{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:35:11Z","timestamp":1773678911669,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jchromb.2024.124190","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T22:46:31Z","timestamp":1718491591000},"page":"124190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Quantitation of thiorphan in human plasma using LC-MS\/MS and its application to a bioequivalence study"],"prefix":"10.1016","volume":"1243","author":[{"given":"Rana","family":"Said","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basel","family":"Arafat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tawfiq","family":"Arafat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2024.124190_b0005","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.febslet.2005.12.058","article-title":"Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase (PAM)","volume":"580","author":"McIntyre","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jchromb.2024.124190_b0010","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1097\/MPG.0000000000001421","article-title":"Racecadotril may reduce diarrhoea in microvillous inclusion disease","volume":"64","author":"Tran","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.jchromb.2024.124190_b0015","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/cvr\/cvy226","article-title":"Telmisartan and thiorphan combination treatment attenuates fibrosis and apoptosis in preventing diabetic cardiomyopathy","volume":"115","author":"Malek","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jchromb.2024.124190_b0020","doi-asserted-by":"crossref","first-page":"e000124","DOI":"10.1136\/bmjgast-2016-000124","article-title":"Racecadotril for the treatment of severe acute watery diarrhoea in children admitted to a tertiary hospital in Kenya","volume":"4","author":"Gharial","year":"2017","journal-title":"BMJ Open Gastroenterol."},{"key":"10.1016\/j.jchromb.2024.124190_b0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/s-0029-1246190","article-title":"Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, Wistar rats","volume":"42","author":"Wu","year":"2010","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.jchromb.2024.124190_b0030","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1211\/002235702667","article-title":"Thiorphan enhances bradykinin-induced vascular relaxation in hypoxic\/hyperkalaemic porcine coronary artery","volume":"55","author":"Krassoi","year":"2003","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jchromb.2024.124190_b0035","article-title":"LC-MS\/MS analytical method for determination of montelukast in human plasma and its application to a bioequivalence study","volume":"19","author":"Said","year":"2022","journal-title":"Curr. Pharm. Anal."},{"key":"10.1016\/j.jchromb.2024.124190_b0040","unstructured":"R. Tentu Nageswara, Validation of Analytical Methods, in: T.S. Mark (Ed.) Calibration and Validation of Analytical Methods, IntechOpen, Rijeka, 2018, pp. Ch. 7."},{"key":"10.1016\/j.jchromb.2024.124190_b0045","doi-asserted-by":"crossref","first-page":"501","DOI":"10.22270\/jddt.v9i2.2403","article-title":"A review on analytical method validation and its regulatory perspectives","volume":"9","author":"Lal","year":"2019","journal-title":"J. Drug Deliv. Therapeut."},{"key":"10.1016\/j.jchromb.2024.124190_b0050","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jpba.2018.12.030","article-title":"Bioanalytical method validation: new FDA guidance vs. EMA guideline. Better or worse?","volume":"165","author":"Kaza","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2024.124190_b0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1570-0232(02)00914-5","article-title":"Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography-tandem mass spectrometry","volume":"785","author":"Polson","year":"2003","journal-title":"J. Chromatogr. B, Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2024.124190_b0060","doi-asserted-by":"crossref","first-page":"650A","DOI":"10.1021\/ac981991q","article-title":"Sample preparation for LC\/MS\/MS: analyzing biological and environmental samples","volume":"70","author":"Henion","year":"1998","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2024.124190_b0065","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1021\/ac051514p","article-title":"A 96-well screen filter plate for high-throughput biological sample preparation and LC-MS\/MS analysis","volume":"78","author":"Peng","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2024.124190_b0070","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jpba.2014.09.030","article-title":"Generic on-line solid phase extraction sample preparation strategies for the analysis of drugs in biological matrices by LC-MS\/MS","volume":"102","author":"Bourgogne","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2024.124190_b0075","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1021\/ac9906633","article-title":"Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC\u2212MS\/MS","volume":"72","author":"Watt","year":"2000","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jchromb.2024.124190_b0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jchromb.2006.12.041","article-title":"Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography\/tandem mass spectrometry","volume":"852","author":"Xu","year":"2007","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2024.124190_b0085","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jchromb.2007.11.038","article-title":"A rapid and validated HPLC method to quantify racecadotril metabolite, thiorphan, in human plasma using solid-phase extraction","volume":"861","author":"Xu","year":"2008","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2024.124190_b0090","doi-asserted-by":"crossref","DOI":"10.1177\/0004563213478938","article-title":"Potential problems with using deuterated internal standards for liquid chromatography-tandem mass spectrometry","volume":"50","author":"Davison","year":"2013","journal-title":"Ann. Clin. Biochem."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023224001995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023224001995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T20:40:31Z","timestamp":1721508031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023224001995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":18,"alternative-id":["S1570023224001995"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2024.124190","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitation of thiorphan in human plasma using LC-MS\/MS and its application to a bioequivalence study","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2024.124190","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124190"}}