{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:56:18Z","timestamp":1777395378680,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jchromb.2025.124465","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:46:52Z","timestamp":1736556412000},"page":"124465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Development and validation of a UPLC\u2013MS\/MS method for simultaneous quantification of polymyxins and caspofungin in human plasma for therapeutic drug monitoring"],"prefix":"10.1016","volume":"1252","author":[{"given":"Tong","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libin","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinliang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunli","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-7690","authenticated-orcid":false,"given":"Chang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jchromb.2025.124465_b0005","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1086\/652237","article-title":"The 10 x '20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020","volume":"50","author":"Infectious Diseases Society of America","year":"2010","journal-title":"Clin. Infect. Dis."},{"issue":"12","key":"10.1016\/j.jchromb.2025.124465_b0010","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1021\/acsinfecdis.2c00307","article-title":"Polymyxin stereochemistry and its role in antibacterial activity and outer membrane disruption","volume":"8","author":"Slingerland","year":"2022","journal-title":"ACS Infect. Dis."},{"issue":"4","key":"10.1016\/j.jchromb.2025.124465_b0015","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01390-18","article-title":"Antimicrobial susceptibility testing for polymyxins: challenges, issues, and recommendations","volume":"57","author":"Ezadi","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jchromb.2025.124465_b0020","unstructured":"L.N. Dongmo Fotsing, T. Bajaj, Caspofungin. 2024 Feb 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. PMID: 31424724."},{"issue":"3","key":"10.1016\/j.jchromb.2025.124465_b0025","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s42770-022-00739-9","article-title":"Caspofungin resistance in Candida albicans: genetic factors and synergistic compounds for combination therapies","volume":"53","author":"Perrine-Walker","year":"2022","journal-title":"Braz. J. Microbiol."},{"issue":"2","key":"10.1016\/j.jchromb.2025.124465_b0030","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/FTD.0000000000001067","article-title":"Optimization of antimicrobial stewardship programs using therapeutic drug monitoring and pharmacokinetics-pharmacodynamics protocols: a cost-benefit review","volume":"45","author":"Telles","year":"2023","journal-title":"Ther. Drug Monit."},{"issue":"2","key":"10.1016\/j.jchromb.2025.124465_b0035","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1473-3099(14)70850-3","article-title":"Framework for optimization of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus","volume":"15","author":"Nation","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jchromb.2025.124465_b0040","unstructured":"Infectious Disease Professional Committee of China Medical Education Association, Respiratory Disease Branch of Chinese Medical Association, Intensive Care Medicine Branch of Chinese Medical Association, etc. Multidisciplinary Expert Consensus on the Rational Clinical Use of Polymyxin Antibiotics in China. Chinese J. Tubercul. Respir. Med., 2021, 44 (4): 19. DOI: 10.3760\/cma.j.cn112147-20201109-01091."},{"issue":"1","key":"10.1016\/j.jchromb.2025.124465_b0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/phar.2209","volume":"39","author":"Tsuji","year":"2019","journal-title":"Pharmacotherapy"},{"issue":"05","key":"10.1016\/j.jchromb.2025.124465_b0050","first-page":"635","article-title":"Advances in population pharmacokinetics-pharmacodynamics of caspofungin","volume":"33","author":"Manna","year":"2022","journal-title":"China Pharmacy"},{"issue":"6","key":"10.1016\/j.jchromb.2025.124465_b0055","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s15010-017-1042-z","article-title":"Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients","volume":"45","author":"Bellmann","year":"2017","journal-title":"Infection"},{"issue":"1","key":"10.1016\/j.jchromb.2025.124465_b0060","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/myc.13386","article-title":"Human plasma protein levels alter the in vitro antifungal activity of caspofungin: an explanation to the effect in critically ill?","volume":"65","author":"Kurland","year":"2022","journal-title":"Mycoses"},{"issue":"16","key":"10.1016\/j.jchromb.2025.124465_b0065","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.2147\/IDR.S390946","article-title":"Management of bacterial and fungal infections in the ICU: diagnosis, treatment, and prevention recommendations","volume":"4","author":"Rawson","year":"2023","journal-title":"Infect. Drug Resist."},{"issue":"3","key":"10.1016\/j.jchromb.2025.124465_b0070","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3855\/jidc.18480","article-title":"Bacterial and fungal secondary infections occurring in COVID-19 patients followed in intensive care: a retrospective study","volume":"18","author":"Ozyurt","year":"2024","journal-title":"J. Infect. Dev. Ctries."},{"issue":"13","key":"10.1016\/j.jchromb.2025.124465_b0075","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.3390\/molecules29133166","article-title":"Development and validation of liquid chromatographic method for fast determination of lincomycin, polymyxin and vancomycin in preservation solution for transplants","volume":"29","author":"Lin","year":"2024","journal-title":"Molecules"},{"issue":"14","key":"10.1016\/j.jchromb.2025.124465_b0080","article-title":"LC-MS\/MS-based multiplex antibacterial platform for therapeutic drug monitoring in intensive care unit patients","volume":"18","author":"Liu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124465_b0085","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jpba.2018.05.015","article-title":"Liquid chromatography-tandem mass spectrometry for the quantification of moxifloxacin, ciprofloxacin, daptomycin, caspofungin, and isavuconazole in human plasma","volume":"157","author":"H\u00f6sl","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jchromb.2025.124465_b0090","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13065-023-01109-8","article-title":"Simultaneous determination of colistin sulfate and tigecycline in human plasma by liquid chromatography-tandem mass spectrometry method","volume":"18","author":"Ma","year":"2024","journal-title":"BMC Chem."},{"key":"10.1016\/j.jchromb.2025.124465_b0095","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jpba.2016.02.045","article-title":"Development and validation of a UHPLC-MS\/MS assay for colistin methanesulphonate (CMS) and colistin in human plasma and urine using weak-cation exchange solid-phase extraction","volume":"124","author":"Zhao","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2025.124465_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115291","article-title":"Determination of polymyxin B in human plasma and epithelial lining fluid using LC-MS\/MS and its clinical application in therapeutic drug monitoring","volume":"227","author":"Zhang","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"06","key":"10.1016\/j.jchromb.2025.124465_b0105","first-page":"607","article-title":"Determination of polymyxin B in plasma by UPLC-MS\/MS and dosage optimization","volume":"43","author":"Qin","year":"2023","journal-title":"Chin. J. Hosp. Pharm."},{"key":"10.1016\/j.jchromb.2025.124465_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123131","article-title":"Determination of polymyxin B in dried blood spots using LC-MS\/MS for therapeutic drug monitoring","volume":"1192","author":"Huang","year":"2022","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2025.124465_b0115","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jchromb.2017.09.031","article-title":"The development and validation of a simple liquid chromatography\u2013tandem mass spectrometry method for polymyxin B1 and B2 quantification in different matrices","volume":"s1065-1066","author":"Covelli","year":"2017","journal-title":"J. Chromatogr. B"},{"issue":"2","key":"10.1016\/j.jchromb.2025.124465_b0120","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.synbio.2023.03.009","article-title":"Microbial synthesis of bacitracin: Recent progress, challenges, and prospects","volume":"8","author":"Zhu","year":"2023","journal-title":"Synth. Syst. Biotechnol."},{"key":"10.1016\/j.jchromb.2025.124465_b0125","unstructured":"FDA (2018). Bioanalytical method validation guidance for industry. Available at: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/bioanalytical-method-validation-guidance-industry."},{"key":"10.1016\/j.jchromb.2025.124465_b0130","series-title":"Pharmacopoeia of the People's Republic of China","first-page":"466","article-title":"Guidelines for validation of methods for quantitative analysis of biological samples","author":"Chinese Pharmacopoeia Commission","year":"2020"},{"issue":"6","key":"10.1016\/j.jchromb.2025.124465_b0135","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00134-020-06050-1","article-title":"Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper","volume":"46","author":"Abdul-Aziz","year":"2020","journal-title":"Intensive Care Med."},{"issue":"10","key":"10.1016\/j.jchromb.2025.124465_b0140","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3390\/antibiotics10101154","article-title":"Beta-lactams dosing in critically ill patients with G- bacterial infections: A PK\/PD approach","volume":"10","author":"Maguigan","year":"2021","journal-title":"Antibiotics (Basel)."},{"key":"10.1016\/j.jchromb.2025.124465_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123497","article-title":"Validation and clinical application of a multiplex high performance liquid chromatography - Tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections","author":"Decosterd","year":"2022","journal-title":"J. Chromatogr., B. Anal. Technol. Biomed. Life Sci."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225000170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225000170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T01:44:38Z","timestamp":1740620678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023225000170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":29,"alternative-id":["S1570023225000170"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124465","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a UPLC\u2013MS\/MS method for simultaneous quantification of polymyxins and caspofungin in human plasma for therapeutic drug monitoring","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124465"}}