{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:37:31Z","timestamp":1793839051122,"version":"4.6.1"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["BIDEB\/2218"],"award-info":[{"award-number":["BIDEB\/2218"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["221\\u202FN359"],"award-info":[{"award-number":["221\\u202FN359"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jchromb.2025.124592","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T03:06:15Z","timestamp":1744340775000},"page":"124592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Recent advancements in the bioactive alkaloids analysis in plant and biological specimen: From the perspective of activity, sample preparation, and analytical method selection"],"prefix":"10.1016","volume":"1258","author":[{"given":"Sevilay","family":"Erdogan-Kablan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyda","family":"Yayla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Mesud","family":"Hurkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Cetinkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emirhan","family":"Nemutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel A.","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2025.124592_bb0005","series-title":"Alkaloids, in: Pharmacognosy: Fundamentals, Applications, and Strategies","first-page":"167","author":"Powder-George","year":"2023"},{"key":"10.1016\/j.jchromb.2025.124592_bb0010","doi-asserted-by":"crossref","unstructured":"Funayama S, Cordell G. A., Alkaloids a Treasury of poisons and medicines, Elsevier, 2015. Doi: https:\/\/doi.org\/10.1016\/b978-0-12-417302-6.00017-9.","DOI":"10.1016\/B978-0-12-417302-6.00017-9"},{"key":"10.1016\/j.jchromb.2025.124592_bb0015","series-title":"Plant alkaloids, in: Phytoconstituents and Antifungals","first-page":"53","author":"Kumar","year":"2022"},{"key":"10.1016\/j.jchromb.2025.124592_bb0020","article-title":"Role of plant derived alkaloids as antioxidant agents for neurodegenerative diseases","volume":"6","author":"Sirin","year":"2023","journal-title":"Health Sci. Rev."},{"key":"10.1016\/j.jchromb.2025.124592_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytol.2014.06.015","article-title":"Alkaloids as drug leads - a predictive structural and biodiversity-based analysis","volume":"10","author":"Amirkia","year":"2014","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jchromb.2025.124592_bb0030","series-title":"Morphine Alkaloids: History, Biology, and Synthesis","first-page":"145","author":"Wicks","year":"2021"},{"key":"10.1016\/j.jchromb.2025.124592_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2019.111870","article-title":"Opioid alkaloids profiling and antioxidant capacity of Papaver species from Iran","volume":"142","author":"Shaghaghi","year":"2019","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jchromb.2025.124592_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114249","article-title":"Berberine for bone regeneration: therapeutic potential and molecular mechanisms","volume":"277","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2025.124592_bb0045","series-title":"Encyclopedia of Toxicology","year":"2005"},{"key":"10.1016\/j.jchromb.2025.124592_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112375","article-title":"Historical chemical annotations of Cinchona bark collections are comparable to results from current day high-pressure liquid chromatography technologies","volume":"249","author":"Canales","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2025.124592_bb0055","article-title":"Pharmacology of caffeine and its effects on the human body","volume":"10","author":"Reddy","year":"2024","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"10.1016\/j.jchromb.2025.124592_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.smrv.2007.07.004","article-title":"Caffeine: sleep and daytime sleepiness","volume":"12","author":"Roehrs","year":"2008","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.jchromb.2025.124592_bb0065","series-title":"Caffeine in the Treatment of Pain","author":"Tavares","year":"2012"},{"key":"10.1016\/j.jchromb.2025.124592_bb0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neubiorev.2016.09.001","article-title":"A review of caffeine's effects on cognitive, physical and occupational performance","volume":"71","author":"McLellan","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jchromb.2025.124592_bb0075","series-title":"Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases","first-page":"63","article-title":"Nicotine","author":"Veljkovic","year":"2018"},{"key":"10.1016\/j.jchromb.2025.124592_bb0080","first-page":"24","article-title":"Harmful effects of nicotine, Indian journal of medical and Paediatric","volume":"36","author":"Mishra","year":"2015","journal-title":"Oncology"},{"key":"10.1016\/j.jchromb.2025.124592_bb0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tins.2004.06.008","article-title":"Smoking, nicotine and Parkinson's disease","volume":"27","author":"Quik","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0090","series-title":"Encyclopedia of Toxicology","first-page":"426","article-title":"Ephedra","author":"Vaidya","year":"2014"},{"key":"10.1016\/j.jchromb.2025.124592_bb0095","doi-asserted-by":"crossref","first-page":"9563","DOI":"10.1039\/D1FO02093E","article-title":"Over a century since ephedrine discovery: an updated revisit to its pharmacological aspects, functionality and toxicity in comparison to its herbal extracts","volume":"12","author":"Gad","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jchromb.2025.124592_bb0100","series-title":"Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics","first-page":"385","article-title":"Analgesic effects of Ephedra herb and ephedrine alkaloids-free Ephedra herb extract (EFE)","author":"Hyuga","year":"2021"},{"key":"10.1016\/j.jchromb.2025.124592_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116153","article-title":"Ephedrae herba: a comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology","volume":"307","author":"Zheng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2025.124592_bb0110","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.fct.2018.04.022","article-title":"Atropa belladonna neurotoxicity: Implications to neurological disorders","volume":"116","author":"Kwakye","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jchromb.2025.124592_bb0115","series-title":"Encyclopedia of Toxicology","first-page":"339","article-title":"Atropine","author":"Scott","year":"2014"},{"key":"10.1016\/j.jchromb.2025.124592_bb0120","series-title":"Recent Advances in Natural Products Analysis","first-page":"505","article-title":"Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)","author":"Dey","year":"2020"},{"key":"10.1016\/j.jchromb.2025.124592_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26113374","article-title":"Diversity in chemical structures and biological properties of plant alkaloids","volume":"26","author":"Bhambhani","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2025.124592_bb0130","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1039\/D0NP00031K","article-title":"The scaffold-forming steps of plant alkaloid biosynthesis","volume":"38","author":"Lichman","year":"2021","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jchromb.2025.124592_bb0135","doi-asserted-by":"crossref","DOI":"10.1007\/s00425-019-03319-8","article-title":"High-throughput metabolomic and transcriptomic analyses vet the potential route of cerpegin biosynthesis in two varieties of Ceropegia bulbosa Roxb","volume":"251","author":"Gharat","year":"2020","journal-title":"Planta"},{"key":"10.1016\/j.jchromb.2025.124592_bb0140","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1017\/jsc.2014.27","article-title":"Nicotine: pharmacology, toxicity and therapeutic use","volume":"9","author":"Fagerstr\u00f6m","year":"2013","journal-title":"J. Smok. Cessat."},{"key":"10.1016\/j.jchromb.2025.124592_bb0145","article-title":"Investigation of health effects of major phenolic compounds in foods: extraction processes, analytical approaches and applications","author":"Hurkul","year":"2024","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00425-014-2056-8","article-title":"Benzylisoquinoline alkaloid biosynthesis in opium poppy","volume":"240","author":"Beaudoin","year":"2014","journal-title":"Planta"},{"key":"10.1016\/j.jchromb.2025.124592_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13211-4","article-title":"Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases","volume":"10","author":"C\u00e1rdenas","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jchromb.2025.124592_bb0160","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1039\/b512615k","article-title":"Chemistry and biology of monoterpene indole alkaloid biosynthesis","volume":"23","author":"O'Connor","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jchromb.2025.124592_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00557","article-title":"Berberine: botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders","volume":"9","author":"Neag","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124592_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25143283","article-title":"A review of the Ephedra genus: distribution, ecology, ethnobotany, phytochemistry and pharmacological properties","volume":"25","author":"Gonz\u00e1lez-Ju\u00e1rez","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2025.124592_bb0175","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuro.2020.10.004","article-title":"Vincristine-induced peripheral neuropathy: a mini-review","volume":"81","author":"Li","year":"2020","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jchromb.2025.124592_bb0180","article-title":"Vincristine in combination therapy of cancer: emerging trends in clinics","volume":"10","author":"\u0160kubn\u00edk","year":"2021","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.jchromb.2025.124592_bb0185","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00280-019-03884-5","article-title":"Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review","volume":"84","author":"Madsen","year":"2019","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124592_bb0190","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.mayocp.2020.02.033","article-title":"Adverse events reported to the United States Food and Drug Administration related to caffeine-containing products","volume":"95","author":"Jagim","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.jchromb.2025.124592_bb0195","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.66306","article-title":"Caffeine-induced psychosis: a case report and review of literature","author":"Mannix","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.jchromb.2025.124592_bb0200","author":"Zenkner"},{"key":"10.1016\/j.jchromb.2025.124592_bb0205","doi-asserted-by":"crossref","unstructured":"S.A. Mcgrath-Morrow, J. Gorzkowski, J.A. Groner, A.M. Rule, K. Wilson, S.E. Tanski, J.M. Collaco, J.D. Klein, The Effects of Nicotine on Development, n.d. http:\/\/publications.aap.org\/pediatrics\/article-pdf\/145\/3\/e20191346\/1078666\/peds_20191346.pdf.","DOI":"10.1542\/peds.2019-1346"},{"key":"10.1016\/j.jchromb.2025.124592_bb0210","article-title":"Taken to heart - arrhythmic potential of heart-leaf sida, a banned ephedrine alkaloid: a case report","volume":"6","author":"Cheng","year":"2022","journal-title":"Eur Heart J Case Rep"},{"key":"10.1016\/j.jchromb.2025.124592_bb0215","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/01658107.2023.2301363","article-title":"A case report of acute bilateral mydriasis induced by herbal medication","volume":"48","author":"Kang","year":"2024","journal-title":"Neuro-Ophthalmology"},{"key":"10.1016\/j.jchromb.2025.124592_bb0220","article-title":"Widened scope of drug repurposing\/chiral switches, elements of secondary pharmaceuticals: the quinine\/quinidine case","volume":"5","author":"D'Acquarica","year":"2023","journal-title":"Future Drug Discov"},{"key":"10.1016\/j.jchromb.2025.124592_bb0225","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1161\/CIRCULATIONAHA.118.038036","article-title":"Quinidine-responsive polymorphic ventricular tachycardia in patients with coronary heart disease","volume":"139","author":"Viskin","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jchromb.2025.124592_bb0230","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1540-8167.1999.tb00183.x","article-title":"Effects of electrophysiologic-guided therapy with class IA antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome","volume":"10","author":"Belhassen","year":"1999","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.jchromb.2025.124592_bb0235","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pedhc.2018.04.016","article-title":"The use of codeine and tramadol in the pediatric population-what is the verdict now?","volume":"33","author":"Fortenberry","year":"2019","journal-title":"J. Pediatr. Health Care"},{"key":"10.1016\/j.jchromb.2025.124592_bb0240","series-title":"Codeine, Ultrarapid-Metabolism Genotype, and Postoperative Death","author":"Ciszkowski","year":"2009"},{"key":"10.1016\/j.jchromb.2025.124592_bb0245","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2011-2538","article-title":"More codeine fatalities after tonsillectomy in north American children","volume":"129","author":"Kelly","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.jchromb.2025.124592_bb0250","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/jcph.1873","article-title":"Pharmacogenomics and morphine","volume":"61","author":"Ofoegbu","year":"2021","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124592_bb0255","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/ptr.5475","article-title":"A randomized clinical trial of Berberine hydrochloride in patients with diarrhea-predominant irritable bowel syndrome","volume":"29","author":"Chen","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jchromb.2025.124592_bb0260","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/iub.2350","article-title":"Berberine: a novel therapeutic strategy for cancer","volume":"72","author":"Samadi","year":"2020","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jchromb.2025.124592_bb0265","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4274\/cayd.galenos.2018.30092","article-title":"Atropa Belladonna poisoning in a child with acute psychiatric findings","volume":"7","author":"Cebeci","year":"2020","journal-title":"Turkish J. Pediatric Emergency Intensive Care Med."},{"key":"10.1016\/j.jchromb.2025.124592_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125883","article-title":"Highly selective and sensitive molecularly imprinted sensors for the electrochemical assay of quercetin in methanol extracts of Rubus sanctus and Fragaria vesca","volume":"273","author":"Hurkul","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2025.124592_bb0275","doi-asserted-by":"crossref","DOI":"10.1039\/D3AY02318D","article-title":"A novel electrochemical sensor based on a molecularly imprinted polymer for highly selective and sensitive determination of rutin from herbal supplements and plant extracts","author":"Hurkul","year":"2024","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jchromb.2025.124592_bb0280","article-title":"A novel co\/Zn-ferrite molecularly imprinted polymer-based electrochemical assay for sensing of gallic acid in plant extracts, wine, and herbal supplement","author":"Gruji\u010di\u0107","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0285","series-title":"The Separation Optimization of Berberine in Anting-Anting Plants (Acalypha Indica Linn) Using High Performance Liquid Chromatography (HPLC)","author":"Hayati","year":"2019"},{"key":"10.1016\/j.jchromb.2025.124592_bb0290","doi-asserted-by":"crossref","first-page":"01","DOI":"10.31579\/2768-0487\/043","article-title":"Quantification of atropine and scopolamine in different plant organs of Datura Metel: development and validation of high-performance liquid chromatography method","volume":"3","author":"Jaber","year":"2021","journal-title":"J. Clinical Laboratory Res."},{"key":"10.1016\/j.jchromb.2025.124592_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126895","article-title":"Selective apigenin assay in plant extracts and herbal supplement with molecularly imprinted polymer-based electrochemical sensor","volume":"281","author":"Yayla","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2025.124592_bb0300","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202400142","article-title":"Simultaneous determination of six catechins and caffeine in tea and wine using salting-out assisted liquid\u2013liquid extraction and high-performance liquid chromatography with ultraviolet detection","volume":"47","author":"Custodio-Mendoza","year":"2024","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/separations11020043","article-title":"Development and validation of an HPLC-DAD method for the determination of seven antioxidants in a Nano-emulsion: formulation and stability study","volume":"11","author":"Kamaris","year":"2024","journal-title":"Separations"},{"key":"10.1016\/j.jchromb.2025.124592_bb0310","article-title":"A review on the extraction methods use in medicinal plants, principle, strength and limitation","volume":"04","author":"Nn","year":"2015","journal-title":"Med Aromat Plants (Los Angel)"},{"key":"10.1016\/j.jchromb.2025.124592_bb0315","article-title":"A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants","volume":"19","author":"Bitwell","year":"2023","journal-title":"Sci Afr"},{"key":"10.1016\/j.jchromb.2025.124592_bb0320","doi-asserted-by":"crossref","first-page":"61","DOI":"10.21123\/bsj.16.1.0061","article-title":"Determination of nicotine extracted from eggplant and green pepper by HPLC","volume":"16","author":"Mohammed","year":"2019","journal-title":"Baghdad Sci. J."},{"key":"10.1016\/j.jchromb.2025.124592_bb0325","series-title":"Conventional Extraction Methods Use in Medicinal Plants, their Advantages and Disadvantages","author":"Rasul","year":"2018"},{"key":"10.1016\/j.jchromb.2025.124592_bb0330","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300582","article-title":"Facile extraction of berberine from different plants, separation, and identification by thin-layer chromatography, high-performance liquid chromatography, and biological evaluation against leishmaniosis","volume":"46","author":"Alam","year":"2023","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0335","doi-asserted-by":"crossref","first-page":"989","DOI":"10.13005\/ojc\/330253","article-title":"Development and validation of RP-HPLC method for quantification of berberine in ethanol fraction of methanol extract and developed formulation of Tinospora cordifolia","volume":"33","author":"Devaliya","year":"2017","journal-title":"Orient. J. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0340","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jchromb.2016.01.034","article-title":"A simple and rapid HPLC-DAD method for simultaneously monitoring the accumulation of alkaloids and precursors in different parts and different developmental stages of Catharanthus roseus plants","volume":"1014","author":"Pan","year":"2016","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0345","article-title":"Sustainable analytical method for determination of bioactive compounds in solid oral formulations (capsules and tablets) containing green tea (Camellia sinensis) marketed in Brazil","volume":"40","author":"Matos","year":"2024","journal-title":"Sustain. Chem. Pharm."},{"key":"10.1016\/j.jchromb.2025.124592_bb0350","first-page":"1238","article-title":"HPLC-dad determination of berberine, chelerythrine and sanguinarine in the mexican prickly poppy (Argemone mexicana L. Papaveraceae), a medicinal plant","volume":"40","author":"Xool-Tamayo","year":"2017","journal-title":"Quim Nova"},{"key":"10.1016\/j.jchromb.2025.124592_bb0355","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902023e22106","article-title":"Development and validation of an analytical method by HPLC-DAD for determination of caffeine in products based on guarana extracts (Paullinia cupana)","volume":"59","author":"Moura-Silva","year":"2023","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0360","doi-asserted-by":"crossref","DOI":"10.1186\/1752-153X-1-13","article-title":"Different extraction methods of biologically active components from propolis; a preliminary study","volume":"1","author":"Trusheva","year":"2007","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.jchromb.2025.124592_bb0365","series-title":"Extraction of Natural Products from Agro-Industrial Wastes: A Green and Sustainable Approach","first-page":"79","article-title":"Supercritical CO2 extraction of natural products","author":"Farooq","year":"2023"},{"key":"10.1016\/j.jchromb.2025.124592_bb0370","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ultsonch.2016.06.035","article-title":"Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review","volume":"34","author":"Chemat","year":"2017","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0375","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5053","article-title":"An ultrasound assisted extraction\u2013solid-phase extraction\u2013ultra-performance liquid chromatography combined strategy for atropine determination in Atropa belladonna leaves","volume":"35","author":"Koetz","year":"2021","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jchromb.2025.124592_bb0380","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/chromsci\/bmad041","article-title":"Determination of atropine by HPLC in Plant of Datura by liquid-liquid extraction and magnet solid-phase extraction","volume":"62","author":"Mahmoudi","year":"2024","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0385","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/jssc.202001026","article-title":"Preparation of a zirconium terephthalate metal-organic framework coated magnetic nanoparticle for the extraction of berberine prior to high-performance liquid chromatography analysis","volume":"44","author":"Wang","year":"2021","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0390","doi-asserted-by":"crossref","first-page":"25201","DOI":"10.1039\/C8RA01745J","article-title":"Extraction in cholinium-based magnetic ionic liquid aqueous two-phase system for the determination of berberine hydrochloride","volume":"8","author":"Nie","year":"2018","journal-title":"Rhizoma coptidis, RSC Adv"},{"key":"10.1016\/j.jchromb.2025.124592_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14100650","article-title":"Improved analytical approach for determination of tropane alkaloids in leafy vegetables based on \u03bc-QuEChERS combined with HPLC-MS\/MS","volume":"14","author":"Gonz\u00e1lez-G\u00f3mez","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jchromb.2025.124592_bb0400","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1002\/jssc.202000520","article-title":"Simultaneous quantification of three tropane alkaloids in goji berries by cleanup of the graphene\/hexagonal boron nitride hybrids and ultra-high-performance liquid chromatography tandem mass spectrometry","volume":"43","author":"Zhao","year":"2020","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0405","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.chroma.2018.04.038","article-title":"Quantitative determination of major alkaloids in Cinchona bark by supercritical fluid chromatography","volume":"1554","author":"Murauer","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2025.124592_bb0410","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1556\/1326.2022.01054","article-title":"Simple HPLC method for simultaneous quantification of nicotine and cotinine levels in rat plasma after exposure to two different tobacco products","volume":"35","author":"Alhusban","year":"2023","journal-title":"Acta Chromatogr."},{"key":"10.1016\/j.jchromb.2025.124592_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijms.2021.116575","article-title":"Qualitative and quantitative analysis of opiate and related metabolites in human urine samples by UPLC-MS\/MS","volume":"464","author":"Jin","year":"2021","journal-title":"Int. J. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2025.124592_bb0420","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.arabjc.2015.01.011","article-title":"Simultaneous quantification of nimesulide, phenylpropanolamine, caffeine and chlorpheniramine in rat plasma by RP\u2013HPLC\/PDA method and application to pharmacokinetic studies in healthy rat subjects","volume":"12","author":"Ramesh","year":"2019","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0425","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1134\/S106193482012014X","article-title":"High performance liquid chromatographic\u2013diode array detector method for simultaneous determination of aspirin, caffeine and ephedrine in weight loss formulations, human plasma and in vitro drug\u2013drug interaction studies","volume":"75","author":"Rabia Zafar","year":"2020","journal-title":"J. Anal. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0430","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5144","article-title":"A rapid LC\u2013MS\/MS method for simultaneous determination of berberine and irbesartan in rat plasma: application to the drug\u2013drug pharmacokinetic interaction study after oral administration in rats","volume":"35","author":"Zhou","year":"2021","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jchromb.2025.124592_bb0435","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8892696","article-title":"A validated liquid chromatographic method for Berberine analysis in tissue and application","volume":"2020","author":"Zhou","year":"2020","journal-title":"Int J Anal Chem"},{"key":"10.1016\/j.jchromb.2025.124592_bb0440","doi-asserted-by":"crossref","DOI":"10.1002\/sscp.202300047","article-title":"LC method for the quantification of quercetin, Berberine, and Phytosterol in lyophilized liposome","volume":"7","author":"Bhavsar","year":"2024","journal-title":"Sep. Sci. Plus"},{"key":"10.1016\/j.jchromb.2025.124592_bb0445","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/chromsci\/bmu164","article-title":"Validation of an UPLC-MS-MS method for quantitative analysis of vincristine in human urine after intravenous Administration of Vincristine Sulfate Liposome Injection","volume":"53","author":"Yang","year":"2015","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0450","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trac.2016.02.021","article-title":"Enlarging the bottleneck in the analysis of alkaloids: a review on sample preparation in herbal matrices","volume":"80","author":"Klein-J\u00fanior","year":"2016","journal-title":"TrAC - Trends Anal. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0455","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10337-019-03839-1","article-title":"Simultaneous determination of six alkaloids in rat plasma with on-line SPE\u2013HPLC using a homemade four-hydrogen Furfuryl-based polymer monolithic sorbent","volume":"83","author":"Li","year":"2020","journal-title":"Chromatographia"},{"key":"10.1016\/j.jchromb.2025.124592_bb0460","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jchromb.2012.11.012","article-title":"Simultaneous quantification of vinblastine and desacetylvinblastine concentrations in canine plasma and urine samples using LC-APCI-MS\/MS","volume":"913\u2013914","author":"Achanta","year":"2013","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0465","author":"Kandeh","year":"2021","journal-title":"Simultaneous trace-level monitoring of seven opioid analgesic drugs in biological samples by pipette-tip micro solid phase extraction based on PVA-PAA\/CNT-CNC composite nanofibers followed by HPLC-UV analysis"},{"key":"10.1016\/j.jchromb.2025.124592_bb0470","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.1039\/C9AY01773A","article-title":"Determination of nicotine in saliva, urine and wastewater samples using tantalum metal organic framework pipette tip micro-solid phase extraction","volume":"11","author":"Rezaei Kahkha","year":"2019","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jchromb.2025.124592_bb0475","doi-asserted-by":"crossref","DOI":"10.1007\/s00894-019-3925-7","article-title":"Molecular modeling and experimental study of a new peptide-based microextraction fiber for preconcentrating morphine in urine samples","volume":"25","author":"Riahi-Zanjani","year":"2019","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.jchromb.2025.124592_bb0480","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/chromsci\/bmaa108","article-title":"Plant extract and herbal products as potential source of sorbent for analytical purpose: an experimental study of morphine and codeine determination using HPLC and LC\u2013MSMS","volume":"59","author":"Ghorani-Azam","year":"2021","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0485","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1007\/s11696-022-02252-7","article-title":"Ultrasound-assisted surfactant-enhanced emulsification microextraction and determination of caffeine and theophylline in human plasma and cocoa powder","volume":"76","author":"Ghoraba","year":"2022","journal-title":"Chem. Pap."},{"key":"10.1016\/j.jchromb.2025.124592_bb0490","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.microc.2018.11.056","article-title":"Magnetic solid phase extraction of trace paracetamol and caffeine in synthetic urine and wastewater samples by a using core shell hybrid material consisting of graphene oxide\/multiwalled carbon nanotube\/Fe3O4\/SiO2","volume":"145","author":"Ulusoy","year":"2019","journal-title":"Microchem. J."},{"key":"10.1016\/j.jchromb.2025.124592_bb0495","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.sna.2018.07.025","article-title":"Synthesis, characterization and application of magnetic carbon nanotubes for the simultaneous extraction and high performance liquid chromatographic determination of codeine and morphine in human urine, blood serum, opium and tablet samples","volume":"280","author":"Soltani","year":"2018","journal-title":"Sens Actuators A Phys"},{"key":"10.1016\/j.jchromb.2025.124592_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113175","article-title":"Inside gel electromembrane extraction: a novel green methodology for the extraction of morphine and codeine from human biological fluids","volume":"184","author":"Rahimi","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2025.124592_bb0505","article-title":"Discovery of chemical markers for improving the quality and safety control of Sinomenium acutum stem by the simultaneous determination of multiple alkaloids using UHPLC-QQQ-MS\/MS","volume":"10","author":"Huang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2025.124592_bb0510","first-page":"387","article-title":"A rapid and cost-effective method based on dispersive liquid-liquid microextraction coupled to injection port silylation-gas chromatography-mass spectrometry for determination of morphine in illicit opium, analytical science","volume":"2","author":"Jain","year":"2021","journal-title":"Advances"},{"key":"10.1016\/j.jchromb.2025.124592_bb0515","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jchromb.2014.12.026","article-title":"Simultaneous determination of six alkaloid components in rat plasma and its application to pharmacokinetic study of danmu preparations by an ultra fast liquid chromatography-electrospray ionization-tandem mass spectrometry","volume":"983\u2013984","author":"Yin","year":"2015","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0520","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jms.3112","article-title":"Studies on the metabolism and toxicological detection of glaucine, an isoquinoline alkaloid from Glaucium flavum (Papaveraceae), in rat urine using GC-MS, LC-MSn and LC-high-resolution MSn","volume":"48","author":"Meyer","year":"2013","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2025.124592_bb0525","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1016\/S0040-4020(03)00813-5","article-title":"A comparative study of NMR chemical shifts of sparteine thiolactams and lactams","volume":"59","author":"Kolano\u015b","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jchromb.2025.124592_bb0530","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s13659-016-0093-7","article-title":"Five new alkaloids from Cephalotaxus lanceolata and C. fortunei var. alpina","volume":"6","author":"Ni","year":"2016","journal-title":"Nat Prod Bioprospect"},{"key":"10.1016\/j.jchromb.2025.124592_bb0535","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30051125","article-title":"Chiral recognition mechanism of Benzyltetrahydroisoquinoline alkaloids: Cyclodextrin-mediated capillary electrophoresis, chiral HPLC, and NMR spectroscopy study","volume":"30","author":"V\u00e1rnagy","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2025.124592_bb0550","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.chroma.2017.10.031","article-title":"Screening for 16-O-methylcafestol in roasted coffee by high-performance thin-layer chromatography\u2013fluorescence detection \u2013 determination of Coffea canephora admixtures to Coffea arabica","volume":"1525","author":"Oellig","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2025.124592_bb0555","doi-asserted-by":"crossref","DOI":"10.1007\/s00764-025-00333-3","article-title":"High-performance thin-layer chromatography-guided chemotaxonomic studies of pharmacologically active steroidal alkaloids in Solanum xanthocarpum Schrad. & Wendl. collected from Central India","author":"Tripathi","year":"2025","journal-title":"J. Planar Chromatography - Modern TLC"},{"key":"10.1016\/j.jchromb.2025.124592_bb0615","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1002\/jssc.201200005","article-title":"Simultaneous, sequential quantitative achiral-chiral analysis by two-dimensional liquid chromatography","volume":"35","author":"Venkatramani","year":"2012","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.110566","article-title":"Chiral liquid chromatography-tandem mass spectrometry for enantiomeric profiling of ten alkaloids in tobacco: assessing interconversion in precursor materials and aerosol","volume":"201","author":"Han","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.jchromb.2025.124592_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115232","article-title":"A sensitive liquid chromatographic-mass spectrometry method for the quantification of vincristine in whole blood collected with volumetric absorptive microsampling","volume":"225","author":"van der Heijden","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2025.124592_bb0675","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpba.2017.12.040","article-title":"Simultaneous quantitative determination of bioactive terpene indole alkaloids in ethanolic extracts of Catharanthus roseus (L.) G. Don by ultra high performance liquid chromatography\u2013tandem mass spectrometry","volume":"151","author":"Kumar","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2025.124592_bb0680","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27227945","article-title":"The development of new methodology for determination of vincristine (VCR) in human serum using LC-MS\/MS-based method for medical diagnostics","volume":"27","author":"Jurowski","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2025.124592_bb0685","first-page":"331","article-title":"Simultaneous determination of acepromazine and atropine residues in porks, livers, kidneys by ultra-high-performance liquid chromatography-tandem mass spectrometry, Vietnam","volume":"59","author":"Hieu","year":"2021","journal-title":"J. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0665","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27030682","article-title":"Application of HPLC-QQQ-MS\/MS and new RP-HPLC-DAD system utilizing the Chaotropic effect for determination of nicotine and its major metabolites cotinine, and trans-3\u2032-hydroxycotinine in human plasma samples","volume":"27","author":"Baj","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2025.124592_bb0690","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.9229","article-title":"Qualitative and quantitative analysis of ephedrine stimulants in urine by ultra-performance liquid chromatography\u2013tandem mass spectrometry","volume":"36","author":"Zhu","year":"2022","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2025.124592_bb0695","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.foodcont.2019.05.030","article-title":"A sensitive UHPLC-ESI-MS\/MS method for the determination of tropane alkaloids in herbal teas and extracts","volume":"105","author":"Cirlini","year":"2019","journal-title":"Food Control"},{"key":"10.1016\/j.jchromb.2025.124592_bb0540","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1039\/C4AN00438H","article-title":"Alkaloids analysis using off-line two-dimensional supercritical fluid chromatography \u00d7 ultra-high performance liquid chromatography","volume":"139","author":"Li","year":"2013","journal-title":"Analyst"},{"key":"10.1016\/j.jchromb.2025.124592_bb0545","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jpba.2017.07.009","article-title":"Two-dimensional liquid chromatography in pharmaceutical analysis. INSTRUMENTAL aspects, trends and applications","volume":"145","author":"Iguiniz","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2025.124592_bb0560","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00216-019-02214-1","article-title":"An integrated microfluidic device for solid-phase extraction and spectrophotometric detection of opium alkaloids in urine samples","volume":"412","author":"Farahani","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0565","series-title":"Recent Advances in Comprehensive Two-Dimensional Liquid Chromatography for the Analysis of Natural Products","first-page":"287","author":"Cacciola","year":"2017"},{"key":"10.1016\/j.jchromb.2025.124592_bb0570","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1007\/s00216-019-01859-2","article-title":"A novel two-dimensional liquid chromatography system for the simultaneous determination of three monoterpene indole alkaloids in biological matrices","volume":"411","author":"Liu","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0575","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jchromb.2017.10.064","article-title":"Determination of tropane alkaloids by heart cutting reversed phase \u2013 strong cation exchange two dimensional liquid chromatography","volume":"1072","author":"Long","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0580","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/jssc.201700863","article-title":"Optimizing separations in online comprehensive two-dimensional liquid chromatography","volume":"41","author":"Pirok","year":"2018","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0585","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jchromb.2018.08.021","article-title":"Analysis of alkaloids from Peganum harmala L. sequential extracts by liquid chromatography coupled to ion mobility spectrometry","volume":"1096","author":"Wang","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123738","article-title":"A guide of column selection for two-dimensional liquid chromatography method development of natural alkaloids","volume":"251","author":"Xu","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.jchromb.2025.124592_bb0595","first-page":"643","article-title":"Research and application Progress of two-dimentional liquid chromatography on quality control for traditional Chinese herbal medicines","volume":"17","author":"Zhu","year":"2020","journal-title":"Chinese J. Pharmacovigilance"},{"key":"10.1016\/j.jchromb.2025.124592_bb0600","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/10610278.2010.506545","article-title":"The enantiomeric separation of 4,5-disubstituted imidazoles by HPLC and CE using cyclodextrin-based chiral selectors","volume":"22","author":"Breitbach","year":"2010","journal-title":"Supramol. Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0605","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/chir.22127","article-title":"The enantiomeric separation of tetrahydrobenzimidazoles cyclodextrins- and cyclofructans","volume":"25","author":"Perera","year":"2013","journal-title":"Chirality"},{"key":"10.1016\/j.jchromb.2025.124592_bb0610","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.phytochem.2008.01.013","article-title":"Stereochemistry of flavonoidal alkaloids from Dracocephalum rupestre","volume":"69","author":"Ren","year":"2008","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jchromb.2025.124592_bb0625","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/pca.3042","article-title":"Profiling and quantitation of alkaloids in different parts of Sophora alopecuroides L. extracts by high-performance liquid chromatography with electrospray ionisation ion mobility spectrometry detection","volume":"32","author":"Jia","year":"2021","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jchromb.2025.124592_bb0630","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300597","article-title":"High-performance liquid chromatography analysis of alkaloids in various parts of lotus extracts with ion mobility spectrometry and mass spectrometry dual detection","volume":"47","author":"Lu","year":"2024","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jchromb.2025.124592_bb0635","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1002\/rcm.5158","article-title":"Profiling the indole alkaloids in yohimbe bark with ultraperformance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry","volume":"25","author":"Sun","year":"2011","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2025.124592_bb0640","doi-asserted-by":"crossref","first-page":"13470","DOI":"10.1021\/acs.jafc.9b01155","article-title":"Mass spectrometry imaging of the spatial and temporal localization of alkaloids in nightshades","volume":"67","author":"Bednarz","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jchromb.2025.124592_bb0645","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/jasms.0c00449","article-title":"Analysis of Erythroxylum coca leaves by imaging mass spectrometry (MALDI-FT-ICR IMS)","volume":"32","author":"Dos Santos","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jchromb.2025.124592_bb0650","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26030580","article-title":"Localization of major ephedra alkaloids in whole aerial parts of ephedrae herba using direct analysis in real time-time of flight-mass spectrometry","volume":"26","author":"Yun","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2025.124592_bb0655","doi-asserted-by":"crossref","DOI":"10.1002\/jms.4674","article-title":"Identification of Sassafras albidum alkaloids by high-performance thin-layer chromatography tandem mass spectrometry and mapping by desorption electrospray ionization mass spectrometry imaging","volume":"56","author":"Concei\u00e7\u00e3o","year":"2021","journal-title":"J. Mass Spectrom."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225001448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225001448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:18:51Z","timestamp":1777619931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023225001448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":138,"alternative-id":["S1570023225001448"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124592","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advancements in the bioactive alkaloids analysis in plant and biological specimen: From the perspective of activity, sample preparation, and analytical method selection","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124592"}}