{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:53:22Z","timestamp":1791831202665,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"am","delay-in-days":717,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100019944","name":"Sanofi-Aventis Deutschland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019944","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006228","name":"Oak Ridge National Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jchromb.2024.124129","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T16:22:45Z","timestamp":1713198165000},"page":"124129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Improved lipid analysis using a 2D-LC-MS system with a novel injection procedure"],"prefix":"10.1016","volume":"1239","author":[{"given":"J\u00f3zsef","family":"P\u00e1ncz\u00e9l","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmos","family":"Kertesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-3118","authenticated-orcid":false,"given":"Matthias","family":"Schiell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2024.124129_b0005","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1007\/s00216-019-02241-y","article-title":"Lipidomics from sample preparation to data analysis: a primer","volume":"412","author":"Z\u00fcllig","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100138","article-title":"Recommendations for good practice in MS-based lipidomics","volume":"62","author":"K\u00f6feler","year":"2021","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.jchromb.2024.124129_b0015","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3390\/molecules27030907","article-title":"Recent developments of liquid chromatography stationary phases for compound separation: from proteins to small organic compounds","volume":"27","author":"Rusli","year":"2022","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.jchromb.2024.124129_b0020","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1021\/cr200295k","article-title":"Bioinformatics and systems biology of the lipidome","volume":"111","author":"Subramaniam","year":"2011","journal-title":"Chem. Rev."},{"issue":"45","key":"10.1016\/j.jchromb.2024.124129_b0025","doi-asserted-by":"crossref","first-page":"15192","DOI":"10.1021\/acs.analchem.1c03905","article-title":"Simultaneous nnalysis of the metabolome and lipidome using polarity partition two-dimensional liquid chromatography-mass spectrometry","volume":"93","author":"Feng","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0030","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/mas.21627","article-title":"High resolution mass spectrometry in lipidomics","volume":"40","author":"Z\u00fcllig","year":"2021","journal-title":"Mass. Spec. Rev."},{"issue":"1","key":"10.1016\/j.jchromb.2024.124129_b0035","doi-asserted-by":"crossref","first-page":"FSO157","DOI":"10.4155\/fsoa-2016-0067","article-title":"Quantitative analysis of lipids: a higher-throughput LC\u2013MS\/MS-based method and its comparison to ELISA","volume":"3","author":"Gandhi","year":"2017","journal-title":"Future Sci. OA"},{"key":"10.1016\/j.jchromb.2024.124129_b0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s13361-017-1829-2","article-title":"Easy, fast, and reproducible quantification of cholesterol and other lipids in human plasma by combined high resolution MSX and FTMS analysis","volume":"29","author":"Gallego","year":"2018","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2024.124129_b0045","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00216-022-04490-w","article-title":"Robust and high\u2011throughput lipidomic quantitation of human blood samples using flow injection analysis with tandem mass spectrometry for clinical use","volume":"415","author":"Idkowiak","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0050","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1038\/s41467-020-17026-6","article-title":"Fast and sensitive flow-injection mass spectrometry metabolomics by analyzing sample-specific ion distributions","volume":"11","author":"Sarvin","year":"2020","journal-title":"Nat. Comm."},{"key":"10.1016\/j.jchromb.2024.124129_b0055","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s41467-023-36520-1","article-title":"Four-dimensional trapped ion mobility spectrometry lipidomics for high throughput clinical profiling of human blood samples","volume":"14","author":"Lerner","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jchromb.2024.124129_b0060","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.trac.2014.04.017","article-title":"Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry","volume":"61","author":"Cajka","year":"2014","journal-title":"Trend. Analyt. Chem."},{"issue":"1","key":"10.1016\/j.jchromb.2024.124129_b0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/lipd.12263","article-title":"A review of efforts to improve lipid stability during sample preparation and standardization efforts to ensure accuracy in the reporting of lipid measurements","volume":"56","author":"Ulmer","year":"2021","journal-title":"Lipids."},{"key":"10.1016\/j.jchromb.2024.124129_b0070","first-page":"25","article-title":"Two-dimensional liquid chromatography in Metabolomics and Lipidomics","volume":"vol. 159","author":"Cova","year":"2021"},{"key":"10.1016\/j.jchromb.2024.124129_b0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chroma.2013.10.069","article-title":"A novel stop-flow two-dimensional liquid chromatography\u2013mass spectrometry method for lipid analysis","volume":"1321","author":"Wang","year":"2013","journal-title":"J. Chrom. A."},{"key":"10.1016\/j.jchromb.2024.124129_b0080","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1007\/s00216-013-7109-5","article-title":"Lipid profiling of human plasma from peritoneal dialysis patients using an improved 2D (NP\/RP) LC-QtoF MS method","volume":"405","author":"Li","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0085","unstructured":"Application note TP259 (shimadzu.com)."},{"key":"10.1016\/j.jchromb.2024.124129_b0090","doi-asserted-by":"crossref","first-page":"462106","DOI":"10.1016\/j.chroma.2021.462106","article-title":"A comprehensive two-dimensional liquid chromatography method for the simultaneous separation of lipid species and their oxidation products","volume":"1644","author":"Lazaridi","year":"2021","journal-title":"J. Chrom. A."},{"key":"10.1016\/j.jchromb.2024.124129_b0095","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1007\/s00216-015-8528-2","article-title":"Continuous comprehensive two-dimensional liquid chromatography\u2013electrospray ionization mass spectrometry of complex lipidomic samples","volume":"407","author":"Hol\u010dapek","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0100","unstructured":"D. Root, A. Chavali, T. E. Wheat, P. McConville, An automated approach to increase LC\/MC sensitivity in multi-dimensional methods, Waters corporation, Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (2013) poster."},{"key":"10.1016\/j.jchromb.2024.124129_b0105","unstructured":"S. Krieger, Automated Switching Between 1D-LC and Comprehensive 2D-LC Analysis \u2013The Agilent 1290 Infinity 2D-LC Solution, Agilent Technologies, Inc., (2014) application note."},{"key":"10.1016\/j.jchromb.2024.124129_b0110","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.chroma.2014.10.087","article-title":"High volume injections of biological samples for sensitive metabolite profiling and quantitation","volume":"1372","author":"Koppen","year":"2014","journal-title":"J. Chrom. A."},{"key":"10.1016\/j.jchromb.2024.124129_b0115","doi-asserted-by":"crossref","first-page":"8307","DOI":"10.1021\/acs.analchem.5b01578","article-title":"Direct identification of rituximab main isoforms and subunit analysis by online selective comprehensive two-dimensional liquid chromatography\u2212mass spectrometry","volume":"87","author":"Stoll","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0120","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s00216-020-02392-3","article-title":"Application of the new at-column dilution (ACD) modulator for the two-dimensional RP\u00d7HILIC analysis of Buddleja davidii","volume":"412","author":"Chen","year":"2020","journal-title":"Anal. and Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2019.121906","article-title":"Two-dimensional liquid chromatography coupled to mass spectrometry for impurity analysis of dye-conjugated oligonucleotides","volume":"1137","author":"Koshel","year":"2020","journal-title":"J. Chrom. b."},{"issue":"2","key":"10.1016\/j.jchromb.2024.124129_b0130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/1872312814666210813114700","article-title":"An effective QWBA\/UHPLC-MS\/tissue punch approach: solving a pharmacokinetic issue via quantitative Met-ID","volume":"14","author":"P\u00e1ncz\u00e9l","year":"2021","journal-title":"Drug Metab. Lett."},{"issue":"7\u20138","key":"10.1016\/j.jchromb.2024.124129_b0135","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jlcr.4028","article-title":"Small-scale two-dimensional liquid chromatography for a preparative re-purification of a highly labile tritium-labeled compound","volume":"66","author":"Sandvoss","year":"2023","journal-title":"J. Label Compd. Radiopharm."},{"key":"10.1016\/j.jchromb.2024.124129_b0140","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.1007\/s00216-014-8255-0","article-title":"LC\/MS lipid profiling from human serum: a new method for global lipid extraction","volume":"406","author":"Pellegrino","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0145","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1007\/s00216-018-1200-x","article-title":"One- vs two-phase extraction: re-evaluation of sample preparation procedures for untargeted lipidomics in plasma samples","volume":"410","author":"Gil","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2024.124129_b0150","unstructured":"Agilent 1200 Series High Performance Autosamplers & Micro Well Plate Autosampler, User Manual, Agilent Technologies, https:\/\/www.agilent.com\/Library\/usermanuals\/Public\/G1367-90011_HP-Samplers_ebook.pdf."},{"issue":"10","key":"10.1016\/j.jchromb.2024.124129_b0155","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1194\/jlr.D048439","article-title":"Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS\/MS","volume":"55","author":"Okudaira","year":"2014","journal-title":"J. Lipid Res."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023224001375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023224001375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T13:36:07Z","timestamp":1717335367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023224001375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":31,"alternative-id":["S1570023224001375"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2024.124129","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improved lipid analysis using a 2D-LC-MS system with a novel injection procedure","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2024.124129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"124129"}}