{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:25:53Z","timestamp":1791429953079,"version":"4.3.3"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jchromb.2024.124012","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T03:13:21Z","timestamp":1705806801000},"page":"124012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A LC-MS\/MS method for the simultaneous quantitative determination of aldosterone, its precursor 18-hydroxycorticosterone and its metabolite tetrahydroaldosterone in human urine"],"prefix":"10.1016","volume":"1234","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3023-3281","authenticated-orcid":false,"given":"Haohang","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baorong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-031X","authenticated-orcid":false,"given":"Zhenxia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2024.124012_b0005","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1210\/en.2003-0279","article-title":"Minireview: primary aldosteronism\u2013changing concepts in diagnosis and treatment","volume":"144","author":"Young","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jchromb.2024.124012_b0010","first-page":"2854","article-title":"Prevalence of primary aldosteronism among Asian hypertensive patients in Singapore","volume":"85","author":"Loh","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jchromb.2024.124012_b0015","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/sj.jhh.1001013","article-title":"High prevalence of primary aldosteronism in the Tayside hypertension clinic population","volume":"14","author":"Lim","year":"2000","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.jchromb.2024.124012_b0020","first-page":"1863","article-title":"Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology","volume":"85","author":"Fardella","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jchromb.2024.124012_b0025","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.106.086116","article-title":"Is there an unrecognized epidemic of primary aldosteronism? Pro","volume":"50","author":"Calhoun","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.jchromb.2024.124012_b0030","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/01.HYP.0000040261.30455.B6","article-title":"Hyperaldosteronism among with resistant black and white subjects hypertension","volume":"40","author":"Calhoun","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.jchromb.2024.124012_b0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jchromb.2024.124012_b0040","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/HJH.0000000000001251","article-title":"Plasma aldosterone level within the normal range is less associated with cardiovascular and cerebrovascular risk in primary aldosteronism","volume":"35","author":"Murata","year":"2017","journal-title":"J. Hypertens."},{"key":"10.1016\/j.jchromb.2024.124012_b0045","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1210\/jc.2013-2805","article-title":"Long-term cardio- and cerebrovascular events in patients with primary aldosteronism","volume":"98","author":"Mulatero","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jchromb.2024.124012_b0050","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archinternmed.2007.33","article-title":"Cardiovascular outcomes in patients with primary aldosteronism after treatment","volume":"168","author":"Catena","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jchromb.2024.124012_b0055","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline","volume":"101","author":"J.W. Funder, R.M. Carey, F. Mantero, M.H. Murad, M. Reincke, H. Shibata, M. Stowasser, W.F. Young, S. Endocrine","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jchromb.2024.124012_b0060","doi-asserted-by":"crossref","unstructured":"G.P. Rossi, T.M. Seccia, G. Palumbo, A. Belfiore, G. Bernini, G. Caridi, G. Desideri, B. Fabris, C. Ferri, G. Giacchetti, C. Letizia, M. Maccario, F. Mallamaci, M. Mannelli, A. Patalano, D. Rizzoni, E. Rossi, A.C. Pessina, F. Mantero, h. Primary Aldosteronism Prevalence, Within-Patient Reproducibility of the Aldosterone: Renin Ratio in Primary Aldosteronism, Hypertension 55 (2010) 83-U141.","DOI":"10.1161\/HYPERTENSIONAHA.109.139832"},{"key":"10.1016\/j.jchromb.2024.124012_b0065","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0895-7061(03)00858-6","article-title":"Urinary tetrahydroaldosterone as a screening method for primary aldosteronism: A Comparative Study","volume":"16","author":"Abdelhamid","year":"2003","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jchromb.2024.124012_b0070","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1515\/BC.2002.174","article-title":"The Human Steroid Hydroxylases CYP11B1 and CYP11B2","volume":"383","author":"Bureik","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.jchromb.2024.124012_b0075","first-page":"211","article-title":"Disorders of the Aldosterone Synthase and Steroid 11\u03b2-Hydroxylase Deficiencies","volume":"51","author":"Peter","year":"1999","journal-title":"Horm Res"},{"key":"10.1016\/j.jchromb.2024.124012_b0080","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1210\/jcem-52-2-214","article-title":"Urinary Tetrahydroaldosterone and Aldosterone-18- Glucuronide Excretion in White and Black Normal Subjects and Hypertensive Patients*","volume":"52","author":"Gomez-Sanchezf","year":"1981","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jchromb.2024.124012_b0085","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1210\/er.2018-00262","article-title":"Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism","volume":"40","author":"Storbeck","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jchromb.2024.124012_b0090","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/hr.2010.76","article-title":"Indicators of mineralocorticoid excess in the evaluation of primary aldosteronism","volume":"33","author":"Balas","year":"2010","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jchromb.2024.124012_b0095","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1373\/clinchem.2008.118000","article-title":"Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement","volume":"55","author":"Campbell","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jchromb.2024.124012_b0100","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1515\/jpem-2014-0170","article-title":"Cross-reactivity of adrenal steroids with aldosterone may prevent the accurate diagnosis of congenital adrenal hyperplasia","volume":"28","author":"Tuhan","year":"2015","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jchromb.2024.124012_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.123030","article-title":"Liquid chromatography-tandem mass spectrometry (LC-MS\/MS) based assay for the simultaneous quantification of 18-hydroxycorticosterone, 18-hydroxycortisol and 18-oxocortisol in human plasma","volume":"1188","author":"Chen","year":"2022","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jchromb.2024.124012_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.122740","article-title":"A liquid chromatography-tandem mass spectrometry (LC-MS\/MS)-based assay for simultaneous quantification of aldosterone, renin activity, and angiotensin II in human plasma","volume":"1179","author":"Chen","year":"2021","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jchromb.2024.124012_b0115","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jchromb.2019.03.012","article-title":"Establishment of a rapid and simple liquid chromatography tandem mass spectrometry method for measuring aldosterone in urine","volume":"1113","author":"Yin","year":"2019","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jchromb.2024.124012_b0120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.steroids.2019.04.009","article-title":"Enabling insights into the maturation of the renin-angiotensin-aldosterone system in children Development of a low-volume LC-MS assay for the simultaneous determination of aldosterone, its precursor, and main metabolite","volume":"148","author":"Makowski","year":"2019","journal-title":"Steroids"},{"key":"10.1016\/j.jchromb.2024.124012_b0125","series-title":"Liquid Chromatography-Mass Spectrometry Methods; Approved Guideline, CLSI document C62-A","author":"Clsi","year":"2014"},{"key":"10.1016\/j.jchromb.2024.124012_b0130","first-page":"770","article-title":"Chinese Guidance for Liquid Chromatography and Mass Spectrometry Clinical Application, Chin","volume":"40","author":"C.s.l.m., n.c.c.l.,","year":"2017","journal-title":"J Lab Med"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023224000205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023224000205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:13:00Z","timestamp":1761606780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023224000205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":26,"alternative-id":["S1570023224000205"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2024.124012","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A LC-MS\/MS method for the simultaneous quantitative determination of aldosterone, its precursor 18-hydroxycorticosterone and its metabolite tetrahydroaldosterone in human urine","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2024.124012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"124012"}}