{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:13:03Z","timestamp":1784146383269,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L254031"],"award-info":[{"award-number":["L254031"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7232115"],"award-info":[{"award-number":["7232115"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jchromb.2026.124930","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:09:59Z","timestamp":1768583399000},"page":"124930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Liquid chromatography-tandem mass spectrometry-based urinary steroid profiling applied to primary aldosteronism diagnosis"],"prefix":"10.1016","volume":"1273","author":[{"given":"Jian","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jchromb.2026.124930_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120186","article-title":"Unmasking primary aldosteronism: transforming disease management with advanced steroid profiling","volume":"570","author":"Zhong","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jchromb.2026.124930_bb0010","doi-asserted-by":"crossref","first-page":"e307","DOI":"10.1210\/clinem\/dgz141","article-title":"Urine steroid metabolomics as a novel tool for detection of recurrent adrenocortical carcinoma","volume":"105","author":"Chortis","year":"2020","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.jchromb.2026.124930_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101488","article-title":"Steroid profiling in the diagnosis of mild and overt Cushing's syndrome","volume":"35","author":"Athimulam","year":"2021","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jchromb.2026.124930_bb0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ecl.2015.02.002","article-title":"Adrenal steroidogenesis and congenital adrenal hyperplasia","volume":"44","author":"Turcu","year":"2015","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.jchromb.2026.124930_bb0025","first-page":"1835","article-title":"Application of the steroid profiling detecting by LC-MS\/MS in the diagnosis of primary aldosteronism","volume":"42","author":"Gao","year":"2022","journal-title":"Basic and Clinical Medicine"},{"key":"10.1016\/j.jchromb.2026.124930_bb0030","series-title":"Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism","author":"Adler","year":"2025"},{"key":"10.1016\/j.jchromb.2026.124930_bb0035","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1093\/ejendo\/lvad066","article-title":"European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European network for the study of adrenal Tumors","volume":"189","author":"Fassnacht","year":"2023","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.jchromb.2026.124930_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123294","article-title":"An LC-MS\/MS method for the simultaneous quantification of 32 steroids in human plasma","volume":"1201-1202","author":"\u0160imkov\u00e1","year":"2022","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2026.124930_bb0045","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3390\/toxics10110687","article-title":"Determination of 19 steroid hormones in human serum and urine using liquid chromatography-tandem mass spectrometry","volume":"10","author":"Li","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.jchromb.2026.124930_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2023.123941","article-title":"A comprehensive LC-MS\/MS method for the simultaneous measurement of 24 adrenal steroids: from research to clinical practice","volume":"1232","author":"Yu","year":"2024","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2026.124930_bb0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jmsacl.2022.07.006","article-title":"Targeted metabolic profiling of urinary steroids with a focus on analytical accuracy and sample stability","volume":"25","author":"Vogg","year":"2022","journal-title":"Journal of Mass Spectrometry and Advances in the Clinical Lab"},{"key":"10.1016\/j.jchromb.2026.124930_bb0060","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93136","article-title":"Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism","volume":"2","author":"Arlt","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jchromb.2026.124930_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2024.106596","article-title":"Pre-analytical stability and physiological fluctuations affect plasma steroid hormone outcomes: a real-world study","volume":"244","author":"Zhong","year":"2024","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jchromb.2026.124930_bb0075","doi-asserted-by":"crossref","first-page":"eadg8464","DOI":"10.1126\/scitranslmed.adg8464","article-title":"High-resolution daily profiles of tissue adrenal steroids by portable automated collection","volume":"15","author":"Upton","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jchromb.2026.124930_bb0080","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/HYPERTENSIONAHA.120.16429","article-title":"Intraindividual variability of aldosterone concentrations in primary aldosteronism: implications for case detection","volume":"77","author":"Yozamp","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.jchromb.2026.124930_bb0085","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1373\/clinchem.2017.271106","article-title":"High-resolution, accurate-mass (HRAM) mass spectrometry urine steroid profiling in the diagnosis of adrenal disorders","volume":"63","author":"Hines","year":"2017","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jchromb.2026.124930_bb0090","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0021-9673(01)91676-0","article-title":"Rapid chromatographic purification of urinary steroid glucuronates for determination of aldosterone secretion rate","volume":"317","author":"Risk","year":"1984","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2026.124930_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5694","article-title":"Simultaneous quantitation of urine aldosterone and tetrahydroaldosterone in healthy Chinese subjects using a validated LC\u2013MS\/MS method","volume":"37","author":"Cheng","year":"2023","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jchromb.2026.124930_bb0100","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/clinchem\/hvad065","article-title":"A novel enzymatic hydrolysis method for urine aldosterone quantification: a case for reassessing clinical cut-offs of primary aldosteronism","volume":"69","author":"Yazdanpanah","year":"2023","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jchromb.2026.124930_bb0105","doi-asserted-by":"crossref","unstructured":"S. Yu, J. Zhong, X. Ma, L. Qiu, Establishing a liquid chromatography-tandem mass spectrometry (LC-MS\/MS) method for both 18-hydroxycorticosterone and its interference: revisiting the specificity characteristic of LC-MS\/MS in the steroid measurement, interdisciplinary Medicine, DOI 10.1002\/inmd.20240077(2025) e20240077. doi: https:\/\/doi.org\/10.1002\/inmd.20240077.","DOI":"10.1002\/INMD.20240077"},{"key":"10.1016\/j.jchromb.2026.124930_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344403","article-title":"Enzymatic hydrolysis combined with chemiluminescence immunoassay: foresight for automated and rapid urinary aldosterone detection","volume":"1371","author":"Zhong","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jchromb.2026.124930_bb0115","series-title":"Liquid Chromatography-Mass Spectrometry Methods; Approved Guideline","author":"CLIS","year":"2014"},{"key":"10.1016\/j.jchromb.2026.124930_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117325","article-title":"Reference intervals for LC-MS \/MS measurements of plasma renin activity, aldosterone, angiotensin II, and 24-hour urinary aldosterone in northern Chinese Han population","volume":"543","author":"Yin","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jchromb.2026.124930_bb0125","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The Management of Primary Aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.jchromb.2026.124930_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.122390","article-title":"Quantification of steroid hormones in human urine by DLLME and UHPLC-HRMS detection","volume":"1159","author":"Dmitrieva","year":"2020","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jchromb.2026.124930_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.105553","article-title":"Urinary steroidomic profiles by LC-MS\/MS to monitor classic 21-hydroxylase deficiency","volume":"198","author":"Pussard","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jchromb.2026.124930_bb0140","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1515\/cclm-2023-0250","article-title":"A novel LC-MS\/MS-based assay for the simultaneous quantification of aldosterone-related steroids in human urine","volume":"62","author":"Vogg","year":"2024","journal-title":"Clinical Chemistry and Laboratory Medicine (CCLM)"},{"key":"10.1016\/j.jchromb.2026.124930_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461231","article-title":"Steroid profiling in urine of intact glucuronidated and sulfated steroids using liquid chromatography-mass spectrometry","volume":"1624","author":"De Wilde","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jchromb.2026.124930_bb0150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.aca.2013.09.034","article-title":"Steroid and steroid glucuronide profiles in urine during pregnancy determined by liquid chromatography-electrospray ionization-tandem mass spectrometry","volume":"802","author":"Jantti","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jchromb.2026.124930_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24580","article-title":"A dilute-and-shoot liquid chromatography\u2013tandem mass spectrometry method for urinary 18-hydroxycortisol quantification and its application in establishing reference intervals","volume":"36","author":"Zhao","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.jchromb.2026.124930_bb0160","first-page":"63","article-title":"Urine aldosterone and urine aldsterone-to-active-renin ratio in the diagnosis of primary aldosteronism, Chin","volume":"22","author":"Zeng","year":"2014","journal-title":"J. Hypertens."},{"key":"10.1016\/j.jchromb.2026.124930_bb0165","first-page":"4125","article-title":"Value of 24-hour urinary aldosterone in diagnosis and classification of primary hyperaldosteronism","volume":"104","author":"Zhang","year":"2024","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.jchromb.2026.124930_bb0170","first-page":"261","article-title":"Clinical utility value of urinary aldosterone detection by tandem mass spectrometry in primary hyperaldosteronism screening, Chin","volume":"43","author":"Ma","year":"2020","journal-title":"J Lab Med"},{"key":"10.1016\/j.jchromb.2026.124930_bb0175","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/CM9.0000000000001906","article-title":"Diagnostic value of aldosterone to renin ratio calculated by plasma renin activity or plasma renin concentration in primary aldosteronism: a meta-analysis","volume":"135","author":"Liu","year":"2022","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jchromb.2026.124930_bb0180","doi-asserted-by":"crossref","first-page":"E340","DOI":"10.1210\/jc.2010-1355","article-title":"Are women more at Risk of false-positive primary aldosteronism screening and unnecessary suppression testing than men?","volume":"96","author":"Ahmed","year":"2011","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.jchromb.2026.124930_bb0185","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1210\/jc.2011-1565","article-title":"Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal Tumors","volume":"96","author":"Arlt","year":"2011","journal-title":"J. Clin. Endocrinol. Metabol."}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157002322600019X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S157002322600019X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:46:45Z","timestamp":1775386005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S157002322600019X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":36,"alternative-id":["S157002322600019X"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.124930","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquid chromatography-tandem mass spectrometry-based urinary steroid profiling applied to primary aldosteronism diagnosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.124930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124930"}}