{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:29:49Z","timestamp":1791840589243,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015335","name":"Modern Agricultural Technology Industry System of Shandong province","doi-asserted-by":"publisher","award":["HBCT2023080205"],"award-info":[{"award-number":["HBCT2023080205"]}],"id":[{"id":"10.13039\/501100015335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015335","name":"Modern Agricultural Technology Industry System of Shandong province","doi-asserted-by":"publisher","award":["HBCT2023080201"],"award-info":[{"award-number":["HBCT2023080201"]}],"id":[{"id":"10.13039\/501100015335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2024423015"],"award-info":[{"award-number":["H2024423015"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005064","name":"Hebei Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["25292501D"],"award-info":[{"award-number":["25292501D"]}],"id":[{"id":"10.13039\/501100005064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005064","name":"Hebei Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["246W2501D"],"award-info":[{"award-number":["246W2501D"]}],"id":[{"id":"10.13039\/501100005064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jchromb.2025.124769","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T07:22:55Z","timestamp":1755242575000},"page":"124769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Purification of steroidal saponins from dioscoreae hypoglaucae rhizoma by macroporous resin and evaluation of their anti-inflammatory effect"],"prefix":"10.1016","volume":"1265","author":[{"given":"Zhangyi","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2025.124769_bb0005","series-title":"Pharmacopoeia of the People's Republic of China, Part I","author":"C.P. Commission","year":"2025"},{"issue":"5","key":"10.1016\/j.jchromb.2025.124769_bb0010","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3892\/ijmm.2014.1921","article-title":"Dioscin inhibits adipogenesis through the AMPK\/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice","volume":"34","author":"Poudel","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.jchromb.2025.124769_bb0015","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/TP.0000000000000262","article-title":"Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis","volume":"98","author":"Tao","year":"2014","journal-title":"Transplantation"},{"key":"10.1016\/j.jchromb.2025.124769_bb0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biochi.2014.12.022","article-title":"Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-\u03b1-induced VCAM-1, ICAM-1and EL expression via the NF-\u03baB pathway","volume":"110","author":"Wu","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.jchromb.2025.124769_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118069","article-title":"The genus Dioscorea L. (Dioscoreaceae), a review of traditional uses, phytochemistry, pharmacology, and toxicity","volume":"329","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2025.124769_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2020.102145","article-title":"Surface activity and foaming properties of saponin-rich plants extracts","volume":"279","author":"G\u00f3ral","year":"2020","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.jchromb.2025.124769_bb0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jpba.2015.08.038","article-title":"Comparative analysis of steroidal saponins in four Dioscoreae herbs by high performance liquid chromatography coupled with mass spectrometry","volume":"117","author":"Guo","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jchromb.2025.124769_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123531","article-title":"Identification of anti-inflammatory components in Dioscorea nipponica Makino based on HPLC-MS\/MS, quantitative analysis of multiple components by single marker and chemometric methods","volume":"1213","author":"Yang","year":"2022","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"19","key":"10.1016\/j.jchromb.2025.124769_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27196626","article-title":"Separation and purification of two Saponins from Paris polyphylla var. yunnanensis by a macroporous resin","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"},{"issue":"14","key":"10.1016\/j.jchromb.2025.124769_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26144162","article-title":"Adsorption and desorption characteristics of Total flavonoids from Acanthopanax senticosus on macroporous adsorption resins","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2025.124769_bb0055","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ultsonch.2018.06.016","article-title":"Ultrasound assisted adsorption and desorption of blueberry anthocyanins using macroporous resins","volume":"48","author":"Wu","year":"2018","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.jchromb.2025.124769_bb0060","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.foodchem.2014.09.039","article-title":"Preparative purification of polyphenols from sweet potato (Ipomoea batatas L.) leaves by AB-8 macroporous resins","volume":"172","author":"Xi","year":"2015","journal-title":"Food Chem."},{"issue":"5","key":"10.1016\/j.jchromb.2025.124769_bb0065","first-page":"382","article-title":"Preparation and quality assessment of high-purity ginseng total saponins by ion exchange resin combined with macroporous adsorption resin separation","volume":"12","author":"Zhao","year":"2014","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.jchromb.2025.124769_bb0070","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1039\/C6FO01474G","article-title":"Macroporous resin purification and characterization of flavonoids from Platycladus orientalis (L.) Franco and their effects on macrophage inflammatory response","volume":"8","author":"Ren","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.jchromb.2025.124769_bb0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jhazmat.2017.01.030","article-title":"Adsorption performance of salicylic acid on a novel resin with distinctive double pore structure","volume":"329","author":"Xiao","year":"2017","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.jchromb.2025.124769_bb0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13065-020-00666-6","article-title":"Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method","volume":"14","author":"Zhang","year":"2020","journal-title":"BMC Chem"},{"issue":"12","key":"10.1016\/j.jchromb.2025.124769_bb0085","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1039\/C8RA09319A","article-title":"Enrichment and separation of steroidal saponins from the fibrous roots of Ophiopogon japonicus using macroporous adsorption resins","volume":"9","author":"Zhou","year":"2019","journal-title":"RSC Adv."},{"issue":"5","key":"10.1016\/j.jchromb.2025.124769_bb0090","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/jssc.201600884","article-title":"Enrichment of total steroidal saponins from the extracts of Trillium tschonoskii maxim by macroporous resin and the simultaneous determination of eight steroidal saponins in the final product by HPLC","volume":"40","author":"Zhou","year":"2017","journal-title":"J. Sep. Sci."},{"issue":"1","key":"10.1016\/j.jchromb.2025.124769_bb0095","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/imr.12833","article-title":"Urate-induced immune programming: consequences for gouty arthritis and hyperuricemia","volume":"294","author":"Cab\u0103u","year":"2020","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.jchromb.2025.124769_bb0100","first-page":"1925","article-title":"Aloin suppresses lipopolysaccharide-induced inflammation by inhibiting JAK1-STAT1\/3 activation and ROS production in RAW264.7 cells","volume":"42","author":"Ma","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.jchromb.2025.124769_bb0105","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrrheum.2010.4","article-title":"IL-1 pathways in inflammation and human diseases","volume":"6","author":"Gabay","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.jchromb.2025.124769_bb0110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.2287","article-title":"TNF-mediated inflammatory disease","volume":"214","author":"Bradley","year":"2008","journal-title":"J. Pathol."},{"issue":"12","key":"10.1016\/j.jchromb.2025.124769_bb0115","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","article-title":"Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jchromb.2025.124769_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154385","article-title":"Glycosides from Buyang Huanwu decoction inhibit atherosclerotic inflammation via JAK\/STAT signaling pathway","volume":"105","author":"Fu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2025.124769_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153842","article-title":"Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: a review of pre-clinical research","volume":"96","author":"Passos","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2025.124769_bb0130","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jep.2017.04.024","article-title":"Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2\/4-IL1R receptor singnal pathway in rats of gouty arthritis","volume":"206","author":"Zhou","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jchromb.2025.124769_bb0135","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/pca.2876","article-title":"Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC-QTOF-MS\/MS analysis","volume":"31","author":"Li","year":"2020","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jchromb.2025.124769_bb0140","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/08923973.2020.1775248","article-title":"Dioscin exhibits anti-inflammatory effects in IL-1\u03b2-stimulated human osteoarthritis chondrocytes by activating LXR\u03b1","volume":"42","author":"Wang","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"5","key":"10.1016\/j.jchromb.2025.124769_bb0145","first-page":"1027","article-title":"Highly selective separation and purification of chicoric acid from Echinacea purpurea by quality control methods in macroporous adsorption resin column chromatography","volume":"42","author":"Bai","year":"2019","journal-title":"J. Sep. Sci."},{"issue":"24","key":"10.1016\/j.jchromb.2025.124769_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28248116","article-title":"Chemical comparison and identification of xanthine oxidase inhibitors of Dioscoreae Hypoglaucae Rhizoma and Dioscoreae Spongiosae Rhizoma by Chemometric analysis and Spectrum-effect relationship","volume":"28","author":"Rui","year":"2023","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.jchromb.2025.124769_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24071284","article-title":"Purification of polyphenols from distiller\u2019s grains by macroporous resin and analysis of the polyphenolic components","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jchromb.2025.124769_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23051167","article-title":"Enrichment and purification of Total Ginkgo flavonoid O-glycosides from Ginkgo biloba extract with macroporous resin and evaluation of anti-inflammation activities in vitro","volume":"23","author":"Zhang","year":"2018","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.jchromb.2025.124769_bb0165","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1002\/fsn3.2464","article-title":"Purification and antioxidant properties of triterpenic acids from blackened jujube (Ziziphus jujuba mill.) by macroporous resins","volume":"9","author":"Fu","year":"2021","journal-title":"Food Sci. Nutr."},{"issue":"6","key":"10.1016\/j.jchromb.2025.124769_bb0170","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11926-001-0069-3","article-title":"Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis","volume":"3","author":"Abramson","year":"2001","journal-title":"Curr. Rheumatol. Rep."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157002322500323X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157002322500323X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:12:26Z","timestamp":1762553546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S157002322500323X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":34,"alternative-id":["S157002322500323X"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124769","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Purification of steroidal saponins from dioscoreae hypoglaucae rhizoma by macroporous resin and evaluation of their anti-inflammatory effect","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124769"}}