{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:08:31Z","timestamp":1792620511137,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["202213030509"],"award-info":[{"award-number":["202213030509"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jchromb.2025.124709","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T20:08:50Z","timestamp":1750277330000},"page":"124709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["In vivo sequential metabolism by UPLC\/MS, network pharmacology and cell experimentation for screening Q-markers of Penthorum chinense Pursh"],"prefix":"10.1016","volume":"1263","author":[{"given":"Miao","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2025.124709_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154511","article-title":"Development of a three-step-based novel strategy integrating DMPK with network pharmacology and bioactivity evaluation for the discovery of Q-markers of traditional Chinese medicine prescriptions: Danlou tablet as an example","volume":"108","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2025.124709_bb0010","first-page":"1443","article-title":"A new concept on quality marker of Chinese materia medica: quality control for Chinese medicinal products","volume":"47","author":"Liu","year":"2016","journal-title":"Chin. Trad. Herb. Drugs"},{"key":"10.1016\/j.jchromb.2025.124709_bb0015","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jpha.2022.05.001","article-title":"Multimodal integrated strategy for the discovery and identification of quality markers in traditional Chinese medicine","volume":"12","author":"Lu","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jchromb.2025.124709_bb0020","first-page":"3149","article-title":"Recognizing healthy development of Chinese medicine industry from resourcesquality-quality markers of Chinese medicine","volume":"47","author":"Liu","year":"2016","journal-title":"Chin. Trad. Herb. Drugs"},{"key":"10.1016\/j.jchromb.2025.124709_bb0025","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1039\/D3MO00029J","article-title":"A Q-marker screening strategy based on ADME studies and systems biology for Chinese herbal medicine, taking Qianghuo Shengshi decoction in treating rheumatoid arthritis as an example","volume":"19","author":"Wang","year":"2023","journal-title":"Mol Omics."},{"key":"10.1016\/j.jchromb.2025.124709_bb0030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.phymed.2018.03.031","article-title":"Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: based on preparation quantitative analysis and PK-PD study","volume":"54","author":"Gao","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2025.124709_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153535","article-title":"Discovery of potential Q-marker of traditional Chinese medicine based on plant metabolomics and network pharmacology: Periplocae cortex as an example","volume":"85","author":"Li","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2025.124709_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116157","article-title":"Study on the pharmacokinetics, tissue distribution and excretion of Penthorum chinense Pursh in normal and acute alcoholic liver injury rats using validated UPLC-MS\/MS method","volume":"245","author":"Tian","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2025.124709_bb0045","first-page":"117","article-title":"Effect of Gansu granule on liver function and liver damage for Perchlormethane-induced hepatic fibrosis of rats","volume":"23","author":"Xie","year":"2017","journal-title":"Chin. J. Exp. Trad. Med. Formulae."},{"key":"10.1016\/j.jchromb.2025.124709_bb0050","first-page":"857","article-title":"Clinical observation of Gansu granules combined with polyene phosphatidylcholine in the treatment of non alcoholic fatty liver disease","volume":"30","author":"Xu","year":"2014","journal-title":"J. Pract. Tradit. Chin. Med."},{"key":"10.1016\/j.jchromb.2025.124709_bb0055","first-page":"1477","article-title":"Potential pharmacodynamic substances basis and mechanism of Penthorum chinense in liver protection based on UPLC-Q-Exactive Orbitrap-MS and network pharmacology","volume":"55","author":"Tian","year":"2024","journal-title":"Chin. Trad. Herb. Drugs"},{"key":"10.1016\/j.jchromb.2025.124709_bb0060","first-page":"2212","article-title":"Study on Q-marker of Leonurus japonicus and Penthorum chinense based on basic conditions of Q-marker","volume":"47","author":"Xiong","year":"2016","journal-title":"Chin. Trad. Herb. Drugs"},{"key":"10.1016\/j.jchromb.2025.124709_bb0065","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/bmc.3626","article-title":"Metabolic routes along digestive system of licorice: multicomponent sequential metabolism method in rat","volume":"30","author":"Zhang","year":"2016","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jchromb.2025.124709_bb0070","first-page":"1663","article-title":"Analysis on theory and technology method of multicomponent drug metabolism","volume":"45","author":"Liu","year":"2014","journal-title":"Chin. Trad. Herb. Drugs"},{"key":"10.1016\/j.jchromb.2025.124709_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154844","article-title":"Screening quality markers (Q-markers) of Xiaoer Chaige Tuire Oral liquid by in vitro sequential metabolism and in vivo biopharmaceutical analysis","volume":"116","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2025.124709_bb0080","first-page":"329","article-title":"Selection of quality control components from Paeoniae Radix Alba based on sequential metabolism in rats","volume":"44","author":"Li","year":"2021","journal-title":"Drug Eval. Res."},{"key":"10.1016\/j.jchromb.2025.124709_bb0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphar.2019.00123","article-title":"Network pharmacology databases for traditional Chinese medicine, review and assessment","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124709_bb0090","series-title":"The Protect Effect of the Extracts from Penthorum Chinese Pursh on Cholestatic Hepatocyte Damage","author":"Xie","year":"2016"},{"key":"10.1016\/j.jchromb.2025.124709_bb0095","first-page":"638","article-title":"Network pharmacology, molecular docking, and untargeted metabolomics reveal molecular mechanisms of multi-targets effects of Qingfei Tongluo plaster improving respiratory syncytial virus pneumonia","volume":"16","author":"Yang","year":"2024","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jchromb.2025.124709_bb0100","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btae615","article-title":"DAVID Ortholog: an integrative tool to enhance functional analysis through orthologs","volume":"40","author":"Sherman","year":"2024","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jchromb.2025.124709_bb0105","first-page":"114","article-title":"Analysis on components absorbed into blood and cerebrospinal fluid of Schisandrae Chinensis Fructus based on sequential metabolism","volume":"30","author":"Yu","year":"2024","journal-title":"Chin. J. Exp. Trad. Med. Formulae."},{"key":"10.1016\/j.jchromb.2025.124709_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114629","article-title":"Chemical components analysis and in vivo metabolite profiling of Jian\u2019er Xiaoshi oral liquid by UHPLC-Q-TOF-MS\/MS","volume":"211","author":"Chen","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2025.124709_bb0115","first-page":"3465","article-title":"Research progress on the interactions between gut bacterial \u03b2-glucuronidases and Chinese herbal medicines","volume":"57","author":"Chen","year":"2022","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.jchromb.2025.124709_bb0120","first-page":"8895950","article-title":"Using network pharmacology to explore the mechanism of panax notoginseng in the treatment of myocardial fibrosis","author":"Han","year":"2022","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.jchromb.2025.124709_bb0125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ptr.7605","article-title":"Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1\/TLR4 signal pathway","volume":"37","author":"Ma","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jchromb.2025.124709_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150130","article-title":"Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1\u03b1 mediated oxidative stress","volume":"721","author":"Sun","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jchromb.2025.124709_bb0135","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.micpath.2018.11.007","article-title":"Protective effects of alpinetin on lipopolysaccharide\/d-Galactosamine-induced liver injury through inhibiting inflammatory and oxidative responses","volume":"126","author":"Liu","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jchromb.2025.124709_bb0140","doi-asserted-by":"crossref","first-page":"G387","DOI":"10.1152\/ajpgi.00350.2018","article-title":"AKT activator SC79 protects hepatocytes from TNF-\u03b1-mediated apoptosis and alleviates d-gal\/LPS-induced liver injury","volume":"316","author":"Jing","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jchromb.2025.124709_bb0145","article-title":"Effect and mechanism of carvacrol on liver injury in type 2 diabetes mellitus","volume":"42","author":"Qing","year":"2024","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.jchromb.2025.124709_bb0150","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/TP.0000000000004356","article-title":"Transcription factor YY1 ameliorates liver ischemia-reperfusion injury through modulating the miR-181a-5p\/ESR1\/ERBB2 Axis","volume":"107","author":"Wu","year":"2023","journal-title":"Transplantation"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225002636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225002636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:12:13Z","timestamp":1762553533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023225002636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":30,"alternative-id":["S1570023225002636"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124709","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo sequential metabolism by UPLC\/MS, network pharmacology and cell experimentation for screening Q-markers of Penthorum chinense Pursh","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124709"}}