{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:07:26Z","timestamp":1781197646042,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jchromb.2025.124842","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:05:48Z","timestamp":1762211148000},"page":"124842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Biotransformation and its effects on anxiolytic activity and toxicity of Polygalae Radix saponins"],"prefix":"10.1016","volume":"1268","author":[{"given":"Yuhan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqian","family":"Kui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Jianmei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2025.124842_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138146","article-title":"Immobilization of snailase on glutamate modified MIL-88B(Fe) to efficiently convert the rare ginsenoside CK with high enzyme recyclability and stability","volume":"285","author":"Cao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jchromb.2025.124842_bb0010","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.phymed.2016.10.015","article-title":"Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice","author":"Cao","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jchromb.2025.124842_bb0015","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8855536","article-title":"Comparative study on the chemical components and gastrointestinal function on rats of the raw product and licorice-simmered product of Polygala tenuifolia","volume":"2021","author":"Cui","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jchromb.2025.124842_bb0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jpba.2018.12.005","article-title":"Comprehensive characterization of in vivo metabolic profile of Polygalae radix based on ultra-high-performance liquid chromatography-tandem mass spectrometry","volume":"165","author":"Feng","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"10.1016\/j.jchromb.2025.124842_bb0025","first-page":"398","article-title":"Study on acute toxicity test of different processed products of Radix polygalae","volume":"32","author":"Guan","year":"2012","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"5","key":"10.1016\/j.jchromb.2025.124842_bb0030","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1007\/s12035-023-03240-y","article-title":"Derivatives of 3, 4, 5-Trimethoxycinnamic acid ameliorate stress-induced anxiety in mice and rats","volume":"60","author":"Hong","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.jchromb.2025.124842_bb0035","first-page":"2538","article-title":"Research progress on processing of polygalae radix","volume":"48","author":"Hui","year":"2017","journal-title":"Chin. Tradit. Herb. Drug"},{"issue":"1","key":"10.1016\/j.jchromb.2025.124842_bb0040","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1089\/can.2022.0078","article-title":"Effects of \u0394(9)-THC and Type-1 cannabinoid receptor agonists in the elevated plus maze test of anxiety: a systematic review and Meta-analysis","volume":"8","author":"Iglesias","year":"2023","journal-title":"Cannabis Cannabinoid Res"},{"issue":"1","key":"10.1016\/j.jchromb.2025.124842_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19768354.2014.982176","article-title":"Polygala tenuifolia prevents anxiety-like behaviors in mice exposed to repeated restraint stress","volume":"19","author":"Lee","year":"2015","journal-title":"Animal Cells & Systems"},{"key":"10.1016\/j.jchromb.2025.124842_bb0050","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neulet.2014.11.016","article-title":"3,4,5-Trimethoxycinnamin acid ameliorates restraint stress-induced anxiety and depression","volume":"585","author":"Leem","year":"2015","journal-title":"Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences"},{"issue":"11","key":"10.1016\/j.jchromb.2025.124842_bb0055","first-page":"94","article-title":"Study on the preparation technology of complex seasoning by boletus edulis enzymatic hydrolysate","volume":"43","author":"Lei","year":"2018","journal-title":"China Condiment"},{"issue":"6","key":"10.1016\/j.jchromb.2025.124842_bb0060","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/10286020500173358","article-title":"New acylated triterpene saponins from Polygala tenuifolia willd","volume":"8","author":"Li","year":"2006","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jchromb.2025.124842_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2022.108677","article-title":"Co-immobilized \u03b2-glucosidase and snailase in green synthesized Zn-BTC for ginsenoside CK biocatalysis","volume":"188","author":"Li","year":"2022","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.jchromb.2025.124842_bb0070","first-page":"1","article-title":"The gastrointestinal irritation of Polygala Saponins and its potential mechanism in vitro and in vivo","volume":"2015","author":"Li","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jchromb.2025.124842_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpba.2013.06.011","volume":"85","author":"Ling","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"6","key":"10.1016\/j.jchromb.2025.124842_bb0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/pca.2454","article-title":"Analysis of multiple constituents in Cong-Ming-Tang, a Chinese herbal formula for the treatment of amnesia, by high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry","volume":"24","author":"Ling","year":"2013","journal-title":"Phytochem. Anal."},{"issue":"10","key":"10.1016\/j.jchromb.2025.124842_bb0085","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.phymed.2010.01.004","article-title":"Potential antidepressant properties of Radix Polygalae (Yuan Zhi)","volume":"17","author":"Liu","year":"2010","journal-title":"Phytomedicine"},{"issue":"13","key":"10.1016\/j.jchromb.2025.124842_bb0090","article-title":"Study on the anti-dementia and neural protection effects of ethamol soluble extract of Polygalae Radix","volume":"6","author":"Luo","year":"2012","journal-title":"Afr. J. Pharm. Pharmacol"},{"issue":"6","key":"10.1016\/j.jchromb.2025.124842_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27622","article-title":"Comprehensive evaluation of chemical constituents and antioxidant activity between crude and processed Polygalae radix based on UPLC-Q-TOF-MS\/MS combined with multivariate statistical analysis","volume":"10","author":"Luo","year":"2024","journal-title":"Heliyon"},{"issue":"19","key":"10.1016\/j.jchromb.2025.124842_bb0100","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1038\/sj.emboj.7600781","article-title":"A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression","volume":"24","author":"Peinado","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.jchromb.2025.124842_bb0105","series-title":"Microspheres immobilized snailase prepared by method of microemulsion-coacervation for transform icariin","first-page":"3326","volume":"46","author":"Peng","year":"2015"},{"key":"10.1016\/j.jchromb.2025.124842_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biteb.2022.100948","article-title":"Production, optimization, partial-purification and pyrolysis kinetic studies of exopolysaccharide from a native brown-rot fungi Fomitopsis meliae AGDP-2","volume":"17","author":"Prajapati","year":"2022","journal-title":"Bioresource Technology Reports"},{"issue":"7","key":"10.1016\/j.jchromb.2025.124842_bb0115","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/jms.3773","article-title":"Identification and determination of the major constituents in Kai-Xin-san by UPLC-Q\/TOF MS and UFLC-MS\/MS method","volume":"51","author":"Qing","year":"2016","journal-title":"Journal of mass spectrometry: JMS"},{"issue":"1","key":"10.1016\/j.jchromb.2025.124842_bb0120","first-page":"196","article-title":"Advances in studies on oral absorption and metabolism of pentacyclic triterpenoid saponins","volume":"43","author":"Wang","year":"2012","journal-title":"Chin. Tradit. Herb. Drug"},{"key":"10.1016\/j.jchromb.2025.124842_bb0125","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/918048","article-title":"The gastrointestinal irritation of polygala saponins and its potential mechanism in vitro and in vivo","volume":"2015","author":"Wen","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jchromb.2025.124842_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.enzmictec.2020.109690","article-title":"Efficient and clean preparation of rare prosaikogenin D by enzymatic hydrolysis of saikosaponin B2 and response surface methodology optimization","volume":"142","author":"Wu","year":"2020","journal-title":"Enzym. Microb. Technol."},{"issue":"03","key":"10.1016\/j.jchromb.2025.124842_bb0135","first-page":"29","article-title":"Comparative study on acute toxicity of extracts from different processed products of aconiti lateralis radix praeparata","volume":"3","author":"Xiao-Fang","year":"2012","journal-title":"Pharmacy and Clinics of Chinese Materia Medica"},{"issue":"7","key":"10.1016\/j.jchromb.2025.124842_bb0140","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3109\/13880200903280042","article-title":"Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice","volume":"48","author":"Yao","year":"2010","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.jchromb.2025.124842_bb0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/00498254.2016.1163753","article-title":"In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes","volume":"47","author":"Yu","year":"2017","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jchromb.2025.124842_bb0150","first-page":"3092","article-title":"Transformation of rare ginsenoside compound K from ginsenoside Rb1 catalyzed by snailase immobilization onto microspheres","volume":"45","author":"Yu","year":"2014","journal-title":"Chin. Tradit. Herb. Drug"},{"issue":"8","key":"10.1016\/j.jchromb.2025.124842_bb0155","article-title":"UPLC\/Q-TOF MS-based metabolomics and qRT-PCR in enzyme gene screening with key role in triterpenoid Saponin biosynthesis of Polygala tenuifolia","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jchromb.2025.124842_bb0160","first-page":"456","article-title":"Chemical pattern recognition of YuanZhi san capsule based on FTIR and HPLC analysis","volume":"47","author":"Zhao","year":"2020","journal-title":"Journal of International Pharmaceutical Research"},{"issue":"02","key":"10.1016\/j.jchromb.2025.124842_bb0165","first-page":"412","article-title":"Study on the preparation of rare ginsenoside compound K by enzymolysis of ginsenoside Rb1 with snailase","volume":"30","author":"Zhao-hu","year":"2015","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225003964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023225003964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:26:29Z","timestamp":1781195189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023225003964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":33,"alternative-id":["S1570023225003964"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124842","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biotransformation and its effects on anxiolytic activity and toxicity of Polygalae Radix saponins","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2025.124842","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124842"}}