{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:58:28Z","timestamp":1785189508772,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017552","name":"Zhejiang Association for Science and Technology","doi-asserted-by":"publisher","award":["2024ZY01009"],"award-info":[{"award-number":["2024ZY01009"]}],"id":[{"id":"10.13039\/501100017552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017552","name":"Zhejiang Association for Science and Technology","doi-asserted-by":"publisher","award":["2017Y20001"],"award-info":[{"award-number":["2017Y20001"]}],"id":[{"id":"10.13039\/501100017552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017710","name":"Zhejiang Province Department of Agriculture and Rural Affairs","doi-asserted-by":"publisher","award":["2021C02073"],"award-info":[{"award-number":["2021C02073"]}],"id":[{"id":"10.13039\/100017710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jchromb.2025.124626","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T14:50:03Z","timestamp":1745679003000},"page":"124626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Pharmacokinetic and tissue distribution analysis of sporoderm-removed Ganoderma lucidum spore powder in rats"],"prefix":"10.1016","volume":"1259","author":[{"given":"Huanhuan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2025.124626_bb0005","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1360\/N972018-00188","article-title":"Archaeological evidence suggests earlier use of Ganoderma in Neolithic China","volume":"63","author":"Yuan","year":"2018","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.jchromb.2025.124626_bb0010","article-title":"Ganoderma lucidum polysaccharide alleviates cognitive dysfunction by inhibiting neuroinflammation via NLRP3\/NF-\u03baB signaling pathway","volume":"338","author":"Jiang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0015","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fphar.2020.00287","article-title":"Screening Immunoactive compounds of Ganoderma lucidum spores by mass spectrometry molecular networking combined with in vivo zebrafish assays","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0020","article-title":"Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer's disease","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0025","doi-asserted-by":"crossref","DOI":"10.7150\/thno.80250","article-title":"GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1\/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis","volume":"13","author":"Zheng","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.jchromb.2025.124626_bb0030","doi-asserted-by":"crossref","first-page":"176","DOI":"10.21147\/j.issn.1000-9604.2023.02.07","article-title":"Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma","volume":"35","author":"Wu","year":"2023","journal-title":"Chin. J. Cancer Res."},{"key":"10.1016\/j.jchromb.2025.124626_bb0035","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3892\/ol.2021.12686","article-title":"Polysaccharides from sporodermremoved spores of Ganoderma lucidum induce apoptosis in human gastric cancer cells via disruption of autophagic flux","volume":"21","author":"Zhong","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jchromb.2025.124626_bb0040","first-page":"203","article-title":"Study on content determination and immunomodulatory and Cardioprotective effects of Sporoderm-removed Ganoderma lucidum spore powder tablet","volume":"41","author":"Yang","year":"2024","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"10.1016\/j.jchromb.2025.124626_bb0045","first-page":"125","article-title":"Synergy of de-walled Ganoderma lucidum spore powder (GLSP) on targeted therapy in advanced non-squamous non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutant: protocol for a randomized, double-blind, placebo-controlled study","volume":"24","author":"Wu","year":"2024","journal-title":"BMC Comp. Med."},{"key":"10.1016\/j.jchromb.2025.124626_bb0050","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3390\/antiox13121501","article-title":"Ganoderma lucidum spore powder alleviates metabolic-associated fatty liver disease by improving lipid accumulation and oxidative stress via autophagy","volume":"13","author":"Zhang","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jchromb.2025.124626_bb0055","doi-asserted-by":"crossref","first-page":"6657","DOI":"10.1002\/jsfa.13490","article-title":"Effects of different wall-breaking methods on the nutrient release of Ganoderma lucidum spore powder during in vitro digestion","volume":"104","author":"Qi","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.jchromb.2025.124626_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1006127","article-title":"Removing the sporoderm from the sporoderm-broken spores of improves the anticancer and immune-regulatory activity of water-soluble polysaccharide","volume":"9","author":"Fang","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jchromb.2025.124626_bb0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.joim.2021.01.004","article-title":"Antitumor effects of different Ganoderma lucidum spore powder in cell- and zebrafish-based bioassays","volume":"19","author":"Shi","year":"2021","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.jchromb.2025.124626_bb0070","article-title":"Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114175","article-title":"A 26-week repeated dose toxicity evaluation of sporoderm-removed Ganoderma lucidum spores in rats","volume":"182","author":"Xia","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0080","article-title":"Comparative pharmacokinetic analysis of sporoderm-broken and sporoderm-removed Ganoderma lucidum spore in rat by using a sensitive plasma UPLC-QqQ-MS method","volume":"38","author":"Chen","year":"2023","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jchromb.2025.124626_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118299","article-title":"Pharmacokinetics and tissue distribution of Yigong san in rats","volume":"331","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fphar.2017.00101","article-title":"Ganoderic acid a metabolites and their metabolic kinetics","volume":"8","author":"Cao","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0095","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jchromb.2013.10.006","article-title":"Metabolite identification of crude extract from Ganoderma lucidum in rats using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry","volume":"941","author":"Cheng","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2025.124626_bb0100","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41401-019-0329-2","article-title":"Ganoderic acid a is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease","volume":"41","author":"Meng","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jchromb.2025.124626_bb0105","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41401-019-0324-7","article-title":"Ganoderic acid hinders renal fibrosis via suppressing the TGF-\u03b2\/Smad and MAPK signaling pathways","volume":"41","author":"Geng","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jchromb.2025.124626_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109529","article-title":"Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid a on carbon tetrachloride induced nephrotoxicity by regulating the Trx\/TrxR and JAK\/ROCK pathway","volume":"344","author":"Ma","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jchromb.2025.124626_bb0115","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317695530","article-title":"Navgeet, Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer","volume":"39","author":"Gill","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0120","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/jpp\/rgad116","article-title":"Ganoderic acid a suppresses autophagy by regulating the circFLNA\/miR-486-3p\/CYP1A1\/XRCC1 axis to strengthen the sensitivity of lung cancer cells to cisplatin","volume":"76","author":"Gong","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124626_bb0125","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190301","article-title":"Ganoderic acid a attenuates lipopolysaccharide-induced lung injury in mice","volume":"39","author":"Wan","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jchromb.2025.124626_bb0130","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1159\/000505297","article-title":"Ganoderic acid a inhibits bleomycin-induced lung fibrosis in mice","volume":"105","author":"Wen","year":"2020","journal-title":"Pharmacology"},{"key":"10.1016\/j.jchromb.2025.124626_bb0135","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3390\/metabo13111164","article-title":"Metabolomic insights into the mechanisms of Ganoderic acid: protection against \u03b1-Amanitin-induced liver injury","volume":"13","author":"Zheng","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.jchromb.2025.124626_bb0140","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s12272-020-01256-9","article-title":"Ganoderic acid a attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation","volume":"43","author":"Liu","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jchromb.2025.124626_bb0145","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.4314\/tjpr.v19i12.23","article-title":"Effect of ganoderic acid on diethylnitrosamine-induced liver cancer in mice","volume":"19","author":"Sun","year":"2021","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.jchromb.2025.124626_bb0150","doi-asserted-by":"crossref","first-page":"8664","DOI":"10.3390\/ijms21228664","article-title":"Molecular mechanisms of microbiota-mediated pathology in irritable bowel syndrome","volume":"21","author":"Mishima","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jchromb.2025.124626_bb0155","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jchromb.2025.124626_bb0160","first-page":"133","article-title":"The brain-gut-microbiome Axis","volume":"6","author":"Martin","year":"2018","journal-title":"Cell Mol. Gastroenter."},{"key":"10.1016\/j.jchromb.2025.124626_bb0165","doi-asserted-by":"crossref","first-page":"14204","DOI":"10.1021\/acs.jafc.1c06304","article-title":"Ganoderic acid a to alleviate Neuroinflammation of Alzheimer\u2019s disease in mice by regulating the imbalance of the Th17\/Tregs Axis","volume":"69","author":"Zhang","year":"2021","journal-title":"J. Agric. Food Chem."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225001801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225001801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:11:28Z","timestamp":1762553488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023225001801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":33,"alternative-id":["S1570023225001801"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124626","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetic and tissue distribution analysis of sporoderm-removed Ganoderma lucidum spore powder in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124626","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124626"}}