{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:57:57Z","timestamp":1781215077787,"version":"3.54.1"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021772","name":"The University of Jordan Deanship of Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jchromb.2025.124824","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:06:08Z","timestamp":1760544368000},"page":"124824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["LC-MS-based metabolomics revealed promising role of leukotriene receptor antagonists against colorectal cancer"],"prefix":"10.1016","volume":"1267","author":[{"given":"Farah","family":"Hudaib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaa","family":"Bardaweel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesam","family":"Darwish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah","family":"Abdelrazig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina A.","family":"Dahabiyeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2025.124824_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jchromb.2025.124824_bb0010","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","article-title":"Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN","volume":"72","author":"Morgan","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.jchromb.2025.124824_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers13092025","article-title":"A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis","volume":"13","author":"Sawicki","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jchromb.2025.124824_bb0020","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.3748\/wjg.v22.i30.6876","article-title":"Mechanisms of drug resistance in colon cancer and its therapeutic strategies","volume":"22","author":"Hu","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0025","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jchromb.2025.124824_bb0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41392-020-00213-8","article-title":"Overcoming cancer therapeutic bottleneck by drug repurposing","volume":"5","author":"Zhang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jchromb.2025.124824_bb0035","first-page":"651","article-title":"New drugs are not enough-drug repositioning in oncology: an update","volume":"56","author":"Armando","year":"2020","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms20143580","article-title":"The role of leukotrienes as potential therapeutic targets in allergic disorders","volume":"20","author":"Jo-Watanabe","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jchromb.2025.124824_bb0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ccm.2018.10.014","article-title":"Proinflammatory pathways in the pathogenesis of asthma","volume":"40","author":"Peebles","year":"2019","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.jchromb.2025.124824_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2020.01289","article-title":"Leukotrienes in tumor-associated inflammation","volume":"11","author":"Tian","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0055","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.canlet.2020.05.023","article-title":"Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells","volume":"488","author":"Satapathy","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jchromb.2025.124824_bb0060","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1158\/1940-6207.CAPR-22-0331","article-title":"Targeting the leukotriene pathway for colon cancer interception","volume":"15","author":"Mohammed","year":"2022","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.jchromb.2025.124824_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.858855","article-title":"Cysteinyl leukotriene receptor antagonists associated with a decreased incidence of cancer: a retrospective cohort study","volume":"12","author":"Jang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0070","article-title":"Cysteinyl leukotriene receptor antagonists decrease cancer risk in asthma patients","volume":"6","author":"Tsai","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jchromb.2025.124824_bb0075","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1139\/cjpp-2017-0757","article-title":"Cysteinyl leukotriene receptor antagonists induce apoptosis and inhibit proliferation of human glioblastoma cells by downregulating B-cell lymphoma 2 and inducing cell cycle arrest","volume":"96","author":"Piromkraipak","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0080","first-page":"123","article-title":"Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding","volume":"69","author":"Arai","year":"2020","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.jchromb.2025.124824_bb0085","first-page":"833","article-title":"Leukotriene receptor antagonists inhibit mitogenic activity in triple negative breast cancer cells","volume":"19","author":"Suknuntha","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.jchromb.2025.124824_bb0090","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.3390\/molecules29143379","article-title":"Potential of anti-leukotriene drugs as new therapeutic agents for inhibiting cholangiocarcinoma progression","volume":"29","author":"Kito","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.jchromb.2025.124824_bb0095","series-title":"Herbs and Spices","article-title":"Metabolomics","author":"Kumar Dubey","year":"2020"},{"key":"10.1016\/j.jchromb.2025.124824_bb0100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4939-7172-5_13","article-title":"NMR and MS methods for metabolomics","volume":"1641","author":"Amberg","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0105","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1186\/s12885-024-12321-7","article-title":"UHPLC-HRMS-based multiomics to explore the potential mechanisms and biomarkers for colorectal cancer","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jchromb.2025.124824_bb0110","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/cancers14030725","article-title":"The application of metabolomics in recent colorectal cancer studies: a state-of-the-art review","volume":"14","author":"Gold","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.jchromb.2025.124824_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2013.35","article-title":"Epigenetic and genetic features of 24 colon cancer cell lines","volume":"2","author":"Ahmed","year":"2013","journal-title":"Oncogenesis"},{"key":"10.1016\/j.jchromb.2025.124824_bb0120","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0016-5085(89)80072-1","article-title":"Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability","volume":"96","author":"Hidalgo","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jchromb.2025.124824_bb0125","doi-asserted-by":"crossref","first-page":"15204","DOI":"10.1021\/acsomega.4c10939","article-title":"Unraveling the anticancer potential of SSRIs in prostate cancer by combining computational systems biology and in vitro analyses","volume":"10","author":"Bardaweel","year":"2025","journal-title":"ACS Omega"},{"key":"10.1016\/j.jchromb.2025.124824_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2023.106378","article-title":"Mass spectrometry-based metabolomics approach and in vitro assays revealed promising role of 2,3-dihydroquinazolin-4(1H)-one derivatives against colorectal cancer cell lines","volume":"182","author":"Dahabiyeh","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jchromb.2025.124824_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom11030364","article-title":"Phospholipid-gold nanorods induce energy crisis in MCF-7 cells: cytotoxicity evaluation using LC-MS-based metabolomics approach","volume":"11","author":"Dahabiyeh","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jchromb.2025.124824_bb0140","doi-asserted-by":"crossref","first-page":"20745","DOI":"10.1039\/D5RA01044F","article-title":"LC-MS Orbitrap-based metabolomics using a novel hybrid zwitterionic hydrophilic interaction liquid chromatography and rigorous metabolite identification reveals doxorubicin-induced metabolic perturbations in breast cancer cells","volume":"15","author":"Abdelrazig","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.jchromb.2025.124824_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106057","article-title":"Investigating the effect of the probiotic lactobacillus plantarum and the prebiotic fructooligosaccharides on Pseudomonas aeruginosa metabolome, virulence factors and biofilm formation as potential quorum sensing inhibitors","volume":"177","author":"Al-Saafin","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jchromb.2025.124824_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13568-023-01523-0","article-title":"Micafungin effect on Pseudomonas aeruginosa metabolome, virulence and biofilm: potential quorum sensing inhibitor","volume":"13","author":"Hijazi","year":"2023","journal-title":"AMB Express"},{"key":"10.1016\/j.jchromb.2025.124824_bb0155","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s11306-014-0739-6","article-title":"Proposed quantitative and alphanumeric metabolite identification metrics","volume":"10","author":"Sumner","year":"2014","journal-title":"Metabolomics"},{"key":"10.1016\/j.jchromb.2025.124824_bb0160","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3390\/metabo13090990","article-title":"Serum-based lipid panels for diagnosis of idiopathic Parkinson's disease","volume":"13","author":"Dahabiyeh","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.jchromb.2025.124824_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e30452","article-title":"Diagnosing Parkinson's disease and monitoring its progression: biomarkers from combined GC-TOF MS and LC-MS\/MS untargeted metabolomics","volume":"10","author":"Dahabiyeh","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jchromb.2025.124824_bb0170","first-page":"92","article-title":"Multivariate analysis in metabolomics","volume":"1","author":"Worley","year":"2013","journal-title":"Curr. Metabolomics"},{"key":"10.1016\/j.jchromb.2025.124824_bb0175","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1039\/B820224A","article-title":"A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry","volume":"5","author":"Yin","year":"2009","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.jchromb.2025.124824_bb0180","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4939-7643-0_2","article-title":"Quality control and validation issues in LC-MS metabolomics","volume":"1738","author":"Begou","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0185","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1021\/pr070183p","article-title":"Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine","volume":"6","author":"Gika","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jchromb.2025.124824_bb0190","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.3390\/ijms18071353","article-title":"Montelukast induces apoptosis-inducing factor-mediated cell death of lung cancer cells","volume":"18","author":"Tsai","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jchromb.2025.124824_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2019.104489","article-title":"Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis","volume":"109","author":"Kumar","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0200","first-page":"15","article-title":"Evaluation of anticancer activity of boswellic acid and montelukast sodium against human prostate cancer cell line PC-3","volume":"12","author":"Gandhi","year":"2016","journal-title":"Iran. J. Pharm. Sci."},{"key":"10.1016\/j.jchromb.2025.124824_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073466","article-title":"CysLT1R antagonists inhibit tumor growth in a xenograft model of colon cancer","volume":"8","author":"Savari","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jchromb.2025.124824_bb0210","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201952R","article-title":"Targeting thiol isomerase activity with zafirlukast to treat ovarian cancer from the bench to clinic","volume":"37","author":"Gelzinis","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.jchromb.2025.124824_bb0215","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.3892\/mmr.2024.13265","article-title":"Differential effects of montelukast and zafirlukast on MDA-MB-231 triple-negative breast cancer cells: cell cycle regulation, apoptosis, autophagy, DNA damage and endoplasmic reticulum stress","volume":"30","author":"Vivithanaporn","year":"2024","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jchromb.2025.124824_bb0220","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.137","article-title":"Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation","volume":"6","author":"Brockmann","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jchromb.2025.124824_bb0225","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3892\/ijo.2024.5654","article-title":"Daunorubicin induces GLI1-dependent apoptosis in colorectal cancer cell lines","volume":"64","author":"Kim","year":"2024","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0230","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3892\/ol.2025.15042","article-title":"[retracted] 5-fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-\u03b4","volume":"29","author":"Mhaidat","year":"2025","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jchromb.2025.124824_bb0235","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","article-title":"Oxidative stress in cancer","volume":"38","author":"Hayes","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jchromb.2025.124824_bb0240","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jsps.2011.06.002","article-title":"Effects of montelukast on free radical production in whole blood and isolated human polymorphonuclear neutrophils (PMNs) in asthmatic children","volume":"19","author":"Al Saadi","year":"2011","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.jchromb.2025.124824_bb0245","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.curtheres.2005.08.013","article-title":"Effects of zafirlukast on the function of human polymorphonuclear neutrophil leukocytes in asthmatic patients: a prospective, controlled, in vitro study","volume":"66","author":"Al-Zamil","year":"2005","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"10.1016\/j.jchromb.2025.124824_bb0250","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lfs.2018.04.002","article-title":"Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: role of the JNK\/ERK pathway","volume":"202","author":"El-Dessouki","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.jchromb.2025.124824_bb0255","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22479","article-title":"Radioprotective effects of montelukast, a selective leukotriene CysLT1 receptor antagonist, against nephrotoxicity induced by gamma radiation in mice","volume":"34","author":"Hormati","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0260","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/s41467-020-15136-9","article-title":"A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer","volume":"11","author":"Kodama","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jchromb.2025.124824_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202000169","article-title":"A second Warburg-like effect in cancer metabolism: the metabolic shift of glutamine-derived nitrogen","volume":"42","author":"Kodama","year":"2020","journal-title":"BioEssays"},{"key":"10.1016\/j.jchromb.2025.124824_bb0270","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3892\/ol.2012.928","article-title":"Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (review)","volume":"4","author":"Zheng","year":"2012","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jchromb.2025.124824_bb0275","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.drudis.2016.12.003","article-title":"Targeting amino acid metabolism for cancer therapy","volume":"22","author":"Lukey","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jchromb.2025.124824_bb0280","first-page":"4117","article-title":"The chemistry and biological activities of N-acetylcysteine","volume":"2013","author":"Samuni","year":"1830","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jchromb.2025.124824_bb0285","first-page":"1","article-title":"Modulation of redox homeostasis: a strategy to overcome cancer drug resistance","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0290","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3390\/antiox9111156","article-title":"Redox potential of antioxidants in cancer progression and prevention","volume":"9","author":"George","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.jchromb.2025.124824_bb0295","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrc.2016.71","article-title":"From Krebs to clinic: glutamine metabolism to cancer therapy","volume":"16","author":"Altman","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jchromb.2025.124824_bb0300","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jchromb.2025.124824_bb0305","first-page":"1","article-title":"Taurine attenuates the hypotaurine-induced progression of CRC via ERK\/RSK signaling, front. Cell","volume":"9","author":"Hou","year":"2021","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fmmed.2022.1044585","article-title":"Acetyl-CoA: an interplay between metabolism and epigenetics in cancer","volume":"2","author":"Hao","year":"2022","journal-title":"Front. Mol. Med."},{"key":"10.1016\/j.jchromb.2025.124824_bb0315","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1074\/mcp.RA118.000752","article-title":"Butyrate suppresses the proliferation of colorectal cancer cells via targeting pyruvate kinase M2 and metabolic reprogramming","volume":"17","author":"Li","year":"2018","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jchromb.2025.124824_bb0320","first-page":"1606","article-title":"Short-chain fatty acids reprogram metabolic profiles with the induction of reactive oxygen species production in human colorectal adenocarcinoma cells, Comput. Struct","volume":"21","author":"Huang","year":"2023","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.jchromb.2025.124824_bb0325","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc3981","article-title":"Deoxyribonucleotide metabolism, mutagenesis and cancer","volume":"15","author":"Mathews","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jchromb.2025.124824_bb0330","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in cancer: mechanisms and clinical implications","volume":"15","author":"Pinho","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jchromb.2025.124824_bb0335","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1158\/0008-5472.CAN-17-2834","article-title":"Polyol pathway links glucose metabolism to the aggressiveness of cancer cells","volume":"78","author":"Schwab","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.jchromb.2025.124824_bb0340","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000519784","article-title":"The pentose phosphate pathway in cancer: regulation and therapeutic opportunities","volume":"66","author":"Ghanem","year":"2021","journal-title":"Chemotherapy"},{"key":"10.1016\/j.jchromb.2025.124824_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12071731","article-title":"Targeting altered energy metabolism in colorectal cancer: oncogenic reprogramming, the central role of the TCA cycle and therapeutic opportunities","volume":"12","author":"Neitzel","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jchromb.2025.124824_bb0350","series-title":"Encyclopedia of Microbiology","first-page":"296","article-title":"Nucleotide metabolism","author":"Nygaard","year":"2009"},{"key":"10.1016\/j.jchromb.2025.124824_bb0355","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jchromb.2025.124824_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers11050688","article-title":"Cancer cells tune the signaling pathways to empower de novo synthesis of nucleotides","volume":"11","author":"Villa","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jchromb.2025.124824_bb0365","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2011.03.044","article-title":"Nucleotide deficiency promotes genomic instability in early stages of cancer development","volume":"145","author":"Bester","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jchromb.2025.124824_bb0370","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.molonc.2011.07.001","article-title":"The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings","volume":"5","author":"Helleday","year":"2011","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.jchromb.2025.124824_bb0375","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1038\/onc.2017.227","article-title":"Disrupting G6PD-mediated redox homeostasis enhances chemosensitivity in colorectal cancer","volume":"36","author":"Ju","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.jchromb.2025.124824_bb0380","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jchromb.2016.01.003","article-title":"Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line","volume":"1014","author":"Gao","year":"2016","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2025.124824_bb0385","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1172\/JCI99169","article-title":"Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors","volume":"128","author":"Weiss","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jchromb.2025.124824_bb0390","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1084\/jem.20180118","article-title":"Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection","volume":"215","author":"Nair","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jchromb.2025.124824_bb0395","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41586-018-0052-z","article-title":"Electrophilic properties of itaconate and derivatives regulate the I\u03baB\u03b6-ATF3 inflammatory axis","volume":"556","author":"Bambouskova","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jchromb.2025.124824_bb0400","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41577-019-0128-5","article-title":"Itaconate: the poster child of metabolic reprogramming in macrophage function","volume":"19","author":"O'Neill","year":"2019","journal-title":"Nat. Rev. Immunol."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225003782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225003782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:05:24Z","timestamp":1781211924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023225003782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":80,"alternative-id":["S1570023225003782"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124824","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LC-MS-based metabolomics revealed promising role of leukotriene receptor antagonists against colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124824"}}