{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:46:03Z","timestamp":1775389563170,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003807","name":"People's Government of Jilin Province","doi-asserted-by":"publisher","award":["2024A143"],"award-info":[{"award-number":["2024A143"]}],"id":[{"id":"10.13039\/501100003807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003807","name":"People's Government of Jilin Province","doi-asserted-by":"publisher","award":["[2023]96"],"award-info":[{"award-number":["[2023]96"]}],"id":[{"id":"10.13039\/501100003807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Chromatography B"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jchromb.2026.124955","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:00:08Z","timestamp":1770480008000},"page":"124955","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Study on the improvement of cough variant asthma by the Tongfu Zhike formula via the TLR4\/MyD88\/NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"1273","author":[{"given":"Zhen","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikai","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jchromb.2026.124955_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2023.04.017","article-title":"Identification of cough-variant asthma phenotypes based on clinical and pathophysiologic data","volume":"152","author":"Zhan","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jchromb.2026.124955_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.987887","article-title":"Prediction of bronchodilation test in adults with chronic cough suspected of cough variant asthma","volume":"9","author":"Hao","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.jchromb.2026.124955_bb0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2147\/JAA.S452097","article-title":"Bibliometric analysis of cough variant asthma from 1993 to 2022","volume":"17","author":"Zhu","year":"2024","journal-title":"J. Asthma Allergy."},{"key":"10.1016\/j.jchromb.2026.124955_bb0020","doi-asserted-by":"crossref","unstructured":"Wang C, Xu J, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China pulmonary health [CPH] study): a national cross-sectional study. The Lancet Journal. 2018;391(10131):1706\u20131717.","DOI":"10.1016\/S0140-6736(18)30841-9"},{"key":"10.1016\/j.jchromb.2026.124955_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.720538","article-title":"Airway sensory nerve plasticity in asthma and chronic cough","volume":"12","author":"Drake","year":"2021","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.jchromb.2026.124955_bb0030","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S2213-2600(23)00187-X","article-title":"Cough and cough hypersensitivity as treatable traits of asthma","volume":"11","author":"Lai","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.jchromb.2026.124955_bb0035","doi-asserted-by":"crossref","unstructured":"Jin L, Gong H, Zhang Q. The clinical differences between cough variant asthma cells and humoral immunology indicators. Cellular and Molecular Biology by CMB Association. 2022;68(4):188\u2013193, Cell. Mol. Biol.","DOI":"10.14715\/cmb\/2022.68.4.22"},{"key":"10.1016\/j.jchromb.2026.124955_bb0040","doi-asserted-by":"crossref","unstructured":"Chen ZA-O, Jin K, Huang K, et al. Sputum metabolomic signature and dynamic change of cough variant asthma. Am. J. Respir. Cell Mol. Biol. 2025;72(3):285\u2013296.","DOI":"10.1165\/rcmb.2024-0219OC"},{"issue":"4","key":"10.1016\/j.jchromb.2026.124955_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042449","article-title":"Microbiota alterations in lung, ileum, and colon of Guinea pigs with cough variant asthma","volume":"25","author":"Dou","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jchromb.2026.124955_bb0050","doi-asserted-by":"crossref","first-page":"1699429","DOI":"10.1155\/2022\/1699429","article-title":"Suhuang antitussive capsule ameliorates corticosteroid insensitivity in cough variant asthma Guinea pigs by inhibiting p38 MAPK signal pathway","volume":"2022","author":"Lyu","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"11","key":"10.1016\/j.jchromb.2026.124955_bb0055","first-page":"1939","article-title":"Pediatric chronic cough: allergies, environmental factors, and asthma-associated inflammation","volume":"62","author":"Zheng","year":"2025","journal-title":"Journal of Asthma and Allergy"},{"key":"10.1016\/j.jchromb.2026.124955_bb0060","doi-asserted-by":"crossref","unstructured":"Lou NA-O, Ma XA-O, Luo Q, et al. Retrospective, observational study of different medication regimens and outcome in children with cough variant asthma. Immunity Inflamm. Dis. 2024;12(8):e1357.","DOI":"10.1002\/iid3.1357"},{"key":"10.1016\/j.jchromb.2026.124955_bb0065","doi-asserted-by":"crossref","unstructured":"Turner RA-O, Birring SS. Chronic cough as a disease. LID - 00459-2024 [pii] LID - https:\/\/doi.org\/10.1183\/23120541.00459-2024 [doi]. Header ERS Logo. 2024;10(6):00459\u201302024.","DOI":"10.1183\/23120541.00459-2024"},{"key":"10.1016\/j.jchromb.2026.124955_bb0070","doi-asserted-by":"crossref","unstructured":"Jayasooriya SM, Devereux G, Soriano JB, et al. Asthma: epidemiology, risk factors, and opportunities for prevention and treatment. Lancet Respir. Med. 2025;13(8):725\u2013738.","DOI":"10.1016\/S2213-2600(24)00383-7"},{"key":"10.1016\/j.jchromb.2026.124955_bb0075","doi-asserted-by":"crossref","first-page":"1698571","DOI":"10.1155\/2022\/1698571","article-title":"Exploration in the mechanism of Zhisou San for the treatment of cough variant asthma based on network pharmacology","volume":"2022","author":"Guo","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jchromb.2026.124955_bb0080","doi-asserted-by":"crossref","unstructured":"Xia QA-O, Liu M, Li H, Tian LA-O, Qi JA-O, Zhang YA-O. Network pharmacology strategy to investigate the pharmacological mechanism of HuangQiXiXin decoction on cough variant asthma and evidence-based medicine approach validation. Evid. Based Complement. Alternat. Med. 2020;2020:3829092.","DOI":"10.1155\/2020\/3829092"},{"issue":"1","key":"10.1016\/j.jchromb.2026.124955_bb0085","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12890-025-03478-3","article-title":"Development and validation of a nomogram for predicting cough variant asthma diagnosis","volume":"25","author":"Min","year":"2025","journal-title":"BMC Pulm. Med."},{"issue":"3","key":"10.1016\/j.jchromb.2026.124955_bb0090","doi-asserted-by":"crossref","first-page":"98","DOI":"10.26442\/00403660.2020.03.000404","article-title":"The cough variant asthma","volume":"92","author":"Uryasjev","year":"2020","journal-title":"Therapeutic archive"},{"key":"10.1016\/j.jchromb.2026.124955_bb0095","article-title":"Outsourcing covid-19 vaccination to the private sector will increase health inequalities","volume":"382","author":"Altmann","year":"2012","journal-title":"The BMJ."},{"key":"10.1016\/j.jchromb.2026.124955_bb0100","doi-asserted-by":"crossref","unstructured":"Hoskinson C, Petersen C, Turvey SE. How the early life microbiome shapes immune programming in childhood asthma and allergies. Society for Mucosal Immunology 2025;18(1):26\u201335.","DOI":"10.1016\/j.mucimm.2024.12.005"},{"key":"10.1016\/j.jchromb.2026.124955_bb0105","doi-asserted-by":"crossref","unstructured":"Liu C, Makrinioti H, Saglani S, et al. Microbial dysbiosis and childhood asthma development: integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response. Front. Immunol. 2022;13:1028209.","DOI":"10.3389\/fimmu.2022.1028209"},{"key":"10.1016\/j.jchromb.2026.124955_bb0110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fped.2018.00197","article-title":"The prebiotic and probiotic properties of human Milk: implications for infant immune development and Pediatric asthma","volume":"6","author":"Moossavi","year":"2018","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.jchromb.2026.124955_bb0115","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2014.14036","article-title":"Childhood asthma: causes, risks, and protective factors; a role of innate immunity","volume":"144","author":"Noutsios","year":"2014","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.jchromb.2026.124955_bb0120","first-page":"118","article-title":"Understanding the immunology of asthma: pathophysiology, biomarkers, and treatments for asthma endotypes","volume":"36","author":"Gans","year":"2019","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.jchromb.2026.124955_bb0125","article-title":"IL-4\/IL-13 axis as therapeutic targets in allergic rhinitis and asthma","volume":"10","author":"Nur Husna","year":"2022","journal-title":"PeerJ Journals."},{"issue":"9","key":"10.1016\/j.jchromb.2026.124955_bb0130","article-title":"Stunting as a risk factor for asthma: the role of vitamin D, leptin, IL-4, and CD23","volume":"58","author":"Sapartini","year":"2022","journal-title":"Medicina (Kaunas)."},{"issue":"1","key":"10.1016\/j.jchromb.2026.124955_bb0135","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12979-023-00383-3","article-title":"Toll-like receptor 4 (TLR4): new insight immune and aging","volume":"20","author":"Kim","year":"2023","journal-title":"Immun. Ageing"},{"issue":"2","key":"10.1016\/j.jchromb.2026.124955_bb0140","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1538\/expanim.23-0068","article-title":"Lonicerin alleviates ovalbumin-induced asthma of mice via inhibiting enhancer of zeste homolog 2\/nuclear factor-kappa B signaling pathway","volume":"73","author":"Dai","year":"2024","journal-title":"Exp. Anim."},{"key":"10.1016\/j.jchromb.2026.124955_bb0145","doi-asserted-by":"crossref","unstructured":"Lim JO, Kim WI, Pak SW, et al. Toll-like receptor 4 is a key regulator of asthma exacerbation caused by aluminum oxide nanoparticles via regulation of NF-\u03baB phosphorylation. J. Hazard. Mater. 2023;448:130884.","DOI":"10.1016\/j.jhazmat.2023.130884"},{"key":"10.1016\/j.jchromb.2026.124955_bb0150","doi-asserted-by":"crossref","unstructured":"Tang Y, Zhao Y, Guan Y, et al. Silencing TRIM8 alleviates allergic asthma and suppressing Th2 differentiation through inhibiting NF-\u03baB\/NLRP3 signaling pathway. Immunol. Lett. 2024;270:106923.","DOI":"10.1016\/j.imlet.2024.106923"},{"key":"10.1016\/j.jchromb.2026.124955_bb0155","doi-asserted-by":"crossref","unstructured":"Hammad H, Chieppa M Fau - Perros F, Perros F Fau - Willart MA, Willart Ma Fau - Germain RN, Germain Rn Fau - Lambrecht BN, Lambrecht BN. House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells. Nat. Med. 2009;15(4):410\u2013416.","DOI":"10.1038\/nm.1946"},{"key":"10.1016\/j.jchromb.2026.124955_bb0160","doi-asserted-by":"crossref","unstructured":"Si Z, Zhang B. Amygdalin attenuates airway epithelium apoptosis, inflammation, and epithelial-mesenchymal transition through restraining the TLR4\/NF-\u03baB signaling pathway on LPS-treated BEAS-2B bronchial epithelial cells. Logo of Journal International Archives of Allergy and Immunology. 2021;182(10):997\u20131007, Int. Arch. Allergy Immunol.","DOI":"10.1159\/000514209"},{"issue":"4","key":"10.1016\/j.jchromb.2026.124955_bb0165","first-page":"817","article-title":"Efficacy and safety of Suhuang Zhike capsule for cough variant asthma: a multicenter, single-arm, open-label phase IV real-world clinical trial","volume":"45","author":"Hongchun","year":"2025","journal-title":"J. Tradit. Chin. Med."},{"issue":"34","key":"10.1016\/j.jchromb.2026.124955_bb0170","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000043957","article-title":"Persistent cough due to cough variant asthma following upper respiratory tract infection treated by traditional Chinese medicine: a case report","volume":"104","author":"Li","year":"2025","journal-title":"Medicine"},{"key":"10.1016\/j.jchromb.2026.124955_bb0175","doi-asserted-by":"crossref","unstructured":"Lai KA-O, Peng W, Zhan WA-O, et al. Clinical characteristics in adult patients with somatic cough syndrome. Ther. Adv. Respir. Dis. 2022;16:17534666221092993.","DOI":"10.1177\/17534666221092993"},{"key":"10.1016\/j.jchromb.2026.124955_bb0180","doi-asserted-by":"crossref","unstructured":"Zhan W, Wu F, Zhang Y, et al. Identification of cough-variant asthma phenotypes based on clinical and pathophysiologic data. J. Allergy Clin. Immunol. 2023;152(3):622\u2013632.","DOI":"10.1016\/j.jaci.2023.04.017"},{"issue":"1","key":"10.1016\/j.jchromb.2026.124955_bb0185","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01136-2019","article-title":"ERS guidelines on the diagnosis and treatment of chronic cough in adults and children","volume":"55","author":"Morice","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jchromb.2026.124955_bb0190","doi-asserted-by":"crossref","unstructured":"Cao C, Li W, Hua W, et al. Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma. J. Transl. Med. 2017;15(1):171.","DOI":"10.1186\/s12967-017-1264-y"},{"issue":"7","key":"10.1016\/j.jchromb.2026.124955_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/cells12071091","article-title":"Asthma: the use of animal models and their translational utility","volume":"12","author":"Woodrow","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jchromb.2026.124955_bb0200","doi-asserted-by":"crossref","unstructured":"Kips JC, Anderson Gp Fau - Fredberg JJ, Fredberg Jj Fau - Herz U, et al. Murine models of asthma. ERS Publ. 2003;22(2):374\u2013382.","DOI":"10.1183\/09031936.03.00026403"},{"issue":"4","key":"10.1016\/j.jchromb.2026.124955_bb0205","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1378\/chest.129.4.1068","article-title":"Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation","volume":"129","author":"Bergeron","year":"2006","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.jchromb.2026.124955_bb0210","first-page":"454","article-title":"Targeting cytokines to treat asthma and chronic obstructive pulmonary disease. Targeting cytokines to treat asthma and chronic obstructive pulmonary disease","volume":"18","author":"Barnes","year":"2018"},{"key":"10.1016\/j.jchromb.2026.124955_bb0215","doi-asserted-by":"crossref","unstructured":"Chung KF, Pavord ID. Prevalence, pathogenesis, and causes of chronic cough. Lancet Journal. 2008;371(9621):1364\u20131374.","DOI":"10.1016\/S0140-6736(08)60595-4"}],"container-title":["Journal of Chromatography B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226000449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570023226000449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:46:58Z","timestamp":1775386018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570023226000449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S1570023226000449"],"URL":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.124955","relation":{},"ISSN":["1570-0232"],"issn-type":[{"value":"1570-0232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the improvement of cough variant asthma by the Tongfu Zhike formula via the TLR4\/MyD88\/NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Chromatography B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jchromb.2026.124955","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124955"}}