spectrometry for the therapeutic drug monitoring of seven cardiovascular drugs in clinical usage","volume":"1214","author":"Abady","year":"2023","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jchromb.2023.123925_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.122129","article-title":"A simple and rapid LC-MS\/MS method for the simultaneous determination of eight antipsychotics in human serum, and its application to therapeutic drug monitoring","volume":"1147","author":"Cao","year":"2020","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jchromb.2023.123925_b0085","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.clinbiochem.2016.05.001","article-title":"LC-MS\/MS as a tool for TDM services: Where are we?","volume":"49","author":"Shipkova","year":"2016","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jchromb.2023.123925_b0090","first-page":"5","article-title":"A Questionnaire Survey on General Status and Opinions about Clinical Mass Spectrometric Analysis in Korea (2018), Laboratory Medicine","volume":"9","author":"Sung-Eun Cho","year":"2019","journal-title":"Online"},{"key":"10.1016\/j.jchromb.2023.123925_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10020273","article-title":"Favipiravir in Therapy of Viral Infections","volume":"10","author":"Lagocka","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jchromb.2023.123925_b0100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3851\/IMP3362","article-title":"Combination antiviral therapy with lopinavir\/ritonavir, arbidol and interferon-alpha1b for COVID-19","volume":"25","author":"Xie","year":"2020","journal-title":"Antivir Ther"},{"key":"10.1016\/j.jchromb.2023.123925_b0105","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.antiviral.2014.04.006","article-title":"Arbidol as a broad-spectrum antiviral: an update","volume":"107","author":"Blaising","year":"2014","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jchromb.2023.123925_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123510","article-title":"Simultaneous quantification of nirmatrelvir and ritonavir by LC-MS\/MS in patients treated for COVID-19","volume":"1212","author":"Martens-Lobenhoffer","year":"2022","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jchromb.2023.123925_b0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jchromb.2017.04.027","article-title":"A reference measurement procedure for amino acids in blood using isotope dilution ultra-performance liquid chromatography-tandem mass spectrometry","volume":"1055\u20131056","author":"Kim","year":"2017","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jchromb.2023.123925_b0120","unstructured":"F.a.D.A. U.S. Department of Health and Human Services, Bioanalytical Method Validation-Guideline for Industry, (2018)."},{"key":"10.1016\/j.jchromb.2023.123925_b0125","unstructured":"E.M. Agency, ICH guideline M10 on bioanalytical method validation and study sample analysis, (2022)."},{"key":"10.1016\/j.jchromb.2023.123925_b0130","doi-asserted-by":"crossref","unstructured":"G.A. Reed, Stability of Drugs, Drug Candidates, and Metabolites in Blood and Plasma, Curr Protoc Pharmacol, 75 (2016) 7 6 1-7 6 12.","DOI":"10.1002\/cpph.16"},{"key":"10.1016\/j.jchromb.2023.123925_b0135","series-title":"Practical HPLC Method Development","author":"Snyder","year":"1997"},{"key":"10.1016\/j.jchromb.2023.123925_b0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1310\/4CCJ-KT1T-H6PV-NLFC","article-title":"Therapeutic drug monitoring in HIV treatment: a literature review","volume":"7","author":"Wertheimer","year":"2006","journal-title":"HIV Clin Trials"},{"key":"10.1016\/j.jchromb.2023.123925_b0145","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.5740\/jaoacint.13-295","article-title":"Rapid simultaneous determination of eperisone, tolperisone, and tizanidine in human serum by using a MonoSpin(R) C18 extraction column and liquid chromatography\/tandem mass spectrometry","volume":"97","author":"Miura","year":"2014","journal-title":"J AOAC Int"},{"key":"10.1016\/j.jchromb.2023.123925_b0150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.chroma.2012.12.047","volume":"1277","author":"Lee","year":"2013","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.jchromb.2023.123925_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132483","article-title":"Development of isotope dilution-liquid chromatography\/tandem mass spectrometry for the accurate determination of zearalenone and its metabolites in corn","volume":"384","author":"Lijalem","year":"2022","journal-title":"Food Chem"},{"key":"10.1016\/j.jchromb.2023.123925_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26102989","article-title":"Trends in the Hydrogen-Deuterium Exchange at the Carbon Centers. Preparation of Internal Standards for Quantitative Analysis by LC-MS","volume":"26","author":"Grocholska","year":"2021","journal-title":"Molecules"},{"issue":"Suppl 2","key":"10.1016\/j.jchromb.2023.123925_b0165","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1002\/lt.21914","article-title":"Obesity, hyperlipidemia, and metabolic syndrome","volume":"15","author":"Charlton","year":"2009","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jchromb.2023.123925_b0170","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1365-2125.2011.04159.x","article-title":"Therapeutic drug monitoring to adjust dosing in morbid obesity - a new use for an old methodology","volume":"73","author":"Martin","year":"2012","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jchromb.2023.123925_b0175","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1136\/bmjnph-2021-000375","article-title":"Overweight and obesity as risk factors for COVID-19-associated hospitalisations and death: systematic review and meta-analysis","volume":"5","author":"Sawadogo","year":"2022","journal-title":"BMJ Nutr Prev Health"},{"key":"10.1016\/j.jchromb.2023.123925_b0180","doi-asserted-by":"crossref","first-page":"e1977","DOI":"10.1002\/rmv.1977","article-title":"Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis","volume":"28","author":"Morra","year":"2018","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.jchromb.2023.123925_b0185","doi-asserted-by":"crossref","first-page":"70","DOI":"10.11613\/BM.2013.009","article-title":"The effect of storage time and freeze-thaw cycles on the stability of serum samples","volume":"23","author":"Cuhadar","year":"2013","journal-title":"Biochem Med (zagreb)"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023223003355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023223003355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:12:45Z","timestamp":1761606765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023223003355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":37,"alternative-id":["S1570023223003355"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2023.123925","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous quantification method for multiple antiviral drugs in serum using isotope dilution liquid chromatography\u2013tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2023.123925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"123925"}}